Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
GRK5	2869	VERAPAMIL	CHEMBL6966		PharmGKB
GRK5	2869	ATENOLOL	CHEMBL24		PharmGKB
GRK5	2869	TRANDOLAPRIL	CHEMBL1519		PharmGKB
GRK5	2869	HYDROCHLOROTHIAZIDE	CHEMBL435		PharmGKB

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
GRK5	rs2230345	AA	atenolol	efficacy	no	Subjects performed exercise on a supine bicycle ergometer. No differences between genotypes were seen for change in heart rate at rest, heart rate at maximal exercise, or heart rate area under the curve (AUC) after atenolol administration.	Genotype AA is not associated with response to atenolol in healthy individuals as compared to genotypes AT + TT.	19842931	1183615604
GRK5	rs2230345	AA + AT	Beta Blocking Agents	efficacy	not stated	P value is comparing with and without drug, not genotypes. When not treated with beta blockers patients with GRK-Q41 have increased risk of death or transplantation compared to patients with GRK-L41. When treated with beta blockers patients with GRK-Q41 showed improvements with beta blockers that brought the Kaplan Meier curve up to the same as that for GRK-L41. When treated with beta blockers patients with the GRK-L41 (TT) did not show any change in outcome.	Genotypes AA + AT are associated with response to Beta Blocking Agents in people with Heart Failure as compared to genotype TT.	18425130	827864486