PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MLX	0	ZBTB32	0	two hybrid	Rolland T (2014)	1
GATA2	0	ZBTB16	4	affinity chromatography technology, pull down	Tsuzuki S (2002), Tsuzuki S (2002)	2
ATXN1	2	RBPMS	0	two hybrid, affinity chromatography technology, two hybrid	Lim J (2006), Lim J (2006), Rolland T (2014)	3
FMOD	2	ZBTB32	0	two hybrid, affinity chromatography technology	Wimuttisuk W (2014), Wimuttisuk W (2014)	2
ATXN1	2	RHOXF2	0	two hybrid, affinity chromatography technology	Lim J (2006), Lim J (2006)	2
ZBTB32	0	ZNF490	1	two hybrid	Ravasi T (2010)	1
FANCC	0	ZBTB32	0	two hybrid, affinity chromatography technology	Reuter TY (2003), Hoatlin ME (1999)	2
TXNIP	2	ZBTB16	4	affinity chromatography technology	Han SH (2003)	1
DAB1	1	RHOXF2	0	two hybrid	Rolland T (2014)	1
RBPMS	0	RHOXF2	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
ZBTB16	4	64006	0	two hybrid, two hybrid, pull down, affinity chromatography technology	Boese A (2000), Boese A (2000), Boese A (2000), Boese A (2000)	4
ZBTB32	0	PRDM1	5	affinity chromatography technology	Yoon HS (2012)	1
ZBTB32	0	AR	3	affinity chromatography technology, pull down	Kaufmann S (2010), Kaufmann S (2010)	2
PRKAB2	0	ZBTB32	0	two hybrid	Corominas R (2014)	1
ATXN1	2	PRDM1	5	two hybrid	Lim J (2006)	1
MVP	1	ZBTB32	0	two hybrid	Corominas R (2014)	1
ATXN1	2	ZBTB32	0	two hybrid	Lim J (2006)	1
CFAP206	1	ZBTB32	0	two hybrid	Yu H (2011)	1
PITX1	2	RHOXF2	0	two hybrid	Rual JF (2005)	1
64006	0	ZBTB32	0	affinity chromatography technology, affinity chromatography technology, pull down	Kaufmann S (2010), Kaufmann S (2010), Kaufmann S (2010)	3
AR	3	ZBTB16	4	two hybrid	van de Wijngaart DJ (2009)	1
MVP	1	RBPMS	0	two hybrid	Corominas R (2014)	1
DAB1	1	ZBTB32	0	two hybrid	Rolland T (2014)	1
ZBTB32	0	RHOXF2	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Xin X (2009), Rolland T (2014)	3
MVP	1	RHOXF2	0	two hybrid	Corominas R (2014)	1
RBPMS	0	ZBTB32	0	two hybrid	Rolland T (2014)	1
PITX1	2	RBPMS	0	two hybrid, two hybrid, two hybrid	Rual JF (2005), Corominas R (2014), Rolland T (2014)	3
TXNIP	2	ZBTB32	0	two hybrid, affinity chromatography technology	Han SH (2003), Han SH (2003)	2
GATA2	0	ZBTB32	0	affinity chromatography technology	Tsuzuki S (2002)	1
PRKAB2	0	RBPMS	0	two hybrid	Corominas R (2014)	1
ELF2	1	ZBTB32	0	two hybrid	Ravasi T (2010)	1
ZBTB16	4	ZBTB32	0	two hybrid, affinity chromatography technology	Hoatlin ME (1999), Hoatlin ME (1999)	2
PITX1	2	ZBTB32	0	two hybrid	Corominas R (2014)	1
HOXD4	2	ZBTB32	0	two hybrid	Ravasi T (2010)	1