PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
CDK2	0	GLG1	0	affinity chromatography technology	Neganova I (2011)	1
PAN2	3	SQSTM1	0	affinity chromatography technology	Bett JS (2013)	1
RNF2	1	GLG1	0	affinity chromatography technology	Cao Q (2014)	1
KLK2	0	GLG1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RNF2	1	KLK2	0	affinity chromatography technology	Cao Q (2014)	1
RFWD3	5	GLG1	0	affinity chromatography technology	Hein MY (2015)	1
SQSTM1	0	UBC	7	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, affinity chromatography technology, unspecified method, pull down, pull down, pull down, affinity chromatography technology, imaging technique, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, imaging technique, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique	Vinayagam A (2011), Vadlamudi RK (1996), Tanji K (2012), Matsumoto G (2011), Long J (2008), Long J (2008), Najat D (2009), Najat D (2009), Hocking LJ (2004), Boh BK (2011), Long J (2010), Seibenhener ML (2004), Seibenhener ML (2004), Seibenhener ML (2004), Fenner BJ (2009), Nathan JA (2013), Ciani B (2003), Shi J (2013), Goode A (2014), Bish RA (2007), Lu K (2014), Zhou L (2014), Zhou L (2014), Vadlamudi RK (1996), Long J (2008), Cavey JR (2006), Cavey JR (2006), Kirkin V (2009), Nakayasu ES (2013), Nakayasu ES (2013), Lim J (2015), Milan E (2015), Milan E (2015), Ordureau A (2015), Wurzer B (2015), Zhang X (2017), Wang L (2017), Liu X (2017), Peng H (2017), Donohue E (2014), Nibe Y (2017), Nibe Y (2017), Govindaraju VK (2017)	43
GLG1	0	SELE	0	pull down	Wild MK (2001)	1
UST	1	GLG1	0	affinity chromatography technology	Huttlin EL (2017)	1
RIPK4	0	SQSTM1	0	affinity chromatography technology	Rodriguez J (2016)	1
DKK3	3	GLG1	0	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	GLG1	0	pull down	Zhang X (2017)	1
SPPL2B	0	GLG1	0	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	GLG1	0	affinity chromatography technology	Emdal KB (2015)	1
SCGB2A2	0	GLG1	0	affinity chromatography technology	Huttlin EL (2017)	1
NFKB2	3	GLG1	0	affinity chromatography technology	Bouwmeester T (2004)	1
GINM1	1	GLG1	0	affinity chromatography technology	Huttlin EL (2015)	1
PAN2	3	RNF2	1	affinity chromatography technology	Boldt K (2016)	1
NTRK1	1	CDK2	0	affinity chromatography technology	Emdal KB (2015)	1
SQSTM1	0	NTRK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wooten MW (2001), Geetha T (2003), Jadhav T (2008), Wooten MW (2008), Wooten MW (2008), Zheng C (2015)	6
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
PLA2G12B	2	GLG1	0	affinity chromatography technology	Huttlin EL (2015)	1
MLKL	1	GLG1	0	affinity chromatography technology	Hein MY (2015)	1
ITM2B	2	GLG1	0	affinity chromatography technology	Huttlin EL (2015)	1
FAM8A1	5	GLG1	0	affinity chromatography technology	Huttlin EL (2017)	1
PTPRK	1	GLG1	0	affinity chromatography technology	Huttlin EL (2015)	1
PAN2	3	GLG1	0	affinity chromatography technology	Bett JS (2013)	1
CGRRF1	0	GLG1	0	affinity chromatography technology	Huttlin EL (2015)	1
RIPK4	0	GLG1	0	affinity chromatography technology	Rodriguez J (2016)	1
GRK5	7	GLG1	0	affinity chromatography technology	Wu Z (2012)	1
SQSTM1	0	GLG1	0	affinity chromatography technology	Behrends C (2010)	1