Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
TREML4 rs9369266 A duloxetine efficacy yes Variant was suggestively significant, but did not reach genome-wide significance. Variant was associated with an decreased likelihood of the patient entering remission, as defined by a score of 10 or more on the Montgomery-Asberg Depression Rating Scale (MADRS) score at the end of treatment. Allele A is associated with decreased response to duloxetine in people with Depressive Disorder, Major as compared to allele G. 29407288 1449168143
TREML4 rs13204353 G duloxetine efficacy yes Variant was suggestively significant, but did not reach genome-wide significance. Variant was associated with an decreased likelihood of the patient entering remission, as defined by a score of 10 or more on the Montgomery-Asberg Depression Rating Scale (MADRS) score at the end of treatment. Allele G is associated with decreased response to duloxetine in people with Depressive Disorder, Major as compared to allele A. 29407288 1449168137