PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GRIK2	4	PICK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003), Laezza F (2008)	4
GRIA1	5	PICK1	2	pull down	Hirbec H (2002)	1
GRIA2	4	MYO5A	17	affinity chromatography technology, affinity chromatography technology	Correia SS (2008), Correia SS (2008)	2
GRIK2	4	GRIP1	1	pull down	Hirbec H (2003)	1
GRIA1	5	MYO5A	17	affinity chromatography technology	Correia SS (2008)	1
GRIA2	4	TSPYL2	4	affinity chromatography technology	Hein MY (2015)	1
AGAP2	14	GRIP1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Chan CB (2011), Chan CB (2011), Chan CB (2011), Chan CB (2011), Chan CB (2011)	5
GRIA2	4	NDUFV3	2	affinity chromatography technology	Hein MY (2015)	1
HAX1	1	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRIA2	4	SDCBP	0	pull down	Hirbec H (2002)	1
GRIA1	5	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
DLG4	11	GRIA2	4	affinity chromatography technology	Fukata Y (2006)	1
GRIA2	4	KCNAB2	3	affinity chromatography technology	Hein MY (2015)	1
GRIA2	4	GRID2	5	affinity chromatography technology	Kohda K (2003)	1
GRIA2	4	GAPDH	0	affinity chromatography technology, affinity chromatography technology, pull down	Wang M (2012), Wang M (2012), Wang M (2012)	3
GRIA1	5	GRIP1	1	pull down	Hirbec H (2002)	1
REST	3	GRIA2	4	affinity chromatography technology	Ekici M (2012)	1
GRIA1	5	SDCBP	0	pull down	Hirbec H (2002)	1
SPTBN1	6	GRIA2	4	far western blotting	Hirai H (1999)	1
GRIP1	1	GRIA2	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hirbec H (2002), Hirbec H (2002), Correia SS (2008), Chan CB (2011), Chan CB (2011)	5
CACNG2	0	GRIA1	5	affinity chromatography technology	Chen L (2001)	1
DGUOK	1	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GRIA2	4	ATP5F1	0	affinity chromatography technology	Hein MY (2015)	1
PICK1	2	GRIA2	4	two hybrid, pull down, pull down	Hirbec H (2002), Hirbec H (2002), Dutta P (2014)	3
GRIA1	5	RAB11A	4	affinity chromatography technology	Correia SS (2008)	1
GRIK2	4	GRIA1	5	affinity chromatography technology	Wenthold RJ (1994)	1
SPTAN1	9	SPTBN1	6	biochemical, pull down, biochemical, two hybrid	Havugimana PC (2012), Bignone PA (2003), Wan C (2015), Oh Y (2007)	4
GRIA2	4	DPP9	4	affinity chromatography technology	Hein MY (2015)	1
GRIA2	4	GTF3C2	2	two hybrid	Wang J (2011)	1
GRIA2	4	TRMT6	0	affinity chromatography technology	Hein MY (2015)	1
NUFIP1	0	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CACNG2	0	GRIA2	4	affinity chromatography technology	Chen L (2001)	1
GRIK2	4	SDCBP	0	two hybrid, pull down, affinity chromatography technology	Hirbec H (2003), Hirbec H (2003), Hirbec H (2003)	3
GRIA2	4	TXNL4A	0	affinity chromatography technology	Hein MY (2015)	1
GRIK2	4	GRIA2	4	affinity chromatography technology	Wenthold RJ (1994)	1
GRIA1	5	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Leuschner WD (1999), Correia SS (2008)	2
GRIA2	4	RAB11A	4	affinity chromatography technology	Correia SS (2008)	1
GRIK2	4	DLG4	11	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Hirbec H (2003), Hirbec H (2003), Mehta S (2001), Garcia EP (1998), Garcia EP (1998), Piserchio A (2002)	6
CACNG2	0	DLG4	11	affinity chromatography technology, biochemical, affinity chromatography technology	Chen L (2001), Chen L (2001), Choi J (2002)	3
GRIA2	4	POM121	5	affinity chromatography technology	Hein MY (2015)	1
GRIA2	4	SPTAN1	9	far western blotting, far western blotting, affinity chromatography technology	Hirai H (1999), Hirai H (1999), Hirai H (1999)	3
GRIA2	4	ECD	3	affinity chromatography technology	Hein MY (2015)	1
GRIK2	4	GRID2	5	affinity chromatography technology, affinity chromatography technology	Kohda K (2003), Kohda K (2003)	2
DNAAF2	2	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AGAP2	14	GRIA2	4	affinity chromatography technology, affinity chromatography technology	Chan CB (2011), Chan CB (2011)	2
GRIA2	4	NCOA4	4	affinity chromatography technology	Hein MY (2015)	1