Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GRIA3 2892 CX1739 CHEMBL3707399 positive allosteric modulator ChemblInteractions
GRIA3 2892 BECAMPANEL CHEMBL2107735 antagonist ChemblInteractions
GRIA3 2892 MIBAMPATOR CHEMBL1277001 positive allosteric modulator ChemblInteractions
GRIA3 2892 ZONAMPANEL CHEMBL119625 antagonist ChemblInteractions
GRIA3 2892 TOPIRAMATE CHEMBL220492 antagonist ChemblInteractions
GRIA3 2892 L-GLUTAMATE CHEMBL575060 DrugBank 17139284, 17016423, 7679210
GRIA3 2892 TEZAMPANEL CHEMBL14935 antagonist TdgClinicalTrial, ChemblInteractions
GRIA3 2892 Selurampanel CHEMBL3545042 antagonist TdgClinicalTrial, ChemblInteractions
GRIA3 2892 IRAMPANEL CHEMBL29741 antagonist ChemblInteractions
GRIA3 2892 MK-8777 CHEMBL3707401 positive allosteric modulator ChemblInteractions
GRIA3 2892 FARAMPATOR CHEMBL1276138 positive allosteric modulator ChemblInteractions
GRIA3 2892 ANIRACETAM CHEMBL36994 DrugBank 10592235
GRIA3 2892 DASOLAMPANEL CHEMBL2103869 antagonist ChemblInteractions
GRIA3 2892 PERAMPANEL CHEMBL1214124 antagonist TdgClinicalTrial, ChemblInteractions
GRIA3 2892 PF-04958242 CHEMBL3707379 positive allosteric modulator ChemblInteractions
GRIA3 2892 TALAMPANEL CHEMBL61872 TdgClinicalTrial, DrugBank 12581229, 17199027, 16861112
GRIA3 2892 PHENOBARBITAL CHEMBL40 NCI 8786535

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GRIA3 rs3761554 TT Selective serotonin reuptake inhibitors efficacy yes Regression model looking at interaction between genetic and environemental factors. The TT genotype with nLES high adversity was associated with non-response, compared to the CC/CT genotype and nLES low adversity. Please note; in the paper this SNP was reported with A and G alleles - here we use T and C to represent these. nLES = life event scale. Genotype TT is associated with decreased response to Selective serotonin reuptake inhibitors or venlafaxine in people with Depressive Disorder, Major as compared to genotypes CC + CT. 23394390 982030375
GRIA3 rs502434 CC Selective serotonin reuptake inhibitors efficacy yes Regression model looking at interaction between genetic and environemental factors. The CC genotype with CTQ-SF high adversity was associated with non-response, compared to the TT/TC genotype and CTQ-SF low adversity. Please note; in the paper this SNP was reported with A and G alleles - here we use T and C to represent these. CTQ-SF = childhood trauma questionaire 28-item short form. Genotype CC is associated with decreased response to Selective serotonin reuptake inhibitors or venlafaxine in people with Depressive Disorder, Major as compared to genotypes CT + TT. 23394390 982030355
GRIA3 rs3761555 TT Selective serotonin reuptake inhibitors efficacy yes Regression model looking at interaction between genetic and environemental factors. The TT genotype with nLES high adversity was associated with non-response, compared to the CC/CT genotype and nLES low adversity. Please note; in the paper this SNP was reported with A and G alleles - here we use T and C to represent these. nLES = life event scale. Genotype TT is associated with decreased response to Selective serotonin reuptake inhibitors or venlafaxine in people with Depressive Disorder, Major as compared to genotypes CC + CT. 23394390 982030363