PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBA6	4	UCHL3	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CDC5L	2	TPX2	4	affinity chromatography technology	Lleres D (2010)	1
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
MEPCE	1	SRP68	2	affinity chromatography technology	Jeronimo C (2007)	1
USP2	0	EGFR	5	affinity chromatography technology	Kim J (2012)	1
PRKN	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Imai Y (2003), Sarraf SA (2013), Huttlin EL (2017)	3
ANAPC11	0	UBE2S	2	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Huang NJ (2012), Wang W (2013), Frye JJ (2013), Chang L (2014), Brown NG (2014), Wu T (2010), Sedgwick GG (2013), Fukushima H (2013), Yamaguchi M (2015), Brown NG (2015), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Zhang S (2016), Williamson A (2011), Qiao R (2016), Brown NG (2016), Li Q (2016)	19
TRIM25	5	PMF1	0	affinity chromatography technology	Choudhury NR (2017)	1
CDC5L	2	HSPA1L	2	biochemical	Havugimana PC (2012)	1
CDC20	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP5	2	APP	1	pull down	Olah J (2011)	1
ANAPC4	0	ANAPC5	2	biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	8
USP2	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
SYNCRIP	6	ELMO3	4	affinity chromatography technology	Hein MY (2015)	1
ZRANB1	3	UBC	7	affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, x-ray crystallography, pull down	Tran H (2008), Tran H (2008), Tran H (2008), Bremm A (2010), Komander D (2009), Licchesi JD (2012), Licchesi JD (2012), Mevissen TE (2013), Komander D (2009), Wauer T (2015), Kristariyanto YA (2015), Kristariyanto YA (2015), Kristariyanto YA (2015), Michel MA (2015), Michel MA (2015), Michel MA (2015), Michel MA (2015), Zhang X (2017)	18
FZR1	1	AKT1	1	fluorescent resonance energy transfe	Ivanov AA (2017)	1
CYLD	2	USP10	2	affinity chromatography technology	Elliott PR (2016)	1
ANAPC5	2	CDC16	2	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
ANAPC1	1	ANAPC5	2	biochemical, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015)	4
EGFR	5	HSPA5	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lavictoire SJ (2003), Foerster S (2013), Li J (2013), Yao Z (2017)	4
APP	1	HSPA8	4	affinity chromatography technology	Yamamoto YH (2010)	1
CDC20	1	ANAPC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Hein JB (2014), Lischetti T (2014), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	8
UBE2S	2	CDC16	2	pull down	Brown NG (2014)	1
ANAPC2	0	CREBBP	29	affinity chromatography technology	Turnell AS (2005)	1
UBE2S	2	CDC20	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Williamson A (2009), Williamson A (2009), Brown NG (2014), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016)	7
EGFR	5	AKT1	1	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
CDC5L	2	CDC16	2	affinity chromatography technology	Lleres D (2010)	1
USP10	2	USP15	4	biochemical	Havugimana PC (2012)	1
UBE2S	2	ELMO3	4	affinity chromatography technology	Hein MY (2015)	1
FZR1	1	UBE2D3	1	pull down	Jin L (2008)	1
SYNCRIP	6	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CDC5L	2	ZC3H18	4	biochemical	Havugimana PC (2012)	1
OTUB1	0	HSPA5	0	affinity chromatography technology	Scholz CC (2016)	1
BIRC2	1	UBE2S	2	two hybrid, pull down	Dynek JN (2010), Phu L (2011)	2
NCL	1	XRCC6	3	pull down	Kobayashi J (2012)	1
VHL	0	NCL	1	pull down	Lai Y (2012)	1
FBXO5	2	ANAPC4	0	pull down, biochemical, affinity chromatography technology	Miller JJ (2006), Chang L (2015), Voets E (2015)	3
DLD	1	TTC4	1	affinity chromatography technology	Malty RH (2017)	1
CDC27	2	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Hein MY (2015), Qiao R (2016), Qiao R (2016), Boldt K (2016)	18
USP5	2	UCHL3	1	biochemical	Havugimana PC (2012)	1
CDC27	2	ANAPC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Koloteva-Levine N (2004), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Fehr AR (2012), Holzmann J (2011), Havugimana PC (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Kelly A (2014), Craney A (2016), Qiao R (2016)	15
TPX2	4	UBE2S	2	biochemical	Havugimana PC (2012)	1
CDC20	1	CREBBP	29	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Townsend K (2009)	3
OTUB1	0	STAMBP	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Sowa ME (2009)	2
HNRNPDL	1	UBE2S	2	biochemical	Havugimana PC (2012)	1
CDC20	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	DAngiolella V (2003), Kallio MJ (2002), Wassmann K (1998), Kramer ER (1998), Kallio M (1998), Kallio M (1998), Nilsson J (2008), Jeganathan KB (2006), Nath S (2011), Lee YJ (2008), Lara-Gonzalez P (2011), Mansfeld J (2011), Braunstein I (2007), Visconti R (2010), Ma HT (2011), Lee YJ (2008), DAngiolella V (2003), Lee SJ (2012), Fang G (1998), Fang G (1998), Wolthuis R (2008), Ban KH (2007), Ge S (2009), Tipton AR (2011), Westhorpe FG (2011), Uzunova K (2012), Kwan PS (2013), Sedgwick GG (2012), Eytan E (2013), Hyun SY (2013), Lim HJ (2013), Choi BH (2014), Fogeron ML (2013), Sackton KL (2014), Shoji S (2014), Han JS (2014), Lara-Gonzalez P (2011), Hein JB (2014), Vodermaier HC (2003), Yen AH (2010), Voets E (2015), Boekhout M (2015), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Craney A (2016), Listovsky T (2013), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Qiao R (2016), Hein JB (2016)	54
CDC27	2	NCL	1	biochemical	Wan C (2015)	1
MEPCE	1	SYNCRIP	6	affinity chromatography technology	Jeronimo C (2007)	1
ANAPC2	0	ANAPC7	2	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003)	3
UBE2S	2	CREBBP	29	biochemical	Wan C (2015)	1
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
TPRKB	1	UBE2S	2	biochemical	Havugimana PC (2012)	1
RBCK1	0	UBC	7	affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, pull down, pull down, pull down, pull down, enzymatic study, pull down	Tatematsu K (2008), Yoshimoto N (2009), Sato Y (2011), Kirisako T (2006), Haas TL (2009), Yoshimoto N (2009), Sato Y (2011), Emmerich CH (2013), Emmerich CH (2013), Zhang X (2017)	10
PDCD4	2	UBE2S	2	affinity chromatography technology	Xu H (2015)	1
UBE2S	2	NCL	1	affinity chromatography technology	Hu L (2017)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
CYLD	2	USP15	4	affinity chromatography technology	Elliott PR (2016)	1
AKT1	1	CREBBP	29	pull down, enzymatic study	Drendall CI (2010), Drendall CI (2010)	2
UBE2S	2	ZC3H18	4	biochemical	Havugimana PC (2012)	1
OTUD7B	3	EGFR	5	affinity chromatography technology	Pareja F (2011)	1
DLD	1	UBA1	1	affinity chromatography technology	Malty RH (2017)	1
FZR1	1	TPX2	4	affinity chromatography technology, affinity chromatography technology	Stewart S (2005), Stewart S (2005)	2
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
NFATC2	1	XRCC6	3	affinity chromatography technology	Gabriel CH (2016)	1
MEPCE	1	IGF2BP1	2	affinity chromatography technology	Jeronimo C (2007)	1
CDC27	2	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kraft C (2003), Lara-Gonzalez P (2011), Dube P (2005), Dube P (2005), Holzmann J (2011), Lee SJ (2012), Hayes MJ (2006), Havugimana PC (2012), Gmachl M (2000), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Gmachl M (2000), Kelly A (2014), Craney A (2016), Qiao R (2016)	17
VHL	0	XRCC5	5	affinity chromatography technology	Lai Y (2011)	1
CDC16	2	ANAPC7	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hutchins JR (2010), Havugimana PC (2012), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	5
UBE2S	2	ZC3H14	3	biochemical	Havugimana PC (2012)	1
UBA1	1	UBE2D3	1	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Song AX (2014), Huguenin-Dezot N (2016)	4
CYLD	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, pull down	Almeida S (2008), Bremm A (2010), Komander D (2009), Kwasna D (2018)	4
CDK9	3	HSPA5	0	affinity chromatography technology	Jeronimo C (2007)	1
VHL	0	APP	1	pull down	Olah J (2011)	1
USP7	14	RBCK1	0	two hybrid	Hayes SD (2012)	1
UBE2S	2	VHL	0	pull down, pull down, enzymatic study, affinity chromatography technology	Lim JH (2016), Lim JH (2016), Lim JH (2016), Lim JH (2016)	4
UBC	7	NARS	3	affinity chromatography technology	Matsumoto M (2005)	1
HERC1	12	UBE2D3	1	pull down	Hattori T (2013)	1
BIRC2	1	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology, unspecified method	Graber TE (2010), Graber TE (2010), Faye MD (2015)	3
FBXO5	2	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Moshe Y (2011), Miller JJ (2006), Miller JJ (2006), Miller JJ (2006), Miller JJ (2006), Huttlin EL (2017)	6
CDC27	2	ANAPC1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sumara I (2000), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Vodermaier HC (2003), Tran K (2010), Wan C (2015), Qiao R (2016), Qiao R (2016)	12
PRKN	1	UBE2S	2	pull down	Kazlauskaite A (2014)	1
CDK9	3	IGF2BP1	2	affinity chromatography technology	Jeronimo C (2007)	1
CDC20	1	ANAPC5	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sedgwick GG (2012), Kelly A (2014), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016)	6
CYLD	2	NCL	1	affinity chromatography technology	Elliott PR (2016)	1
CDC20	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Stewart S (2005), Jia L (2011), Zhang Y (2001), Fogeron ML (2013), Lee SB (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	9
USP15	4	UBE2S	2	enzymatic study	Bremm A (2010)	1
CYLD	2	HSPA5	0	affinity chromatography technology	Elliott PR (2016)	1
CREBBP	29	ANAPC5	2	affinity chromatography technology, pull down	Turnell AS (2005), Turnell AS (2005)	2
USP15	4	USP7	14	enzymatic study	Loch CM (2012)	1
FZR1	1	PRKN	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
CDC20	1	HSPA1L	2	affinity chromatography technology	Fogeron ML (2013)	1
CYLD	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
TPX2	4	ZNF598	6	biochemical	Havugimana PC (2012)	1
UBA6	4	UBE2S	2	pull down	Jin J (2007)	1
BIRC2	1	EGFR	5	affinity chromatography technology	Puliyappadamba VT (2013)	1
USP7	14	UBE2S	2	enzymatic study	Bremm A (2010)	1
CDC20	1	CDC16	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Kallio MJ (2002), Kallio M (1998), Nilsson J (2008), Hutchins JR (2010), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Listovsky T (2013), Qiao R (2016), Izawa D (2012)	12
ATXN3	2	HSPA8	4	affinity chromatography technology	Kristensen LV (2018)	1
VCP	6	UBE2S	2	affinity chromatography technology	Yu CC (2013)	1
UBE2S	2	UBFD1	0	biochemical	Havugimana PC (2012)	1
NCL	1	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park JJ (2015), Park JJ (2015), Lim KH (2015), Lim KH (2015)	4
USP21	2	UCHL3	1	enzymatic study	Loch CM (2012)	1
UBE2S	2	ANAPC7	2	pull down	Brown NG (2014)	1
KARS	1	UBA1	1	biochemical	Havugimana PC (2012)	1
PIN4	0	UBE2S	2	biochemical	Havugimana PC (2012)	1
PPP2R5A	2	UBE2S	2	affinity chromatography technology	Craney A (2016)	1
CYLD	2	AKT1	1	enzymatic study, affinity chromatography technology	Yang WL (2013), Yang WL (2013)	2
UBA1	1	UBE2C	1	pull down, enzymatic study, enzymatic study	Jin J (2007), Huang DT (2009), Kang D (2002)	3
TRIM25	5	TTC4	1	affinity chromatography technology	Choudhury NR (2017)	1
FBXO5	2	CDC16	2	affinity chromatography technology, pull down, affinity chromatography technology	Miller JJ (2006), Miller JJ (2006), Hein MY (2015)	3
USP21	2	RBCK1	0	two hybrid	Hayes SD (2012)	1
ANAPC1	1	CDC23	3	biochemical, biochemical, affinity chromatography technology	Sumara I (2000), Havugimana PC (2012), Hein MY (2015)	3
TRIM25	5	HNRNPR	3	affinity chromatography technology	Choudhury NR (2017)	1
CDC5L	2	ANAPC7	2	affinity chromatography technology	Lleres D (2010)	1
ANAPC2	0	ANAPC4	0	biochemical, biochemical, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Boekhout M (2015)	11
USP21	2	ATXN3	2	enzymatic study	Loch CM (2012)	1
CREBBP	29	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nath S (2011), Nath S (2011), Townsend K (2009)	3
CDC20	1	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Mansfeld J (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Wolthuis R (2008), Sedgwick GG (2012), Zhang Z (2012), Chang L (2014), Fogeron ML (2013), Hein JB (2014), Hein JB (2014), Voets E (2015), Voets E (2015), Tipton AR (2013), Boekhout M (2015), Kelly A (2014), Craney A (2016), Craney A (2016), Sedgwick GG (2016), Qiao R (2016), Izawa D (2012), Izawa D (2012), Izawa D (2012), Izawa D (2012), Salsi V (2016)	25
RNF8	2	UBE2D3	1	pull down, pull down, pull down, two hybrid	Mallette FA (2012), Zhang S (2008), Zhang S (2013), Schimmack G (2017)	4
XRCC5	5	NCL	1	biochemical	Kristensen AR (2012)	1
VCP	6	TTC4	1	affinity chromatography technology	Yu CC (2013)	1
UBE2S	2	ANAPC5	2	pull down	Brown NG (2014)	1
CDC16	2	CDC23	3	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	6
USP10	2	UBC	7	enzymatic study, unspecified method, pull down	Bomberger JM (2009), Ernst A (2013), Kwasna D (2018)	3
HSPA5	0	HSPA1L	2	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
RBCK1	0	APP	1	pull down	Olah J (2011)	1
UBE2D3	1	UBE2C	1	biochemical	Wan C (2015)	1
SYNCRIP	6	ZNF598	6	biochemical	Wan C (2015)	1
UBE2S	2	RBCK1	0	two hybrid	Markson G (2009)	1
CDC16	2	XRCC5	5	two hybrid	Wang J (2011)	1
USP7	14	UBB	4	x-ray crystallography	Rouge L (2016)	1
USP10	2	ZC3H18	4	biochemical	Havugimana PC (2012)	1
ZRANB1	3	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBE2S	2	UBE2S	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Bremm A (2010), Baboshina OV (1996), David Y (2010), Brown NG (2014), Lim JH (2016), Lim JH (2016)	6
UBC	7	UBA1	1	affinity chromatography technology, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, pull down	Nicassio F (2007), Zhao B (2012), Schaefer A (2014), Schaefer A (2014), Bish RA (2007), Zhang X (2017)	6
FBXO5	2	CDC23	3	pull down, affinity chromatography technology	Miller JJ (2006), Hein MY (2015)	2
CDC5L	2	SRP68	2	affinity chromatography technology	Lleres D (2010)	1
CDC27	2	PPP2R5A	2	affinity chromatography technology	Craney A (2016)	1
FBXO5	2	ANAPC11	0	pull down	Miller JJ (2006)	1
BIRC2	1	USP15	4	affinity chromatography technology	Goncharov T (2013)	1
UBE2S	2	RNF40	11	affinity chromatography technology	Hein MY (2015)	1
UBE2S	2	IGF2BP1	2	affinity chromatography technology	Hu L (2017)	1
RNF8	2	UBC	7	enzymatic study, enzymatic study, enzymatic study	Feng L (2012), Hodge CD (2015), Ho YK (2015)	3
USP5	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
TRIM25	5	USP5	2	affinity chromatography technology	Choudhury NR (2017)	1
USP21	2	USP7	14	enzymatic study	Loch CM (2012)	1
ANAPC1	1	ANAPC2	0	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003)	4
CREBBP	29	XRCC6	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Barlev NA (1998), Barlev NA (1998), Cohen HY (2004), Cohen HY (2004), Cohen HY (2004)	5
ZNF598	6	UBE2D3	1	affinity chromatography technology, biochemical	Garzia A (2017), Garzia A (2017)	2
UBE2S	2	DPM3	0	affinity chromatography technology	Hu L (2017)	1
APP	1	UBB	4	protein complementation assay	Kajiwara Y (2010)	1
KARS	1	UBE2S	2	biochemical	Havugimana PC (2012)	1
ZNF598	6	VCP	6	affinity chromatography technology	Garzia A (2017)	1
CDC20	1	UBC	7	enzymatic study, enzymatic study	Kelly A (2014), Craney A (2016)	2
BIRC2	1	USP7	14	affinity chromatography technology	Goncharov T (2013)	1
PRKN	1	SYNCRIP	6	affinity chromatography technology	Zanon A (2013)	1
CREBBP	29	NFATC2	1	pull down, pull down	Garcia-Rodriguez C (1998), Falvo JV (2008)	2
NCL	1	ANAPC1	1	biochemical	Wan C (2015)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
ANAPC11	0	UBE2D3	1	pull down	Choudhury R (2016)	1
CDC5L	2	UBE2S	2	affinity chromatography technology	Lleres D (2010)	1
USP2	0	RBCK1	0	two hybrid	Hayes SD (2012)	1
UBE2S	2	ATP6V1A	3	biochemical	Havugimana PC (2012)	1
VCP	6	USP10	2	affinity chromatography technology	Yu CC (2013)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
TRIM25	5	XRCC5	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
UBC	7	ANAPC7	2	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
FZR1	1	ANAPC1	1	pull down, unspecified method, affinity chromatography technology	Vodermaier HC (2003), Vodermaier HC (2003), Huttlin EL (2017)	3
EGFR	5	XRCC5	5	affinity chromatography technology	Tong J (2014)	1
TRIM25	5	HSPA8	4	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
MEPCE	1	HNRNPR	3	affinity chromatography technology	Jeronimo C (2007)	1
ANAPC1	1	ANAPC7	2	biochemical, biochemical, biochemical	Sumara I (2000), Havugimana PC (2012), Wan C (2015)	3
NCL	1	TRIM25	5	affinity chromatography technology	Salvetti A (2016)	1
UBC	7	UBFD1	0	pull down	Fenner BJ (2009)	1
USP7	14	SRP68	2	affinity chromatography technology	Sowa ME (2009)	1
ATXN3	2	UBB	4	affinity chromatography technology, affinity chromatography technology	Kristensen LV (2018), Kristensen LV (2018)	2
HSPA8	4	UBC	7	two hybrid	Stelzl U (2005)	1
MEPCE	1	UBE2S	2	affinity chromatography technology	Jeronimo C (2007)	1
ANAPC4	0	CDC16	2	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mansfeld J (2011), Ma HT (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Masuda K (2015), Boekhout M (2015), Huttlin EL (2017)	14
RNF8	2	XRCC5	5	affinity chromatography technology	Feng L (2012)	1
ANAPC2	0	CDC23	3	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Hein MY (2015)	4
ANAPC11	0	ANAPC2	0	pull down, pull down, two hybrid, biochemical, affinity chromatography technology	Tang Z (2001), Tang Z (2001), Ohta T (1999), Lu L (2013), Vodermaier HC (2003)	5
UBE2S	2	UBE2D3	1	affinity chromatography technology	Kuang P (2016)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
FZR1	1	VHL	0	affinity chromatography technology, affinity chromatography technology	Liu W (2011), Liu W (2011)	2
HSPA5	0	XRCC6	3	biochemical	Havugimana PC (2012)	1
TTC4	1	UBE2S	2	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBA1	1	affinity chromatography technology	Goncharov T (2013)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
DLD	1	VCP	6	affinity chromatography technology	Malty RH (2017)	1
USP15	4	RNF40	11	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Long L (2014)	2
UCHL3	1	UBE2S	2	enzymatic study	Bremm A (2010)	1
UBC	7	ANAPC11	0	x-ray crystallography, pull down	Brown NG (2014), Brown NG (2016)	2
USP15	4	UCHL3	1	enzymatic study	Loch CM (2012)	1
UBE2S	2	ZNF598	6	biochemical	Havugimana PC (2012)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
CDC20	1	CDC23	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Fogeron ML (2013), Hein JB (2014), Hein MY (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Qiao R (2016)	8
FZR1	1	CDC27	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou Y (2003), Kramer ER (1998), Farhana L (2002), Cen B (2010), Sorensen CS (2001), Binne UK (2007), Wang X (2008), Tran K (2008), Wang LY (2012), Wang LY (2012), Ban KH (2007), Lv XB (2010), Huang KT (2012), Song MS (2011), Fukushima H (2013), Lau AW (2013), Cotto-Rios XM (2011), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Choi BH (2014), Jeganathan KB (2006), Fang G (1998), Sedgwick GG (2012), Kelly A (2014), Listovsky T (2013), Pavlides SC (2016), Huttlin EL (2017)	28
UBE2S	2	PMF1	0	affinity chromatography technology	Hu L (2017)	1
EGFR	5	NCL	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liccardi G (2014), Yao Z (2017), Goldshmit Y (2014)	3
XRCC5	5	XRCC6	3	two hybrid, biochemical, two hybrid, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, enzymatic study, x-ray crystallography, affinity chromatography technology, pull down, biochemical, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology	Gell D (1999), Barlev NA (1998), Yang CR (1999), Singleton BK (1999), Song K (2000), Gell D (1999), Gell D (1999), Willis DM (2002), Willis DM (2002), Drouet J (2005), Drouet J (2005), Cohen HY (2004), Lan L (2010), Cooper MP (2000), Cooper MP (2000), Velma V (2010), Zheng Y (2011), Sucharov CC (2004), Sucharov CC (2004), Sibani S (2005), Sibani S (2005), Walker JR (2001), Nick McElhinny SA (2000), Nick McElhinny SA (2000), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Sand-Dejmek J (2011), Pucci S (2009), Trougakos IP (2009), Havugimana PC (2012), Sartorius CA (2000), Sartorius CA (2000), Rivera-Calzada A (2007), Kelavkar UP (2001), Kelavkar UP (2001), Kristensen AR (2012), Kim E (2008), Wan C (2015), Hein MY (2015), Hein MY (2015), Nolens G (2009), Nolens G (2009), Nolens G (2009), Nolens G (2009), Huttlin EL (2017), Fantini D (2017)	46
TRIM25	5	HSPA1L	2	affinity chromatography technology	Pauli EK (2014)	1
HSPA5	0	RNF40	11	affinity chromatography technology	Hein MY (2015)	1
UBC	7	HNRNPR	3	affinity chromatography technology	Matsumoto M (2005)	1
UBE2S	2	FZR1	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, pull down, pull down	Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Williamson A (2009), Wang W (2013), Brown NG (2014), Kelly A (2014)	8
RUSC1	5	APP	1	pull down	Olah J (2011)	1
PRKN	1	APP	1	affinity chromatography technology, imaging technique	Rosen KM (2010), Lonskaya I (2012)	2
PMF1	0	ZRANB1	3	affinity chromatography technology	Huttlin EL (2015)	1
CYLD	2	HSPA8	4	affinity chromatography technology	Elliott PR (2016)	1
PRKN	1	RBCK1	0	two hybrid	Corominas R (2014)	1
ANAPC4	0	FZR1	1	biochemical, biochemical, unspecified method, biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Boekhout M (2015), Huttlin EL (2017)	6
UBE2S	2	XRCC5	5	affinity chromatography technology	Hu L (2017)	1
EGFR	5	UBE2S	2	affinity chromatography technology	Tong J (2014)	1
FBXO5	2	ANAPC2	0	pull down	Miller JJ (2006)	1
CYLD	2	CDC5L	2	affinity chromatography technology	Elliott PR (2016)	1
UBE2D3	1	OTUB1	0	two hybrid, enzymatic study, pull down, affinity chromatography technology	Rolland T (2014), Li Y (2014), Li Y (2014), Scholz CC (2016)	4
FZR1	1	ANAPC11	0	affinity chromatography technology, pull down, unspecified method	Bassermann F (2008), Vodermaier HC (2003), Vodermaier HC (2003)	3
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
SRP68	2	FZR1	1	affinity chromatography technology	Huttlin EL (2017)	1
ANAPC2	0	CDC16	2	biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
USP21	2	USP15	4	enzymatic study, enzymatic study	Loch CM (2012), Loch CM (2012)	2
ZNF598	6	RNF40	11	affinity chromatography technology	Garzia A (2017)	1
HERC1	12	UBE2S	2	pull down	Zhang W (2016)	1
TRIM25	5	BIRC2	1	affinity chromatography technology	Choudhury NR (2017)	1
ZC3H18	4	ZC3H14	3	affinity chromatography technology	Huttlin EL (2017)	1
UBE2S	2	CSNK1E	0	affinity chromatography technology	Huttlin EL (2015)	1
TRIM25	5	FZR1	1	affinity chromatography technology	Choudhury NR (2017)	1
USP2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
EGFR	5	HERC1	12	affinity chromatography technology	Yao Z (2017)	1
FZR1	1	CDC20	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Stewart S (2005), Stewart S (2005), Wang Y (2007), Wang Y (2007), Tian W (2012), Hyun SY (2013), Hyun SY (2013)	7
CDC20	1	HSPA5	0	affinity chromatography technology	Fogeron ML (2013)	1
YAF2	1	UBE2S	2	affinity chromatography technology	Huttlin EL (2017)	1
RNF7	0	VHL	0	affinity chromatography technology	Tan M (2008)	1
YAF2	1	USP7	14	affinity chromatography technology, affinity chromatography technology	Gao Z (2012), Huttlin EL (2017)	2
ANAPC11	0	CDC16	2	biochemical	Lu L (2013)	1
CYLD	2	SYNCRIP	6	affinity chromatography technology	Elliott PR (2016)	1
VCP	6	ANAPC7	2	affinity chromatography technology	Yu CC (2013)	1
USP6NL	2	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
CDC5L	2	ANAPC1	1	affinity chromatography technology	Lleres D (2010)	1
FZR1	1	ANAPC2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Stewart S (2005), Wen H (2010), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Huttlin EL (2017)	6
ZNF598	6	USP2	0	affinity chromatography technology	Morita M (2012)	1
ATXN3	2	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, biochemical, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doss-Pepe EW (2003), Wang Q (2008), Matsumoto M (2004), Matsumoto M (2004), Reina CP (2010), Zhong X (2006), Morreale G (2009), Fernandez-Saiz V (2010), Laco MN (2012), Laco MN (2012), Yu CC (2013), Liu S (2013), Yang H (2014), Yang H (2014), Yang H (2014), Liu H (2016), Pfeiffer A (2017), Tu Y (2017)	18
UBE2S	2	HSPA1L	2	affinity chromatography technology	Hu L (2017)	1
UBC	7	SYNCRIP	6	affinity chromatography technology	Matsumoto M (2005)	1
UBE2S	2	CDC23	3	affinity chromatography technology, pull down, pull down	Wang W (2013), Brown NG (2014), Kelly A (2014)	3
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
CDK9	3	SYNCRIP	6	affinity chromatography technology	Jeronimo C (2007)	1
CDC27	2	CDC16	2	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Ollendorff V (1997), Kallio M (1998), Gmachl M (2000), Kraft C (2003), Li Y (1997), Lara-Gonzalez P (2011), Binne UK (2007), van Zon W (2010), Dube P (2005), Holzmann J (2011), Hayes MJ (2006), Tugendreich S (1995), Havugimana PC (2012), Vodermaier HC (2003), Wan C (2015), Hein MY (2015), Kelly A (2014), Listovsky T (2013), Qiao R (2016), Huttlin EL (2017), Boldt K (2016)	22
STAMBP	2	UBC	7	enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Bremm A (2010), Komander D (2009), McCullough J (2006), Nakasone MA (2013), Davies CW (2013), Trang VH (2014), Wauer T (2015), Michel MA (2015), Bueno AN (2015), Baiady N (2016), Baiady N (2016), Castaneda CA (2016), Kliza K (2017)	13
CYLD	2	VCP	6	affinity chromatography technology	Elliott PR (2016)	1
ANAPC4	0	CDC23	3	biochemical, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015)	8
TRIM25	5	UBE2S	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Choudhury NR (2017)	2
AKT1	1	HSPA8	4	affinity chromatography technology	Klein JB (2005)	1
UBE2S	2	SVOPL	2	affinity chromatography technology	Hu L (2017)	1
PRKN	1	HSPA5	0	affinity chromatography technology	Zanon A (2013)	1
UBC	7	NCL	1	affinity chromatography technology	Matsumoto M (2005)	1
NCL	1	CDC5L	2	affinity chromatography technology	Salvetti A (2016)	1
PRKN	1	XRCC6	3	affinity chromatography technology	Zanon A (2013)	1
CDC27	2	ANAPC4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Mansfeld J (2011), Lara-Gonzalez P (2011), Mansfeld J (2011), Izawa D (2011), Ma HT (2011), Ma HT (2011), Ma HT (2011), Dube P (2005), Holzmann J (2011), Wolthuis R (2008), Havugimana PC (2012), Uzunova K (2012), Song MS (2011), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Vodermaier HC (2003), Vodermaier HC (2003), Tran K (2010), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Hein MY (2015), Voets E (2015), Masuda K (2015), Boekhout M (2015), Craney A (2016), Qiao R (2016), Izawa D (2012), Hein JB (2016)	34
NARS	3	XRCC6	3	biochemical	Kristensen AR (2012)	1
STAMBP	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
CDC27	2	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Lara-Gonzalez P (2011), Tran K (2008), Dube P (2005), Holzmann J (2011), Havugimana PC (2012), Sedgwick GG (2012), Song MS (2011), Vodermaier HC (2003), Tran K (2010), Yamaguchi M (2015), Yamaguchi M (2015), Wan C (2015), Kelly A (2014), Craney A (2016), Qiao R (2016), Boldt K (2016)	19
USP5	2	UBC	7	pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down	Reyes-Turcu FE (2008), Nicassio F (2007), Zhang YH (2012), Bremm A (2010), Komander D (2009), Melandri F (1996), Sokratous K (2012), Fenner BJ (2009), Schulz S (2012), Raasi S (2005), Nathan JA (2013), Ernst A (2013), Bish RA (2007), Reyes-Turcu FE (2006), Reyes-Turcu FE (2006), Zhang YH (2012), Liu Y (2014), Scott D (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	22
VHL	0	HSPA8	4	affinity chromatography technology, pull down	Lai Y (2011), Lai Y (2012)	2
UBA6	4	UBE2D3	1	pull down	Jin J (2007)	1
RBCK1	0	UBE2D3	1	pull down, pull down, pull down, pull down	Zenke-Kawasaki Y (2007), Yamanaka K (2003), Inn KS (2011), Kirisako T (2006)	4
USP21	2	STAMBP	2	enzymatic study	Loch CM (2012)	1
VHL	0	HSPA5	0	pull down	Lai Y (2012)	1
FZR1	1	ANAPC5	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012), Huttlin EL (2017)	3
UBE2S	2	XRCC6	3	affinity chromatography technology	Hu L (2017)	1
UBC	7	OTUD7B	3	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, pull down	Pareja F (2011), Bremm A (2010), Mevissen TE (2013), Michel MA (2015), Kristariyanto YA (2015), Castaneda CA (2016), Mevissen TE (2016), Mevissen TE (2016), Kwasna D (2018)	9
USP5	2	ATP6V1A	3	biochemical	Havugimana PC (2012)	1
ANAPC1	1	ANAPC4	0	biochemical, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Sumara I (2000), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Hein JB (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015)	9
C11orf74	0	UBE2S	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM25	5	XRCC6	3	affinity chromatography technology	Choudhury NR (2017)	1
TANGO6	0	UBE2S	2	biochemical	Havugimana PC (2012)	1
CSNK1E	0	HSPA8	4	affinity chromatography technology	Huttlin EL (2017)	1
CYLD	2	HNRNPR	3	affinity chromatography technology	Elliott PR (2016)	1
CDC27	2	ANAPC11	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Gmachl M (2000), Kraft C (2003), Dube P (2005), Lu L (2013), Gmachl M (2000), Vodermaier HC (2003), Craney A (2016)	8
PRKN	1	HNRNPR	3	affinity chromatography technology	Zanon A (2013)	1
USP21	2	UBE2S	2	enzymatic study	Bremm A (2010)	1
RNF8	2	UBE2S	2	affinity chromatography technology	Paul A (2017)	1
PRKN	1	HNRNPDL	1	affinity chromatography technology	Zanon A (2013)	1
TRIM25	5	ANAPC1	1	affinity chromatography technology	Choudhury NR (2017)	1
PRKN	1	UBE2C	1	pull down	Kazlauskaite A (2014)	1
MEPCE	1	CDK9	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Jeronimo C (2007), Varjosalo M (2013), Varjosalo M (2013), Lu H (2014), Huttlin EL (2015), Huttlin EL (2017)	7
CDC16	2	CREBBP	29	affinity chromatography technology	Turnell AS (2005)	1
ANAPC5	2	ANAPC7	2	biochemical, affinity chromatography technology	Havugimana PC (2012), Sedgwick GG (2012)	2
PRKN	1	EGFR	5	affinity chromatography technology, affinity chromatography technology	Lin DC (2015), Lin DC (2015)	2
UBE2S	2	HNRNPR	3	affinity chromatography technology	Hu L (2017)	1
CDC5L	2	CDK9	3	affinity chromatography technology	Lleres D (2010)	1
UBE2S	2	RUSC1	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	RNF8	2	affinity chromatography technology	Choudhury NR (2017)	1
EGFR	5	HSPA8	4	protein complementation assay, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deribe YL (2009), Lavictoire SJ (2003), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013), Yao Z (2017)	8
TRIM25	5	HSPA5	0	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	USP7	14	affinity chromatography technology	Choudhury NR (2017)	1
AKT1	1	VHL	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, unspecified method	Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016), Guo J (2016)	5
TRIM25	5	RBCK1	0	affinity chromatography technology, imaging technique, pull down, enzymatic study	Inn KS (2011), Inn KS (2011), Inn KS (2011), Inn KS (2011)	4
AKT1	1	HSPA5	0	affinity chromatography technology	Klein JB (2005)	1
RNF40	11	CDK9	3	biochemical	Wu L (2014)	1
NCL	1	HNRNPR	3	affinity chromatography technology	Salvetti A (2016)	1
FZR1	1	ANAPC7	2	unspecified method, affinity chromatography technology	Vodermaier HC (2003), Sedgwick GG (2012)	2
HSPA8	4	CREBBP	29	affinity chromatography technology	Du C (2017)	1
ATXN3	2	XRCC6	3	affinity chromatography technology	Li Y (2007)	1
ZNF598	6	HSPA8	4	affinity chromatography technology	Garzia A (2017)	1
UBE2S	2	APP	1	pull down	Olah J (2011)	1
USP15	4	UBC	7	pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Hetfeld BK (2005), Bremm A (2010), Komander D (2009), Loch CM (2012), Herhaus L (2014), Wauer T (2015), Das T (2017), Zhang X (2017), Kwasna D (2018)	9
OTUB1	0	HSPA8	4	affinity chromatography technology	Scholz CC (2016)	1
CYLD	2	KARS	1	affinity chromatography technology	Elliott PR (2016)	1
FBXO5	2	FZR1	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Hsu JY (2002), Hsu JY (2002), Reimann JD (2001), Miller JJ (2006), Huttlin EL (2017)	5
KARS	1	NARS	3	biochemical	Havugimana PC (2012)	1
AKT1	1	APP	1	pull down	Olah J (2011)	1
CDC5L	2	HSPA5	0	affinity chromatography technology	Lleres D (2010)	1
FBXO5	2	ANAPC1	1	affinity chromatography technology, pull down	Miller JJ (2006), Miller JJ (2006)	2
VCP	6	CDC27	2	affinity chromatography technology	Yu CC (2013)	1
TRIM25	5	PPP2R5A	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CREBBP	29	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
UBA1	1	UBE2S	2	enzymatic study, pull down, enzymatic study, enzymatic study	Tokgoez Z (2012), Jin J (2007), Wauer T (2015), Huguenin-Dezot N (2016)	4
USP5	2	UBA1	1	affinity chromatography technology	Song AX (2014)	1
FZR1	1	UBE2C	1	pull down, pull down, enzymatic study	Jin L (2008), Williamson A (2009), Williamson A (2011)	3
USP2	0	UBC	7	x-ray crystallography, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, unspecified method, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Renatus M (2006), Matsumoto M (2005), Bremm A (2010), Komander D (2009), Bozza WP (2012), Bozza WP (2012), Ernst A (2013), Durcan TM (2011), Mullen JR (2010), Ernst A (2013), Wauer T (2015), Louis M (2015), Castaneda CA (2016), Kliza K (2017), Kwasna D (2018), Leung I (2016)	16
UBE2S	2	UBB	4	x-ray crystallography, enzymatic study	Lorenz S (2016), Lorenz S (2016)	2
HSPA8	4	VCP	6	affinity chromatography technology, biochemical, affinity chromatography technology	Vij N (2006), Havugimana PC (2012), Yu CC (2013)	3
ANAPC11	0	UBE2C	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Wu T (2010), Ke PY (2007), Jia L (2011), Braunstein I (2007), van Zon W (2010), Eytan E (2006), Ping Z (2012), Townsend K (2009), Huang NJ (2012), Chow C (2011), Zhang Z (2012), Bassermann F (2008), Wang W (2013), Frye JJ (2013), Han JS (2013), Chang L (2014), Lara-Gonzalez P (2011), He J (2013), Lau AW (2013), Han JS (2014), Sedgwick GG (2013), von Klitzing C (2011), Tang Z (2001), Shoji S (2014), Fukushima H (2013), Yamaguchi M (2015), Sajman J (2015), Brown NG (2015), Brown NG (2014), Cao J (2015), Zhang S (2016), Williamson A (2011), Qiao R (2016), Alfieri C (2016), Brown NG (2016), Li Q (2016), Izawa D (2012)	37
VCP	6	PDCD4	2	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Yu CC (2013)	2
CSNK1E	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
USP15	4	OTUB1	0	enzymatic study	Loch CM (2012)	1
CDC20	1	ANAPC11	0	affinity chromatography technology, imaging technique, affinity chromatography technology, enzymatic study	Nilsson J (2008), Chen TC (2014), Lee SB (2015), Alfieri C (2016)	4
USP15	4	MEPCE	1	affinity chromatography technology	Sowa ME (2009)	1
SYNCRIP	6	HNRNPR	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
CDC20	1	PPP2R5A	2	affinity chromatography technology, affinity chromatography technology	Craney A (2016), Craney A (2016)	2
CDC5L	2	CDC20	1	affinity chromatography technology	Lleres D (2010)	1
FBXO5	2	ANAPC7	2	affinity chromatography technology, pull down	Miller JJ (2006), Miller JJ (2006)	2
OTUD7B	3	UBE2S	2	enzymatic study	Bremm A (2010)	1
CDC5L	2	HSPA8	4	affinity chromatography technology, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Lleres D (2010)	3
UBE2S	2	SRP68	2	affinity chromatography technology	Hu L (2017)	1
PRKN	1	HSPA1L	2	affinity chromatography technology	Zanon A (2013)	1
PRKN	1	ATXN3	2	pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography	Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Durcan TM (2011), Bai JJ (2013)	7
UBE2S	2	ANAPC2	0	affinity chromatography technology, pull down, pull down, pull down	Wang W (2013), Brown NG (2014), Brown NG (2014), Kelly A (2014)	4
USP15	4	ANAPC1	1	affinity chromatography technology	Greenblatt MB (2016)	1
UBE2S	2	UBC	7	enzymatic study, pull down, x-ray crystallography, enzymatic study, enzymatic study	Bremm A (2010), Wickliffe KE (2011), Wickliffe KE (2011), Kelly A (2014), Michel MA (2017)	5
SRP68	2	CDC27	2	affinity chromatography technology	Huttlin EL (2017)	1
CDC5L	2	CDC23	3	affinity chromatography technology	Lleres D (2010)	1
ZNF598	6	HSPA5	0	affinity chromatography technology	Garzia A (2017)	1
UBC	7	HSPA5	0	pull down	Nathan JA (2013)	1
CDC5L	2	USP10	2	affinity chromatography technology	Lleres D (2010)	1
RNF7	0	UBE2S	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kuang P (2016), Kuang P (2016), Kuang P (2016), Zhou W (2017)	4
ANAPC4	0	ANAPC11	0	affinity chromatography technology, biochemical, biochemical, pull down, biochemical, affinity chromatography technology	Mansfeld J (2011), Zhang Z (2012), Chang L (2014), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015)	6
USP15	4	RBCK1	0	two hybrid	Hayes SD (2012)	1
ATXN3	2	UBC	7	pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, pull down, x-ray crystallography, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, x-ray crystallography, pull down, imaging technique, enzymatic study, pull down	Winborn BJ (2008), Mao Y (2005), Berke SJ (2005), Matsumoto M (2005), Bremm A (2010), Nicastro G (2010), Nicastro G (2010), Donaldson KM (2003), Chai Y (2004), Chai Y (2004), Nathan JA (2013), Seki T (2013), Yang H (2014), Yang H (2014), Blount JR (2014), Evers MM (2013), Weeks SD (2011), Donaldson KM (2003), Winborn BJ (2008), Faggiano S (2015), Wauer T (2015), Satoh T (2014), Satoh T (2014), Zhang X (2017), Toonen LJA (2017), Toonen LJA (2017), Kwasna D (2018)	27
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
UBC	7	HERC1	12	pull down	Zhang X (2017)	1
CDC20	1	ANAPC7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nilsson J (2008), Townsend K (2009), Townsend K (2009), Townsend K (2009), Sedgwick GG (2012), Fogeron ML (2013), Hein JB (2014), Vodermaier HC (2003), Kelly A (2014), Craney A (2016), Craney A (2016), Qiao R (2016), Hein JB (2016)	13
USP21	2	OTUB1	0	enzymatic study	Loch CM (2012)	1
PRKN	1	CDC20	1	affinity chromatography technology, affinity chromatography technology	Lee SB (2015), Lee SB (2015)	2
PRKN	1	UBC	7	enzymatic study, imaging technique, enzymatic study, fluorescent resonance energy transfe, pull down, pull down, pull down, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study, enzymatic study, pull down, x-ray crystallography, enzymatic study	Kondapalli C (2012), Kane LA (2014), Kane LA (2014), Koyano F (2014), Zheng X (2013), Shiba-Fukushima K (2014), Shiba-Fukushima K (2014), Kumar A (2015), Kumar A (2015), Okatsu K (2015), Okatsu K (2015), Okatsu K (2015), Yamano K (2015), Fiesel FC (2015), Ordureau A (2015), Kazlauskaite A (2015), Kazlauskaite A (2015), Kumar A (2017), Kliza K (2017)	19
UBC	7	ANAPC1	1	pull down	Nathan JA (2013)	1
UBE2S	2	HSPA8	4	affinity chromatography technology	Hu L (2017)	1
CDC5L	2	HNRNPR	3	biochemical	Havugimana PC (2012)	1
DLD	1	OTUB1	0	affinity chromatography technology	Malty RH (2017)	1
ANAPC2	0	UBE2C	1	pull down, biochemical, pull down, x-ray crystallography, pull down	Tang Z (2001), Reddy SK (2007), Tang Z (2001), Brown NG (2015), Brown NG (2015)	5
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
VHL	0	HNRNPR	3	affinity chromatography technology	Lai Y (2011)	1
TRIM25	5	IGF2BP1	2	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
AKT1	1	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Vandermoere F (2006), Vandermoere F (2006), Vandermoere F (2006), Klein JB (2005), Klein JB (2005), Klein JB (2005), Yu CC (2013), Yu CC (2013)	8
ANAPC4	0	ANAPC7	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Mansfeld J (2011), Havugimana PC (2012), Zhang Z (2012), Chang L (2014), Sedgwick GG (2013), Vodermaier HC (2003), Chang L (2015), Yamaguchi M (2015), Wan C (2015), Sedgwick GG (2016)	10
HNRNPDL	1	HNRNPR	3	biochemical	Havugimana PC (2012)	1
TRIM25	5	ANAPC11	0	affinity chromatography technology	Choudhury NR (2017)	1
CDC5L	2	CDC27	2	affinity chromatography technology	Lleres D (2010)	1
PRKN	1	HSPA8	4	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Imai Y (2002), Imai Y (2002), Imai Y (2003), Zanon A (2013)	4
NCL	1	IGF2BP1	2	affinity chromatography technology	Salvetti A (2016)	1
VHL	0	HNRNPDL	1	affinity chromatography technology	Lai Y (2011)	1
ATXN3	2	APP	1	pull down	Olah J (2011)	1
XRCC5	5	NARS	3	biochemical	Kristensen AR (2012)	1
OTUB1	0	KARS	1	affinity chromatography technology	Scholz CC (2016)	1
UBE2S	2	FBXO5	2	affinity chromatography technology	Wang W (2013)	1
VCP	6	RNF7	0	affinity chromatography technology	Yu CC (2013)	1
FZR1	1	CDC23	3	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
CDK9	3	HNRNPR	3	affinity chromatography technology	Jeronimo C (2007)	1
OTUB1	0	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, unspecified method, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, x-ray crystallography, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down, pull down	Wang T (2009), Bremm A (2010), Juang YC (2012), Ernst A (2013), Ernst A (2013), Nakasone MA (2013), Wiener R (2013), Edelmann MJ (2009), Bish RA (2007), Mevissen TE (2013), Juang YC (2012), Herhaus L (2013), Ernst A (2013), Herhaus L (2015), Herhaus L (2015), Herhaus L (2015), Wauer T (2015), Michel MA (2015), Kristariyanto YA (2015), Scholz CC (2016), Scholz CC (2016), Altun M (2015), Flierman D (2016), Castaneda CA (2016), Zhang X (2017), Kwasna D (2018)	26
CDC20	1	HSPA8	4	affinity chromatography technology	Fogeron ML (2013)	1
FZR1	1	CDC16	2	unspecified method, affinity chromatography technology, affinity chromatography technology	Vodermaier HC (2003), Hein MY (2015), Huttlin EL (2017)	3
ANAPC11	0	CDC23	3	biochemical	Lu L (2013)	1
ANAPC1	1	CDC16	2	biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Sumara I (2000), Hutchins JR (2010), Havugimana PC (2012), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	6
NFATC2	1	UBE2S	2	affinity chromatography technology	Gabriel CH (2016)	1
ATXN3	2	CREBBP	29	pull down, affinity chromatography technology, affinity chromatography technology	Li F (2002), Li F (2002), Li Y (2007)	3
HSPA5	0	HSPA8	4	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Hein MY (2015)	3
TRIM25	5	ANAPC7	2	affinity chromatography technology	Choudhury NR (2017)	1
CYLD	2	BIRC2	1	affinity chromatography technology	Elliott PR (2016)	1
DLD	1	XRCC6	3	affinity chromatography technology	Malty RH (2017)	1
CYLD	2	HNRNPDL	1	affinity chromatography technology	Elliott PR (2016)	1
RNF7	0	UBE2C	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Kuang P (2016), Kuang P (2016), Kuang P (2016), Zhou W (2017)	4
VCP	6	UBB	4	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
CDC5L	2	ANAPC2	0	affinity chromatography technology	Lleres D (2010)	1
NFATC2	1	HSPA5	0	affinity chromatography technology	Gabriel CH (2016)	1
UBE2S	2	UBE2C	1	affinity chromatography technology, affinity chromatography technology	Kuang P (2016), Kuang P (2016)	2
DLD	1	UBE2S	2	affinity chromatography technology	Malty RH (2017)	1
USP21	2	USP2	0	enzymatic study	Loch CM (2012)	1
ANAPC2	0	ANAPC5	2	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Gmachl M (2000), Vodermaier HC (2003), Vodermaier HC (2003)	4
FBXO5	2	ANAPC5	2	affinity chromatography technology, pull down	Miller JJ (2006), Miller JJ (2006)	2
ANAPC5	2	CDC23	3	biochemical, affinity chromatography technology	Havugimana PC (2012), Hein MY (2015)	2
BIRC2	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down	Hu S (2003), Dynek JN (2010), Hu S (2003)	3
USP7	14	UBC	7	enzymatic study, enzymatic study, unspecified method, enzymatic study, pull down	Bremm A (2010), Faesen AC (2011), Ernst A (2013), Holowaty MN (2003), Kwasna D (2018)	5
ZNF598	6	KARS	1	affinity chromatography technology	Garzia A (2017)	1
EGFR	5	PIN4	0	protein complementation assay	Deribe YL (2009)	1
OTUB1	0	UBE2S	2	enzymatic study	Bremm A (2010)	1
NCL	1	ANAPC7	2	biochemical	Wan C (2015)	1
CDC20	1	UBB	4	affinity chromatography technology	Fogeron ML (2013)	1
UBE2S	2	ANAPC1	1	pull down	Brown NG (2014)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
UBE2S	2	AKT1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Hu L (2017), Hu L (2017), Hu L (2017)	3
CDC23	3	ANAPC7	2	biochemical, affinity chromatography technology, affinity chromatography technology	Wan C (2015), Hein MY (2015), Boldt K (2016)	3
VCP	6	RNF8	2	two hybrid	Rolland T (2014)	1
PRKN	1	UBE2D3	1	pull down, pull down, pull down	Shin JH (2011), Wenzel DM (2011), Kazlauskaite A (2014)	3
UBE2S	2	USP6NL	2	affinity chromatography technology	Hein MY (2015)	1
UBE2S	2	NARS	3	biochemical	Wan C (2015)	1
RNF7	0	UBE2D3	1	pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Tan M (2010), Kershaw NJ (2014), Raducu M (2016), Kuang P (2016), Kuang P (2016)	5
DLD	1	CDK9	3	affinity chromatography technology	Malty RH (2017)	1
TRIM25	5	ZNF598	6	affinity chromatography technology	Choudhury NR (2017)	1
YAF2	1	UBB	4	affinity chromatography technology	Huttlin EL (2017)	1
ANAPC7	2	CREBBP	29	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Turnell AS (2005), Turnell AS (2005), Turnell AS (2005), Townsend K (2009)	4
UBE2S	2	USP10	2	biochemical	Havugimana PC (2012)	1
UBE2C	1	CDC20	1	biochemical, pull down	Reddy SK (2007), Garnett MJ (2009)	2
SYNCRIP	6	IGF2BP1	2	biochemical	Havugimana PC (2012)	1
HSPA5	0	HNRNPR	3	biochemical	Wan C (2015)	1
UBE2S	2	HSPA5	0	affinity chromatography technology	Hu L (2017)	1
PRKN	1	IGF2BP1	2	affinity chromatography technology	Zanon A (2013)	1
FBXO5	2	CDC20	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hsu JY (2002), Hsu JY (2002), Reimann JD (2001), Reimann JD (2001), Voets E (2015)	5
DLD	1	XRCC5	5	affinity chromatography technology	Malty RH (2017)	1
TRIM25	5	SYNCRIP	6	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
LRRC4C	3	UBE2S	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2S	2	CDC27	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Williamson A (2009), Brown NG (2014), Kelly A (2014), Craney A (2016)	4
DLD	1	UCHL3	1	biochemical	Wan C (2015)	1
BIRC2	1	OTUB1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Goncharov T (2013), Goncharov T (2013), Goncharov T (2013)	3
UBE2S	2	ANAPC4	0	pull down, pull down	Brown NG (2014), Brown NG (2014)	2
CDK9	3	UBE2S	2	biochemical	Havugimana PC (2012)	1
HSPA5	0	HNRNPDL	1	affinity chromatography technology	Li J (2013)	1
UBE2S	2	SYNCRIP	6	biochemical	Wan C (2015)	1
NFATC2	1	HSPA8	4	affinity chromatography technology	Gabriel CH (2016)	1
UBA1	1	UCHL3	1	biochemical	Wan C (2015)	1
UBA6	4	UBC	7	pull down, enzymatic study, unspecified method, affinity chromatography technology	Gavin JM (2012), Gavin JM (2012), Zhao B (2012), Bish RA (2007)	4
TRIM25	5	USP15	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Pauli EK (2014), Pauli EK (2014), Pauli EK (2014), Pauli EK (2014)	4
USP21	2	UBC	7	enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, unspecified method, enzymatic study, enzymatic study, pull down, enzymatic study	Bremm A (2010), Faesen AC (2011), Ye Y (2011), Urbe S (2012), Loch CM (2012), Ernst A (2013), Ye Y (2011), Wauer T (2015), Leung I (2016), Michel MA (2017)	10
MEPCE	1	HSPA5	0	affinity chromatography technology	Jeronimo C (2007)	1
NFATC2	1	XRCC5	5	affinity chromatography technology	Gabriel CH (2016)	1
ATXN3	2	UBE2S	2	enzymatic study	Bremm A (2010)	1