PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GJB2	1	SLC35E1	1	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	MUC13	0	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	ANTXR1	3	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	CLSPN	1	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	TFRC	1	two hybrid	Dittmer TA (2014)	1
GJB2	1	SKP1	0	affinity chromatography technology	Henzl MT (2004)	1
GJB2	1	SLC38A2	1	affinity chromatography technology	Hein MY (2015)	1
GJB3	2	GJB2	1	genetic interference	Liu XZ (2009)	1
GJB2	1	ACKR3	0	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	CAV1	0	affinity chromatography technology	Schubert AL (2002)	1
FBXO2	0	GJB2	1	pull down, affinity chromatography technology	Henzl MT (2004), Henzl MT (2004)	2
GJB2	1	PATJ	5	affinity chromatography technology	Hein MY (2015)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
SKP1	0	FBXO2	0	x-ray crystallography, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, two hybrid, affinity chromatography technology	Mizushima T (2007), Lievens S (2009), Nelson RF (2007), Henzl MT (2004), Henzl MT (2004), Glenn KA (2008), Tan A (2008), Erhardt JA (1998), Winston JT (1999), Rolland T (2014), Hauri S (2016)	11
LMNA	2	GJB2	1	two hybrid	Dittmer TA (2014)	1
GJB2	1	SNX3	1	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	PIEZO1	11	affinity chromatography technology	Hein MY (2015)	1
GJB2	1	PSMD2	2	affinity chromatography technology	Hein MY (2015)	1
CAV1	0	TFRC	1	affinity chromatography technology	Hinrichs JW (2004)	1
GJB2	1	PACSIN3	2	affinity chromatography technology	Hein MY (2015)	1
CREB3	1	GJB2	1	two hybrid	Yu H (2011)	1
CNST	5	GJB3	2	pull down	del Castillo FJ (2010)	1
CNST	5	GJB2	1	pull down	del Castillo FJ (2010)	1
GJB2	1	RAB11FIP2	2	affinity chromatography technology	Hein MY (2015)	1
CD14	3	GJB2	1	two hybrid	Wang J (2011)	1
GJB2	1	TFRC	1	affinity chromatography technology	Hein MY (2015)	1