PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
FYN	1	SYK	3	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
LAT	0	MAP4K1	1	affinity chromatography technology, biochemical	Ling P (2001), Ling P (2001)	2
LAT	0	ITK	7	affinity chromatography technology, enzymatic study	Shan X (1999), Perez-Villar JJ (2002)	2
PLCG2	11	GAB2	3	affinity chromatography technology, affinity chromatography technology	Boudot C (2002), Boudot C (2002)	2
SLA	2	ZAP70	5	affinity chromatography technology	Tang J (1999)	1
SLA	2	VAV1	2	affinity chromatography technology, pull down	Sosinowski T (2000), Sosinowski T (2000)	2
LCK	0	SYK	3	affinity chromatography technology, pull down, two hybrid	Thome M (1995), Thome M (1995), Moon KD (2005)	3
EGFR	5	SLA	2	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
SH3BP2	4	CBL	7	pull down, affinity chromatography technology	Deckert M (1998), GuezGuez A (2010)	2
CD3E	0	LCK	0	affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003)	2
PTPN1	2	GRB2	2	pull down, pull down, affinity chromatography technology	Goldstein BJ (2000), Liu F (1996), Li X (2016)	3
SHB	4	LAT	0	affinity chromatography technology, affinity chromatography technology	Lindholm CK (1999), Lindholm CK (2002)	2
PLCG2	11	SYK	3	affinity chromatography technology	Guo B (2000)	1
SH3BP2	4	PLCG1	6	pull down, far western blotting	Deckert M (1998), Jevremovic D (2001)	2
LMNA	2	LAT	0	two hybrid	Dittmer TA (2014)	1
LMNA	2	LCP2	0	two hybrid	Dittmer TA (2014)	1
VAV1	2	LCP2	0	affinity chromatography technology, pull down, affinity chromatography technology	Raab M (1997), Onodera H (1996), Shen M (2009)	3
LCP2	0	GRAP2	0	two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, x-ray crystallography, biochemical, affinity chromatography technology, unspecified method, two hybrid, two hybrid	Rual JF (2005), Ellis JH (2000), Liu SK (1999), Liu SK (1999), Liu SK (1999), Liu SK (1999), Asada H (1999), Asada H (1999), Berry DM (2002), Berry DM (2002), Berry DM (2002), Harkiolaki M (2003), Yankee TM (2003), Yankee TM (2003), Seet BT (2007), Rolland T (2014), Yu H (2011)	17
PTPN6	0	PLCG2	11	affinity chromatography technology, fluorescent resonance energy transfe	Matalon O (2016), Matalon O (2016)	2
PTPN6	0	LAT	0	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Matalon O (2016), Matalon O (2016), Matalon O (2016)	3
LCK	0	PIK3R1	6	pull down	Kapeller R (1994)	1
EGFR	5	PTPN6	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid	Tomic S (1995), Keilhack H (1998), Keilhack H (1998), Yao Z (2017)	4
SGTA	1	LAT	0	two hybrid	Rolland T (2014)	1
SOS1	5	LAT	0	imaging technique	Houtman JC (2006)	1
MAP4K1	1	EGFR	5	biochemical, two hybrid, protein complementation assay	Anafi M (1997), Kotlyar M (2015), Petschnigg J (2014)	3
SPRY1	2	GRB2	2	affinity chromatography technology	Lao DH (2006)	1
SLA	2	SYK	3	affinity chromatography technology	Tang J (1999)	1
GRB2	2	PIK3R1	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Saleem A (1995), Saleem A (1995), Wang J (1995), Wang J (1995), Wang J (1995), Bandyopadhyay S (2010), Takahashi Y (1999), Gelkop S (2001), Jain SK (1997), Ren SY (2005), Brehme M (2009), Cerboni C (1998), Cerboni C (1998), Bisson N (2011), Bisson N (2011), Weinger JG (2008), Weinger JG (2008), Weinger JG (2008)	18
PLCG1	6	LAT	0	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, fluorescent resonance energy transfe	Zhang W (1998), Paz PE (2001), Paz PE (2001), Zhang W (1998), Jiang Y (2007), Braiman A (2006), Braiman A (2006), Matalon O (2016), Matalon O (2016)	9
FCGR2A	0	LAT	0	affinity chromatography technology	Tridandapani S (2000)	1
SPRY1	2	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mason JM (2004), Lee JS (2009), Lao DH (2006)	3
LCK	0	SOS1	5	unspecified method	Tran T (2005)	1
GRAP	0	GAB2	3	pull down	Zhao C (1999)	1
USP12	1	GRB2	2	bioid	Jahan AS (2016)	1
PTPN6	0	PIK3R1	6	two hybrid	Sathish JG (2001)	1
SHB	4	ZAP70	5	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
PTPRJ	5	LAT	0	enzymatic study	Baker JE (2001)	1
EGFR	5	CBL	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Ettenberg SA (1999), Tvorogov D (2002), Pennock S (2008), Umebayashi K (2008), Ng C (2008), Ng C (2008), Povlsen GK (2008), Khan EM (2008), Su X (2007), Shtiegman K (2007), Han W (2006), Visser GD (2005), Tsacoumangos A (2005), Prasad NK (2005), Gur G (2004), Kowanetz K (2004), Feshchenko EA (2004), Wu WJ (2003), Schmidt MH (2003), Bao J (2003), Rubin C (2003), Waterman H (1999), Bonaccorsi L (2007), Dey N (2011), Miraoui H (2010), Guo HB (2009), Tong J (2009), Tong J (2009), Sun Q (2010), Sanada F (2009), Rafiq K (2011), Ravid T (2004), Ravid T (2004), Duan L (2011), Duan L (2011), Haglund K (2005), Oksvold MP (2003), Oksvold MP (2003), Gui A (2012), Yang S (2006), de Melker AA (2004), Crovello CS (1998), Graus-Porta D (1997), Oksvold MP (2001), Raguz J (2007), de Melker AA (2004), Thien CB (2001), Kassenbrock CK (2004), Tarcic G (2009), Schroeder B (2012), Adachi S (2009), Shen F (2007), Mitsushima M (2006), Choi JH (2003), Burke P (2001), Tanaka S (1995), Meisner H (1995), Meisner H (1995), Kumar EA (2012), Tong J (2008), Dou H (2012), Levkowitz G (1999), Levkowitz G (1999), Bode AM (2009), Thomas C (2012), Meijer IM (2013), Chang CC (2012), Chang CC (2012), Smith CJ (2013), Gan Y (2010), Scott RP (2005), Fukazawa T (1996), Fukazawa T (1996), Fukazawa T (1996), Wang L (2013), Hong SY (2013), Sigismund S (2013), Sigismund S (2013), Sigismund S (2013), Meisner H (1997), Odintsova E (2013), Kondratov KA (2010), He Z (2014), Tong J (2014), Balaji K (2012), Kiuchi T (2014), Zhang B (2005), Waterman H (1999), Ha Thi HT (2015), Yao S (2015), Kortuem F (2015), Igloi Z (2015), Song F (2016), Song F (2016), Lin TY (2017), Conte A (2017)	96
CBL	7	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jain SK (1997), Liu SK (1998), Ettenberg SA (1999), Wong A (2002), Wong A (2002), Robertson H (1997), Donovan JA (1994), Park RK (1999), Erdreich-Epstein A (1999), Gesbert F (1998), Gesbert F (1998), Gesbert F (1998), Husson H (1997), Saci A (2002), Odai H (1997), Ng C (2008), Khan EM (2008), Bandyopadhyay S (2010), Jiang X (2003), Waterman H (2002), Miraoui H (2010), Ravid T (2004), Ingham RJ (1996), Erdreich-Epstein A (1997), Rellahan BL (2003), Izadi KD (1998), Wang Y (1999), Chu J (1998), Bonita DP (1997), Boussiotis VA (1997), Meisner H (1995), Meisner H (1995), Barber DL (1997), Shishido T (2000), Bartkiewicz M (1999), Buday L (1996), Tarcic G (2009), Belleudi F (2007), Brizzi MF (1996), Brenner B (2001), Donovan JA (1996), Donovan JA (1996), Donovan JA (1996), Gaston I (2004), Gaston I (2004), Tsygankov AY (1996), Tsygankov AY (1996), Hunter S (1997), Jain SK (1997), Levkowitz G (1996), Liu YC (1997), Odai H (1995), Odai H (1995), Meisner H (1995), Huang JY (2000), Panchamoorthy G (1996), Panchamoorthy G (1996), Yokouchi M (1997), Oda A (1996), Fukazawa T (1995), Fukazawa T (1995), Selbach M (2006), Brehme M (2009), Brehme M (2009), Fukazawa T (1995), Cerboni C (1998), Cerboni C (1998), Fixman ED (1997), Anderson SM (1997), Houtman JC (2006), Brizzi MF (1996), Scott RP (2005), Scott RP (2005), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Umehara H (2002), Taipale M (2014), Taipale M (2014), Grossmann A (2015), Grossmann A (2015), Igloi Z (2015), Huttlin EL (2017)	83
CD3E	0	PIK3R1	6	affinity chromatography technology, affinity chromatography technology	de Aos I (1997), Alcazar I (2009)	2
PLCG2	11	VAV1	2	affinity chromatography technology	Guo B (2000)	1
ITK	7	CBL	7	pull down	Bunnell SC (1996)	1
EGFR	5	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, imaging technique	Tong J (2009), Wen G (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Chen TC (2014)	6
PLCG1	6	SOS1	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kim MJ (2000), Kim MJ (2000), Kim MJ (2000), Kim MJ (2000), Scholler JK (2000)	5
PLCG2	11	PLCG1	6	imaging technique	Chen TC (2014)	1
CBL	7	PLCG1	6	far western blotting, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique	Tvorogov D (2002), Tvorogov D (2002), Tvorogov D (2002), Graham LJ (1998), Singh AJ (2007), Rellahan BL (2003), Rellahan BL (2003), Okabe S (2006), Choi JH (2003), Choi JH (2003), Braiman A (2006), Braiman A (2006), Braiman A (2006), Chen TC (2014)	14
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
LAT	0	PIK3R1	6	affinity chromatography technology, pull down	Paz PE (2001), Paz PE (2001)	2
USP12	1	LAT	0	bioid	Jahan AS (2016)	1
VAV1	2	PTPN6	0	pull down	Kon-Kozlowski M (1996)	1
PLCG1	6	PTPN6	0	affinity chromatography technology, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
LAT	0	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down	Paz PE (2001), Zhang W (1998), Perez-Villar JJ (2002), Motto DG (1994), Houtman JC (2006)	5
FCGR2A	0	CBL	7	biochemical	Marois L (2009)	1
ALB	1	LAT	0	affinity chromatography technology	Zhou M (2004)	1
GRB2	2	PTPRJ	5	affinity chromatography technology	Bisson N (2011)	1
LCK	0	LAT	0	biochemical, affinity chromatography technology, enzymatic study, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Jiang Y (2007), Jiang Y (2007)	4
SHB	4	PLCG1	6	affinity chromatography technology	Lindholm CK (1999)	1
SYK	3	PIK3R1	6	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Moon KD (2005), Moon KD (2005), Moon KD (2005), Moon KD (2005), Huang ZY (2006)	5
SYK	3	GRAP2	0	affinity chromatography technology	de Castro RO (2012)	1
SYK	3	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yamada T (2001), Lin YC (2013), Wu NL (2014)	3
SH3BP2	4	ZAP70	5	affinity chromatography technology, pull down	Deckert M (1998), Deckert M (1998)	2
CBL	7	ZAP70	5	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, x-ray crystallography	Lupher ML (1996), Meng W (1999), Wang HY (2001), Rao N (2000), Lupher ML (1997), Okabe S (2006), Zhang Z (1999), Lupher ML (1996), Dou H (2012), Dou H (2012), Gabrielsen M (2017)	11
VAV1	2	EGFR	5	affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Moores SL (2000), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	4
VAV1	2	ZAP70	5	pull down, affinity chromatography technology	Katzav S (1994), Huby RD (1995)	2
VAV1	2	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Bertagnolo V (1998), Bertagnolo V (1998), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
SH3BP2	4	LAT	0	pull down, affinity chromatography technology	Deckert M (1998), Jevremovic D (2001)	2
SHB	4	PIK3R1	6	pull down, affinity chromatography technology	Karlsson T (1995), Karlsson T (1995)	2
USP12	1	ZAP70	5	bioid	Jahan AS (2016)	1
FYN	1	SH3BP2	4	two hybrid	Deckert M (1998)	1
GAB2	3	CD247	1	affinity chromatography technology	Yamasaki S (2001)	1
GRB2	2	PTPN6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Kon-Kozlowski M (1996), Saci A (2002)	3
CBL	7	PTPN6	0	affinity chromatography technology	Kant AM (2002)	1
LAT	0	CBL	7	affinity chromatography technology	Jiang Y (2007)	1
USP19	1	LAT	0	affinity chromatography technology	Sowa ME (2009)	1
ITK	7	PLCG1	6	pull down, affinity chromatography technology, enzymatic study	Perez-Villar JJ (1999), Perez-Villar JJ (1999), Hao S (2002)	3
ZAP70	5	LCP2	0	enzymatic study, enzymatic study	Raab M (1997), Kim KS (2002)	2
FYN	1	PLCG2	11	pull down	Pleiman CM (1993)	1
LMNA	2	CREB3	1	two hybrid	Dittmer TA (2014)	1
SLA	2	LAT	0	affinity chromatography technology	Tang J (1999)	1
PTPRJ	5	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Tarcic G (2009), Tarcic G (2009)	2
LAT	0	VAV1	2	pull down, pull down, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Perez-Villar JJ (2002)	3
SOS1	5	EGFR	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qian X (2000), Qian X (1998), Buday L (1994), Tong J (2009), Kurada BR (2009), Tong J (2008), Foerster S (2013), Tong J (2014), Kapoor GS (2010)	9
FYN	1	CBL	7	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Taher TE (2002), Deckert M (1998), Deckert M (1998), Deckert M (1998), Ghosh AK (2004), Rellahan BL (2003), Boussiotis VA (1997), Andoniou CE (2000), Shishido T (2000), Okabe S (2006), Kaabeche K (2004), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tsygankov AY (1996), Tanaka S (1995), Reedquist KA (1996), Grossmann AH (2004), Panchamoorthy G (1996), Fukazawa T (1995), Fukazawa T (1995), Fukazawa T (1995), Nishio H (2002), Anderson SM (1997), Fukazawa T (1996), Grossmann A (2015)	27
ZAP70	5	PTPN6	0	pull down	Plas DR (1996)	1
CBL	7	VAV1	2	affinity chromatography technology, affinity chromatography technology, pull down, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Marengere LE (1997), Bertagnolo V (2001), Miura-Shimura Y (2003), Simmons A (2005), Shen M (2009), Shen M (2009), Lottin-Divoux S (2006), Lottin-Divoux S (2006), Peterson ME (2008)	12
EGFR	5	GRAP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
GRAP2	0	GAB2	3	pull down, affinity chromatography technology, affinity chromatography technology	Berry DM (2002), Huttlin EL (2015), Huttlin EL (2017)	3
LCK	0	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pelosi M (1999), Thome M (1995), Lupher ML (1996)	3
VAV1	2	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology	Song JS (1996), Ye ZS (1994), Ye ZS (1994), Germani A (1999), Lee IS (1997)	5
CBL	7	SYK	3	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Lupher ML (1998), Lupher ML (1998), Bertagnolo V (2001), Melander F (2003), Macglashan D (2004), Rao N (2001), Rao N (2001), Yankee TM (1999), Saci A (2000), Moon KD (2005), Lottin-Divoux S (2006), Grossmann AH (2004), Ota S (2000), Ota S (2000), Panchamoorthy G (1996), Marcilla A (1995), Justa-Schuch D (2016)	17
EGFR	5	ZAP70	5	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
SHB	4	VAV1	2	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
GRAP	0	SOS1	5	biochemical	Feng GS (1996)	1
CD247	1	LCK	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Munoz P (2003), Munoz P (2003), Yang M (2015)	3
LCK	0	CBL	7	affinity chromatography technology, pull down, pull down, affinity chromatography technology	Rao N (2002), Tsygankov AY (1996), Reedquist KA (1996), Nervi S (2005)	4
EGFR	5	PLCG2	11	unspecified method, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Petschnigg J (2014)	5
TRAF6	0	LAT	0	affinity chromatography technology, biochemical, affinity chromatography technology	Xie JJ (2013), Xie JJ (2013), Yang Y (2015)	3
GAB2	3	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, pull down	Lynch DK (2002), Crouin C (2001), Crouin C (2001), Schaeper U (2000), Ren SY (2005), Momose H (2003)	6
PTPN6	0	SYK	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Ganju RK (2000), Dustin LB (1999), Dustin LB (1999)	3
GRB2	2	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid	Lewitzky M (2001), Robinson A (1996), Erdreich-Epstein A (1999), Hendricks-Taylor LR (1997), Asada H (1999), Bandyopadhyay S (2010), Chu J (1998), Berry DM (2002), Brehme M (2009), Rolland T (2014)	10
ZAP70	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down	Nel AE (1995), Braiman A (2006), Hubert P (1996)	3
PLCG1	6	GAB2	3	pull down	Zhao C (1999)	1
LAT	0	CLYBL	0	affinity chromatography technology	Paz PE (2001)	1
ZAP70	5	LAT	0	enzymatic study, enzymatic study, imaging technique, affinity chromatography technology	Paz PE (2001), Perez-Villar JJ (2002), Houtman JC (2006), Xie JJ (2013)	4
CBL	7	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Gesbert F (1998), Gesbert F (1998), Zhang S (1999), Dufour C (2008), Feshchenko EA (2004), Kassenbrock CK (2002), Fang D (2001), Valiya Veettil M (2011), Miao H (2002), Miao H (2002), Ueno H (1998), Gelkop S (2001), Wang Y (1999), Saci A (2000), Matsuo T (1996), Matsuo T (1996), Jackson JG (2000), Meisner H (1995), Saci A (1999), Saci A (1999), Beckwith M (1996), Beckwith M (1996), Song JJ (2010), Hartley D (1996), Finkelstein LD (2000), Ren SY (2005), Hunter S (1997), Hunter S (1997), Jain SK (1997), Jain SK (1997), Swaminathan G (2007), van Leeuwen JE (1999), Ren SY (2005), Ren SY (2005), Alcazar I (2009), Liu YC (1997), Matsuo T (1996), Matsuo T (1996), Lottin-Divoux S (2006), Kitanaka A (1996), Liu YC (1997), Grossmann AH (2004), Panchamoorthy G (1996), Panchamoorthy G (1996), Chernock RD (2001), Chernock RD (2001), Fukazawa T (1995), Fukazawa T (1995), Brehme M (2009), Hakak Y (2000), Hakak Y (2000), Fukazawa T (1995), Liu Y (1999), Cerboni C (1998), Cerboni C (1998), Momose H (2003), Fukazawa T (1996), Fukazawa T (1996), Bulut GB (2013), Bulut GB (2013), Grossmann A (2015)	61
ITK	7	FYN	1	pull down, pull down	Bunnell SC (2000), Bunnell SC (1996)	2
EGFR	5	LMNA	2	affinity chromatography technology	Liccardi G (2014)	1
PLCG1	6	SPRY1	2	affinity chromatography technology	Lee JS (2009)	1
LAT	0	GRAP	0	affinity chromatography technology, pull down	Zhang W (1998), Perez-Villar JJ (2002)	2
SOS1	5	PTPN6	0	affinity chromatography technology	Kon-Kozlowski M (1996)	1
PTPN6	0	LCK	0	enzymatic study, enzymatic study, pull down	Yu CL (2000), Chiang GG (2001), Lorenz U (1994)	3
CD247	1	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mustelin T (1995), Wang HY (2001), La Face DM (1997), Huang H (2010), Huang H (2010), Hubert P (1996), Yang M (2015)	7
CBL	7	SOS1	5	affinity chromatography technology	Wang Y (1999)	1
SPRY1	2	LAT	0	affinity chromatography technology, affinity chromatography technology	Lee JS (2009), Lee JS (2009)	2
LCP2	0	ITK	7	affinity chromatography technology, pull down, enzymatic study	Shim EK (2004), Bunnell SC (2000), Kim KS (2002)	3
VAV1	2	PIK3R1	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Bertagnolo V (1998), Bertagnolo V (1998), Bertagnolo V (1998), Shigematsu H (1997), Shigematsu H (1997), Shigematsu H (1997)	6
PIK3R1	6	SOS1	5	imaging technique	Chen TC (2014)	1
SYK	3	CD3E	0	pull down	Bu JY (1995)	1
ZAP70	5	CD3E	0	pull down, affinity chromatography technology	Bu JY (1995), Hubert P (1996)	2
PIK3R1	6	CD247	1	affinity chromatography technology	Fang D (2001)	1
FYN	1	VAV1	2	affinity chromatography technology, two hybrid	Michel F (1998), Tartare-Deckert S (2001)	2
ALB	1	GRAP2	0	affinity chromatography technology	Zhou M (2004)	1
CREB3	1	LAT	0	two hybrid	Yu H (2011)	1
CBL	7	SLA	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tang J (1999), Myers MD (2006), Sirvent A (2008), Swaminathan G (2007)	4
EGFR	5	LAT	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
FYN	1	LAT	0	enzymatic study	Jiang Y (2007)	1
SHB	4	GRB2	2	affinity chromatography technology	Welsh M (1998)	1
LCP2	0	PLCG1	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Yablonski D (2001), Yablonski D (2001), Braiman A (2006), Braiman A (2006), Braiman A (2006)	5
SYK	3	VAV1	2	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, two hybrid	Deckert M (1996), Deckert M (1996), Deckert M (1996), Song JS (1996), Bertagnolo V (2001), Bertagnolo V (2001), Tartare-Deckert S (2001)	7
SYK	3	SH3BP2	4	two hybrid, affinity chromatography technology	Deckert M (1998), GuezGuez A (2010)	2
SHB	4	LCP2	0	affinity chromatography technology, pull down	Lindholm CK (2002), Lindholm CK (2002)	2
FYN	1	PIK3R1	6	pull down	Kapeller R (1994)	1
GRAP2	0	LAT	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Liu SK (1999), Liu SK (1999), Liu SK (1999), Asada H (1999)	4
SLA	2	CD247	1	affinity chromatography technology	Tang J (1999)	1
PTPN1	2	EGFR	5	x-ray crystallography, enzymatic study, two hybrid, protein complementation assay, affinity chromatography technology, pull down, pull down	Sarmiento M (2000), Zhang ZY (1996), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Milarski KL (1993), Milarski KL (1993)	7
SH3BP2	4	VAV1	2	affinity chromatography technology, far western blotting, two hybrid, affinity chromatography technology	Jevremovic D (2001), Jevremovic D (2001), Le Bras S (2007), GuezGuez A (2010)	4
TRAF6	0	FYN	1	pull down	Liu A (2012)	1
PIK3R1	6	PLCG2	11	imaging technique	Chen TC (2014)	1
MAP4K1	1	SPRY1	2	affinity chromatography technology	Lee JS (2009)	1
GRB2	2	GAB2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Million RP (2004), Lynch DK (2002), Zhao C (1999), Zhao C (1999), Bandyopadhyay S (2010), Brehme M (2009), Bisson N (2011), Rolland T (2014), Huttlin EL (2017), Yu WM (2006), Yu WM (2006)	11
GRB2	2	SYK	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ganju RK (2000), Saci A (2002), de Castro RO (2012), de Castro RO (2012)	4
PTPN1	2	LAT	0	biochemical, enzymatic study	Ragab A (2003), Ragab A (2003)	2
SOS1	5	FYN	1	pull down	Park C (1998)	1
SYK	3	LCP2	0	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
SYK	3	FCGR1A	0	imaging technique	Chen TC (2014)	1
CD3E	0	CD247	1	affinity chromatography technology, affinity chromatography technology, imaging technique	Munoz P (2003), Munoz P (2003), Chen TC (2014)	3
GRAP2	0	MAP4K1	1	affinity chromatography technology, pull down, two hybrid, genetic interference, biochemical, affinity chromatography technology	Ma W (2001), Ma W (2001), Ma W (2001), Ma W (2001), Yankee TM (2003), Yankee TM (2003)	6
EGFR	5	LCP2	0	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
LAT	0	ZHX2	3	two hybrid	Wang J (2011)	1
EGFR	5	ITK	7	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PTPN6	0	LCP2	0	pull down, pull down, affinity chromatography technology	Binstadt BA (1998), Mizuno K (1996), Mizuno K (1996)	3
FCGR2A	0	PIK3R1	6	affinity chromatography technology, pull down	Chacko GW (1996), Ibarrola I (1997)	2
GAB2	3	PTPN6	0	affinity chromatography technology	Yu WM (2002)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
CBL	7	CD247	1	affinity chromatography technology, affinity chromatography technology	Wang HY (2001), Wang HY (2001)	2
GRAP2	0	CBL	7	biochemical, affinity chromatography technology, two hybrid	Yankee TM (2003), Yankee TM (2003), Grossmann A (2015)	3
LAT	0	PLCG2	11	fluorescent resonance energy transfe, affinity chromatography technology	Matalon O (2016), Matalon O (2016)	2
LCP2	0	PIK3R1	6	two hybrid, affinity chromatography technology	Shim EK (2004), Shim EK (2004)	2
GRB2	2	MAP4K1	1	pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Oehrl W (1998), Anafi M (1997), Anafi M (1997), Anafi M (1997), Ling P (1999), Ling P (2001)	6
PTPRJ	5	PLCG1	6	enzymatic study	Baker JE (2001)	1
FCGR2A	0	SYK	3	pull down, affinity chromatography technology	Ibarrola I (1997), Kim MK (2001)	2
ZAP70	5	GRB2	2	affinity chromatography technology, affinity chromatography technology	Nel AE (1995), Jin HS (2013)	2
GAB2	3	LAT	0	affinity chromatography technology	Yamasaki S (2001)	1
EGFR	5	SYK	3	unspecified method	Jones RB (2006)	1
LAT	0	CD247	1	affinity chromatography technology	Munoz P (2003)	1
CBL	7	LCP2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Park RK (1999), Erdreich-Epstein A (1999), Chu J (1998), Shen M (2009)	4
ITK	7	GRB2	2	pull down, pull down	Bunnell SC (2000), Andreotti AH (1997)	2
FCGR1A	0	LAT	0	affinity chromatography technology	Tridandapani S (2000)	1
SYK	3	LAT	0	enzymatic study	Paz PE (2001)	1
LAT	0	LCP2	0	affinity chromatography technology	Xie JJ (2013)	1
GAB2	3	ZAP70	5	affinity chromatography technology	Yamasaki S (2001)	1
GRB2	2	SOS1	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Blagoev B (2003), Liu SK (1998), Oneyama C (2002), Puil L (1994), Robinson A (1996), Li N (1993), Wong A (2002), Wong A (2002), Reif K (1994), DAngelo G (1999), Nel AE (1995), Pandey P (1995), Buday L (1994), Tong XK (2000), Park RK (1999), Okada S (1996), Okada S (1996), Okada S (1996), Germani A (1999), Park RK (1999), Chin H (1997), Saci A (2002), Sastry L (1997), Spivak-Kroizman T (1994), Ingham RJ (1996), Wang Y (1999), Chu J (1998), Brehme M (2009), Houtman JC (2006), Lao DH (2006), Bisson N (2011), Wang J (2011), Ng MY (2017), Huttlin EL (2017), Kapoor GS (2010), Saito T (2004), Klint P (1995)	37
ZAP70	5	FYN	1	genetic interference, affinity chromatography technology	Neumeister EN (1995), Neumeister EN (1995)	2
LAT	0	CD3E	0	affinity chromatography technology	Munoz P (2003)	1
PLCG1	6	SYK	3	affinity chromatography technology	Sidorenko SP (1995)	1
SH3BP2	4	GRB2	2	pull down	Deckert M (1998)	1
PIK3R1	6	ZAP70	5	affinity chromatography technology	Moon KD (2005)	1