PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
DISC1	6	TNIK	4	two hybrid	Camargo LM (2007)	1
H2AFX	1	TIAM2	1	two hybrid	Vinayagam A (2011)	1
TNIK	4	TIAM2	1	two hybrid	Camargo LM (2007)	1
RNF2	1	TIAM2	1	affinity chromatography technology	Cao Q (2014)	1
H2AFX	1	RNF2	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Pan MR (2011), Pan MR (2011), Pan MR (2011), Pan MR (2011), Yang XX (2016)	5
DNM2	2	SH3GL2	1	pull down	Solomaha E (2005)	1
UFD1	1	TIAM2	1	two hybrid	Vinayagam A (2011)	1
TK1	0	TIAM2	1	two hybrid	Vinayagam A (2011)	1
DNM2	2	TIAM2	1	two hybrid	Vinayagam A (2011)	1
ANXA7	0	TIAM2	1	two hybrid	Vinayagam A (2011)	1
DISC1	6	TIAM2	1	two hybrid	Camargo LM (2007)	1
SH3GL2	1	TIAM2	1	two hybrid	Vinayagam A (2011)	1