PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GLUL	2	DMXL2	11	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2I	0	EP300	36	enzymatic study, affinity chromatography technology	Girdwood D (2003), Bian XL (2017)	2
GLUL	2	FAM129B	4	biochemical	Kristensen AR (2012)	1
MCM2	3	TARDBP	4	affinity chromatography technology	Drissi R (2015)	1
NFKB1	2	EP300	36	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Deng WG (2003), Deng WG (2003), Furia B (2002), Wang H (2010), Wang H (2010), Sen GS (2011), Hassa PO (2003), Hassa PO (2003), Deng WG (2003)	9
EP300	36	PIAS1	4	pull down, affinity chromatography technology	Ledsaak M (2016), Ledsaak M (2016)	2
RBBP6	7	UBE2I	0	two hybrid	Wang J (2008)	1
EP300	36	UBC	7	enzymatic study, affinity chromatography technology	Delvecchio M (2013), Kirilyuk A (2012)	2
GLUL	2	NFKB1	2	two hybrid	Wang J (2011)	1
GLUL	2	ND5	0	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
GLUL	2	PIAS2	2	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	HIPK3	5	affinity chromatography technology	Choudhury NR (2017)	1
MAPK6	1	UBC	7	affinity chromatography technology	Rodriguez J (2016)	1
MAPK6	1	GLUL	2	affinity chromatography technology	Rodriguez J (2016)	1
MCM2	3	TRIM25	5	affinity chromatography technology	Drissi R (2015)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
CASP8AP2	3	PIAS1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011), Alm-Kristiansen AH (2011)	4
TRIM25	5	GLUL	2	affinity chromatography technology	Choudhury NR (2017)	1
ZFAND2B	1	GLUL	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MCM2	3	GLUL	2	affinity chromatography technology	Drissi R (2015)	1
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
GLUL	2	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	FAM129B	4	affinity chromatography technology, pull down, enzymatic study	Ji H (2016), Ji H (2016), Ji H (2016)	3
UBC	7	GLUL	2	affinity chromatography technology	Matsumoto M (2005)	1
NME7	0	TCHP	0	two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Boldt K (2016)	3
TARDBP	4	GLUL	2	affinity chromatography technology	Davis SA (2018)	1
PPARD	4	GLUL	2	two hybrid	Albers M (2005)	1
SKIL	3	PIAS3	2	two hybrid	Colland F (2004)	1
TRIM25	5	MAPK6	1	affinity chromatography technology	Choudhury NR (2017)	1
GLUL	2	NUDT18	0	two hybrid	Rual JF (2005)	1
TRIM25	5	ND5	0	affinity chromatography technology	Choudhury NR (2017)	1
C1orf94	1	GLUL	2	affinity chromatography technology	Huttlin EL (2017)	1
ZFAND2B	1	UBC	7	affinity chromatography technology, pull down	Braunstein I (2015), Zhang X (2017)	2
GLUL	2	ZNRF1	1	affinity chromatography technology, affinity chromatography technology	Saitoh F (2010), Saitoh F (2010)	2
EP300	36	PIAS3	2	affinity chromatography technology	Long J (2004)	1
UBE2I	0	HIPK1	1	two hybrid	Bandyopadhyay S (2010)	1
UBE2I	0	CASP8AP2	3	two hybrid, enzymatic study	Bandyopadhyay S (2010), Gocke CB (2005)	2
TBC1D22B	2	GLUL	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	ASPSCR1	3	affinity chromatography technology	Matsumoto M (2005)	1
EGFR	5	HSD17B10	1	affinity chromatography technology	Tong J (2014)	1
GLUL	2	TCHP	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RBBP6	7	GLUL	2	two hybrid	Wang J (2008)	1
GLUL	2	HIPK1	1	two hybrid	Bandyopadhyay S (2010)	1
ZNRF1	1	UBC	7	enzymatic study	Hoxhaj G (2012)	1
MCM2	3	UBC	7	affinity chromatography technology	Drissi R (2015)	1
GLUL	2	PIAS3	2	two hybrid	Bandyopadhyay S (2010)	1
CRBN	2	GLUL	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Nguyen TV (2016), Nguyen TV (2016), Nguyen TV (2016)	3
TRIM25	5	UBAP2	5	affinity chromatography technology	Choudhury NR (2017)	1
MCM2	3	HSD17B10	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Malty RH (2017)	2
CYP39A1	1	GLUL	2	two hybrid	Wang J (2011)	1
GLUL	2	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
GLUL	2	CASP8AP2	3	two hybrid	Bandyopadhyay S (2010)	1
TARDBP	4	ZFAND2B	1	two hybrid	Rolland T (2014)	1
RBBP6	7	PIAS1	4	two hybrid	Wang J (2008)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
UBE2I	0	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
EGFR	5	GLUL	2	affinity chromatography technology	Yao Z (2017)	1
GLUL	2	GLUL	2	two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Wang J (2011), Rolland T (2014)	4
PPARD	4	EP300	36	pull down, two hybrid	Cho MC (2006), Mochizuki K (2008)	2
SKIL	3	HIPK1	1	two hybrid	Colland F (2004)	1
HSD17B10	1	TARDBP	4	biochemical	Wan C (2015)	1
GLUL	2	PLEKHF2	1	two hybrid	Rual JF (2005)	1
EP300	36	GLUL	2	enzymatic study, affinity chromatography technology	Nguyen TV (2016), Nguyen TV (2016)	2
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
SKIL	3	GLUL	2	two hybrid	Colland F (2004)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
SKIL	3	PIAS1	4	two hybrid	Colland F (2004)	1
GLUL	2	HIPK3	5	two hybrid	Bandyopadhyay S (2010)	1
TRIM25	5	PPARD	4	affinity chromatography technology	Choudhury NR (2017)	1
GLUL	2	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
GLUL	2	NME7	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
GLUL	2	UBAP2	5	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	FAM129B	4	affinity chromatography technology	Choudhury NR (2017)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
GLUL	2	RABEPK	0	two hybrid	Wang J (2011)	1
HSD17B10	1	GLUL	2	two hybrid	Narayan SB (2012)	1