PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	CSNK1D	3	pull down	Zemlickova E (2004)	1
PSMD4	1	PSMD2	2	biochemical, biochemical, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology	Hamazaki J (2007), Havugimana PC (2012), Su V (2013), Kristensen AR (2012), Wan C (2015), Sparks A (2014)	6
KCNK16	3	GJA1	0	affinity chromatography technology	Huttlin EL (2015)	1
UPK1A	1	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
FAM189A2	2	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ADGRG5	1	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
TJP1	2	GJA1	0	affinity chromatography technology, two hybrid, affinity chromatography technology	Giepmans BN (1998), Giepmans BN (1998), Chen VC (2006)	3
GJA1	0	PRKCE	6	affinity chromatography technology	Doble BW (2000)	1
GPR52	1	GJA1	0	affinity chromatography technology	Huttlin EL (2015)	1
UBQLN4	2	YWHAQ	0	two hybrid	Lim J (2006)	1
NEDD4	2	HGS	5	enzymatic study, affinity chromatography technology, affinity chromatography technology	Katz M (2002), Sun Y (2013), Tan X (2015)	3
UBQLN4	2	HGS	5	two hybrid	Lim J (2006)	1
MAPK7	1	GJA1	0	enzymatic study, affinity chromatography technology	Cameron SJ (2003), Cameron SJ (2003)	2
UBQLN4	2	GJA5	0	pull down, affinity chromatography technology	Kopanic JL (2015), Kopanic JL (2015)	2
YWHAZ	1	PRKCA	7	affinity chromatography technology	Gannon-Murakami L (2002)	1
DPEP1	1	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
GJA1	0	TSG101	1	imaging technique	Leithe E (2009)	1
PRKCA	7	MAPK7	1	biochemical	Wan C (2015)	1
PRKCA	7	GJA1	0	affinity chromatography technology	Bowling N (2001)	1
SLC39A4	4	GJA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FAM189A2	2	YWHAQ	0	affinity chromatography technology	Huttlin EL (2017)	1
GJA1	0	STAMBP	2	affinity chromatography technology, imaging technique	Ribeiro-Rodrigues TM (2014), Ribeiro-Rodrigues TM (2014)	2
SLC39A12	8	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
S100A1	1	GJA1	0	affinity chromatography technology, pull down	Kiewitz R (2003), Kiewitz R (2003)	2
GJA1	0	GJA3	0	affinity chromatography technology	Das Sarma J (2001)	1
GJA1	0	NDUFA7	0	affinity chromatography technology	Huttlin EL (2015)	1
TSPAN17	1	GJA1	0	affinity chromatography technology	Huttlin EL (2015)	1
PSMD4	1	GJA1	0	affinity chromatography technology	Su V (2013)	1
GJA1	0	CAV1	0	biochemical, affinity chromatography technology, pull down	Schubert AL (2002), Schubert AL (2002), Schubert AL (2002)	3
FSHR	2	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
GJA1	0	EEF1A2	18	affinity chromatography technology	Huttlin EL (2015)	1
GJA1	0	HGS	5	imaging technique	Leithe E (2009)	1
HTR3C	2	GJA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GJA1	0	EPS15	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Catarino S (2011), Girao H (2009), Ribeiro-Rodrigues TM (2014)	3
GJA1	0	PSMD2	2	affinity chromatography technology, affinity chromatography technology	Su V (2013), Su V (2013)	2
TSG101	1	NEDD4	2	affinity chromatography technology	Medina G (2005)	1
UBQLN4	2	GJA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Su V (2010), Su V (2010), Li X (2008), Li X (2008), Su V (2013), Su V (2013), Kopanic JL (2015)	7
GJA1	0	STXBP1	38	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HGS	5	STXBP1	38	pull down	Pridgeon JW (2009)	1
TJP1	2	GJA3	0	affinity chromatography technology, pull down	Nielsen PA (2003), Nielsen PA (2003)	2
TSG101	1	HGS	5	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, unspecified method, unspecified method, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Rual JF (2005), Lu Q (2003), Lu Q (2003), Lu Q (2003), Kim BY (2007), Im YJ (2010), Schlundt A (2009), Schlundt A (2009), Pornillos O (2003), Pornillos O (2003), Bache KG (2003), Bache KG (2003), Bouamr F (2007), Kim HJ (2007), Kumar B (2016), Kumar B (2016)	16
NEDD4	2	EPS15	1	enzymatic study	Woelk T (2006)	1
FAM189A2	2	GJA1	0	affinity chromatography technology	Huttlin EL (2015)	1
GJA1	0	YWHAQ	0	affinity chromatography technology	Park DJ (2006)	1
FSHR	2	YWHAQ	0	two hybrid, affinity chromatography technology	Cohen BD (2004), Cohen BD (2004)	2
CNST	5	GJA1	0	pull down	del Castillo FJ (2010)	1
NEDD4	2	PSMD4	1	enzymatic study, enzymatic study, enzymatic study	Uchiki T (2009), Kim HT (2012), Puig-Sarries P (2015)	3
FAM189A2	2	NEDD4	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZACN	2	GJA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PSMD4	1	UBQLN4	2	pull down, affinity chromatography technology, affinity chromatography technology	Riley BE (2004), Li X (2008), Su V (2013)	3
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
GJA1	0	YWHAZ	1	affinity chromatography technology	Park DJ (2006)	1
EPS15	1	HGS	5	pull down, two hybrid, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Bean AJ (2000), Bean AJ (2000), Bache KG (2003), Roxrud I (2008), Roxrud I (2008), Yan Q (2005), Gschweitl M (2016)	7
PRKCE	6	YWHAZ	1	affinity chromatography technology, affinity chromatography technology	Gannon-Murakami L (2002), Gannon-Murakami L (2002)	2
GJA1	0	STXBP2	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
STS	0	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMD2	2	UBQLN4	2	affinity chromatography technology, affinity chromatography technology	Li X (2008), Su V (2013)	2
2844	0	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
GJA1	0	NEDD4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Kimura K (2010), Girao H (2009), Girao H (2009)	3
HTR3A	1	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
TMPRSS3	0	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
NT5E	1	GJA1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NEDD4	2	CSNK1D	3	affinity chromatography technology	Liu J (2014)	1
UBE2A	0	UBQLN4	2	biochemical	Havugimana PC (2012)	1
GJA5	0	PSMD2	2	affinity chromatography technology	Kopanic JL (2015)	1
GJA1	0	GJA1	0	biochemical	Das Sarma J (2001)	1
PRKCA	7	STXBP1	38	enzymatic study	Barclay JW (2003)	1
MAPK7	1	YWHAZ	1	affinity chromatography technology	Erazo T (2013)	1
CSNK1D	3	GJA1	0	enzymatic study, affinity chromatography technology	Cooper CD (2002), Cooper CD (2002)	2
GJA1	0	GJA5	0	biochemical	Valiunas V (2001)	1
B4GAT1	2	GJA1	0	affinity chromatography technology	Huttlin EL (2017)	1
UBE2A	0	GJA1	0	affinity chromatography technology	An H (2017)	1