PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GLP1R	4	ACSF3	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GLP1R	4	CCDC167	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	DAD1	0	protein complementation assay	Dai FF (2015)	1
KRTAP10-8	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
GLP1R	4	OST4	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	STMN1	0	protein complementation assay	Huang X (2013)	1
GLP1R	4	ATP6AP2	2	protein complementation assay, affinity chromatography technology	Dai FF (2015), Dai FF (2015)	2
GLP1R	4	GNAS	9	protein complementation assay	Dai FF (2015)	1
GLP1R	4	HPN	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	CLPS	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	SUMO1	0	affinity chromatography technology	Rajan S (2012)	1
RTN3	2	RTN4	4	two hybrid, affinity chromatography technology	Rual JF (2005), Huttlin EL (2017)	2
GLP1R	4	SVOP	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	RTRAF	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	GPR37	3	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	CYSTM1	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	ATP6V0B	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	SYNGR3	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	TOMM6	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
GLP1R	4	CLDN7	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	NUCKS1	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	GCG	0	pull down, unspecified method	Xiao Q (2000), Bosse-Doenecke E (2008)	2
GLP1R	4	MRPL22	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	SLC31A2	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	MYL6	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	TM4SF4	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	5645	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	TSPAN13	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	ARFRP1	2	protein complementation assay	Huang X (2013)	1
GLP1R	4	TMEM147	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
GLP1R	4	STMN3	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	TMBIM6	1	protein complementation assay	Dai FF (2015)	1
KRTAP10-7	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
GLP1R	4	MTCH2	2	protein complementation assay	Dai FF (2015)	1
GLP1R	4	PAQR6	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	SELENOK	0	protein complementation assay	Dai FF (2015)	1
KRTAP10-9	1	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
GLP1R	4	ND4L	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	NRGN	0	protein complementation assay	Huang X (2013)	1
GLP1R	4	PAM	2	protein complementation assay	Dai FF (2015)	1
GLP1R	4	CELA3B	4	protein complementation assay	Dai FF (2015)	1
GLP1R	4	CAND2	7	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
TMCO3	1	TMBIM6	1	affinity chromatography technology	Huttlin EL (2017)	1
GLP1R	4	APLP1	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	GP2	1	protein complementation assay	Dai FF (2015)	1
GLP1R	4	MFSD5	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	C4orf3	1	protein complementation assay	Dai FF (2015)	1
GLP1R	4	AP2M1	5	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
GLP1R	4	CEND1	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
KRTAP10-9	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
GLP1R	4	CD81	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	TMCO3	1	protein complementation assay	Dai FF (2015)	1
GLP1R	4	SCGB2A1	0	protein complementation assay	Dai FF (2015)	1
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GLP1R	4	ERP29	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
GLP1R	4	FDFT1	1	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	GPR108	6	protein complementation assay	Dai FF (2015)	1
GLP1R	4	LINC00269	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	CNIH4	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	SEC11C	2	protein complementation assay	Dai FF (2015)	1
GLP1R	4	RTN3	2	protein complementation assay	Dai FF (2015)	1
GLP1R	4	C18orf32	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	P4HTM	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	ELOVL1	3	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	PIGG	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	IFITM3	0	protein complementation assay, affinity chromatography technology, protein complementation assay	Huang X (2013), Huang X (2013), Dai FF (2015)	3
GLP1R	4	GABBR2	15	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	CFI	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
MYL6	2	STMN1	0	biochemical	Wan C (2015)	1
KRTAP10-7	0	KRTAP10-8	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GLP1R	4	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GLP1R	4	RTN4	4	protein complementation assay	Dai FF (2015)	1
KRTAP10-8	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GLP1R	4	AIG1	3	protein complementation assay	Dai FF (2015)	1
GLP1R	4	STOML2	0	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	EMP2	0	protein complementation assay	Dai FF (2015)	1
GLP1R	4	SLC15A4	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	APH1A	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	ATP13A1	2	protein complementation assay, affinity chromatography technology	Huang X (2013), Huang X (2013)	2
GLP1R	4	CLIP4	2	protein complementation assay	Dai FF (2015)	1
GLP1R	4	SYNGR4	0	protein complementation assay	Dai FF (2015)	1