PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DGUOK	1	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP2A2	3	AMPH	4	pull down, affinity chromatography technology	McMahon HT (1997), Huttlin EL (2017)	2
RAP1A	1	RAB8A	0	biochemical	Wan C (2015)	1
HDAC6	0	ENO1	3	affinity chromatography technology	Watson GW (2016)	1
RAB8B	0	APP	1	pull down	Olah J (2011)	1
ENO1	3	BIN1	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	AP2A2	3	affinity chromatography technology	Castello A (2012)	1
ELAVL1	0	PTK2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
BIN1	2	BIN1	2	pull down	Ramjaun AR (1999)	1
NXF1	0	HDAC6	0	affinity chromatography technology	Castello A (2012)	1
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
MYC	2	RIN3	2	affinity chromatography technology	Agrawal P (2010)	1
SHMT2	3	XRCC6	3	affinity chromatography technology	Castello A (2012)	1
DGUOK	1	APP	1	pull down	Olah J (2011)	1
DNM1	21	BIN1	2	unspecified method	Grelle G (2006)	1
SHMT2	3	HDAC6	0	affinity chromatography technology	Castello A (2012)	1
BIN1	2	XRCC6	3	biochemical	Ramalingam A (2007)	1
UBC	7	DLGAP4	4	two hybrid	Stelzl U (2005)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	RBM12	6	affinity chromatography technology	Choudhury NR (2017)	1
RBM12	6	BIN1	2	biochemical	Kristensen AR (2012)	1
ELAVL1	0	WASL	2	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	AP2A1	1	affinity chromatography technology	Choudhury NR (2017)	1
CLTC	12	AP2A2	3	pull down, two hybrid, affinity chromatography technology	McMahon HT (1997), Knuehl C (2006), Hein MY (2015)	3
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AP2A1	1	AMPH	4	unspecified method, affinity chromatography technology	Brett TJ (2002), Huttlin EL (2017)	2
UBC	7	FHL2	0	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	E2F1	0	affinity chromatography technology	Rizos H (2007)	1
CALM1	0	MAPT	1	pull down	Padilla R (1990)	1
BIN1	2	MAPT	1	x-ray crystallography, pull down	Malki I (2017), Malki I (2017)	2
NXF1	0	CLTC	12	affinity chromatography technology	Castello A (2012)	1
KLF8	0	BIN1	2	affinity chromatography technology	Hein MY (2015)	1
HDAC6	0	UBC	7	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Pai MT (2007), Pozo FM (2011), Sekimoto T (2010), Kovacs JJ (2004), Hao R (2013), Lee JH (2013), Nakashima H (2014), Banerjee I (2014), Hao R (2013), Zhang X (2017), Yu Q (2018)	11
UBC	7	AMPH	4	pull down	Stamenova SD (2007)	1
CALM1	0	ITGA6	3	pull down	Shen X (2005)	1
FHL2	0	BIN1	2	two hybrid	Wixler V (2000)	1
BIN1	2	DNM2	2	unspecified method	Wu T (2014)	1
ITCH	1	BIN1	2	fluorescent resonance energy transfe, affinity chromatography technology, far western blotting, unspecified method	Desrochers G (2015), Desrochers G (2015), Desrochers G (2015), Desrochers G (2017)	4
XRCC4	0	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Drouet J (2005)	2
CUX1	7	BIN1	2	two hybrid	Stelzl U (2005)	1
NXF1	0	E2F1	0	affinity chromatography technology	Castello A (2012)	1
EHBP1L1	5	RAB8B	0	imaging technique	Nakajo A (2016)	1
DNM2	2	DNM1	21	two hybrid	Vinayagam A (2011)	1
XRCC6	3	HDAC6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Subramanian C (2011), Chaudhary N (2014), Chaudhary N (2014)	3
TRIM25	5	DLGAP4	4	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	BIN1	2	pull down	Stamenova SD (2007)	1
HDAC6	0	BIN1	2	affinity chromatography technology	Watson GW (2016)	1
MBNL1	3	BIN1	2	unspecified method	Fugier C (2011)	1
IPO8	9	BIN1	2	affinity chromatography technology	Hein MY (2015)	1
BIN1	2	MTM1	0	pull down, affinity chromatography technology, affinity chromatography technology	Royer B (2013), Royer B (2013), Royer B (2013)	3
BIN1	2	AP2A1	1	pull down	Leprince C (1997)	1
HDAC6	0	CLIP1	2	affinity chromatography technology, affinity chromatography technology	Li D (2014), Li D (2014)	2
DNM2	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
RAB8A	0	BIN1	2	imaging technique, imaging technique	Nakajo A (2016), Nakajo A (2016)	2
MOV10	6	XRCC6	3	affinity chromatography technology	Castello A (2012)	1
CALM1	0	SYNE2	19	pull down	Shen X (2005)	1
ELAVL1	0	CALM1	0	affinity chromatography technology	Abdelmohsen K (2009)	1
FHL2	0	RFX3	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
BIN1	2	CLIP1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Meunier B (2009), Meunier B (2009), Meunier B (2009), DAlessandro M (2015), DAlessandro M (2015), DAlessandro M (2015)	6
PTK2	2	FBP1	2	two hybrid	Vinayagam A (2011)	1
MOV10	6	ITGA6	3	affinity chromatography technology	Castello A (2012)	1
NUFIP1	0	BIN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AP2A1	1	AP2A2	3	biochemical	Havugimana PC (2012)	1
IRS4	2	BIN1	2	affinity chromatography technology, affinity chromatography technology	Taipale M (2014), Taipale M (2014)	2
UBC	7	AP2A2	3	pull down	Zhang X (2017)	1
MYC	2	BIN1	2	pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, two hybrid	Elliott K (1999), Elliott K (1999), Pineda-Lucena A (2005), Pineda-Lucena A (2005), Pineda-Lucena A (2005), Pineda-Lucena A (2005)	6
UBC	7	ACTA1	1	pull down	Zhang X (2017)	1
NUFIP1	0	SYN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DLGAP4	4	BIN1	2	unspecified method, pull down, two hybrid	Grelle G (2006), Grelle G (2006), Grelle G (2006)	3
TRIM25	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	PTK2	2	affinity chromatography technology	Choudhury NR (2017)	1
SHMT2	3	APP	1	pull down	Olah J (2011)	1
NUFIP1	0	DNM1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	ITGA6	3	affinity chromatography technology	Castello A (2012)	1
SHMT2	3	RAB8A	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	CALM1	0	affinity chromatography technology	Castello A (2012)	1
DGUOK	1	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
PDE4D	4	BIN1	2	biochemical	Kristensen AR (2012)	1
MOV10	6	DLGAP4	4	affinity chromatography technology	Castello A (2012)	1
BIN1	2	SOS1	5	pull down	Leprince C (1997)	1
NXF1	0	CALM1	0	affinity chromatography technology	Castello A (2012)	1
ITCH	1	UBC	7	enzymatic study, unspecified method, enzymatic study, enzymatic study	Sheng Y (2012), Ernst A (2013), Maspero E (2013), Kristariyanto YA (2015)	4
APP	1	MYC	2	pull down	Virok DP (2011)	1
FBP1	2	BIN1	2	unspecified method, pull down, two hybrid	Grelle G (2006), Grelle G (2006), Grelle G (2006)	3
ITGA1	1	BIN1	2	two hybrid	Wixler V (1999)	1
ELAVL1	0	RAB8A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DNM1	21	AMPH	4	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Micheva KD (1997), Micheva KD (1997), Micheva KD (1997), Wigge P (1997), McMahon HT (1997), Chen-Hwang MC (2002), Grabs D (1997), Solomaha E (2005), Stamenova SD (2007)	9
BIN1	2	RIN3	2	pull down, affinity chromatography technology	Kajiho H (2003), Kajiho H (2003)	2
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
ELAVL1	0	ITCH	1	affinity chromatography technology	Abdelmohsen K (2009)	1
CALM1	0	BIN1	2	affinity chromatography technology	Myers MD (2016)	1
NXF1	0	RBM12	6	affinity chromatography technology	Castello A (2012)	1
UBC	7	AP2A1	1	pull down	Zhang X (2017)	1
BIN1	2	WASL	2	pull down	Falcone S (2014)	1
TRIM25	5	BIN1	2	affinity chromatography technology	Choudhury NR (2017)	1
PLD2	1	BIN1	2	genetic interference, pull down	Lee C (2000), Lee C (2000)	2
BIN1	2	SOS2	3	pull down	Leprince C (1997)	1
TRIM25	5	ITGA6	3	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	RAP1A	1	affinity chromatography technology	Abdelmohsen K (2009)	1
TRIM25	5	PDE4D	4	affinity chromatography technology	Choudhury NR (2017)	1
BIN1	2	SYNE2	19	two hybrid, pull down, affinity chromatography technology	DAlessandro M (2015), DAlessandro M (2015), DAlessandro M (2015)	3
BIN1	2	ZBTB3	3	two hybrid	Ravasi T (2010)	1
RAP1A	1	BIN1	2	pull down	Stoletov KV (2004)	1
ITGA3	4	BIN1	2	two hybrid	Wixler V (1999)	1
MBNL1	3	APP	1	pull down	Olah J (2011)	1
NCAPD3	6	BIN1	2	affinity chromatography technology	Huttlin EL (2017)	1
NUFIP1	0	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MOV10	6	HYOU1	2	affinity chromatography technology	Castello A (2012)	1
PTK2	2	BIN1	2	affinity chromatography technology	Messina S (2003)	1
ELAVL1	0	HDAC6	0	affinity chromatography technology, affinity chromatography technology	Scott GK (2008), Scott GK (2008)	2
FHL2	0	APP	1	pull down	Olah J (2011)	1
TNK2	7	AMPH	4	affinity chromatography technology	Chan W (2009)	1
AMPH	4	BIN1	2	affinity chromatography technology, affinity chromatography technology	Wigge P (1997), Huttlin EL (2017)	2
VPS18	4	BIN1	2	affinity chromatography technology	Hein MY (2015)	1
HDAC6	0	XRCC5	5	affinity chromatography technology	New M (2013)	1
WASL	2	APP	1	pull down	Olah J (2011)	1
TRIM25	5	RAP1A	1	affinity chromatography technology	Choudhury NR (2017)	1
PDE4D	4	APP	1	pull down	Olah J (2011)	1
PLD2	1	AMPH	4	genetic interference, pull down, affinity chromatography technology	Lee C (2000), Lee C (2000), Lee C (2000)	3
MYC	2	IRS4	2	affinity chromatography technology	Koch HB (2007)	1
ENO1	3	XRCC6	3	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	SYNE2	19	affinity chromatography technology	Choudhury NR (2017)	1
ITGA6	3	BIN1	2	two hybrid	Wixler V (1999)	1
BIN2	0	AMPH	4	affinity chromatography technology	Huttlin EL (2017)	1
SHMT2	3	BIN1	2	affinity chromatography technology	Castello A (2012)	1
BIN1	2	ACTA1	1	pull down	DAlessandro M (2015)	1
DGUOK	1	MAPT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KLF8	0	APP	1	pull down	Olah J (2011)	1
HDAC6	0	MAPT	1	pull down, affinity chromatography technology, affinity chromatography technology	Ding H (2008), Ding H (2008), Yu Q (2018)	3
XRCC6	3	DNM2	2	affinity chromatography technology	Hein MY (2015)	1
NXF1	0	UBC	7	affinity chromatography technology	Castello A (2012)	1
CALM1	0	AMPH	4	affinity chromatography technology	Myers MD (2016)	1
SYN1	1	BIN1	2	affinity chromatography technology	Onofri F (2000)	1
RAB8B	0	RAB8A	0	affinity chromatography technology	Huttlin EL (2017)	1
BIN1	2	BIN2	0	affinity chromatography technology, affinity chromatography technology	Ge K (2000), Huttlin EL (2017)	2
XRCC4	0	XRCC6	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Drouet J (2005), Drouet J (2005), Hein MY (2015)	3
TRIM25	5	XRCC6	3	affinity chromatography technology	Choudhury NR (2017)	1
ELAVL1	0	ZBTB3	3	affinity chromatography technology	Abdelmohsen K (2009)	1
PTK2	2	APP	1	pull down	Olah J (2011)	1
MOV10	6	BIN1	2	affinity chromatography technology	Castello A (2012)	1
TNK2	7	BIN1	2	affinity chromatography technology	Chan W (2009)	1
NXF1	0	IPO8	9	affinity chromatography technology	Castello A (2012)	1
BIN1	2	RFX3	7	two hybrid	Ravasi T (2010)	1
ITGA6	3	APP	1	pull down	Olah J (2011)	1
MOV10	6	UBC	7	affinity chromatography technology	Castello A (2012)	1
BIN1	2	APP	1	pull down	Olah J (2011)	1
ELAVL1	0	MYC	2	affinity chromatography technology	Abdelmohsen K (2009)	1
DGUOK	1	BIN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NXF1	0	NCAPD3	6	affinity chromatography technology	Castello A (2012)	1
HYOU1	2	XRCC6	3	biochemical	Kristensen AR (2012)	1
BIN1	2	XRCC5	5	biochemical	Ramalingam A (2007)	1
BIN1	2	EHBP1L1	5	imaging technique, imaging technique	Nakajo A (2016), Nakajo A (2016)	2
NXF1	0	AP2A2	3	affinity chromatography technology	Castello A (2012)	1
MYC	2	FHL2	0	affinity chromatography technology	Agrawal P (2010)	1
AMPH	4	CLTC	12	pull down, affinity chromatography technology	Ramjaun AR (1998), Slepnev VI (2000)	2
CLTC	12	XRCC6	3	two hybrid	Goehler H (2004)	1
ITCH	1	HDAC6	0	affinity chromatography technology	OConnor HF (2015)	1
DGUOK	1	SYN1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TNK2	7	CLTC	12	pull down, pull down, affinity chromatography technology, affinity chromatography technology	Teo M (2001), Liu NS (2009), Hein MY (2015), Mahendrarajah N (2017)	4
ENO1	3	NCAPD3	6	affinity chromatography technology	Castello A (2012)	1
AP2A2	3	APP	1	pull down	Olah J (2011)	1
NXF1	0	BIN1	2	affinity chromatography technology	Castello A (2012)	1
POLR2M	0	BIN1	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBC	7	RBM12	6	affinity chromatography technology	Matsumoto M (2005)	1
MYC	2	XRCC5	5	affinity chromatography technology	Koch HB (2007)	1
NUFIP1	0	AMPH	4	affinity chromatography technology	Huttlin EL (2015)	1
SYN1	1	AMPH	4	affinity chromatography technology	Onofri F (2000)	1
TRIM25	5	CUX1	7	affinity chromatography technology	Choudhury NR (2017)	1
HDAC6	0	FBP1	2	two hybrid	Vinayagam A (2011)	1
BIN1	2	AP2A2	3	affinity chromatography technology	Ramjaun AR (1997)	1
UBC	7	SYNE2	19	pull down	Nathan JA (2013)	1
CALM1	0	XRCC4	0	pull down	Shen X (2005)	1
MOV10	6	NCAPD3	6	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	EHBP1L1	5	affinity chromatography technology	Choudhury NR (2017)	1
PTK2	2	AMPH	4	affinity chromatography technology	Messina S (2003)	1
NXF1	0	XRCC6	3	affinity chromatography technology	Castello A (2012)	1
CALM1	0	CLIP1	2	pull down	Shen X (2005)	1
HYOU1	2	BIN1	2	biochemical	Kristensen AR (2012)	1
ELAVL1	0	BIN1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BIN1	2	SNX4	0	two hybrid, affinity chromatography technology	Leprince C (2003), Leprince C (2003)	2
MYC	2	CALM1	0	affinity chromatography technology, pull down	Agrawal P (2010), Raffeiner P (2017)	2
PLD1	5	AMPH	4	genetic interference, pull down, affinity chromatography technology	Lee C (2000), Lee C (2000), Lee C (2000)	3
FHL2	0	ITGA3	4	two hybrid, affinity chromatography technology, affinity chromatography technology	Wixler V (2000), Wixler V (2000), Wixler V (2000)	3
PLD1	5	BIN1	2	genetic interference, pull down	Lee C (2000), Lee C (2000)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
TRIM25	5	ENO1	3	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MAPT	1	UBC	7	affinity chromatography technology	Mesco ER (1991)	1
RAB8A	0	EHBP1L1	5	imaging technique, imaging technique	Nakajo A (2016), Nakajo A (2016)	2
MOV10	6	E2F1	0	affinity chromatography technology	Castello A (2012)	1
DNM2	2	AMPH	4	pull down, pull down	Solomaha E (2005), Elhamdani A (2006)	2
HYOU1	2	XRCC5	5	biochemical	Kristensen AR (2012)	1
MOV10	6	RBM12	6	affinity chromatography technology	Castello A (2012)	1
RAP1A	1	RAB8B	0	biochemical	Wan C (2015)	1
E2F1	0	FHL2	0	two hybrid	Schlisio S (2002)	1
TRIM25	5	DNM2	2	affinity chromatography technology	Choudhury NR (2017)	1
UBC	7	CALM1	0	affinity chromatography technology	Bish RA (2007)	1
NXF1	0	HYOU1	2	affinity chromatography technology	Castello A (2012)	1
BIN1	2	CLTC	12	affinity chromatography technology	Ramjaun AR (1997)	1
BIN1	2	CHMP4B	2	affinity chromatography technology, imaging technique	Xu B (2017), Xu B (2017)	2
MYC	2	XRCC6	3	affinity chromatography technology, affinity chromatography technology	Koch HB (2007), Koch HB (2007)	2
CLTC	12	AP2A1	1	affinity chromatography technology	Hein MY (2015)	1
BIN1	2	RAB8B	0	imaging technique	Nakajo A (2016)	1
CLTC	12	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
BIN1	2	E2F1	0	affinity chromatography technology, pull down	Kumari A (2015), Kumari A (2015)	2
XRCC4	0	BIN1	2	unspecified method, pull down, two hybrid	Grelle G (2006), Grelle G (2006), Grelle G (2006)	3
NXF1	0	DLGAP4	4	affinity chromatography technology	Castello A (2012)	1