PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
HSP90AA1	7	SKP1	0	pull down	Zhang M (2008)	1
DCP2	0	FBXO3	0	affinity chromatography technology	Li S (2014)	1
CDC73	1	FBXO3	0	affinity chromatography technology	Herr P (2015)	1
AIRE	3	CUL1	7	affinity chromatography technology	Shao W (2016)	1
MCM2	3	FBXO3	0	affinity chromatography technology	Drissi R (2015)	1
CDC73	1	CUL1	7	affinity chromatography technology	Herr P (2015)	1
EGLN3	0	FBXO3	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL1	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Shima Y (2008), Reitsma JM (2017)	3
HIPK2	0	FBXO3	0	affinity chromatography technology	Shima Y (2008)	1
PML	7	RBX1	2	affinity chromatography technology, enzymatic study	Shima Y (2008), Yuan WC (2011)	2
COPS5	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Min KW (2005), Min KW (2005), Chua YS (2011), Boh BK (2011), Emberley ED (2012), Emberley ED (2012), Choo YY (2011), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Enchev RI (2012), Birol M (2014), Pick E (2012), Sharon M (2009), Enchev RI (2012), Bornstein G (2015), Rockel B (2014), Schlierf A (2016), Reitsma JM (2017), Reitsma JM (2017)	23
MCM2	3	SKP1	0	affinity chromatography technology	Drissi R (2015)	1
SMURF1	4	NEDD8	0	affinity chromatography technology, pull down	He S (2017), He S (2017)	2
ZNHIT2	0	FBXO3	0	affinity chromatography technology	Cloutier P (2017)	1
CDC73	1	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Mak AB (2010), Herr P (2015)	2
PTPDC1	3	FBXO3	0	affinity chromatography technology	St-Denis N (2016)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
HIPK2	0	EP300	36	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006), Aikawa Y (2006)	4
EP300	36	MCM2	3	pull down	Karmakar S (2010)	1
PML	7	CUL1	7	affinity chromatography technology	Shima Y (2008)	1
NEDD8	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
FBXL2	2	SKP1	0	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Ilyin GP (1999), Kuchay S (2013), Winston JT (1999), Li LQ (2016), Kuchay S (2017), Hauri S (2016)	7
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXL2	2	FBXO3	0	affinity chromatography technology	Krzysiak TC (2016)	1
COPS5	0	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
EGLN3	0	SKP1	0	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	FBXO3	0	affinity chromatography technology	Taipale M (2012)	1
PML	7	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Shima Y (2008), Shima Y (2008)	3
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
FBXO3	0	SKP1	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Yu H (2011), Cloutier P (2017), Hauri S (2016)	4
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
CUL1	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
EGLN3	0	PML	7	affinity chromatography technology	Rodriguez J (2016)	1
HSP90AA1	7	TNFAIP3	3	affinity chromatography technology	Taipale M (2012)	1
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
FBXO3	0	FBXO3	0	affinity chromatography technology	Cloutier P (2017)	1
HSP90AA1	7	FBXL2	2	affinity chromatography technology	Taipale M (2012)	1
NEDD8	0	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
IDS	0	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
INO80B	0	FBXO3	0	affinity chromatography technology	Cloutier P (2017)	1
AIRE	3	MCM2	3	affinity chromatography technology	Abramson J (2010)	1
HIPK2	0	PML	7	affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	de la Vega L (2011), Renner F (2010), Sung KS (2011), Sung KS (2011), Gresko E (2009), Gresko E (2009), Gresko E (2009)	7
EGLN3	0	INO80B	0	affinity chromatography technology	Rodriguez J (2016)	1
CUL3	17	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Taipale M (2012)	2
EGLN3	0	DCP2	0	affinity chromatography technology	Rodriguez J (2016)	1
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
COPS5	0	HSP90AA1	7	affinity chromatography technology	Bennett EJ (2010)	1
EP300	36	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Shima Y (2008), Wang SA (2014)	2
EGLN3	0	NEDD8	0	affinity chromatography technology	Rodriguez J (2016)	1
RBX1	2	FBXO3	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Shima Y (2008)	2
PML	7	SKP1	0	affinity chromatography technology	Shima Y (2008)	1
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
MCM2	3	HSP90AA1	7	affinity chromatography technology	Drissi R (2015)	1
TNFAIP3	3	FBXO3	0	affinity chromatography technology	Sowa ME (2009)	1
AIRE	3	RBX1	2	affinity chromatography technology	Shao W (2016)	1
CUL3	17	FBXO3	0	affinity chromatography technology	Bennett EJ (2010)	1
FBXO3	0	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Li D (2015), Li D (2015), Li D (2015), Li D (2015)	4
HIPK2	0	CUL1	7	affinity chromatography technology	Kanei-Ishii C (2008)	1
AIRE	3	FBXO3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shao W (2016), Shao W (2016), Shao W (2016)	3
IDS	0	CUL1	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
COPS5	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Sowa ME (2009), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Birol M (2014)	5
COPS5	0	RBX1	2	affinity chromatography technology	Olma MH (2009)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
FBXL2	2	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Watanabe T (2012), Li LQ (2016), Kuchay S (2017), Reitsma JM (2017)	4