PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RAB1B	3	STX7	2	biochemical	Wan C (2015)	1
CUL5	1	TEX35	0	affinity chromatography technology	Bennett EJ (2010)	1
GOLGA2	2	TCF19	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	CUL5	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
STX7	2	STX12	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	RBM17	1	affinity chromatography technology	Neganova I (2011)	1
RAB1B	3	RAB2A	4	biochemical	Wan C (2015)	1
CDK2	0	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	FBXO28	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RAB1B	3	GOLGA2	2	two hybrid, pull down	Weide T (2001), Weide T (2001)	2
STK25	1	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	UBE3C	5	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RAB1A	0	STX12	2	biochemical	Wan C (2015)	1
RAB1B	3	RAB1A	0	affinity chromatography technology, biochemical, genetic interference, genetic interference, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Blomen VA (2015), Blomen VA (2015), Huttlin EL (2017)	5
GOLGA2	2	KANK2	4	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	RAB2A	4	two hybrid, pull down, two hybrid, two hybrid	Rual JF (2005), Short B (2001), Short B (2001), Rolland T (2014)	4
STX12	2	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RUSC2	6	GOLGA2	2	two hybrid, pull down	Bayer M (2005), Bayer M (2005)	2
GOLGA2	2	SCEL	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
STX7	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RAB1A	0	RAB2A	4	biochemical	Wan C (2015)	1
GOLGA2	2	TRIM29	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
GOLGA2	2	KANSL1	11	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	ITPKB	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
CCNH	3	GOLGA2	2	two hybrid, two hybrid, two hybrid	Wang J (2011), Rolland T (2014), Yu H (2011)	3
GOLGA2	2	RAB39B	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
ZDHHC17	1	RAB39B	1	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
GOLGA2	2	C1orf35	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RAB1B	3	STX12	2	biochemical	Wan C (2015)	1
RAB1A	0	STX7	2	biochemical	Wan C (2015)	1
RAB1A	0	GOLGA2	2	two hybrid, pull down, pull down	Weide T (2003), Valsdottir R (2001), Short B (2001)	3
CCNH	3	CDK2	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Xu X (1999), Higashi H (1996), Garrett S (2001), Lolli G (2004), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	7
DCX	5	GOLGA2	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
USO1	1	RAB1A	0	pull down	Allan BB (2000)	1
ZDHHC17	1	STK25	1	two hybrid	Butland SL (2014)	1
GOLGA2	2	ATP6V1C2	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	DCTN4	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	UBE2U	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
STK25	1	GOLGA2	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
GOLGA2	2	FAM126B	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
GOLGA2	2	GORASP2	1	two hybrid, pull down, pull down, pull down, two hybrid, two hybrid, affinity chromatography technology	Shorter J (1999), Barr FA (2001), Short B (2001), Shorter J (1999), Vinayagam A (2011), Rolland T (2014), Huttlin EL (2017)	7
GOLGA2	2	TSSK3	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TEX35	0	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TEX35	0	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STX7	2	GORASP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GORASP1	1	GOLGA2	2	affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, pull down, pull down, two hybrid, affinity chromatography technology	Barr FA (2001), Barr FA (2001), Barr FA (2001), Marra P (2001), Short B (2001), Shorter J (1999), Shorter J (1999), Huttlin EL (2017)	8
RAB1A	0	RUSC2	6	two hybrid, pull down	Bayer M (2005), Bayer M (2005)	2
GOLGA2	2	ZNF250	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZDHHC17	1	GOLGA2	2	two hybrid, affinity chromatography technology	Butland SL (2014), Butland SL (2014)	2
RASSF8	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GOLGA2	2	RBM17	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RAB2A	4	GORASP2	1	pull down	Short B (2001)	1
GOLGA2	2	USO1	1	pull down, affinity chromatography technology	Dirac-Svejstrup AB (2000), van Zuylen WJ (2012)	2
STX12	2	GOLGA2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PRKAB2	0	GOLGA2	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
CDK2	0	GOLGA2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015)	4
GOLGA2	2	RITA1	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2