PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGLN3	0	CEP170B	10	affinity chromatography technology	Rodriguez J (2016)	1
DCTN1	6	CEP170B	10	bioid	Gupta GD (2015)	1
YWHAB	1	CEP170	4	affinity chromatography technology	Couzens AL (2013)	1
CNTRL	5	CEP170	4	bioid	Gupta GD (2015)	1
HNRNPL	3	CEP170	4	affinity chromatography technology	Fei T (2017)	1
LCA5	1	CEP170B	10	bioid	Gupta GD (2015)	1
CEP170B	10	KIAA0368	0	two hybrid	Gorbea C (2010)	1
KIF2B	2	CEP170	4	affinity chromatography technology	Huttlin EL (2017)	1
CEP128	1	CEP170	4	bioid	Gupta GD (2015)	1
LCA5	1	CEP170	4	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
KIF2A	3	CEP170B	10	affinity chromatography technology	Hein MY (2015)	1
TYK2	1	CEP170B	10	affinity chromatography technology	So J (2015)	1
LCA5	1	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	NINL	1	bioid	Gupta GD (2015)	1
SLMAP	3	OFD1	3	bioid	Couzens AL (2013)	1
HNRNPL	3	PRKAA2	1	affinity chromatography technology	Fei T (2017)	1
CEP128	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
EGLN3	0	CARM1	0	affinity chromatography technology	Rodriguez J (2016)	1
CEP170	4	CEP170B	10	affinity chromatography technology, bioid, affinity chromatography technology	Huttlin EL (2015), Gupta GD (2015), Huttlin EL (2017)	3
RPGRIP1L	2	CEP170B	10	affinity chromatography technology	Gupta GD (2015)	1
HNRNPL	3	TYK2	1	affinity chromatography technology	Fei T (2017)	1
DEFA5	1	CEP170B	10	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	CEP170	4	bioid	Gupta GD (2015)	1
PCGF6	0	CEP170B	10	affinity chromatography technology	Huttlin EL (2015)	1
CEP170	4	KIF2A	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CNTRL	5	RPGRIP1L	2	bioid	Gupta GD (2015)	1
EGLN3	0	KIF2A	3	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	CEP170B	10	affinity chromatography technology	Fei T (2017)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
RPGRIP1L	2	CEP170	4	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
KIAA0368	0	DCTN1	6	imaging technique	Gorbea C (2010)	1
NINL	1	CEP170B	10	bioid	Gupta GD (2015)	1
RPGRIP1L	2	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
LCA5	1	YWHAB	1	affinity chromatography technology	Gupta GD (2015)	1
CEP170B	10	CARM1	0	affinity chromatography technology	Huttlin EL (2017)	1
NINL	1	DCTN1	6	affinity chromatography technology	Boldt K (2016)	1
CEP170	4	DCTN1	6	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
EGLN3	0	DCTN1	6	affinity chromatography technology	Rodriguez J (2016)	1
OFD1	3	CEP170	4	bioid	Gupta GD (2015)	1
NINL	1	OFD1	3	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
SLMAP	3	CEP170B	10	bioid	Couzens AL (2013)	1
CNTRL	5	CEP170B	10	bioid	Gupta GD (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP170B	10	bioid	Gupta GD (2015)	1
CNTRL	5	OFD1	3	bioid	Gupta GD (2015)	1
RPGRIP1L	2	KIF2A	3	affinity chromatography technology	Gupta GD (2015)	1
EGLN3	0	YWHAB	1	affinity chromatography technology	Rodriguez J (2016)	1
DCTN1	6	KIF2A	3	bioid	Gupta GD (2015)	1
YWHAB	1	CEP170B	10	affinity chromatography technology	Couzens AL (2013)	1
LCA5	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
EGLN3	0	KIAA0368	0	affinity chromatography technology	Rodriguez J (2016)	1
HNRNPL	3	KIAA0368	0	affinity chromatography technology	Fei T (2017)	1
KIF2B	2	CEP170B	10	affinity chromatography technology	Huttlin EL (2017)	1
OFD1	3	CEP170B	10	affinity chromatography technology	Gupta GD (2015)	1
EGLN3	0	CEP170	4	affinity chromatography technology	Rodriguez J (2016)	1
PRKAA2	1	CEP170B	10	affinity chromatography technology	Behrends C (2010)	1