PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TTN	102	TRIM63	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid	Centner T (2001), Centner T (2001), Witt SH (2005), Mrosek M (2007), Bogomolovas J (2014), Witt CC (2008)	6
TRIM55	2	TTN	102	two hybrid	Witt CC (2008)	1
MYPN	7	TTN	102	two hybrid	Miller MK (2003)	1
TRIM63	0	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
TRIM55	2	ANKRD1	0	two hybrid, pull down	Witt CC (2008), Witt CC (2008)	2
ANKRD1	0	MYPN	7	two hybrid, two hybrid, two hybrid, pull down	Miller MK (2003), Miller MK (2003), Bang ML (2001), Bang ML (2001)	4
TTN	102	ANKRD1	0	two hybrid, pull down, two hybrid	Miller MK (2003), Miller MK (2003), Miller MK (2003)	3
TRIM63	0	TRIM55	2	two hybrid, two hybrid	Centner T (2001), Witt CC (2008)	2
ANKRD1	0	UBE2O	5	affinity chromatography technology	Huttlin EL (2015)	1