PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USHBP1	1	KANSL1	11	two hybrid	Rual JF (2005)	1
TRIM25	5	KANSL1	11	affinity chromatography technology	Choudhury NR (2017)	1
WDR5	2	MCRS1	1	affinity chromatography technology	Hauri S (2016)	1
RBBP5	3	KANSL1	11	affinity chromatography technology	Shi L (2011)	1
GOLGA2	2	KIFC3	3	two hybrid	Rolland T (2014)	1
ECI2	2	KDM1A	2	two hybrid	Weimann M (2013)	1
KRT15	2	USHBP1	1	two hybrid	Rual JF (2005)	1
NINL	1	TPM2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	OGT	4	affinity chromatography technology	Choudhury NR (2017)	1
PHF20L1	4	KDM1A	2	two hybrid	Weimann M (2013)	1
KANSL1	11	MDFI	1	two hybrid	Yu H (2011)	1
EXOC1	3	KANSL1	11	two hybrid	Camargo LM (2007)	1
DISC1	6	KANSL1	11	two hybrid	Camargo LM (2007)	1
MCRS1	1	CCDC85B	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Du X (2006), Du X (2006)	3
OGT	4	MCRS1	1	affinity chromatography technology	Hauri S (2016)	1
CEP70	1	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KANSL1	11	PHF20	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF1	0	ECI2	2	affinity chromatography technology, affinity chromatography technology	Greenfeld H (2015), Huttlin EL (2017)	2
DHX8	3	CDC5L	2	affinity chromatography technology	Huttlin EL (2015)	1
CDC5L	2	GOLGA2	2	two hybrid	Rolland T (2014)	1
KANSL1	11	TPM2	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM27	2	DTNBP1	1	two hybrid	Rolland T (2014)	1
KANSL1	11	TRAF1	0	affinity chromatography technology	Huttlin EL (2017)	1
KANSL1	11	KAT8	2	affinity chromatography technology, affinity chromatography technology, pull down	Li X (2009), Smith ER (2005), Kadlec J (2011)	3
OGT	4	WDR5	2	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
KANSL1	11	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Li X (2009), Huttlin EL (2015), Dias J (2014), Dias J (2014), Dias J (2014), Huttlin EL (2017), Hauri S (2016)	7
DISC1	6	TFIP11	5	two hybrid	Camargo LM (2007)	1
NECAB2	1	KDM1A	2	two hybrid	Weimann M (2013)	1
KIFC3	3	CCDC136	1	two hybrid	Rolland T (2014)	1
CCDC136	1	CCDC85B	0	affinity chromatography technology	Huttlin EL (2017)	1
DHX8	3	KANSL1	11	biochemical	Havugimana PC (2012)	1
PSME3	0	KANSL1	11	two hybrid	Rual JF (2005)	1
TRIM25	5	HSPB1	2	affinity chromatography technology	Choudhury NR (2017)	1
TRAF4	1	CALCOCO2	0	two hybrid	Rozan LM (2006)	1
KIFC3	3	NECAB2	1	two hybrid	Rolland T (2014)	1
TRIM25	5	KANSL2	6	affinity chromatography technology	Choudhury NR (2017)	1
FOXK2	9	MCRS1	1	affinity chromatography technology	Li X (2015)	1
KIFC3	3	KDM1A	2	two hybrid	Weimann M (2013)	1
TRIM25	5	PSME3	0	affinity chromatography technology	Choudhury NR (2017)	1
FOXK2	9	PHF20L1	4	affinity chromatography technology	Li X (2015)	1
DISC1	6	CDC5L	2	two hybrid	Camargo LM (2007)	1
KAT8	2	PHF20L1	4	affinity chromatography technology	Sharma GG (2010)	1
KANSL1	11	MCRS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CDR2	1	KIFC3	3	two hybrid	Rolland T (2014)	1
TRAF4	1	KDM1A	2	two hybrid	Weimann M (2013)	1
GOLGA2	2	KDM1A	2	two hybrid	Rolland T (2014)	1
KAT8	2	WDR5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dou Y (2005), Sharma GG (2010), Hauri S (2016)	3
TRIM25	5	FOXK2	9	affinity chromatography technology	Choudhury NR (2017)	1
FSD2	4	KANSL1	11	two hybrid	Rolland T (2014)	1
SMAD3	1	DHX8	3	affinity chromatography technology	Brown KA (2008)	1
TRIM25	5	HOOK2	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	PHF20	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	USHBP1	1	affinity chromatography technology	Choudhury NR (2017)	1
PHF20	1	MCRS1	1	affinity chromatography technology	Huttlin EL (2017)	1
CEP70	1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
PNMA1	0	KANSL1	11	two hybrid	Rolland T (2014)	1
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTCF	15	affinity chromatography technology	Choudhury NR (2017)	1
DISC1	6	CCDC136	1	two hybrid	Camargo LM (2007)	1
CTCF	15	KANSL1	11	biochemical	Havugimana PC (2012)	1
MCRS1	1	KDM1A	2	two hybrid	Weimann M (2013)	1
OGT	4	KANSL1	11	affinity chromatography technology	Hauri S (2016)	1
TRIM25	5	TPM2	2	affinity chromatography technology	Choudhury NR (2017)	1
OGT	4	KANSL2	6	affinity chromatography technology	Hauri S (2016)	1
KRT15	2	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NUP62	1	KANSL1	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TFIP11	5	KANSL1	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
WDR5	2	KANSL2	6	biochemical, pull down, affinity chromatography technology	Dias J (2014), Dias J (2014), Hauri S (2016)	3
SPAG5	1	KANSL1	11	two hybrid	Rolland T (2014)	1
GOLGA2	2	KANSL1	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
KIFC3	3	TRIM27	2	two hybrid	Rolland T (2014)	1
KAT8	2	PHF20	1	affinity chromatography technology, affinity chromatography technology	Sharma GG (2010), Huttlin EL (2017)	2
WDR5	2	PHF20	1	affinity chromatography technology	Hauri S (2016)	1
CDC5L	2	KDM1A	2	two hybrid	Camargo LM (2007)	1
NECAB2	1	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
TRAF2	1	TRAF4	1	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Zhang X (2013), Zhang X (2013), Zhang X (2013), Ren HY (2015)	4
CTCF	15	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down	Bergstroem R (2010), Bergstroem R (2010), Bergstroem R (2010)	3
CDC5L	2	EXOC1	3	two hybrid, two hybrid	Camargo LM (2007), Camargo LM (2007)	2
OGT	4	NUP62	1	enzymatic study, enzymatic study, two hybrid	Lazarus BD (2006), Lubas WA (2000), Yu H (2011)	3
MAGEA12	0	KANSL1	11	two hybrid	Rolland T (2014)	1
RBBP5	3	WDR5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yokoyama A (2004), Lee JH (2005), Higa LA (2006), Wysocka J (2005), Wysocka J (2005), Patel SR (2007), Cho YW (2007), Avdic V (2011), Avdic V (2011), Avdic V (2011), Mo R (2006), Gan Q (2011), Mak AB (2010), Mak AB (2010), Wu MZ (2011), Huttlin EL (2015), Bailey JK (2015), Huttlin EL (2017), Carugo A (2016), Hauri S (2016)	20
TRAF2	1	KANSL1	11	two hybrid	Rual JF (2005)	1
HOOK2	0	KANSL1	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
DTNBP1	1	SPAG5	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDC5L	2	HSPB1	2	affinity chromatography technology	Lleres D (2010)	1
SMAD3	1	KANSL1	11	two hybrid	Colland F (2004)	1
MCRS1	1	USHBP1	1	two hybrid	Rolland T (2014)	1
KIFC3	3	KANSL1	11	two hybrid	Rolland T (2014)	1
KANSL1	11	KANSL2	6	affinity chromatography technology	Huttlin EL (2017)	1
OGT	4	RBBP5	3	affinity chromatography technology	Hauri S (2016)	1
CCDC85B	0	KANSL1	11	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
KIFC3	3	TRAF2	1	two hybrid	Rolland T (2014)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
NINL	1	KANSL1	11	two hybrid	Rual JF (2005)	1
HSPB1	2	KANSL1	11	two hybrid	Katsogiannou M (2014)	1
NECAB2	1	USHBP1	1	two hybrid	Yu H (2011)	1
NUTM1	6	KANSL1	11	two hybrid	Rolland T (2014)	1
PHF20	1	KANSL2	6	affinity chromatography technology	Huttlin EL (2017)	1
CCDC85B	0	CEP70	1	two hybrid	Rual JF (2005)	1
CDC5L	2	KANSL1	11	two hybrid, affinity chromatography technology	Camargo LM (2007), Lleres D (2010)	2
KANSL1	11	KDM1A	2	two hybrid	Weimann M (2013)	1
EXOC1	3	KDM1A	2	two hybrid	Camargo LM (2007)	1
KAT8	2	MCRS1	1	affinity chromatography technology	Sharma GG (2010)	1
KAT8	2	RBBP5	3	affinity chromatography technology, affinity chromatography technology	Dou Y (2005), Dou Y (2005)	2
KANSL1	11	PHF20L1	4	affinity chromatography technology	Huttlin EL (2017)	1
KAT8	2	OGT	4	affinity chromatography technology	Sharma GG (2010)	1
FOXK2	9	KANSL2	6	affinity chromatography technology	Li X (2015)	1
CCDC136	1	KANSL1	11	two hybrid	Rolland T (2014)	1
PLEKHA5	2	KANSL1	11	two hybrid	Bandyopadhyay S (2010)	1
CDC5L	2	CCDC136	1	two hybrid	Camargo LM (2007)	1
DTNBP1	1	EXOC1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KANSL1	11	ECI2	2	affinity chromatography technology	Huttlin EL (2017)	1
FOXK2	9	KANSL1	11	affinity chromatography technology, affinity chromatography technology	Li X (2015), Huttlin EL (2017)	2
DTNBP1	1	KANSL1	11	two hybrid	Rolland T (2014)	1
KIFC3	3	KRT15	2	two hybrid	Rolland T (2014)	1
TRAF2	1	CALCOCO2	0	two hybrid	Rual JF (2005)	1
FOXK2	9	RBBP5	3	affinity chromatography technology	Li X (2015)	1
KIFC3	3	DTNBP1	1	two hybrid	Rolland T (2014)	1
CALCOCO2	0	KANSL1	11	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
DTNBP1	1	PSME3	0	two hybrid	Camargo LM (2007)	1
TRIM27	2	KANSL1	11	two hybrid	Rolland T (2014)	1
DISC1	6	EXOC1	3	two hybrid	Camargo LM (2007)	1
CDC5L	2	RBBP5	3	affinity chromatography technology	Lleres D (2010)	1
KANSL1	11	DUS2	4	affinity chromatography technology	Huttlin EL (2017)	1
CDR2	1	KANSL1	11	two hybrid	Rolland T (2014)	1
KIFC3	3	NUP62	1	two hybrid	Rolland T (2014)	1
TRIM25	5	DHX8	3	affinity chromatography technology	Choudhury NR (2017)	1
TRAF4	1	KANSL1	11	two hybrid	Rolland T (2014)	1