PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MYCBP	0	TPT1	1	biochemical	Wan C (2015)	1
DPP7	1	MYCBP	0	biochemical	Havugimana PC (2012)	1
MYCBP	0	DISP3	5	two hybrid	Stelzl U (2005)	1
EGFR	5	SSRP1	1	affinity chromatography technology	Yao Z (2017)	1
MYCBP	0	SSRP1	1	two hybrid	Stelzl U (2005)	1
EGFR	5	NPM1	0	affinity chromatography technology	Liccardi G (2014)	1
ZZEF1	5	MYCBP	0	biochemical	Kristensen AR (2012)	1
MYCBP	0	REPIN1	3	biochemical	Kristensen AR (2012)	1
NPM1	0	CFL1	0	affinity chromatography technology	Chen R (2013)	1
EGFR	5	MYCBP	0	affinity chromatography technology	Tong J (2008)	1
PAN2	3	MYCBP	0	affinity chromatography technology	Bett JS (2013)	1
OTUD4	2	UBC	7	enzymatic study, enzymatic study, pull down, pull down	Mevissen TE (2013), Zhao Y (2015), Zhang X (2017), Kwasna D (2018)	4
MYCBP	0	MAATS1	3	two hybrid, pull down, affinity chromatography technology	Yukitake H (2002), Yukitake H (2002), Yukitake H (2002)	3
PA2G4	1	MYCBP	0	biochemical	Wan C (2015)	1
FBXW11	2	MYCBP	0	affinity chromatography technology	Coyaud E (2015)	1
MYCBP	0	PTN	0	two hybrid	Stelzl U (2005)	1
UBC	7	NPM1	0	affinity chromatography technology, pull down	Matsumoto M (2005), Koike A (2010)	2
HIST1H3E	0	OTUD4	2	affinity chromatography technology	Campos EI (2015)	1
MAATS1	3	AKAP1	3	affinity chromatography technology, pull down, pull down	Yukitake H (2002), Yukitake H (2002), Yukitake H (2002)	3
YWHAQ	0	NPM1	0	affinity chromatography technology, pull down, affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Meek SE (2004), Pozuelo-Rubio M (2010), Pozuelo-Rubio M (2010)	4
COPS6	0	NPM1	0	affinity chromatography technology	Bennett EJ (2010)	1
UROD	2	MYCBP	0	biochemical	Wan C (2015)	1
MYCBP	0	GDF9	2	two hybrid	Stelzl U (2005)	1
UBC	7	ACTR1A	1	affinity chromatography technology	Matsumoto M (2005)	1
PARK7	0	YWHAQ	0	affinity chromatography technology	Malty RH (2017)	1
EIF5A2	2	MYCBP	0	biochemical	Wan C (2015)	1
MYCBP	0	COPS6	0	two hybrid	Stelzl U (2005)	1
EGLN3	0	OTUD4	2	affinity chromatography technology	Rodriguez J (2016)	1
MYCBP	0	CFL1	0	two hybrid	Stelzl U (2005)	1
CORO1C	2	MYCBP	0	biochemical	Wan C (2015)	1
NPM1	0	PA2G4	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Okada M (2007), Okada M (2007), Okada M (2007), Liu Z (2009), Oh SM (2010), Hein MY (2015)	6
HEXIM2	0	MYCBP	0	affinity chromatography technology	Huttlin EL (2017)	1
AGO4	5	MYCBP	0	affinity chromatography technology	Weinmann L (2009)	1
YWHAQ	0	CFL1	0	pull down	Meek SE (2004)	1
YWHAQ	0	MYCBP	0	affinity chromatography technology	Ichimura T (2013)	1
EGFR	5	YWHAQ	0	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
HIST1H3E	0	NPM1	0	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
NPM1	0	PARK7	0	affinity chromatography technology	Chen R (2013)	1
AKAP1	3	MYCBP	0	pull down, two hybrid, pull down, affinity chromatography technology	Yukitake H (2002), Furusawa M (2001), Furusawa M (2001), Furusawa M (2001)	4
PAN2	3	CFL1	0	affinity chromatography technology	Bett JS (2013)	1
NPM1	0	MYCBP	0	affinity chromatography technology	Chen R (2013)	1
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
EGFR	5	UROD	2	protein complementation assay	Deribe YL (2009)	1
EGLN3	0	AKAP1	3	affinity chromatography technology	Rodriguez J (2016)	1
PAN2	3	NPM1	0	affinity chromatography technology	Bett JS (2013)	1
EGFR	5	CFL1	0	protein complementation assay	Deribe YL (2009)	1
ACTR1A	1	MYCBP	0	biochemical	Kristensen AR (2012)	1
MYCBP	0	MYCBPAP	2	two hybrid, affinity chromatography technology	Yukitake H (2002), Yukitake H (2002)	2
EGLN3	0	YWHAQ	0	affinity chromatography technology	Rodriguez J (2016)	1
HIST1H3E	0	SSRP1	1	affinity chromatography technology	Campos EI (2015)	1
COPS6	0	UBC	7	affinity chromatography technology	Bennett EJ (2010)	1
PAN2	3	CORO1C	2	affinity chromatography technology	Bett JS (2013)	1
HIST1H3E	0	MYCBP	0	affinity chromatography technology	Campos EI (2015)	1
OTUD4	2	MYCBP	0	affinity chromatography technology	Sowa ME (2009)	1
EGLN3	0	CFL1	0	affinity chromatography technology	Rodriguez J (2016)	1
MYC	2	MYCBP	0	two hybrid, pull down, affinity chromatography technology	Taira T (1998), Taira T (1998), Taira T (1998)	3
EGFR	5	UBC	7	affinity chromatography technology, affinity chromatography technology	Tong J (2009), Bishop N (2002)	2
MYCBP	0	ARHGEF40	0	two hybrid	Stelzl U (2005)	1
EGLN3	0	MYCBP	0	affinity chromatography technology	Rodriguez J (2016)	1
EGLN3	0	PARK7	0	affinity chromatography technology	Rodriguez J (2016)	1
MYCBP	0	EIF5AL1	0	biochemical	Wan C (2015)	1
UBC	7	MYCBP	0	pull down	Zhang X (2017)	1
PARK7	0	MYCBP	0	affinity chromatography technology	Malty RH (2017)	1