PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
CBX6	1	AHDC1	28	affinity chromatography technology	Vandamme J (2011)	1
HNRNPL	3	AHDC1	28	affinity chromatography technology	Fei T (2017)	1
CBX3	1	SENP7	5	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
AHDC1	28	TRIM68	2	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	APP	1	affinity chromatography technology	Choudhury NR (2017)	1
ZNF324B	1	AHDC1	28	affinity chromatography technology	Huttlin EL (2017)	1
MYH9	19	AHDC1	28	affinity chromatography technology	Hein MY (2015)	1
CBX1	0	CBX3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Rosnoblet C (2011), Hauri S (2016), Hauri S (2016)	8
HIST3H3	0	CBX6	1	unspecified method, x-ray crystallography, affinity chromatography technology	Kaustov L (2011), Kaustov L (2011), Vandamme J (2011)	3
CBX5	3	HIST3H3	0	affinity chromatography technology, unspecified method, x-ray crystallography, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down	Quivy JP (2004), Kaustov L (2011), Kaustov L (2011), Bartke T (2010), Li X (2012), Li X (2012), Vermeulen M (2007), Kubota S (2013), Vermeulen M (2010), Vermeulen M (2010), Lacroix M (2008)	11
HIST3H3	0	AHDC1	28	unspecified method	Vermeulen M (2010)	1
HIST3H3	0	CBX1	0	unspecified method, unspecified method, affinity chromatography technology, unspecified method	Kaustov L (2011), Pichler G (2012), Pichler G (2012), Vermeulen M (2010)	4
CBX3	1	AHDC1	28	affinity chromatography technology	Hauri S (2016)	1
ITSN2	7	AHDC1	28	two hybrid	Wong KA (2012)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
CBX1	0	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Mateos-Langerak J (2007), Rosnoblet C (2011), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	10
TRIM68	2	HNRNPL	3	affinity chromatography technology	Wynne C (2014)	1
CBX5	3	ZNF324B	1	affinity chromatography technology	Nozawa RS (2010)	1
ATXN1	2	AHDC1	28	two hybrid	Lim J (2006)	1
HIST3H3	0	CBX3	1	unspecified method, x-ray crystallography, unspecified method	Kaustov L (2011), Kaustov L (2011), Vermeulen M (2010)	3
CBX5	3	SENP7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Garvin AJ (2013), Garvin AJ (2013), Hauri S (2016), Hauri S (2016)	5
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
TRIM25	5	AHDC1	28	affinity chromatography technology	Choudhury NR (2017)	1
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
IKZF5	0	AHDC1	28	affinity chromatography technology	Huttlin EL (2017)	1
SENP7	5	AHDC1	28	affinity chromatography technology	Hauri S (2016)	1
AHDC1	28	UBR3	13	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
AHDC1	28	APP	1	pull down	Olah J (2011)	1
HIST3H3	0	HNRNPL	3	unspecified method	Vermeulen M (2010)	1
DOK5	0	AHDC1	28	two hybrid	Grossmann A (2015)	1
FBL	1	AHDC1	28	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CBX5	3	AHDC1	28	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Vermeulen M (2010), Hauri S (2016)	3
TRIM25	5	MYH9	19	affinity chromatography technology	Choudhury NR (2017)	1
ZDHHC17	1	AHDC1	28	two hybrid	Butland SL (2014)	1
APP	1	CBX6	1	affinity chromatography technology	Huttlin EL (2017)	1
CBX1	0	AHDC1	28	affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hauri S (2016)	2