PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	HDAC7	4	two hybrid, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
SFN	1	TRIM32	2	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Ichimura T (2013)	2
G3BP1	4	YWHAQ	0	affinity chromatography technology	Jain S (2016)	1
HDAC4	10	YWHAQ	0	two hybrid, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Wang AH (2005), Zhao X (2001), Xu C (2012), Xu C (2012), Li J (2012), Li J (2012), Ichimura T (2013), Rosner M (2007), Joshi P (2013), Meek SE (2004), Walkinshaw DR (2013)	11
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
SFN	1	PLD6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM32	2	YWHAZ	1	affinity chromatography technology	Ichimura T (2013)	1
COPS6	0	HNRNPD	3	affinity chromatography technology	Bennett EJ (2010)	1
SFN	1	COPS6	0	affinity chromatography technology, affinity chromatography technology, biochemical	Choi HH (2011), Choi HH (2011), Choi HH (2011)	3
YWHAZ	1	KIAA0930	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
SFN	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Benzinger A (2005), Eisenhardt AE (2016), Ivanov AA (2017)	3
SFN	1	MDM2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang HY (2007), Yang HY (2007), Yang HY (2007), Wood NT (2009)	4
SFN	1	ARAF	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Benzinger A (2005), So J (2015), Ivanov AA (2017)	3
BRAF	12	BAD	1	enzymatic study	Polzien L (2009)	1
AKT1	1	SFN	1	affinity chromatography technology, affinity chromatography technology	Calvo N (2010), Calvo N (2010)	2
EGFR	5	EIF4B	3	affinity chromatography technology	Yao Z (2017)	1
BRAF	12	EGFR	5	genetic interference	Shen JP (2017)	1
EIF4B	3	YWHAQ	0	biochemical	Wan C (2015)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
RNF115	1	SFN	1	two hybrid, pull down, affinity chromatography technology	Bacopulos S (2012), Bacopulos S (2012), Bacopulos S (2012)	3
AKT1	1	BAD	1	pull down, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Wang X (2001), Deregibus MC (2002), Song JJ (2005), Song JJ (2005), Polzien L (2009), Urschel S (2005), Yuan ZQ (2005), Rena G (1999), Kim J (2013), Chen TC (2014)	10
ARAF	0	TP53	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
YWHAZ	1	MARK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Al-Hakim AK (2005), Brajenovic M (2004), Goeransson O (2006), Goeransson O (2006), Nichols RJ (2010), So J (2015), Hein MY (2015)	7
YWHAG	5	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	6
HDAC7	4	MARK3	2	affinity chromatography technology, enzymatic study	Dequiedt F (2006), Dequiedt F (2006)	2
YWHAG	5	ARAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), So J (2015), Ivanov AA (2017)	4
AKT1	1	RNF115	1	enzymatic study	Connor MK (2005)	1
YWHAQ	0	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Chen C (2008), Gloeckner CJ (2007), Huttlin EL (2017), Eisenhardt AE (2016)	5
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
SFN	1	EIF2S1	2	far western blotting, affinity chromatography technology	Wilker EW (2007), Wilker EW (2007)	2
TRIM32	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
EGFR	5	ERRFI1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2009), Pao-Chun L (2009), Tong J (2008), Foerster S (2013), Li J (2013), Tong J (2014), Li J (2013), Park E (2015), Park E (2015), Park E (2015), Park E (2015), Yao Z (2017)	12
SFN	1	PLK4	1	two hybrid, affinity chromatography technology	Rual JF (2005), Rual JF (2005)	2
DTL	0	SFN	1	affinity chromatography technology, affinity chromatography technology	Dar A (2014), Dar A (2014)	2
COPS6	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Bennett EJ (2010), Olma MH (2009), Higa LA (2006)	4
DTL	0	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Dar A (2014), Dar A (2014)	2
YWHAG	5	MARK3	2	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Nichols RJ (2010)	2
EGFR	5	RAF1	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
YWHAZ	1	ERRFI1	1	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Li J (2013)	2
TP53	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Tian H (2002), Yang HY (2007), Yang HY (2003), Yang HY (2003), Choi HH (2011)	5
YWHAZ	1	SFN	1	biochemical, affinity chromatography technology, affinity chromatography technology	Kristensen AR (2012), Huttlin EL (2015), Huttlin EL (2017)	3
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
SFN	1	TP63	0	affinity chromatography technology, affinity chromatography technology	Fomenkov A (2004), Fomenkov A (2004)	2
YWHAG	5	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005), Huttlin EL (2015), Huttlin EL (2017)	4
TRIM32	2	YWHAG	5	affinity chromatography technology	Ichimura T (2013)	1
TNK1	0	YWHAQ	0	affinity chromatography technology	So J (2015)	1
GAN	4	EIF4B	3	affinity chromatography technology	Johnson-Kerner BL (2015)	1
YWHAG	5	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Hein MY (2015)	2
YWHAQ	0	RAF1	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Ewing RM (2007), Yeung K (2000), Van Der Hoeven PC (2000), Liu YC (1996), Subramanian RR (2001), ONeill E (2004), Rajalingam K (2005), Zhu J (2005), Bonnefoy-Berard N (1995), So J (2015)	10
YWHAZ	1	RAF1	3	pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, fluorescent resonance energy transfe	Clark GJ (1997), Tzivion G (2000), Tzivion G (2000), Koyama S (1995), Koyama S (1995), Van Der Hoeven PC (2000), Chow CW (2000), Andersen SD (2012), Subramanian RR (2001), Wang H (1998), Wang H (1998), Wang H (1998), Dougherty MK (2005), Rajalingam K (2005), Zhu J (2005), So J (2015), Powell DW (2003), Ivanov AA (2017)	18
MAP3K2	1	YWHAQ	0	affinity chromatography technology	Hein MY (2015)	1
SFN	1	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Benzinger A (2005), Subramanian RR (2001), Rajalingam K (2005), Zhu J (2005), So J (2015), Mo XL (2015)	6
TNK1	0	YWHAG	5	affinity chromatography technology	So J (2015)	1
MDM2	2	YWHAQ	0	affinity chromatography technology, pull down, affinity chromatography technology	Pereg Y (2006), Wang B (2010), Wang B (2010)	3
DTL	0	MDM2	2	affinity chromatography technology	Banks D (2006)	1
YWHAZ	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Jin J (2004), Gloeckner CJ (2007), Hein MY (2015), Huttlin EL (2017), Eisenhardt AE (2016), Ivanov AA (2017)	7
ERRFI1	1	YWHAQ	0	affinity chromatography technology	Li J (2013)	1
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
YWHAQ	0	SFN	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pozuelo-Rubio M (2010), Huttlin EL (2015), Huttlin EL (2017)	3
YWHAZ	1	BAD	1	pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yang H (2001), Yang H (2001), Bandyopadhyay S (2010), Liang X (2010), Subramanian RR (2001), Polzien L (2009), Wang J (2011), Jin L (2009), Mortenson JB (2015), Dong S (2007)	10
HDAC7	4	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Margariti A (2010), Margariti A (2010), Joshi P (2013)	3
YWHAQ	0	KIAA0930	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
PPIB	1	SFN	1	biochemical, affinity chromatography technology	Wan C (2015), Wilker EW (2007)	2
AKT1	1	RAF1	3	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Zimmermann S (1999), Zimmermann S (1999), Wang J (2009), Wang J (2009), Ivanov AA (2017)	5
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
TP53	0	G3BP1	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kim MM (2007), Kim MM (2007), Kim MM (2007), Kim MM (2007)	4
RNF115	1	EGFR	5	affinity chromatography technology, enzymatic study	Smith CJ (2013), Smith CJ (2013)	2
MAP3K2	1	YWHAZ	1	affinity chromatography technology	Hein MY (2015)	1
HNRNPD	3	SFN	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	He C (2006), He C (2006), He C (2006), He C (2006), He C (2006)	5
BRAF	12	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weber CK (2001), Weber CK (2001), Kilili GK (2010), Chen C (2008), Chen C (2008), Lito P (2012), Huttlin EL (2017)	7
SFN	1	GAN	4	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Huttlin EL (2015)	2
AKT1	1	YWHAG	5	affinity chromatography technology	Klein JB (2005)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
YWHAG	5	HDAC4	10	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Miska EA (2001), Jin J (2004), Joshi P (2013), Rolland T (2014)	4
ARAF	0	BAD	1	enzymatic study	Polzien L (2009)	1
SFN	1	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
EIF4B	3	SFN	1	biochemical, far western blotting, affinity chromatography technology	Wan C (2015), Wilker EW (2007), Wilker EW (2007)	3
YWHAG	5	HDAC7	4	affinity chromatography technology, affinity chromatography technology	Jin J (2004), Joshi P (2013)	2
SFN	1	HDAC4	10	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Joshi P (2013)	2
YWHAZ	1	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology	Waterman MJ (1998), Waterman MJ (1998), Gu YM (2006)	3
MDM2	2	AKT1	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, imaging technique	Lin HK (2002), Ogawara Y (2002), Zhou BP (2001), Zhou BP (2001), Kim CK (2011), Kim CK (2011), Zhu QS (2011), Milne D (2004), Deep G (2008), Deep G (2008), Chen TC (2014)	11
BRAF	12	ARAF	0	affinity chromatography technology, imaging technique, affinity chromatography technology, fluorescent resonance energy transfe	Gloeckner CJ (2007), Chen TC (2014), Huttlin EL (2017), Ivanov AA (2017)	4
SFN	1	AJUBA	2	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005)	2
SFN	1	TRIM62	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HDAC7	4	YWHAQ	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Dequiedt F (2006), Gao C (2006), Gao C (2006), Parra M (2007), Joshi P (2013), Meek SE (2004)	6
TRIM32	2	YWHAQ	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ichimura T (2013), Ichimura T (2013), Ichimura T (2013)	3
YWHAG	5	RAF1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Ewing RM (2007), Autieri MV (1999), Van Der Hoeven PC (2000), Rajalingam K (2005), Zhu J (2005), So J (2015), Ivanov AA (2017)	7
BAD	1	YWHAQ	0	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, pull down	Chen L (2005), Hsu SY (1997), Subramanian RR (2001), Watabe M (2004), Wang J (2011), Schuermann A (2000)	6
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
YWHAZ	1	HDAC4	10	pull down, affinity chromatography technology	Miska EA (2001), Joshi P (2013)	2
BAD	1	SFN	1	two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Subramanian RR (2001), Wang J (2011), Calvo N (2010), Calvo N (2010)	5
YWHAQ	0	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
EXO1	3	YWHAZ	1	two hybrid, affinity chromatography technology, two hybrid, pull down	Engels K (2011), Engels K (2011), Andersen SD (2012), Andersen SD (2012)	4
ARAF	0	YWHAZ	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Bandyopadhyay S (2010), So J (2015), Ivanov AA (2017)	3
YWHAZ	1	AJUBA	2	affinity chromatography technology	Benzinger A (2005)	1
YWHAG	5	EXO1	3	two hybrid, pull down	Andersen SD (2012), Andersen SD (2012)	2
SFN	1	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Wilker EW (2007), Jain S (2016)	2
DTL	0	TP53	0	affinity chromatography technology, enzymatic study	Banks D (2006), Banks D (2006)	2
G3BP1	4	EIF4B	3	affinity chromatography technology	Jain S (2016)	1
EGFR	5	SFN	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Li J (2013)	5
EIF4B	3	YWHAZ	1	biochemical	Wan C (2015)	1
ARAF	0	YWHAQ	0	affinity chromatography technology	So J (2015)	1
ARAF	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
EGFR	5	PPIB	1	affinity chromatography technology	Yao Z (2017)	1
YWHAG	5	KIAA0930	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2015), Huttlin EL (2017)	3
HDAC4	10	MARK3	2	affinity chromatography technology	Dequiedt F (2006)	1
AKT1	1	BRAF	12	affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique, fluorescent resonance energy transfe	Guan KL (2000), Guan KL (2000), Guan KL (2000), Chen TC (2014), Ivanov AA (2017)	5
DTL	0	YWHAQ	0	affinity chromatography technology, affinity chromatography technology	Dar A (2014), Dar A (2014)	2
SFN	1	SFN	1	fluorescent resonance energy transfe, fluorescent resonance energy transfe	Mo XL (2015), Ivanov AA (2017)	2
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
SFN	1	MARK3	2	two hybrid, affinity chromatography technology	Rual JF (2005), Benzinger A (2005)	2
SFN	1	ERRFI1	1	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Benzinger A (2005)	2
MDM2	2	HNRNPD	3	affinity chromatography technology	Jacob AG (2014)	1
RAF1	3	BAD	1	enzymatic study, enzymatic study, imaging technique	Jin S (2005), Polzien L (2009), Chen TC (2014)	3
SFN	1	HDAC7	4	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Joshi P (2013)	2
SFN	1	TNK1	0	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), So J (2015)	2
TP53	0	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
AKT1	1	YWHAZ	1	affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Powell DW (2002), Powell DW (2002), Powell DW (2002), Klein JB (2005)	4
COPS6	0	TP63	0	two hybrid	Wang J (2011)	1
DTL	0	YWHAG	5	affinity chromatography technology, affinity chromatography technology	Dar A (2014), Dar A (2014)	2
TNK1	0	YWHAZ	1	affinity chromatography technology	So J (2015)	1
KIAA0930	0	SFN	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
YWHAG	5	BAD	1	two hybrid	Bandyopadhyay S (2010)	1
TP53	0	EGFR	5	genetic interference, genetic interference	Xie L (2013), Ye H (2016)	2
MDM2	2	PPIB	1	unspecified method	Nicholson J (2014)	1
YWHAQ	0	MARK3	2	affinity chromatography technology, affinity chromatography technology, pull down	Ewing RM (2007), Nichols RJ (2010), Meek SE (2004)	3
HDAC7	4	HDAC4	10	pull down	Dressel U (2001)	1
SFN	1	MAP3K2	1	affinity chromatography technology, affinity chromatography technology	Benzinger A (2005), Hein MY (2015)	2
YWHAZ	1	MDM2	2	affinity chromatography technology	Zhang B (2017)	1