PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DAPP1	2	FCHSD2	3	two hybrid	Wang J (2011)	1
DAPP1	2	HSD3B7	3	two hybrid	Wang J (2011)	1
ERBB3	3	DAPP1	2	unspecified method	Jones RB (2006)	1
DAPP1	2	MGARP	0	two hybrid	Grossmann A (2015)	1
DAPP1	2	HSPA1A	0	two hybrid	Wang J (2011)	1
DAPP1	2	APBB3	2	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
DAPP1	2	RPL23	0	two hybrid	Wang J (2011)	1
DAPP1	2	ZNHIT1	0	two hybrid	Grossmann A (2015)	1
ERBB3	3	RPL23	0	affinity chromatography technology	Li J (2013)	1
DAPP1	2	MYLIP	1	two hybrid	Grossmann A (2015)	1
DAPP1	2	GSTCD	1	two hybrid	Grossmann A (2015)	1
DAPP1	2	PLAGL2	1	two hybrid	Grossmann A (2015)	1
ERBB3	3	HSPA1A	0	affinity chromatography technology	Li J (2013)	1
DAPP1	2	RBP7	3	two hybrid	Grossmann A (2015)	1
DAPP1	2	TNFAIP1	4	two hybrid	Grossmann A (2015)	1
DAPP1	2	TM4SF19	1	two hybrid	Grossmann A (2015)	1
DAPP1	2	CNDP2	3	two hybrid	Grossmann A (2015)	1
CNDP2	3	RPL23	0	biochemical	Kristensen AR (2012)	1
DAPP1	2	WDR20	6	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2