PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NEK8	3	RPAP3	1	bioid	Gupta GD (2015)	1
TCF4	26	NEK8	3	two hybrid	Rolland T (2014)	1
NEK9	1	NEK7	0	enzymatic study, affinity chromatography technology, affinity chromatography technology	Belham C (2003), Behrends C (2010), Boldt K (2016)	3
HSP90AA1	7	HSPA1L	2	affinity chromatography technology	Gano JJ (2010)	1
EGFR	5	MOB4	0	protein complementation assay	Deribe YL (2009)	1
EGFR	5	STIP1	1	protein complementation assay	Deribe YL (2009)	1
CDC37	0	UNC45A	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
EGFR	5	HSPA1B	1	imaging technique	Chen TC (2014)	1
NEK8	3	UNC45A	1	bioid	Gupta GD (2015)	1
EGFR	5	FKBP4	0	protein complementation assay	Deribe YL (2009)	1
NUDCD2	2	TTC1	3	biochemical	Havugimana PC (2012)	1
NEK8	3	CDKAL1	2	bioid	Gupta GD (2015)	1
NEK8	3	HSPA6	1	bioid	Gupta GD (2015)	1
NEK8	3	FKBP4	0	bioid	Gupta GD (2015)	1
HSP90AA1	7	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gano JJ (2010), Skarra DV (2011), Taipale M (2014), Taipale M (2014)	4
NEK9	1	NEK8	3	enzymatic study	Holland PM (2002)	1
EGFR	5	AIP	1	protein complementation assay	Deribe YL (2009)	1
EGFR	5	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay	Citri A (2002), Yang S (2006), Shimamura T (2005), Lavictoire SJ (2003), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014)	8
SUGT1	1	AIP	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
TTC1	3	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
RPAP3	1	SUGT1	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AA1	7	SUGT1	1	pull down, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Zhang M (2008), Lee YT (2004), Lee YT (2004), Mayor A (2007), Spiechowicz M (2007), Spiechowicz M (2007), Gano JJ (2010), Niikura Y (2006), Niikura Y (2006), Niikura Y (2006), Liu XS (2012), Goral A (2016), Goral A (2016)	13
HSP90AA1	7	HSPA1B	1	affinity chromatography technology, affinity chromatography technology	Skarra DV (2011), Woodford MR (2016)	2
HSP90AA1	7	TUBA1A	13	affinity chromatography technology, affinity chromatography technology	Hu Y (2003), Skarra DV (2011)	2
NEK8	3	STIP1	1	bioid	Gupta GD (2015)	1
UBC	7	MTR	4	affinity chromatography technology	Matsumoto M (2005)	1
NEK7	0	NEK8	3	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	NUDCD3	0	affinity chromatography technology	Gano JJ (2010)	1
FKBP4	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Li J (2011), Esposito V (2012), Schuelke JP (2010), Gano JJ (2010), Skarra DV (2011), Shimamoto S (2010), Shimamoto S (2010), Kristensen AR (2012), Taipale M (2014), Taipale M (2014), Graumann K (2000), Graumann K (2000), Sun L (2012), Huttlin EL (2017)	14
NEK8	3	HSPA1L	2	bioid	Gupta GD (2015)	1
CDC37	0	FKBP4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
NEK8	3	CDC37	0	bioid	Gupta GD (2015)	1
NEK8	3	UXT	0	bioid	Gupta GD (2015)	1
RPAP3	1	PIH1D1	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Huttlin EL (2015), Inoue M (2010), Wan C (2015), Mir RA (2016), Huttlin EL (2017), Bizarro J (2014), Cloutier P (2017)	12
HSPA1B	1	STIP1	1	biochemical	Wan C (2015)	1
CDC37	0	RPAP3	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
NEK8	3	ANKS6	1	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
HSP90AA1	7	NEK8	3	affinity chromatography technology	Taipale M (2012)	1
HSP90AA1	7	UNC45A	1	affinity chromatography technology, pull down, two hybrid	Gano JJ (2010), Chadli A (2008), Gomez-Escalante S (2016)	3
HSP90AA1	7	NEK9	1	affinity chromatography technology, affinity chromatography technology	Taipale M (2012), Taipale M (2012)	2
ANKS3	5	NEK7	0	affinity chromatography technology	Boldt K (2016)	1
NEK8	3	TTC4	1	bioid	Gupta GD (2015)	1
HSP90AA1	7	CACYBP	0	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Gano JJ (2010), Goral A (2016), Goral A (2016), Goral A (2016)	4
NEK8	3	CACYBP	0	bioid	Gupta GD (2015)	1
FKBP4	0	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AA1	7	HSPA6	1	affinity chromatography technology	Gano JJ (2010)	1
AIP	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Li J (2011), Schuelke JP (2010), Taipale M (2014), Taipale M (2014), Kazlauskas A (2000)	5
AIP	1	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
NEK8	3	MOB4	0	bioid	Gupta GD (2015)	1
RPAP3	1	HSPA6	1	affinity chromatography technology	Jeronimo C (2007)	1
UBC	7	NEK8	3	pull down	Nathan JA (2013)	1
ANKS6	1	NEK7	0	affinity chromatography technology	Boldt K (2016)	1
PIH1D1	0	UXT	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPAP3	1	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
CDC37	0	TTC4	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
EGFR	5	TUBA1A	13	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
NUDC	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Zhu XJ (2010), Gano JJ (2010)	2
NEK8	3	MTR	4	bioid	Gupta GD (2015)	1
NEK8	3	SUGT1	1	bioid	Gupta GD (2015)	1
HSP90AA1	7	PIH1D1	0	affinity chromatography technology	Gano JJ (2010)	1
NUDCD2	2	HSP90AA1	7	affinity chromatography technology	Yang Y (2010)	1
FKBP4	0	STIP1	1	pull down	Li J (2011)	1
NEK8	3	TUBA1A	13	bioid	Gupta GD (2015)	1
NEK8	3	NUDCD3	0	bioid	Gupta GD (2015)	1
ANKS3	5	ANKS6	1	affinity chromatography technology	Boldt K (2016)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
NEK8	3	PIH1D1	0	bioid	Gupta GD (2015)	1
NEK8	3	NUDC	1	bioid	Gupta GD (2015)	1
RPAP3	1	UXT	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2009), Taipale M (2014), Taipale M (2014), Huttlin EL (2017)	5
HSP90AA1	7	RPAP3	1	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Gano JJ (2010), Skarra DV (2011), Pal M (2014), Pal M (2014), Pal M (2014)	5
NEK8	3	HSPA1B	1	bioid	Gupta GD (2015)	1
EGFR	5	CDC37	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Li J (2013)	4
STIP1	1	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Scheufler C (2000), Johnson BD (1998), Mollapour M (2010), Li J (2011), Kundrat L (2010), Tsutsumi S (2012), Sarkar S (2012), Gano JJ (2010), Skarra DV (2011), Horibe T (2011), Brinker A (2002), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Graumann K (2000), Hein MY (2015), Chadli A (2010), Chadli A (2008), Woodford MR (2016), Scholz GM (2001), Sun L (2012), Woodford MR (2016), Huttlin EL (2017)	23
HSPA1L	2	HSPA6	1	biochemical	Havugimana PC (2012)	1
NEK8	3	NUDCD2	2	bioid	Gupta GD (2015)	1
FKBP4	0	SUGT1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014), Taipale M (2014), Taipale M (2014)	4
HSP90AA1	7	CDC37	0	x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Roe SM (2004), Silverstein AM (1998), Mollapour M (2010), Basso AD (2002), Tsutsumi S (2012), De Nardo D (2005), Sarkar S (2012), Gano JJ (2010), Taipale M (2012), Skarra DV (2011), Zhang H (2004), Taipale M (2014), Taipale M (2014), Mollapour M (2014), Hein MY (2015), Hein MY (2015), Li J (2013), Woodford MR (2016), Shao J (2003), Scholz GM (2001), Sun L (2012), Sun L (2012), Woodford MR (2016), Synoradzki K (2015)	24
TRIM69	0	NEK8	3	two hybrid	Rolland T (2014)	1
ANKS3	5	NEK8	3	affinity chromatography technology	Boldt K (2016)	1
AIP	1	STIP1	1	pull down	Li J (2011)	1
SUGT1	1	CACYBP	0	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
HSP90AA1	7	TTC1	3	affinity chromatography technology	Hein MY (2015)	1
NEK8	3	AIP	1	bioid	Gupta GD (2015)	1
NEK8	3	TTC1	3	bioid	Gupta GD (2015)	1
TUBA1A	13	UBC	7	affinity chromatography technology	Seiberlich V (2012)	1
EGFR	5	NEK8	3	affinity chromatography technology	Yao Z (2017)	1