PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
POLL	3	RPA1	0	affinity chromatography technology	Boldt K (2016)	1
TRIM23	3	POLL	3	two hybrid	Rolland T (2014)	1
RPA3	2	RPA2	0	biochemical, x-ray crystallography, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Havugimana PC (2012), Du Y (2009), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	7
SSX2IP	0	KRT40	0	two hybrid	Rolland T (2014)	1
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
RPA1	0	RPA2	0	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao RG (1999), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Kristensen AR (2012), Ghospurkar PL (2014), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Elia AE (2015), Elia AE (2015), Huttlin EL (2017), Feeney L (2017)	13
SEMG1	1	SEMG2	1	affinity chromatography technology	Peter A (1998)	1
POLL	3	SULT1C2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLL	3	MED1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLL	3	C9orf64	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2H	3	POLL	3	enzymatic study	Hoeller D (2007)	1
TFIP11	5	SSX2IP	0	two hybrid	Rolland T (2014)	1
POLL	3	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
POLL	3	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
POLL	3	CST4	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
POLL	3	RPA3	2	affinity chromatography technology	Boldt K (2016)	1
POLL	3	SSX2IP	0	two hybrid	Rolland T (2014)	1
POLL	3	SCGB1D1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOSIP	2	UBE2D3	1	pull down	Hoffmeister M (2014)	1
RPA2	0	SSRP1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	UBE2H	3	enzymatic study	Lv Z (2017)	1
RPA1	0	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Elia AE (2015)	2
HUWE1	22	PCNA	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Markkanen E (2011), Thompson JW (2014), Choe KN (2016), Choe KN (2016), Choe KN (2016), Choe KN (2016)	6
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
RPA2	0	SUPT16H	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	PCNA	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Koundrioukoff S (2000), Zhang H (1993), Neganova I (2011), Wu SM (1998), Chen Z (2002), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	8
RPA3	2	WRN	6	affinity chromatography technology, affinity chromatography technology	Marechal A (2014), Boldt K (2016)	2
TFCP2	1	POLL	3	two hybrid	Rolland T (2014)	1
CDK2	0	SEMG1	1	affinity chromatography technology	Neganova I (2011)	1
PNMA1	0	POLL	3	two hybrid	Rolland T (2014)	1
HUWE1	22	UBE2D3	1	pull down, pull down	Yang Y (2010), Kristariyanto YA (2015)	2
CDK2	0	POLL	3	enzymatic study	Markkanen E (2012)	1
TRIM23	3	UBE2E1	1	pull down, pull down, pull down, enzymatic study, pull down	Ko JA (2006), Vichi A (2005), Vichi A (2006), Vichi A (2005), Dawidziak DM (2017)	5
POLL	3	PCNA	0	pull down, pull down, pull down	Haracska L (2002), Maga G (2002), Shimazaki N (2002)	3
POLL	3	RIOX2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LACRT	1	APP	1	pull down	Olah J (2011)	1
POLL	3	FAM9B	0	two hybrid	Rolland T (2014)	1
POLL	3	LACRT	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
POLL	3	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
HUWE1	22	POLL	3	enzymatic study	Markkanen E (2012)	1
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
PCNA	0	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Ogi T (2010), Takasaki Y (2001), Gong Z (2011), Miccoli L (2005), Han J (2014)	6
UBE2D2	0	POLL	3	enzymatic study	Hoeller D (2007)	1
POLL	3	RPA2	0	affinity chromatography technology	Boldt K (2016)	1
HUWE1	22	RPA2	0	affinity chromatography technology	Thompson JW (2014)	1
POLL	3	3493	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNA	0	RPA3	2	affinity chromatography technology	Takasaki Y (2001)	1
POLL	3	SEMG2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	PCNA	0	enzymatic study	Hibbert RG (2012)	1
POLL	3	SERPINB4	1	affinity chromatography technology	Huttlin EL (2017)	1
POLL	3	SUPT16H	4	affinity chromatography technology	Boldt K (2016)	1
POLL	3	NOSIP	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CDK2	0	SUPT16H	4	affinity chromatography technology	Neganova I (2011)	1
UBE2H	3	TRIM23	3	two hybrid	Markson G (2009)	1
POLL	3	KRT40	0	two hybrid	Rolland T (2014)	1
CDK2	0	RPA1	0	enzymatic study	Pan ZQ (1993)	1
MAGEA12	0	POLL	3	two hybrid	Rolland T (2014)	1
POLL	3	SEMG1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RPA2	0	WRN	6	affinity chromatography technology	Marechal A (2014)	1
SSX2IP	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
POLL	3	SYN2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PCNA	0	RPA2	0	affinity chromatography technology	Takasaki Y (2001)	1
UBE2D3	1	POLL	3	enzymatic study	Hoeller D (2007)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HUWE1	22	UBE2D2	0	pull down, pull down, pull down, pull down	Warr MR (2005), Kristariyanto YA (2015), Li L (2015), Zhang W (2016)	4
RPA3	2	RPA1	0	biochemical, x-ray crystallography, affinity chromatography technology, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Bochkareva E (1998), Bochkareva E (2002), Gong Z (2011), Havugimana PC (2012), Du Y (2009), Wan C (2015), Hein MY (2015), Elia AE (2015)	8
KRTAP10-7	0	APP	1	pull down	Olah J (2011)	1
TFIP11	5	POLL	3	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
HUWE1	22	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Zhang J (2011), Adhikary S (2005), Schwarz SE (1998), Chen D (2005), Kristariyanto YA (2015), Lee CK (2015), Zhao X (2008)	7
UBE2E1	1	POLL	3	enzymatic study	Hoeller D (2007)	1
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
POLL	3	LTF	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCKDHB	3	BCKDHA	1	affinity chromatography technology	Huttlin EL (2017)	1
POLL	3	WRN	6	affinity chromatography technology	Boldt K (2016)	1
BCKDHA	1	POLL	3	affinity chromatography technology	Boldt K (2016)	1
POLL	3	SSRP1	1	affinity chromatography technology	Boldt K (2016)	1
LDOC1	0	POLL	3	two hybrid	Rual JF (2005)	1
POLL	3	FSD2	4	two hybrid	Rolland T (2014)	1
RPA2	0	APP	1	pull down	Olah J (2011)	1
RIOX2	1	APP	1	pull down	Olah J (2011)	1
UBE2D1	0	POLL	3	enzymatic study	Hoeller D (2007)	1
DCUN1D1	0	POLL	3	affinity chromatography technology	Bennett EJ (2010)	1
SUPT16H	4	WRN	6	affinity chromatography technology	Boldt K (2016)	1
POLL	3	IMPDH1	2	affinity chromatography technology	Huttlin EL (2015)	1
POLL	3	BCKDHB	3	affinity chromatography technology	Boldt K (2016)	1
SUPT16H	4	RPA3	2	affinity chromatography technology	Boldt K (2016)	1