PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCL2L2	0	BBC3	1	affinity chromatography technology	Huttlin EL (2017)	1
MCL1	1	BCL2L1	0	affinity chromatography technology	Bae J (2000)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
EGFR	5	BBC3	1	affinity chromatography technology	Zhu H (2010)	1
BBC3	1	BCL2L1	0	affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology	Chen L (2005), Kuwana T (2005), Chipuk JE (2008), Certo M (2006), Tong J (2017)	5
ALB	1	BBC3	1	affinity chromatography technology	Zhou M (2004)	1
BBC3	1	MCL1	1	affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Chen L (2005), Warr MR (2011), Pervin S (2011), Kuwana T (2005), Certo M (2006), Huttlin EL (2015), Tong J (2017), Tong J (2017), Huttlin EL (2017)	9
BBC3	1	BCL2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Chen L (2005), Nakano K (2001), Nakano K (2001), Certo M (2006)	4
BCL2A1	0	BBC3	1	unspecified method	Certo M (2006)	1