PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
KLHL3	1	CFAP206	1	two hybrid	Rolland T (2014)	1
CUL3	17	PRKACA	2	affinity chromatography technology	Bennett EJ (2010)	1
KEAP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang DD (2005), Ichikawa T (2009), Lau A (2010), Li Y (2012), Niture SK (2013), Kaspar JW (2012), Kaspar JW (2012), Zhang DD (2004), Lo SC (2006)	9
SQSTM1	0	KLHL3	1	affinity chromatography technology, affinity chromatography technology	Mori Y (2015), Mori Y (2015)	2
KLHL2	0	WNK1	7	affinity chromatography technology, unspecified method, affinity chromatography technology	Takahashi D (2013), Schumacher FR (2014), Huttlin EL (2017)	3
AKT1	1	WNK4	5	enzymatic study	Heise CJ (2010)	1
KLHL2	0	KLHL12	4	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Rual JF (2005), Mai A (2004), Yu H (2011), Huttlin EL (2017)	4
KLHL3	1	WNK2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ohta A (2013), Ohta A (2013), Takahashi D (2013)	3
KEAP1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang XJ (2008), Rachakonda G (2008), Rachakonda G (2008), Nioi P (2007), Chew EH (2007), Chew EH (2007), Zhang DD (2005), Furukawa M (2005), Furukawa M (2005), Furukawa M (2005), Zhang DD (2004), Cullinan SB (2004), Kobayashi A (2004), Kobayashi A (2004), McMahon M (2006), Ichikawa T (2009), Lee DF (2009), Wong DP (2010), Wong DP (2010), Lau A (2010), Lau A (2010), Hur W (2010), Bennett EJ (2010), Yao JW (2012), Li Y (2012), Choo YY (2012), Kansanen E (2011), Kansanen E (2011), Niture SK (2013), Hast BE (2014), Cleasby A (2014), Kaspar JW (2012), Kaspar JW (2012), Su C (2015), Su C (2015), Huo L (2015), Dubiel D (2015), Lo SC (2006), Wu G (2017), Villeneuve NF (2013), Villeneuve NF (2013), Villeneuve NF (2013), Dong T (2016)	43
KLHL3	1	KLHL12	4	two hybrid	Rolland T (2014)	1
KLHL2	0	KLHL3	1	affinity chromatography technology	Huttlin EL (2017)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
KLHL2	0	WNK2	5	affinity chromatography technology	Takahashi D (2013)	1
WNK4	5	CUL3	17	affinity chromatography technology, affinity chromatography technology	Wakabayashi M (2013), Shibata S (2013)	2
MORF4L2	0	KLHL3	1	two hybrid	Rolland T (2014)	1
KEAP1	0	KLHL3	1	two hybrid	Rolland T (2014)	1
KLHL2	0	WNK4	5	affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography	Takahashi D (2013), Takahashi D (2013), Schumacher FR (2014), Schumacher FR (2014)	4
ELAVL1	0	KLHL3	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PRKACA	2	KLHL3	1	enzymatic study	Yoshizaki Y (2015)	1
KLHL3	1	RBX1	2	affinity chromatography technology	Ohta A (2013)	1
KEAP1	0	SQSTM1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Jain A (2010), Jain A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Lau A (2010), Inami Y (2011), Fan W (2010), Copple IM (2010), Copple IM (2010), Wright T (2013), Tanji K (2013), Ichimura Y (2013), Ichimura Y (2013), Ichimura Y (2013), Hast BE (2014), Hast BE (2014), Lerner C (2013), Rolland T (2014), Gjyshi O (2015), Bakkar N (2015), Milan E (2015), Park S (2016), Ge W (2017), Mildenberger J (2017), Lu K (2017), Lee Y (2017)	30
SLC12A3	1	KLHL3	1	affinity chromatography technology	Louis-Dit-Picard H (2012)	1
KLHL3	1	WNK1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study	Ohta A (2013), Ohta A (2013), Ohta A (2013), Shibata S (2013), Takahashi D (2013), Ohta A (2013), Schumacher FR (2015)	7
SQSTM1	0	CUL3	17	imaging technique, affinity chromatography technology	Lau A (2010), Mori Y (2015)	2
KLHL3	1	WNK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method	Ohta A (2013), Ohta A (2013), Takahashi D (2013), Schumacher FR (2014)	4
AKT1	1	KLHL3	1	enzymatic study	Yoshizaki Y (2015)	1
KLHL2	0	WNK3	2	affinity chromatography technology, affinity chromatography technology	Takahashi D (2013), Huttlin EL (2017)	2
WNK4	5	KLHL3	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wakabayashi M (2013), Wakabayashi M (2013), Shibata S (2013), Shibata S (2013), Takahashi D (2013), Mori Y (2013), Schumacher FR (2014), Schumacher FR (2014), Shibata S (2014), Shibata S (2014), Schumacher FR (2015), Yoshizaki Y (2015), Mori Y (2015), Wu G (2013)	14
KLHL2	0	KEAP1	0	affinity chromatography technology, affinity chromatography technology	Mai A (2004), Huttlin EL (2017)	2
KLHL3	1	CLDN8	1	affinity chromatography technology, affinity chromatography technology	Gong Y (2015), Gong Y (2015)	2
CUL3	17	ELAVL1	0	affinity chromatography technology	Bennett EJ (2010)	1
KLHL3	1	KLHL3	1	affinity chromatography technology, affinity chromatography technology, two hybrid	Ohta A (2013), Ohta A (2013), Rolland T (2014)	3
KLHL12	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rondou P (2008), Rondou P (2008), Angers S (2006), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	10
CUL3	17	KLHL2	0	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Bennett EJ (2010), Takahashi D (2013), Rolland T (2014), Huttlin EL (2017)	4
KLHL3	1	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Ohta A (2013), Ohta A (2013), Wakabayashi M (2013), Ji AX (2013), Shibata S (2013), Shibata S (2013), Takahashi D (2013), McCormick JA (2014), Rolland T (2014), Ibeawuchi SR (2015), Schumacher FR (2015), Schumacher FR (2015), Wu G (2013)	13
ELAVL1	0	RBX1	2	affinity chromatography technology	Abdelmohsen K (2009)	1
WNK1	7	WNK2	5	two hybrid	Bandyopadhyay S (2010)	1