PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CEP120	5	MED4	2	bioid	Gupta GD (2015)	1
LCA5	1	CEP120	5	bioid	Gupta GD (2015)	1
LCA5	1	CCDC66	2	bioid	Gupta GD (2015)	1
CEP104	4	CEP162	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP89	2	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
LCA5	1	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
PCM1	5	CEP120	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP120	5	bioid	Gupta GD (2015)	1
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP120	5	CCDC66	2	bioid	Gupta GD (2015)	1
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
CEP104	4	CCDC66	2	bioid	Gupta GD (2015)	1
LCA5	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP162	3	CCDC66	2	bioid	Gupta GD (2015)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	CCDC66	2	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
SPICE1	2	CCDC66	2	bioid	Gupta GD (2015)	1
NINL	1	CEP162	3	bioid	Gupta GD (2015)	1
CEP162	3	CEP120	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
POC1A	3	CCDC66	2	bioid	Gupta GD (2015)	1
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
MED4	2	CCDC66	2	bioid	Lambert JP (2015)	1
PCM1	5	CCDC66	2	bioid	Gupta GD (2015)	1
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
NINL	1	PCM1	5	bioid	Gupta GD (2015)	1
CEP63	2	CCDC66	2	bioid	Gupta GD (2015)	1
PCM1	5	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
ODF2	1	CEP120	5	bioid	Gupta GD (2015)	1
LCA5	1	MED4	2	bioid	Gupta GD (2015)	1
NINL	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP162	3	CEP89	2	bioid	Gupta GD (2015)	1
CEP89	2	CCDC66	2	bioid	Gupta GD (2015)	1
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CCDC66	2	bioid	Gupta GD (2015)	1
NINL	1	CCDC66	2	bioid	Gupta GD (2015)	1
CEP120	5	SPICE1	2	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	3
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
MED4	2	CEP162	3	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
ODF2	1	CCDC66	2	bioid	Gupta GD (2015)	1
CEP128	1	ODF2	1	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CEP135	2	CEP120	5	bioid	Gupta GD (2015)	1
CEP104	4	PCM1	5	bioid	Gupta GD (2015)	1
MED4	2	ODF2	1	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2