PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
UBC	7	AGO3	4	affinity chromatography technology	Matsumoto M (2005)	1
GTSE1	3	TNRC6A	6	affinity chromatography technology	Hein MY (2015)	1
AGO1	11	AGO2	10	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang V (2013), Huang V (2013), Huang V (2013), Li S (2014), Li S (2014)	5
CUL3	17	SMARCB1	1	affinity chromatography technology	Bennett EJ (2010)	1
CEP250	4	AGO2	10	affinity chromatography technology	Fogeron ML (2013)	1
AGO2	10	CNOT8	1	affinity chromatography technology	Braun JE (2011)	1
CNTROB	6	TNRC6A	6	bioid	Gupta GD (2015)	1
CEP152	2	CNOT3	11	bioid	Gupta GD (2015)	1
PICALM	0	TNRC6A	6	affinity chromatography technology	Hein MY (2015)	1
TRIM65	1	TNRC6A	6	affinity chromatography technology, affinity chromatography technology, enzymatic study	Li S (2014), Li S (2014), Li S (2014)	3
CEP135	2	CEP152	2	bioid	Gupta GD (2015)	1
GTSE1	3	PICALM	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	3
CNOT7	0	CNOT6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fabian MR (2009), Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	4
BTRC	1	FANCM	5	affinity chromatography technology	Kee Y (2009)	1
TNRC6A	6	PAN3	1	affinity chromatography technology	Braun JE (2011)	1
CNOT6	2	CNOT1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Hein MY (2015), Boldt K (2016)	3
CUL3	17	TNRC6A	6	affinity chromatography technology	Bennett EJ (2010)	1
TNRC6A	6	CNOT10	0	pull down, affinity chromatography technology	Fabian MR (2011), Fabian MR (2011)	2
BRCA1	7	AGO3	4	affinity chromatography technology	Ertych N (2016)	1
CNTRL	5	TNRC6A	6	bioid	Gupta GD (2015)	1
TNRC6A	6	CNOT7	0	pull down, affinity chromatography technology, affinity chromatography technology	Fabian MR (2011), Fabian MR (2011), Braun JE (2011)	3
CENPJ	6	CNOT1	10	bioid	Gupta GD (2015)	1
CENPJ	6	SSX2IP	0	bioid	Gupta GD (2015)	1
NINL	1	CNOT9	1	bioid	Gupta GD (2015)	1
CNOT1	10	CNOT9	1	biochemical, biochemical, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down	Havugimana PC (2012), Wan C (2015), Hein MY (2015), Chen Y (2014), Chen Y (2014), Chen Y (2014)	6
BRCA1	7	CNOT1	10	affinity chromatography technology	Ertych N (2016)	1
TNRC6A	6	ITGB4	11	affinity chromatography technology	Hein MY (2015)	1
CNOT6	2	CNOT2	2	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
TNRC6A	6	CNOT9	1	pull down, pull down	Chen Y (2014), Chen Y (2014)	2
BTRC	1	CNOT1	10	bioid	Coyaud E (2015)	1
ODF2	1	CEP135	2	bioid	Gupta GD (2015)	1
AGO3	4	TNRC6A	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Baillat D (2009), Lazzaretti D (2009), Lazzaretti D (2009), Li S (2014), Hein MY (2015)	5
CNOT6	2	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
CENPJ	6	TNRC6A	6	bioid	Gupta GD (2015)	1
ODF2	1	TNRC6A	6	bioid	Gupta GD (2015)	1
TNRC6A	6	AGO2	10	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	El-Shami M (2007), Baillat D (2009), Lazzaretti D (2009), Lazzaretti D (2009), Fabian MR (2009), Li S (2014), Li S (2014)	7
CUL3	17	AGO3	4	affinity chromatography technology	Bennett EJ (2010)	1
SAV1	0	TNRC6A	6	bioid	Couzens AL (2013)	1
AGO2	10	CNOT6	2	affinity chromatography technology	Braun JE (2011)	1
BRCA1	7	TNRC6A	6	affinity chromatography technology	Ertych N (2016)	1
SAV1	0	CNTROB	6	bioid	Couzens AL (2013)	1
GTSE1	3	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
TNRC6A	6	CNOT2	2	affinity chromatography technology	Braun JE (2011)	1
EYA2	2	AGO2	10	bioid	St-Denis N (2016)	1
BTRC	1	CNOT9	1	bioid	Coyaud E (2015)	1
PAN2	3	PAN3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Uchida N (2004), Sowa ME (2009), Bett JS (2013), Jonas S (2014)	4
AGO4	5	AGO3	4	affinity chromatography technology, affinity chromatography technology	Weinmann L (2009), Li S (2014)	2
AGO3	4	AGO1	11	affinity chromatography technology	Li S (2014)	1
AGO1	11	CNOT7	0	affinity chromatography technology	Fabian MR (2009)	1
BTRC	1	CNOT10	0	bioid	Coyaud E (2015)	1
CNOT8	1	CNOT10	0	affinity chromatography technology	Ewing RM (2007)	1
GTSE1	3	CLTC	12	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
CNOT7	0	CNOT9	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
AGO4	5	TNRC6A	6	affinity chromatography technology, affinity chromatography technology, pull down	Weinmann L (2009), Lazzaretti D (2009), Lazzaretti D (2009)	3
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
TNRC6A	6	CNOT3	11	pull down, affinity chromatography technology, affinity chromatography technology	Fabian MR (2011), Fabian MR (2011), Braun JE (2011)	3
BRCA1	7	AGO2	10	affinity chromatography technology	Ertych N (2016)	1
TNRC6A	6	CNOT8	1	affinity chromatography technology	Braun JE (2011)	1
BTRC	1	CNOT2	2	affinity chromatography technology	Huttlin EL (2017)	1
CNTROB	6	CNOT1	10	bioid	Gupta GD (2015)	1
CEP152	2	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CNOT8	1	CNOT1	10	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Albert TK (2000), Winkler GS (2006), Winkler GS (2006), Hein MY (2015)	5
CLTC	12	CLTB	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015), Zlatic SA (2011)	3
CNOT7	0	CNOT1	10	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	4
CNOT6L	1	CNOT3	11	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007)	2
TNRC6A	6	CNOT6	2	affinity chromatography technology	Braun JE (2011)	1
SSX2IP	0	BRCA1	7	two hybrid	Hill SJ (2014)	1
CNOT7	0	CNOT2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
CEP152	2	CNOT10	0	bioid	Gupta GD (2015)	1
CNOT2	2	CNOT3	11	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Rual JF (2005), Winkler GS (2006), Wan C (2015), Hein MY (2015)	4
CNTRL	5	GTSE1	3	bioid	Gupta GD (2015)	1
CUL3	17	CLTC	12	affinity chromatography technology	Bennett EJ (2010)	1
EYA2	2	TNRC6A	6	bioid	St-Denis N (2016)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
CNOT7	0	CNOT3	11	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
PICALM	0	CLTC	12	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tebar F (1999), Tebar F (1999), Hein MY (2015), Hein MY (2015)	4
AGO4	5	AGO2	10	affinity chromatography technology	Weinmann L (2009)	1
WNK1	7	TNRC6A	6	two hybrid	Bandyopadhyay S (2010)	1
TRIP13	0	TNRC6A	6	two hybrid	Rolland T (2014)	1
PAN2	3	CLTC	12	affinity chromatography technology	Bett JS (2013)	1
AGO2	10	CNOT6L	1	affinity chromatography technology	Braun JE (2011)	1
TNRC6A	6	PAN2	3	pull down	Fabian MR (2011)	1
CEP250	4	TNRC6A	6	affinity chromatography technology	Fogeron ML (2013)	1
CNOT7	0	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CUL3	17	AGO2	10	affinity chromatography technology	Bennett EJ (2010)	1
CNOT2	2	CNOT9	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
PABPC1	5	UBR5	13	x-ray crystallography	Kozlov G (2010)	1
CNTRL	5	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CNOT6L	1	CNOT6	2	affinity chromatography technology	Boldt K (2016)	1
UBC	7	AGO1	11	affinity chromatography technology	Matsumoto M (2005)	1
NINL	1	CNOT10	0	bioid	Gupta GD (2015)	1
CNTROB	6	CNOT10	0	bioid	Gupta GD (2015)	1
CNOT6L	1	CNOT9	1	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007)	2
UBC	7	TNRC6A	6	affinity chromatography technology, pull down	Matsumoto M (2005), Nathan JA (2013)	2
ODF2	1	SSX2IP	0	bioid	Gupta GD (2015)	1
PAN2	3	PABPC1	5	affinity chromatography technology, pull down, affinity chromatography technology	Uchida N (2004), Ezzeddine N (2007), Bett JS (2013)	3
SSX2IP	0	TNRC6A	6	bioid	Gupta GD (2015)	1
TNRC6A	6	FANCM	5	affinity chromatography technology	Hein MY (2015)	1
TNRC6A	6	CNOT6L	1	pull down, affinity chromatography technology, affinity chromatography technology	Fabian MR (2011), Fabian MR (2011), Braun JE (2011)	3
AGO2	10	BTRC	1	unspecified method	Elcheva I (2009)	1
AGO2	10	PABPC1	5	affinity chromatography technology	Fabian MR (2009)	1
CEP152	2	TNRC6A	6	bioid	Gupta GD (2015)	1
CEP152	2	CNOT9	1	bioid	Gupta GD (2015)	1
BRCA1	7	PABPC1	5	far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Dizin E (2006), Dizin E (2006), Dizin E (2006), Dizin E (2006), Dacheux E (2013), Ertych N (2016)	6
TNRC6A	6	CNOT1	10	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Fabian MR (2011), Fabian MR (2011), Fabian MR (2011), Braun JE (2011), Huntzinger E (2013), Huntzinger E (2013), Chen Y (2014)	7
CNOT7	0	CNOT6L	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Boldt K (2016)	3
CUL3	17	UBR5	13	affinity chromatography technology	Bennett EJ (2010)	1
NINL	1	GTSE1	3	bioid	Gupta GD (2015)	1
GTSE1	3	WNK1	7	affinity chromatography technology	Hein MY (2015)	1
RPGRIP1L	2	TNRC6A	6	bioid	Gupta GD (2015)	1
CEP135	2	TNRC6A	6	bioid	Gupta GD (2015)	1
CNTRL	5	CEP152	2	bioid	Gupta GD (2015)	1
SMARCB1	1	BRCA1	7	biochemical, biochemical, affinity chromatography technology	Bochar DA (2000), Bochar DA (2000), Fontana GA (2017)	3
PABPC1	5	CNOT6	2	pull down	Ezzeddine N (2007)	1
CNOT6L	1	CNOT1	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Morita M (2007), Hein MY (2015)	3
EYA2	2	CNOT1	10	bioid	St-Denis N (2016)	1
CNOT2	2	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Boldt K (2016)	2
CUL3	17	TRIP13	0	affinity chromatography technology	Bennett EJ (2010)	1
CEP152	2	CNOT1	10	bioid	Gupta GD (2015)	1
NINL	1	BRCA1	7	affinity chromatography technology, affinity chromatography technology	Jin S (2009), Jin S (2009)	2
SSX2IP	0	CNOT1	10	bioid	Gupta GD (2015)	1
PICALM	0	CLTB	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Hein MY (2015)	2
AGO3	4	AGO2	10	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Weinmann L (2009), Li S (2014), Li S (2014)	3
CEP250	4	UBR5	13	affinity chromatography technology	Fogeron ML (2013)	1
SMARCB1	1	TNRC6A	6	two hybrid	Daakour S (2016)	1
CLTB	0	WNK1	7	affinity chromatography technology	Hein MY (2015)	1
CLTB	0	TNRC6A	6	affinity chromatography technology	Hein MY (2015)	1
NINL	1	CENPJ	6	bioid	Gupta GD (2015)	1
BTRC	1	SSX2IP	0	bioid	Coyaud E (2015)	1
CEP250	4	PABPC1	5	affinity chromatography technology	Fogeron ML (2013)	1
CNOT1	10	CNOT3	11	biochemical, affinity chromatography technology, biochemical, affinity chromatography technology	Havugimana PC (2012), Winkler GS (2006), Wan C (2015), Hein MY (2015)	4
TNRC6A	6	PABPC1	5	affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Huntzinger E (2010), Kozlov G (2010), Kozlov G (2010), Fabian MR (2011), Fabian MR (2011), Huntzinger E (2013)	6
RPGRIP1L	2	SSX2IP	0	bioid	Gupta GD (2015)	1
NINL	1	RPGRIP1L	2	bioid	Gupta GD (2015)	1
CNOT6L	1	CNOT2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morita M (2007), Hein MY (2015), Boldt K (2016)	3
CNTRL	5	ODF2	1	bioid	Gupta GD (2015)	1
NINL	1	CNOT1	10	bioid	Gupta GD (2015)	1
AGO1	11	TNRC6A	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baillat D (2009), Lazzaretti D (2009), Lazzaretti D (2009), Fabian MR (2009), Li S (2014), Li S (2014)	6
PAN2	3	CLTB	0	affinity chromatography technology	Bett JS (2013)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BTRC	1	TNRC6A	6	bioid	Coyaud E (2015)	1
CEP135	2	SSX2IP	0	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CUL3	17	AGO1	11	affinity chromatography technology	Bennett EJ (2010)	1
CNOT6	2	CNOT9	1	affinity chromatography technology	Morita M (2007)	1
PICALM	0	WNK1	7	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	PABPC1	5	affinity chromatography technology	Bennett EJ (2010)	1
AGO2	10	CNOT2	2	affinity chromatography technology	Braun JE (2011)	1
CNOT7	0	PABPC1	5	affinity chromatography technology, pull down	Funakoshi Y (2007), Funakoshi Y (2007)	2
UBC	7	BTRC	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Kumar KG (2007)	2
AGO1	11	PABPC1	5	affinity chromatography technology	Fabian MR (2009)	1
NINL	1	CNOT3	11	bioid	Gupta GD (2015)	1
AGO2	10	CNOT1	10	affinity chromatography technology	Braun JE (2011)	1
CNTROB	6	CNOT9	1	bioid	Gupta GD (2015)	1
CNOT3	11	CNOT9	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CNOT3	11	CNOT8	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Albert TK (2000), Albert TK (2000), Winkler GS (2006)	3
CNOT1	10	CNOT2	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Albert TK (2000), Winkler GS (2006), Winkler GS (2006), Hein MY (2015), Hein MY (2015), Boldt K (2016)	6
CENPJ	6	CNOT10	0	bioid	Gupta GD (2015)	1
CNTRL	5	CLTC	12	bioid	Gupta GD (2015)	1
CNTROB	6	CNOT7	0	bioid	Gupta GD (2015)	1
CNTRL	5	SSX2IP	0	bioid	Gupta GD (2015)	1
CNOT6L	1	CNOT10	0	affinity chromatography technology, affinity chromatography technology	Morita M (2007), Boldt K (2016)	2
CNOT2	2	CNOT8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Winkler GS (2006), Winkler GS (2006), Hein MY (2015)	3
AGO2	10	CNOT7	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fabian MR (2009), Fabian MR (2009), Fabian MR (2009)	3
NINL	1	TNRC6A	6	bioid	Gupta GD (2015)	1
CNOT6	2	CNOT3	11	affinity chromatography technology	Morita M (2007)	1
CEP250	4	SSX2IP	0	affinity chromatography technology	Fogeron ML (2013)	1
PAN3	1	PABPC1	5	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Funakoshi Y (2007), Funakoshi Y (2007), Funakoshi Y (2007), Ezzeddine N (2007), Huang KL (2013)	5
CLTC	12	TNRC6A	6	affinity chromatography technology	Hein MY (2015)	1
CUL3	17	SAV1	0	affinity chromatography technology	Bennett EJ (2010)	1
CNTROB	6	CNOT3	11	bioid	Gupta GD (2015)	1
CNOT1	10	CNOT10	0	affinity chromatography technology	Hein MY (2015)	1
WNK1	7	CLTC	12	two hybrid, affinity chromatography technology	Bandyopadhyay S (2010), Hein MY (2015)	2
CEP152	2	CENPJ	6	bioid	Firat-Karalar EN (2014)	1
BRCA1	7	CLTC	12	affinity chromatography technology	Ertych N (2016)	1
ODF2	1	BRCA1	7	imaging technique	Tarapore P (2012)	1
TNRC6A	6	KIAA2013	0	affinity chromatography technology	Hein MY (2015)	1
UBC	7	AGO2	10	affinity chromatography technology, pull down	Matsumoto M (2005), Zhang X (2017)	2
CEP250	4	NINL	1	affinity chromatography technology	Fogeron ML (2013)	1
UBR5	13	TNRC6A	6	affinity chromatography technology	Su H (2011)	1