PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CUL2	3	SEC23A	3	affinity chromatography technology	Bennett EJ (2010)	1
UBE2V2	0	UBC	7	x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down	McKenna S (2003), McKenna S (2003), McKenna S (2003), Lewis MJ (2006), McKenna S (2001)	5
ELOC	0	ELOB	1	two hybrid, pull down, pull down, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, two hybrid, affinity chromatography technology, x-ray crystallography, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, pull down, two hybrid, biochemical, biochemical, two hybrid	Rual JF (2005), Ohh M (1999), Aso T (1995), Li Z (2002), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Kinoshita K (2007), Lievens S (2009), Brower CS (1999), Stebbins CE (1999), Pause A (1999), Pause A (1999), Havugimana PC (2012), Wang X (2013), Kristensen AR (2012), Costessi A (2011), Rolland T (2014), Kim DY (2013), Wan C (2015), Yu H (2011)	21
UBC	7	UBE2C	1	affinity chromatography technology	Matsumoto M (2005)	1
CUL3	17	CUL1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Bennett EJ (2010), Bennett EJ (2010), Wan C (2015)	3
USP34	7	UFM1	0	biochemical	Havugimana PC (2012)	1
NSFL1C	1	PSMD2	2	affinity chromatography technology	Alexandru G (2008)	1
UBE2V2	0	USP34	7	biochemical	Havugimana PC (2012)	1
UCHL3	1	ZRANB2	0	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
NUBP2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
SMURF1	4	UBE2D2	0	pull down, pull down	Kristariyanto YA (2015), Andrews PS (2010)	2
ATG9A	5	NPLOC4	4	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	FAF1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Song EJ (2005), Song EJ (2005), Shin HY (2010), Haenzelmann P (2011), Haenzelmann P (2011), Kang W (2011), Alexandru G (2012), Lee JJ (2013), Lee JJ (2013), Lee JJ (2013), Yu CC (2013), Baron Y (2014), Franz A (2016), Raman M (2015)	17
SMURF1	4	UBE2D1	0	pull down, enzymatic study	Kristariyanto YA (2015), Andrews PS (2010)	2
JUN	0	APP	1	pull down	Miyamoto-Sato E (2010)	1
FAF1	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Lee JJ (2013), Raman M (2015), Raman M (2015)	7
DCAF1	5	CUL4A	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahn J (2010), Belzile JP (2007), He YJ (2006), McCall CM (2008), McCall CM (2008), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Olma MH (2009), Jin J (2006), Kyei GB (2015)	14
UBE2B	3	UBR1	3	two hybrid, affinity chromatography technology	Stelzl U (2005), Hong JH (2015)	2
UFC1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UFC1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
HIF1A	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chew EH (2007), Sufan RI (2006), Luo W (2010), Heir P (2013), Russell RC (2008)	5
UBE2V2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBXN7	3	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
FAF1	1	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBE4B	5	UCHL3	1	biochemical	Havugimana PC (2012)	1
USP9X	15	ZYX	2	biochemical	Havugimana PC (2012)	1
UBXN1	0	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
UBE2B	3	UBR4	15	affinity chromatography technology	Hong JH (2015)	1
UBE2D1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBC	7	UBR1	3	affinity chromatography technology	Bish RA (2007)	1
UBXN7	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
SULT1A1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
PSMD2	2	UBE2L3	1	biochemical	Havugimana PC (2012)	1
VHL	0	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down	Zhang C (2016), Zhang C (2016), Zhang C (2016)	3
NTRK1	1	UBE4B	5	affinity chromatography technology	Emdal KB (2015)	1
UBXN7	3	ELOB	1	affinity chromatography technology	Alexandru G (2008)	1
TYMS	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
RBX1	2	CUL2	3	affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Dias DC (2002), Ohta T (1999), Ohta T (1999), Maine GN (2007), Hu J (2004), Furukawa M (2002), Mao X (2011), Sufan RI (2006), Sufan RI (2006), Sufan RI (2006), Brower CS (2002), Tron AE (2012), Kamura T (2004), Kristensen AR (2012), Costessi A (2011), Huang DT (2009), Kamura T (1999), Kamura T (1999), Xu J (2015), Cardote TAF (2017)	20
UBXN7	3	USP9X	15	biochemical	Havugimana PC (2012)	1
USP34	7	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBR5	13	UBE2L3	1	pull down, pull down	Honda Y (2002), Flack JE (2017)	2
CUL4B	8	BRWD3	3	affinity chromatography technology	Hein MY (2015)	1
FAF1	1	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
UBXN7	3	UFC1	0	biochemical	Havugimana PC (2012)	1
FAF2	4	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
TTLL12	3	USP9X	15	biochemical	Havugimana PC (2012)	1
ATP6V1B2	3	ZPR1	1	biochemical	Havugimana PC (2012)	1
ERCC8	1	VCP	6	affinity chromatography technology	He J (2016)	1
UBR5	13	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
AMFR	2	UBC	7	pull down, pull down, imaging technique, affinity chromatography technology, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology	Zhong X (2004), Yang H (2010), Ying Z (2009), Jo Y (2011), Ye Y (2003), Xu Y (2012), Liu S (2012), Liu S (2012), Xu Y (2012), Morito D (2008), Flierman D (2006), Liu W (2014), Fang S (2001)	13
CUL4B	8	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Jin J (2006), Wang H (2006), Higa LA (2006), Higa LA (2006), Kawajiri K (2009), Bennett EJ (2010), Havugimana PC (2012), Ji Q (2014), Wan C (2015), Hein MY (2015), Mo Y (2017), Mo Y (2017), Yang Y (2015), Yang Y (2015), Yang Y (2015), Higa LA (2006), Higa LA (2006), Ohtake F (2007), Ohtake F (2007), Ohtake F (2007)	23
UBE2D1	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Wang Y (2014)	3
VCP	6	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Q (2008), Ballar P (2007), Alexandru G (2008), Zhong X (2006), Fernandez-Saiz V (2010), Nagahama M (2009), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Bruderer RM (2004), Erzurumlu Y (2013), Li JM (2013), Fogeron ML (2013), Haenzelmann P (2016), Haenzelmann P (2016), Haenzelmann P (2016), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	21
FAF2	4	ATG9A	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ATP6V1B2	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
FAF2	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Lee JN (2008), Alexandru G (2008), Alexandru G (2008), Mueller B (2008), Alexandru G (2012), Xu Y (2013), Christianson JC (2012), Besten Wd (2012), Madsen L (2014), Raman M (2015)	10
SULT1A1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
SEC23A	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
CUL3	17	BRWD1	6	affinity chromatography technology	Wimuttisuk W (2014)	1
TTLL12	3	UBE2D1	0	biochemical	Havugimana PC (2012)	1
UBE2D1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
RBX1	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Pick E (2007), Lan L (2012), Tsai WB (2010), Hrecka K (2007), Okuda H (2001), Tai T (2006), Ahn J (2011), Gong B (2010), Lu Y (2012), Ohta A (2013), da Silva Almeida AC (2013), Delucia M (2013), Scott DC (2014), Camp ND (2012), Kim S (2014), Theurillat JP (2014), Kigoshi Y (2011), Pashkova N (2010), Beck J (2013), Pierce WK (2015), Wu K (2016), Parameswaran B (2015), Simo S (2013), Groisman R (2006), Marzahn MR (2016), Courtheoux T (2016), Hasanov E (2017), Ferretti LP (2016), Zhou X (2017), Kroenke J (2014), Mulvaney KM (2016)	31
UBE2L3	1	ZPR1	1	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Xu M (2009), Phu L (2011), Oberoi TK (2012), Bertrand MJ (2011), Guicciardi ME (2014), Takeda AN (2014), Wauer T (2015), Vu NT (2016)	11
ATP6V1F	1	ZPR1	1	biochemical	Havugimana PC (2012)	1
USP34	7	UFC1	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	DCAF1	5	affinity chromatography technology	Alexandru G (2008)	1
DDB1	6	PHIP	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Angers S (2006), Jin J (2006), Jin J (2006), Wan C (2015)	4
NEDD8	0	UCHL3	1	pull down, two hybrid, affinity chromatography technology, enzymatic study, pull down	Wada H (1998), Wada H (1998), Norman JA (2006), Wada H (1998), Hemelaar J (2004)	5
SMURF1	4	UBC	7	affinity chromatography technology, enzymatic study, pull down	Xie Y (2013), Kristariyanto YA (2015), Zhang Y (2017)	3
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
NTRK1	1	ATP6V1B2	3	affinity chromatography technology	Emdal KB (2015)	1
UBE4B	5	UFM1	0	biochemical	Havugimana PC (2012)	1
CUL4B	8	PHIP	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Jin J (2006), Hein MY (2015)	3
NTRK1	1	ASPSCR1	3	affinity chromatography technology	Emdal KB (2015)	1
FAF2	4	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
DDB1	6	UBC	7	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Matsumoto M (2005)	2
ATG9A	5	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
NTRK1	1	RANBP6	5	affinity chromatography technology	Emdal KB (2015)	1
FAF1	1	WDR26	6	affinity chromatography technology	Alexandru G (2008)	1
SSSCA1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TTLL12	3	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBXN1	0	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
UBXN7	3	WDR11	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBE2V1	0	UBE2V2	0	biochemical	Havugimana PC (2012)	1
VCP	6	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Alexandru G (2012), Yu CC (2013), Fogeron ML (2013), Rolland T (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Madsen L (2014), Hein MY (2015), Raman M (2015), Huttlin EL (2017)	14
UBE2L3	1	USP34	7	biochemical	Havugimana PC (2012)	1
SRXN1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBR5	13	UBE2B	3	pull down	Honda Y (2002)	1
VCP	6	SKP1	0	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
UBXN1	0	TNFAIP1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
AMFR	2	FAF2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee JN (2008), Lee JN (2008), Alexandru G (2008), Wang Q (2011), Xu Y (2013), Wang Q (2011), Christianson JC (2012), Christianson JC (2012), Zhang T (2015)	9
SRXN1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
CUL4A	2	CUL3	17	affinity chromatography technology	Bennett EJ (2010)	1
NSFL1C	1	ACAD11	0	affinity chromatography technology	Raman M (2015)	1
WDR26	6	DDB1	6	affinity chromatography technology	Lampert F (2018)	1
UBXN1	0	UBC	7	pull down, pull down, affinity chromatography technology, pull down, pull down, pull down	Wu-Baer F (2010), Fenner BJ (2009), Alexandru G (2008), LaLonde DP (2011), McNeill H (2004), Zhang X (2017)	6
CUL3	17	DDB1	6	affinity chromatography technology	Bennett EJ (2010)	1
SRXN1	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	OXCT1	1	affinity chromatography technology	Emdal KB (2015)	1
UBXN7	3	BIRC2	1	affinity chromatography technology	Alexandru G (2008)	1
UBE2V1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
DDB1	6	BRWD1	6	affinity chromatography technology, biochemical	Angers S (2006), Wan C (2015)	2
UBE2V2	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
FAF1	1	CUL2	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBC	7	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Matsumoto M (2005), Bennett EJ (2010), Bish RA (2007), Wu K (2016)	4
UBE2C	1	YAP1	0	biochemical	Havugimana PC (2012)	1
YAP1	0	PSMD2	2	affinity chromatography technology	Enzo E (2015)	1
NEDD8	0	BTBD9	2	affinity chromatography technology	Bennett EJ (2010)	1
SULT1A1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
VHL	0	APP	1	pull down	Olah J (2011)	1
UBXN7	3	KPNA3	0	affinity chromatography technology	Raman M (2015)	1
NSFL1C	1	UBR1	3	affinity chromatography technology	Alexandru G (2008)	1
HIF1A	1	RBX1	2	affinity chromatography technology	Heir P (2013)	1
UBE4B	5	VPS26A	0	biochemical	Havugimana PC (2012)	1
NSFL1C	1	ASPSCR1	3	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Huttlin EL (2017)	2
FAF1	1	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
YAP1	0	ZYX	2	affinity chromatography technology	Enzo E (2015)	1
TTLL12	3	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBE4B	5	UBE2D2	0	pull down, pull down, pull down	Benirschke RC (2010), Wu H (2011), Buetow L (2015)	3
UBXN7	3	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
FAM189B	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
SSSCA1	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
PSMD2	2	SRXN1	0	biochemical	Havugimana PC (2012)	1
UFC1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
ABCF1	5	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
KLHDC3	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Huttlin EL (2017)	3
ATP6V1B2	3	ATP6V1F	1	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TTLL12	3	UFM1	0	biochemical	Havugimana PC (2012)	1
NSFL1C	1	CUL3	17	affinity chromatography technology	Alexandru G (2008)	1
NSFL1C	1	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
CUL3	17	KLHL13	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Maerki S (2009), Sumara I (2007), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Maerki S (2009)	7
SKP1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2D1	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
UBXN7	3	UBR1	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UCHL3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
FAF2	4	PSMD2	2	affinity chromatography technology, pull down	Suzuki M (2012), Suzuki M (2012)	2
NTRK1	1	TTLL12	3	affinity chromatography technology	Emdal KB (2015)	1
UBC	7	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography	Matsumoto M (2005), Bennett EJ (2010), Singh RK (2012), Singh RK (2012)	4
TOPORS	6	UBE2D1	0	pull down, affinity chromatography technology, two hybrid, pull down, pull down	Park HJ (2008), Park HJ (2008), van Wijk SJ (2009), Guan B (2008), Rajendra R (2004)	5
UFM1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
RNF138	0	APP	1	pull down	Olah J (2011)	1
UBC	7	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haque M (2013), Haque M (2013), Kuo YC (2015), Fan CM (1990), Mabjeesh NJ (2003)	5
FAF1	1	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
UBXN7	3	VCPIP1	4	affinity chromatography technology	Raman M (2015)	1
ASPSCR1	3	APP	1	pull down	Olah J (2011)	1
UBXN7	3	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
UCHL3	1	ZYX	2	biochemical	Havugimana PC (2012)	1
NUBP2	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UBE2D1	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	SEC23A	3	affinity chromatography technology	Emdal KB (2015)	1
RBX1	2	CUL4B	8	affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, imaging technique	Dias DC (2002), Ji Q (2014), Huang DT (2009), Hein MY (2015), Yang Y (2015)	5
UBE2D2	0	RNF111	2	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Erker Y (2013), Wright JD (2016), Birkou M (2017), Birkou M (2017)	6
UBXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBC	7	FAF2	4	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Alexandru G (2008)	2
TOPORS	6	UBC	7	enzymatic study	Rajendra R (2004)	1
DPP8	2	UBXN7	3	biochemical	Kristensen AR (2012)	1
SDHAF2	1	KLHDC2	1	affinity chromatography technology	Hein MY (2015)	1
ERCC8	1	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Groisman R (2003), Groisman R (2003), Bennett EJ (2010), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Groisman R (2006)	8
KCNK16	3	UBXN7	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBXN7	3	ASPSCR1	3	affinity chromatography technology	Raman M (2015)	1
SMURF1	4	NEDD8	0	affinity chromatography technology, pull down	He S (2017), He S (2017)	2
SSSCA1	0	USP34	7	biochemical	Havugimana PC (2012)	1
YAP1	0	JUN	0	affinity chromatography technology	Enzo E (2015)	1
UBE2V2	0	VPS26A	0	biochemical	Havugimana PC (2012)	1
KLHDC3	1	NEDD8	0	affinity chromatography technology	Huttlin EL (2015)	1
BIRC2	1	UBE2L3	1	affinity chromatography technology	Hu S (2003)	1
UBXN7	3	CUL4B	8	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012)	2
FAM189B	2	RNF111	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2D1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
NEDD8	0	ATP6V1F	1	biochemical	Wan C (2015)	1
UBXN7	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	SKP1	0	affinity chromatography technology	Alexandru G (2008)	1
UBE4B	5	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2C	1	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
NEDD8	0	ELOC	0	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
UBC	7	NPLOC4	4	affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Wang B (2003), Bish RA (2007), Kristariyanto YA (2015), Zhang X (2017)	5
UBXN7	3	NSFL1C	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
RBX1	2	ELOC	0	affinity chromatography technology	Brower CS (2002)	1
DCAF1	5	RBX1	2	pull down	Ahn J (2010)	1
UBXN7	3	CSNK1E	0	affinity chromatography technology	Raman M (2015)	1
UFC1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UFD1	1	PSMD2	2	affinity chromatography technology	Chen M (2011)	1
UBXN7	3	BRWD3	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBC	7	UBR4	15	affinity chromatography technology, pull down, affinity chromatography technology	Matsumoto M (2005), Nathan JA (2013), Bish RA (2007)	3
SULT1A1	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
UCHL3	1	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	BRWD1	6	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
NEDD8	0	UBE2D2	0	x-ray crystallography	Sakata E (2007)	1
UBE2V1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
AMFR	2	VCP	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, two hybrid, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhong X (2004), Zhong X (2004), Lee JN (2008), Cao J (2007), Ballar P (2007), Ballar P (2007), Ye Y (2005), Ye Y (2005), Zhong X (2004), Yang H (2010), Yang H (2010), Ballar P (2010), Jo Y (2011), St-Pierre P (2012), Grelle G (2006), Scheich C (2007), Ballar P (2006), Haenzelmann P (2011), Haenzelmann P (2011), Haenzelmann P (2011), Wang Q (2011), Yu CC (2013), Erzurumlu Y (2013), Liu S (2013), Wang Q (2011), Grelle G (2006), Grelle G (2006), Grelle G (2006), Grelle G (2006), Christianson JC (2012), Zhang T (2015), Khodayari N (2017)	32
UBXN1	0	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	UFM1	0	biochemical	Havugimana PC (2012)	1
TCEANC2	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
MAP3K1	4	JUN	0	enzymatic study	Park KJ (2003)	1
SKP1	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Kumar R (2005), Wang W (2004), Ohta T (2001), Oshikawa K (2003), Liu J (2002), Li X (2003), Zhou W (2014), Zhou W (2014), Hao J (2015), Hauri S (2016)	11
FAF1	1	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Zhang L (2012), Zhang L (2012)	4
UBXN7	3	RANBP6	5	affinity chromatography technology	Raman M (2015)	1
SEC23A	3	UBE2V2	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	CUL4A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	3
CUL3	17	VCP	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Besten Wd (2012)	2
SSSCA1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2V1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBXN1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Hu Y (2017), Hu Y (2017)	4
VHL	0	ELOB	1	affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Ohh M (1999), Min JH (2002), Hacker KE (2008), Menon S (2008), Kamura T (2002), Kamura T (2002), Kuznetsova AV (2003), Cockman ME (2000), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Kinoshita K (2007), Lai Y (2012), Mahrour N (2008), Mahrour N (2008), Grosfeld A (2007), Foxler DE (2012), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017)	43
NTRK1	1	PSMD2	2	affinity chromatography technology	Emdal KB (2015)	1
SMURF1	4	UBXN7	3	enzymatic study	Andrews PS (2010)	1
UBE4B	5	ZPR1	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	ABCF1	5	affinity chromatography technology	Raman M (2015)	1
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
UCHL3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
RAD23B	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
KLHDC3	1	ELOB	1	affinity chromatography technology	Mahrour N (2008)	1
UBE2V1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
SULT1A1	0	USP34	7	biochemical	Havugimana PC (2012)	1
UBE2D1	0	USP34	7	biochemical	Havugimana PC (2012)	1
NTRK1	1	RAD23B	1	affinity chromatography technology	Emdal KB (2015)	1
RBX1	2	APP	1	pull down	Olah J (2011)	1
UBXN7	3	KIFC1	0	affinity chromatography technology	Raman M (2015)	1
CUL3	17	SKP1	0	affinity chromatography technology	Bennett EJ (2010)	1
SSSCA1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
CUL2	3	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Bish RA (2007), Wu K (2016)	3
SETD7	2	RNF111	2	affinity chromatography technology	Elkouris M (2016)	1
UBXN7	3	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBXN7	3	FAF1	1	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
SSSCA1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBXN7	3	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	UBXN7	3	affinity chromatography technology	Emdal KB (2015)	1
OXCT1	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBR5	13	UBC	7	pull down, x-ray crystallography, pull down	Kozlov G (2007), Kozlov G (2007), Zhang X (2017)	3
CUL4B	8	DCAF1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Jin J (2006), Hein MY (2015), Wang X (2017)	4
JUN	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alfranca A (2002), Yu B (2009), Yu B (2009)	3
UBE2C	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
NTRK1	1	KLHL22	3	affinity chromatography technology	Emdal KB (2015)	1
CUL2	3	UBE2D1	0	pull down, affinity chromatography technology, pull down	Sufan RI (2006), Sufan RI (2006), Maine GN (2007)	3
CUL3	17	KPNA3	0	affinity chromatography technology	Bennett EJ (2010)	1
XKRX	1	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
FAF1	1	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
SDHAF2	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
UFD1	1	NPLOC4	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology	Botta A (2001), Lass A (2008), Vong QP (2005), Bruderer RM (2004), Havugimana PC (2012), Li JM (2013), Pye VE (2007), Wan C (2015), Raman M (2015), Raman M (2015)	10
UBC	7	SKP1	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
NTRK1	1	VPS26A	0	affinity chromatography technology	Emdal KB (2015)	1
FAF1	1	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
NUAK2	1	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
SSSCA1	0	TTLL12	3	biochemical	Havugimana PC (2012)	1
UBXN1	0	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
UBE4B	5	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBE2V1	0	RNF111	2	two hybrid	Markson G (2009)	1
VHL	0	ELOC	0	affinity chromatography technology, pull down, two hybrid, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Tsuchiya H (1996), Min JH (2002), Li Z (2002), Hacker KE (2008), Kim BY (2008), Baek JH (2007), Baek JH (2007), Kuznetsova AV (2003), Cockman ME (2000), Lisztwan J (1999), Stickle NH (2004), Lai Y (2011), Liu YV (2007), Norman JA (2006), Kinoshita K (2007), Cai Q (2010), Lai Y (2012), Miller F (2005), Mahrour N (2008), Mahrour N (2008), Russell RC (2011), He X (2011), McClellan AJ (2005), Bex C (2007), Pause A (1997), Pause A (1997), Stebbins CE (1999), Iliopoulos O (1998), Feldman DE (2003), Kibel A (1995), Kibel A (1995), Pause A (1999), Pause A (1999), Duan DR (1995), Kamura T (2004), Russell RC (2008), Russell RC (2008), Essers PB (2014), Gerez J (2015), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Zhang C (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	48
UBXN7	3	APP	1	pull down	Olah J (2011)	1
SSSCA1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
SMURF1	4	PSMD2	2	affinity chromatography technology	Xie Y (2013)	1
CSNK1E	0	CUL2	3	affinity chromatography technology	Varjosalo M (2013)	1
CUL3	17	PHF6	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	ZRANB2	0	affinity chromatography technology	Bennett EJ (2010)	1
BIRC2	1	USP9X	15	affinity chromatography technology	Goncharov T (2013)	1
NEDD8	0	ELOB	1	affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010)	2
UBXN7	3	WDR26	6	affinity chromatography technology	Alexandru G (2008)	1
VCPIP1	4	UBC	7	enzymatic study, enzymatic study, pull down	Totsukawa G (2013), Mevissen TE (2013), Kwasna D (2018)	3
ACAD11	0	APP	1	pull down	Olah J (2011)	1
FAF2	4	PJA2	4	affinity chromatography technology	Alexandru G (2008)	1
UBE2V1	0	USP34	7	biochemical	Havugimana PC (2012)	1
TTLL12	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
NEDD8	0	KLHDC10	3	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	APP	1	affinity chromatography technology	Jang JK (2017)	1
UBE2D1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
FAF1	1	TNFAIP1	4	affinity chromatography technology	Raman M (2015)	1
UBC	7	ELOC	0	pull down	Zhang X (2017)	1
SRXN1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBE2C	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	RBX1	2	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
UBC	7	KCTD10	1	affinity chromatography technology	Matsumoto M (2005)	1
YAP1	0	CSTF1	1	affinity chromatography technology	Enzo E (2015)	1
RBX1	2	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Furukawa M (2005), Hu J (2004), Furukawa M (2002), Ichikawa T (2009), Ichikawa T (2009), Lee DF (2009), Tron AE (2012), Oshikawa K (2003), Plafker KS (2009), Lu A (2013), Meyer-Schaller N (2009), Theurillat JP (2014), Huang DT (2009), Ibeawuchi SR (2015), Schumacher FR (2015), Kasahara K (2014), Kasahara K (2014)	18
FAF2	4	CUL3	17	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	CUL3	17	affinity chromatography technology	Emdal KB (2015)	1
ATP6V1F	1	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UFM1	0	NPLOC4	4	biochemical	Kristensen AR (2012)	1
VCPIP1	4	NSFL1C	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008), Uchiyama K (2002), Raman M (2015)	4
VHL	0	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Norman JA (2006)	2
UBE2V1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
NTRK1	1	UBR1	3	affinity chromatography technology	Emdal KB (2015)	1
SEC23A	3	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBC	7	UBR2	8	affinity chromatography technology	Matsumoto M (2005)	1
USP9X	15	YAP1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kim M (2016), Kim M (2016)	3
USP9X	15	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
DDB1	6	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down	Wang H (2006), Kapetanaki MG (2006), Hu J (2004), Ahn J (2010), Fischer ES (2011), Groisman R (2006)	6
UBE2L3	1	UBE2B	3	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
CUL2	3	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
YAP1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
SKP1	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Staropoli JF (2003), Min KW (2003), Lisztwan J (1998), Zheng N (2002), Ohta T (1999), Bloom J (2006), Kumar R (2005), Megumi Y (2005), Wang W (2004), Read MA (2000), Wu K (2000), Tan P (1999), Mao X (2011), Lin HK (2009), Yano H (2008), Banerjee S (2010), Gao D (2010), Chua YS (2011), Zhang M (2008), Winston JT (1999), Latres E (1999), Latres E (1999), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Emberley ED (2012), Bennett EJ (2010), Gastaldello S (2012), Michel JJ (1998), Michel JJ (1998), Michel JJ (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Lyapina SA (1998), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Yu ZK (1998), Yu ZK (1998), Postow L (2013), Cordero-Espinoza L (2013), Zhou W (2014), Zhou W (2014), Hao J (2015), Hao J (2015), Han XR (2016), Liu YQ (2015), Gorelik M (2016), Al-Yacoub N (2016), Reiterer V (2017), Hu Y (2017), Hauri S (2016), Reitsma JM (2017), Reitsma JM (2017), Chen F (2017)	59
NTRK1	1	ZPR1	1	affinity chromatography technology	Emdal KB (2015)	1
BIRC2	1	UBE2D2	0	two hybrid, pull down, pull down, pull down	Dynek JN (2010), Li X (2002), Feltham R (2011), Choi YE (2009)	4
KLHDC2	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2017)	4
UBE4B	5	USP34	7	biochemical	Havugimana PC (2012)	1
KLHL13	0	UBE2D1	0	pull down	Sumara I (2007)	1
ASPSCR1	3	CUL1	7	affinity chromatography technology	Hu Y (2017)	1
ASPSCR1	3	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
VCP	6	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down	Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Raman M (2015), Li ZH (2017), Li ZH (2017)	9
CUL4A	2	VCP	6	affinity chromatography technology	Besten Wd (2012)	1
SSSCA1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
KCNK16	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UFC1	0	NEDD8	0	biochemical	Wan C (2015)	1
CUL3	17	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Bennett EJ (2010), Olma MH (2009), Bish RA (2007), Wu K (2016)	4
UBE4B	5	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBXN7	3	YAP1	0	biochemical	Havugimana PC (2012)	1
BIRC2	1	UBC	7	pull down, pull down, pull down, pull down, enzymatic study	Dynek JN (2010), Gyrd-Hansen M (2008), Gyrd-Hansen M (2008), Komander D (2009), Sakamoto H (2015)	5
UBXN7	3	PHIP	20	affinity chromatography technology	Raman M (2015)	1
UBXN7	3	FAM91A1	1	affinity chromatography technology	Raman M (2015)	1
UBXN7	3	MORF4L2	0	affinity chromatography technology	Raman M (2015)	1
RNF111	2	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
VHL	0	UBR5	13	affinity chromatography technology	Lai Y (2011)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
UBE2D2	0	UBE2L3	1	biochemical	Havugimana PC (2012)	1
UBE2D1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2B	3	UBXN7	3	biochemical	Havugimana PC (2012)	1
CUL4A	2	PHIP	20	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Jin J (2006)	4
CUL1	7	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Min KW (2003), Dias DC (2002), Kim J (2002), Zheng N (2002), Kim AY (2008), Ohta T (1999), Ohta T (1999), Ohta T (1999), Bloom J (2006), Block K (2005), Hu J (2004), Hwang JW (2003), Furukawa M (2002), Kawakami T (2001), Ohta T (2001), Chen A (2000), Read MA (2000), Wu K (2000), Tan P (1999), Banerjee S (2010), Gao D (2010), Tron AE (2012), Tron AE (2012), Shteingart S (2012), Tan M (2010), Arai T (2003), Oshikawa K (2003), Oshikawa K (2003), Lee JE (2011), Huang DT (2004), Emberley ED (2012), Gastaldello S (2012), Furukawa M (2000), Furukawa M (2000), Liu J (2002), Liu J (2002), Liu J (2002), Li X (2003), Calabrese MF (2011), Scott DC (2014), Scott DC (2014), Siergiejuk E (2009), Zhou W (2014), Zhou W (2014), Huang DT (2009), Pick E (2007), Morimoto M (2003), Morimoto M (2003), Ohki Y (2009), Duda DM (2008), Duda DM (2008), Wan C (2015), Hao J (2015), Hao J (2015), Han XR (2016), Kuang P (2016), Zhou W (2017), Hu Y (2017), Reitsma JM (2017)	59
YAP1	0	NEDD8	0	biochemical	Wan C (2015)	1
UBXN1	0	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
MAP3K1	4	FAF2	4	enzymatic study	Charlaftis N (2014)	1
SRXN1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBE2C	1	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
ERCC8	1	UBXN7	3	affinity chromatography technology	He J (2016)	1
UFC1	0	UFM1	0	affinity chromatography technology, biochemical, pull down, biochemical	Komatsu M (2004), Havugimana PC (2012), Gavin JM (2014), Wan C (2015)	4
KCTD13	1	TNFAIP1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Sowa ME (2009), Rolland T (2014), Huttlin EL (2015), Yu H (2011), Huttlin EL (2017)	5
UBE2D1	0	UBR5	13	biochemical	Havugimana PC (2012)	1
CUL4A	2	DDB1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Guerrero-Santoro J (2008), Guerrero-Santoro J (2008), Angers S (2006), Angers S (2006), Jin J (2006), Wang H (2006), Kapetanaki MG (2006), Matsuda N (2005), Hu J (2004), Hu J (2004), Hu J (2004), Ahn J (2010), Maddika S (2009), Fischer ES (2011), Tan L (2007), He YJ (2006), He YJ (2006), He YJ (2006), McCall CM (2008), McCall CM (2008), Shiyanov P (1999), Bennett EJ (2010), Gastaldello S (2012), Kanei-Ishii C (2012), Hodgson AJ (2012), Kulaksiz G (2005), Wu Z (2012), Wu Z (2012), Olma MH (2009), Olma MH (2009), Havugimana PC (2012), Rao F (2014), Wan C (2015), Liu Y (2015), Zha Z (2015), Mouysset J (2015), Gao J (2015), Yang Y (2016), Yang Y (2016), Scherer PC (2016), Eichner R (2016), Mo Y (2017), Mo Y (2017), Peng Z (2016), Higa LA (2006), Ohtake F (2007)	46
FAF2	4	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
NSFL1C	1	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
VHL	0	UBE2D2	0	pull down	Xin H (2011)	1
UFM1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
KLHL12	4	SEC23A	3	affinity chromatography technology	McGourty CA (2016)	1
UBE2D1	0	RNF111	2	two hybrid, two hybrid, two hybrid	van Wijk SJ (2009), Markson G (2009), Rolland T (2014)	3
SULT1A1	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
SSSCA1	0	VPS26A	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	CUL1	7	affinity chromatography technology	Emdal KB (2015)	1
RBX1	2	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, unspecified method, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Li Y (2010), Shaik S (2012), Costessi A (2011), Bashir T (2010), Lan L (2012), Welcker M (2011), Wilkins A (2004), Yada M (2004), Li C (2011), Lee DF (2009), Santra MK (2009), Chen BB (2012), Liu J (2002), Duan S (2011), Barbash O (2011), Kamura T (2003), Abbas T (2008), Peschiaroli A (2009), Popov N (2010), Uchida S (2011), Dimitrova YN (2010), Maerki S (2009), Malatesta M (2012), Davis MA (2013), Chen H (2013), Mallampalli RK (2013), Rossi M (2013), Mori Y (2013), Lu A (2013), Fischer ES (2014), Andresen CA (2014), Herrero-Ruiz J (2014), Johansson P (2014), Uchiki T (2009), Min SH (2012), Gao D (2010), Canettieri G (2010), Lin MY (2011), Read MA (2000), Zhang DD (2004), Zhang DD (2005), Fukushima H (2013), Matsumoto S (2015), Ibeawuchi SR (2015), Malonia SK (2015), Liu Y (2015), Liu Y (2015), Gao J (2015), Zhang C (2015), Chu WK (2015), Barbash O (2009), Kershaw NJ (2014), Nam S (2009), Wu HC (2014), Kim JH (2015), Kung YA (2017), Nguyen TV (2016), Shimizu K (2017), Gschweitl M (2016), Terai K (2013), Chandra S (2013), Dai X (2017), Qie S (2017), Chen BB (2013), Kroenke J (2014)	65
NEDD8	0	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012)	4
LZTFL1	2	UBXN7	3	biochemical	Kristensen AR (2012)	1
TGIF2LY	0	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bennett EJ (2010), Besten Wd (2012)	3
UBXN7	3	KCTD10	1	affinity chromatography technology	Raman M (2015)	1
UBE2D2	0	AMFR	2	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Fang S (2001)	3
FAF1	1	KCTD13	1	affinity chromatography technology	Raman M (2015)	1
UBXN7	3	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015)	3
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
UBC	7	PSMD2	2	pull down	Zhang X (2017)	1
UBE2D2	0	TOPORS	6	two hybrid	van Wijk SJ (2009)	1
UBXN1	0	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
ERCC3	3	KPNA3	0	two hybrid	Wang J (2011)	1
UBXN7	3	CSTF1	1	affinity chromatography technology	Raman M (2015)	1
TYMS	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
NEDD8	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
UCHL3	1	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
ZPR1	1	ZYX	2	biochemical	Havugimana PC (2012)	1
FAF2	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
UBXN1	0	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
USP9X	15	UBC	7	unspecified method, pull down	Ernst A (2013), Kwasna D (2018)	2
CUL1	7	DCAF1	5	affinity chromatography technology	McCall CM (2008)	1
UBXN7	3	KBTBD2	1	affinity chromatography technology	Alexandru G (2008)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
FAF2	4	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
UBE4B	5	USP9X	15	biochemical	Havugimana PC (2012)	1
NSUN2	0	ERCC3	3	affinity chromatography technology	Huttlin EL (2017)	1
ZYX	2	VHL	0	affinity chromatography technology	Foxler DE (2012)	1
VHL	0	RBX1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Kohroki J (2005), Kamura T (2002), Kuznetsova AV (2003), Norman JA (2006), Knauth K (2006), Kamura T (2004), Heir P (2013), Essers PB (2014), Lee SB (2016)	10
SULT1A1	0	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBXN7	3	SETD7	2	affinity chromatography technology	Raman M (2015)	1
UBXN7	3	VPS26A	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	UBE4B	5	affinity chromatography technology	Alexandru G (2008)	1
VHL	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Ohh M (1999), Kamura T (2001), Hacker KE (2008), Hacker KE (2008), Menon S (2008), Chew EH (2007), Ietta F (2006), Megumi Y (2005), Kamura T (2002), Kuznetsova AV (2003), Hansen WJ (2002), Cockman ME (2000), Lisztwan J (1999), Lisztwan J (1999), Sufan RI (2006), Sufan RI (2009), Stickle NH (2004), Lai Y (2011), Norman JA (2006), Knauth K (2006), Lonergan KM (1998), Lai Y (2012), Miller F (2005), Mahrour N (2008), Grosfeld A (2007), Russell RC (2011), Foxler DE (2012), Bonicalzi ME (2001), Bennett EJ (2010), Kanaya K (2002), Liakopoulos D (1999), Pause A (1997), Pause A (1997), Pause A (1997), Iliopoulos O (1998), Pause A (1999), Pause A (1999), Xin H (2011), Kamura T (2004), Kamura T (2004), Heir P (2013), Russell RC (2008), Russell RC (2008), Essers PB (2014), Nguyen HC (2015), Lee SB (2016), Uchida T (2016), Heir P (2016), Chen K (2016), Uematsu K (2016), Huttlin EL (2017), Sun W (2017), Sun W (2017)	54
FAF1	1	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
SSSCA1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
SULT1A1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	MAP3K1	4	affinity chromatography technology	Emdal KB (2015)	1
RAD23B	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
TNFAIP1	4	KCTD10	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hu X (2012), Hu X (2012), Hu X (2012), Huttlin EL (2015), Huttlin EL (2017)	5
NTRK1	1	VCPIP1	4	affinity chromatography technology	Emdal KB (2015)	1
TYMS	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
UBXN7	3	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
MAP3K1	4	NPLOC4	4	enzymatic study	Charlaftis N (2014)	1
VHL	0	HIF1A	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, far western blotting, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, pull down, protein complementation assay, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Corn PG (2003), Li Z (2003), Mahon PC (2001), Tanimoto K (2000), Min JH (2002), Yu F (2001), Yu F (2001), Jung JE (2008), Jung JE (2008), Andre H (2008), Park YK (2008), Kim BY (2008), Park SS (2008), Baek JH (2007), Baek JH (2007), Baek JH (2007), Kondo S (2006), Ietta F (2006), Kwon SJ (2005), Bae MK (2005), Baek JH (2005), Hon WC (2002), Hon WC (2002), Lewis MD (2004), Kasuno K (2004), Metzen E (2003), Metzen E (2003), Zhou J (2003), Yuan Y (2003), Maynard MA (2003), Jeong JW (2002), Yoo YG (2008), Hansen WJ (2002), Masson N (2001), Masson N (2001), Clifford SC (2001), Jaakkola P (2001), Jaakkola P (2001), Kamura T (2000), Kamura T (2000), Kamura T (2000), Ohh M (2000), Ohh M (2000), Cockman ME (2000), Cockman ME (2000), Sufan RI (2006), Chang CC (2011), Sufan RI (2009), Stickle NH (2004), Luo W (2010), Lee HY (2011), Roe JS (2011), Ivan M (2001), Ivan M (2001), Huang LE (2002), Callapina M (2005), Callapina M (2005), Maranchie JK (2002), DAngelo G (2003), DAngelo G (2003), Miller F (2005), Grosfeld A (2007), Grosfeld A (2007), Rajakumar A (2008), Bonicalzi ME (2001), Bemis L (2004), Berra E (2001), Yu F (2001), Bex C (2007), Zhou J (2012), Wiesener MS (2002), Maxwell PH (1999), Maxwell PH (1999), Lee SH (2012), Lee SH (2012), Ivan M (2002), Aprelikova O (2009), Choi CY (2009), Choi CY (2009), Heir P (2013), Russell RC (2008), Russell RC (2008), Park JH (2011), Park JH (2011), Liu Q (2013), Yeh IJ (2013), Choi YK (2010), Yang F (2014), Yang F (2014), Yang F (2014), Parsanejad M (2014), Yang C (2013), Yang C (2013), Chen K (2013), Park MH (2014), Gerez J (2015), Hein MY (2015), Park MH (2015), Fu R (2016), Alahari S (2015), Zhang CS (2015), Song D (2013), Chen K (2016), Hicks KC (2016), Groulx I (2002), Groulx I (2002), Groulx I (2002), Huttlin EL (2017), Guo J (2016), Sun W (2017), Sun W (2017), Guo J (2016), Li YM (2005), Yoo YG (2004), Kimura M (2008), Ferrer CM (2014)	116
KLHL13	0	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Maerki S (2009), Huttlin EL (2017)	3
SMURF1	4	VCP	6	affinity chromatography technology	Xie Y (2013)	1
UBE2V1	0	UBE2C	1	biochemical	Havugimana PC (2012)	1
UBXN7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
ATG9A	5	UFD1	1	affinity chromatography technology	Huttlin EL (2017)	1
VCP	6	CUL1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Besten Wd (2012), Zhang Z (2015)	3
UBXN7	3	ZYX	2	biochemical	Havugimana PC (2012)	1
SRXN1	0	SULT1A1	0	biochemical	Havugimana PC (2012)	1
VHL	0	UBC	7	pull down	Lisztwan J (1999)	1
UBXN7	3	RNF138	0	affinity chromatography technology	Raman M (2015)	1
CUL3	17	UBR5	13	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	PHF6	1	affinity chromatography technology	Emdal KB (2015)	1
FAF1	1	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Zhang L (2012), Zhang L (2012)	3
UBXN1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
CUL3	17	ELOC	0	affinity chromatography technology, two hybrid	Bennett EJ (2010), Wang J (2011)	2
CUL1	7	DDB1	6	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
KLHDC3	1	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Bennett EJ (2010), Huttlin EL (2015), Huttlin EL (2017)	5
FAF1	1	SEC23A	3	biochemical	Kristensen AR (2012)	1
UBE2V2	0	UFM1	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	USP9X	15	affinity chromatography technology	Emdal KB (2015)	1
CUL1	7	NSUN2	0	affinity chromatography technology	Bennett EJ (2010)	1
UFM1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
PSMD2	2	RAD23B	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Sun S (2017)	3
UBE2D2	0	RNF138	0	two hybrid	Markson G (2009)	1
NSFL1C	1	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
RAD23B	1	HIF1A	1	affinity chromatography technology	Bandau S (2012)	1
RNF111	2	UBC	7	enzymatic study	Wright JD (2016)	1
VCP	6	UBR5	13	affinity chromatography technology	Yu CC (2013)	1
SSSCA1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
NPLOC4	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Lass A (2008), Ballar P (2007), Alexandru G (2008), Alexandru G (2008), Fernandez-Saiz V (2010), Noguchi M (2005), Bruderer RM (2004), Bruderer RM (2004), Lee JJ (2013), Erzurumlu Y (2013), Raman M (2015), Raman M (2015), Mountassif D (2015), Wang T (2016), Guo X (2017)	15
NEDD8	0	ZYX	2	affinity chromatography technology	Norman JA (2006)	1
FAF2	4	CUL2	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CUL4A	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Angers S (2006), Bennett EJ (2010), Olma MH (2009), Wu K (2016)	4
SULT1A1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
FAF1	1	KCTD10	1	affinity chromatography technology	Raman M (2015)	1
FAM189B	2	VCP	6	affinity chromatography technology	Huttlin EL (2017)	1
CUL2	3	ELOB	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Kamura T (2001), Menon S (2008), Megumi Y (2005), Kamura T (2002), Brower CS (2002), Bennett EJ (2010), Pause A (1997), Kamura T (2004), Kelsall IR (2013)	9
RAD23B	1	KCTD10	1	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	UBE2V1	0	enzymatic study	Andrews PS (2010)	1
VCPIP1	4	UFD1	1	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
SULT1A1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
UBE2D2	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
TTLL12	3	UBE2C	1	biochemical	Havugimana PC (2012)	1
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
RAD23B	1	BTBD9	2	affinity chromatography technology	Huttlin EL (2017)	1
SMURF1	4	ZRANB2	0	affinity chromatography technology	Xie Y (2013)	1
UBE2V2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBC	7	ASPSCR1	3	affinity chromatography technology	Matsumoto M (2005)	1
CUL4B	8	UBC	7	affinity chromatography technology, pull down	Bennett EJ (2010), Nathan JA (2013)	2
UBR1	3	UCHL3	1	biochemical	Havugimana PC (2012)	1
VCPIP1	4	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Raman M (2015)	2
UBE2D2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
KIFC1	0	APP	1	pull down	Olah J (2011)	1
SSSCA1	0	UCHL3	1	biochemical	Havugimana PC (2012)	1
UBE2B	3	UBE2C	1	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UBE2C	1	biochemical	Havugimana PC (2012)	1
SRXN1	0	TTLL12	3	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2B	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UBE2D1	0	USP9X	15	biochemical, biochemical	Havugimana PC (2012), You J (2001)	2
USP34	7	UCHL3	1	biochemical	Havugimana PC (2012)	1
AMFR	2	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Cao J (2007), Cao J (2007), Cao J (2007), Cao J (2007)	4
FAF2	4	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
UBC	7	UBE2L3	1	affinity chromatography technology	Bish RA (2007)	1
UBXN1	0	RBX1	2	affinity chromatography technology	Hu Y (2017)	1
KCTD13	1	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
FAF1	1	ASPSCR1	3	affinity chromatography technology	Raman M (2015)	1
UBC	7	KLHL13	0	pull down	Nathan JA (2013)	1
UBXN7	3	HIF1A	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
USP34	7	UBXN1	0	biochemical	Havugimana PC (2012)	1
TTLL12	3	USP34	7	biochemical	Havugimana PC (2012)	1
SMURF1	4	APP	1	pull down	Olah J (2011)	1
UBXN7	3	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2V2	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	KPNA3	0	affinity chromatography technology	Emdal KB (2015)	1
BIRC2	1	UBE2B	3	two hybrid	Dynek JN (2010)	1
UBE2C	1	USP9X	15	biochemical	Havugimana PC (2012)	1
UBXN7	3	KLHDC3	1	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
UBXN7	3	DDB1	6	affinity chromatography technology	Alexandru G (2008)	1
UBE2B	3	UBR2	8	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Kwon YT (2003), An JY (2010), An JY (2010), Hong JH (2015), Hong JH (2015)	5
DCAF1	5	UBE2D2	0	pull down	Ahn J (2010)	1
RAD23B	1	UFM1	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UBXN7	3	biochemical	Havugimana PC (2012)	1
USP34	7	USP9X	15	biochemical	Havugimana PC (2012)	1
CUL3	17	PHIP	20	affinity chromatography technology	Wimuttisuk W (2014)	1
UBXN7	3	PHF6	1	affinity chromatography technology	Raman M (2015)	1
DDB1	6	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology	Jin J (2006), Groisman R (2003), Groisman R (2003), Meulenbroek EM (2012), Fei J (2012), Jin J (2006), He J (2016), Groisman R (2006), Chitale S (2017), Ohtake F (2007)	10
CUL3	17	ELOB	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	CUL4B	8	affinity chromatography technology	Bennett EJ (2010)	1
USP34	7	UBXN7	3	biochemical	Havugimana PC (2012)	1
CUL3	17	KLHL22	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Maerki S (2009), Huttlin EL (2017), Ferretti LP (2016)	6
FAM189B	2	SETD7	2	affinity chromatography technology	Huttlin EL (2015)	1
NUAK2	1	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
UBE2L3	1	UBE2V2	0	biochemical	Havugimana PC (2012)	1
FAF2	4	ELOC	0	affinity chromatography technology	Alexandru G (2008)	1
KLHDC2	1	ELOB	1	affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Huttlin EL (2017)	2
SSSCA1	0	SULT1A1	0	biochemical	Havugimana PC (2012)	1
UBE2D1	0	UFM1	0	two hybrid, biochemical	van Wijk SJ (2009), Havugimana PC (2012)	2
RBX1	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Norman JA (2006)	2
UBXN1	0	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
SKP1	0	UBE2D1	0	pull down, pull down	Kamura T (2000), Lin DI (2006)	2
CUL4A	2	WDR26	6	affinity chromatography technology	Higa LA (2006)	1
HIF1A	1	TCEANC2	0	affinity chromatography technology	Hein MY (2015)	1
USP34	7	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
CUL3	17	SEC23A	3	affinity chromatography technology	Bennett EJ (2010)	1
NTRK1	1	FAM91A1	1	affinity chromatography technology	Emdal KB (2015)	1
NSUN2	0	CSNK1E	0	biochemical	Wan C (2015)	1
FAF2	4	WDR26	6	affinity chromatography technology	Alexandru G (2008)	1
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
FAM189B	2	YAP1	0	affinity chromatography technology	Huttlin EL (2015)	1
FAF1	1	UBC	7	pull down, affinity chromatography technology, unspecified method, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical	Song EJ (2005), Lee JJ (2012), Song J (2009), Song J (2009), Song J (2009), Lee JJ (2013), Lee JJ (2013), Nathan JA (2013), Baron Y (2014), Alexandru G (2008), Lee JJ (2012)	11
UBXN1	0	UFC1	0	biochemical	Havugimana PC (2012)	1
FAF1	1	KBTBD7	3	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	UBR1	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
ATP6V1B2	3	ZYX	2	biochemical	Havugimana PC (2012)	1
UBXN1	0	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
DDB1	6	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	CUL3	17	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
HIF1A	1	ELOB	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Luo W (2010), Heir P (2013), Russell RC (2008)	3
SMURF1	4	FAF2	4	enzymatic study	Andrews PS (2010)	1
CUL2	3	ELOC	0	pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Kamura T (2001), Maine GN (2007), Megumi Y (2005), Mao X (2009), Lonergan KM (1998), Lonergan KM (1998), Bennett EJ (2010), Pause A (1997), Pause A (1999), Kamura T (2004), Kelsall IR (2013), Lee SB (2016)	12
CUL3	17	BTBD9	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL4B	8	WDR26	6	affinity chromatography technology, affinity chromatography technology	Higa LA (2006), Higa LA (2006)	2
ASPSCR1	3	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
UBXN7	3	KLHL13	0	affinity chromatography technology	Alexandru G (2008)	1
UBC	7	UFD1	1	pull down, x-ray crystallography, affinity chromatography technology, pull down	Nathan JA (2013), Park S (2005), Bish RA (2007), Zhang X (2017)	4
SRXN1	0	USP9X	15	biochemical	Havugimana PC (2012)	1
UBE2C	1	ZRANB2	0	biochemical	Havugimana PC (2012)	1
CUL4B	8	ERCC8	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Fei J (2012), Hein MY (2015)	3
UBXN7	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBC	7	RAD23B	1	affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Ryu KS (2003), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Zhang X (2017)	9
NTRK1	1	ABCF1	5	affinity chromatography technology	Emdal KB (2015)	1
UBE2L3	1	UFM1	0	biochemical	Wan C (2015)	1
UBXN7	3	UFM1	0	biochemical	Havugimana PC (2012)	1
CSNK1E	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
VHL	0	UBE2D1	0	pull down	Gao C (2010)	1
KBTBD7	3	RBX1	2	affinity chromatography technology	Genau HM (2015)	1
CUL3	17	KCTD13	1	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Ibeawuchi SR (2015), Huttlin EL (2017), Pinkas DM (2017)	6
OXCT1	1	SDHAF2	1	biochemical	Havugimana PC (2012)	1
SRXN1	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
CUL4A	2	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Guerrero-Santoro J (2008), Angers S (2006), Bennett EJ (2010), Bennett EJ (2010), Sertic S (2013)	5
CUL2	3	ABCF1	5	affinity chromatography technology	Bennett EJ (2010)	1
FAF1	1	UBR4	15	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBE4B	5	VCP	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Matsumoto M (2004), Matsumoto M (2004), Boehm S (2011), Takahata M (2008), Morreale G (2009), Fernandez-Saiz V (2010), Fernandez-Saiz V (2010), Raman M (2015), Wang T (2016), Huttlin EL (2017)	10
CUL3	17	UBE2D1	0	pull down	Sumara I (2007)	1
NUBP2	0	YAP1	0	biochemical	Havugimana PC (2012)	1
UBE2C	1	UBE4B	5	biochemical	Havugimana PC (2012)	1
UBE2L3	1	UCHL3	1	biochemical	Havugimana PC (2012)	1
NSFL1C	1	FAF1	1	affinity chromatography technology	Raman M (2015)	1
SRXN1	0	USP34	7	biochemical	Havugimana PC (2012)	1
SSSCA1	0	UFC1	0	biochemical	Havugimana PC (2012)	1
VCPIP1	4	FAF2	4	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Alexandru G (2008)	2
UBXN7	3	VHL	0	affinity chromatography technology	Alexandru G (2008)	1
SEC23A	3	TTLL12	3	biochemical	Havugimana PC (2012)	1
HIF1A	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baek JH (2007), Hubbi ME (2011), Liu YV (2007), Luo W (2010), Liu YV (2007), Russell RC (2008)	6
UBXN1	0	FAF1	1	affinity chromatography technology	Raman M (2015)	1
TTLL12	3	ZYX	2	biochemical	Havugimana PC (2012)	1
UBXN7	3	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Bandau S (2012), Besten Wd (2012), Besten Wd (2012), Bennett EJ (2010), Besten Wd (2012), Raman M (2015)	8
NEDD8	0	KLHL22	3	affinity chromatography technology	Bennett EJ (2010)	1
USP34	7	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
UFC1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
UBXN7	3	KLHDC10	3	affinity chromatography technology	Raman M (2015)	1
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
FAF2	4	UBR5	13	affinity chromatography technology	Alexandru G (2008)	1
SSSCA1	0	TYMS	0	biochemical	Havugimana PC (2012)	1
KLHDC2	1	ELOC	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mahrour N (2008), Mahrour N (2008), Huttlin EL (2017)	3
NEDD8	0	DCAF1	5	affinity chromatography technology	Bennett EJ (2010)	1
SMURF1	4	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Cao Y (2014), Xie P (2014), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Andrews PS (2010), He S (2017), Zhang Y (2017)	8
CSNK1E	0	USP9X	15	affinity chromatography technology	Varjosalo M (2013)	1
UBXN7	3	PSMD2	2	affinity chromatography technology	Alexandru G (2008)	1
FAF2	4	UBE2D1	0	pull down	Phan VT (2010)	1
UBE2D1	0	HIF1A	1	enzymatic study	Miller F (2005)	1
ATP6V1B2	3	CUL2	3	biochemical	Kristensen AR (2012)	1
ATG9A	5	VCP	6	affinity chromatography technology	Huttlin EL (2017)	1
TCEANC2	0	DCAF1	5	affinity chromatography technology	Huttlin EL (2017)	1
UBXN1	0	NSFL1C	1	biochemical	Kristensen AR (2012)	1
ATG9A	5	AMFR	2	affinity chromatography technology	Huttlin EL (2017)	1
UBC	7	UBXN7	3	pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kelsall IR (2013), Alexandru G (2008), Besten Wd (2012), Besten Wd (2012)	4
NTRK1	1	FAF1	1	affinity chromatography technology	Emdal KB (2015)	1
UBXN1	0	UBR2	8	affinity chromatography technology	Alexandru G (2008)	1
YAP1	0	VCP	6	affinity chromatography technology	Enzo E (2015)	1
UBXN7	3	POU3F2	2	affinity chromatography technology	Raman M (2015)	1
CUL4A	2	CUL1	7	biochemical	He YJ (2006)	1
TNFAIP1	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Hu X (2012), Bennett EJ (2010), Chen Y (2009), Rolland T (2014), Huttlin EL (2017)	5
NTRK1	1	CUL4B	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CSNK1E	0	affinity chromatography technology	Emdal KB (2015)	1
UBE2D1	0	UBR1	3	biochemical	You J (2001)	1
UBXN7	3	JUN	0	affinity chromatography technology	Raman M (2015)	1
MAP3K1	4	UFD1	1	enzymatic study	Charlaftis N (2014)	1
UBXN1	0	FAF2	4	affinity chromatography technology	Raman M (2015)	1
CSNK1E	0	RBX1	2	two hybrid	Vinayagam A (2011)	1
CUL3	17	PSMD2	2	affinity chromatography technology	Bennett EJ (2010)	1
SRXN1	0	SSSCA1	0	biochemical	Havugimana PC (2012)	1
CUL3	17	NSUN2	0	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	UBXN1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), McNeill H (2004), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), LaLonde DP (2011), Rolland T (2014), McNeill H (2004), Raman M (2015), Park ES (2017)	11
NTRK1	1	NPLOC4	4	affinity chromatography technology	Emdal KB (2015)	1
UBE2D2	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
ACAD11	0	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
NTRK1	1	NSUN2	0	affinity chromatography technology	Emdal KB (2015)	1
FAF2	4	UBR1	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
CUL1	7	SEC23A	3	affinity chromatography technology	Bennett EJ (2010)	1
VCP	6	UBR4	15	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Fogeron ML (2013)	2
NEDD8	0	SKP1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Hauri S (2016)	3
NEDD8	0	CUL4B	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010)	3
UBE2B	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
MAP3K1	4	UBE2V1	0	enzymatic study	Charlaftis N (2014)	1
UBE2L3	1	UBXN1	0	biochemical	Havugimana PC (2012)	1
UBE2L3	1	YAP1	0	biochemical	Havugimana PC (2012)	1
CUL3	17	PJA2	4	affinity chromatography technology	Bennett EJ (2010)	1
BIRC2	1	UBXN1	0	affinity chromatography technology, affinity chromatography technology	Wang YB (2015), Wang YB (2015)	2
FAF1	1	UBR1	3	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008)	2
UBXN7	3	ZPR1	1	biochemical	Havugimana PC (2012)	1
FAF1	1	BTBD9	2	affinity chromatography technology	Raman M (2015)	1
ATP6V1F	1	VPS26A	0	biochemical	Havugimana PC (2012)	1
UBXN1	0	UBXN7	3	affinity chromatography technology	Raman M (2015)	1
KLHDC10	3	CUL2	3	affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CSNK1E	0	KLHDC3	1	affinity chromatography technology	Varjosalo M (2013)	1
UBXN1	0	UFD1	1	affinity chromatography technology	Alexandru G (2008)	1
UBE2D2	0	MAP3K1	4	two hybrid	van Wijk SJ (2009)	1
BIRC2	1	UBE2V1	0	pull down	Bertrand MJ (2008)	1
FAM189B	2	NPLOC4	4	affinity chromatography technology	Huttlin EL (2017)	1
KLHL12	4	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Rondou P (2008), Rondou P (2008), Angers S (2006), Sumara I (2007), Bennett EJ (2010), Olma MH (2009), Rolland T (2014), McGourty CA (2016), McGourty CA (2016), McGourty CA (2016)	10
UBE2D2	0	CUL3	17	pull down	Plafker KS (2009)	1
VCP	6	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, unspecified method, two hybrid, affinity chromatography technology, two hybrid, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Uchiyama K (2003), Uchiyama K (2003), Alexandru G (2008), Alexandru G (2008), Vinayagam A (2011), Madsen L (2011), Fernandez-Saiz V (2010), Noguchi M (2005), Uchiyama K (2002), Uchiyama K (2002), Uchiyama K (2002), Alexandru G (2012), Fogeron ML (2013), Grelle G (2006), Grelle G (2006), Grelle G (2006), Rolland T (2014), Besten Wd (2012), Madsen L (2014), Zhang X (2015), Wan C (2015), Hein MY (2015), Raman M (2015), Raman M (2015), Wang T (2016), Guo X (2017), Park ES (2017), Huttlin EL (2017)	28
UBXN1	0	KLHL12	4	affinity chromatography technology	Alexandru G (2008)	1
CSNK1E	0	ELOB	1	affinity chromatography technology	Varjosalo M (2013)	1
SETD7	2	SMURF1	4	affinity chromatography technology	Elkouris M (2016)	1
RBX1	2	UBE2L3	1	pull down, pull down, pull down	Cui Y (2011), Liu Y (2015), Liu Y (2015)	3
NTRK1	1	CUL2	3	affinity chromatography technology	Emdal KB (2015)	1
UBE2C	1	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
ELOB	1	RBX1	2	affinity chromatography technology, affinity chromatography technology	Kamura T (2002), Brower CS (2002)	2
NSFL1C	1	CUL2	3	affinity chromatography technology	Alexandru G (2008)	1
UBXN7	3	TOPORS	6	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
SEC23A	3	USP9X	15	biochemical	Havugimana PC (2012)	1
UBXN7	3	AMFR	2	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	WDR26	6	affinity chromatography technology	Emdal KB (2015)	1
NSUN2	0	UBXN7	3	biochemical	Kristensen AR (2012)	1
SSSCA1	0	ZRANB2	0	biochemical	Havugimana PC (2012)	1
FAF2	4	UBR2	8	affinity chromatography technology	Alexandru G (2008)	1
NPLOC4	4	RAD23B	1	biochemical	Kristensen AR (2012)	1
BRWD1	6	APP	1	pull down	Olah J (2011)	1
UBC	7	WDR26	6	affinity chromatography technology	Matsumoto M (2005)	1
DDB1	6	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Angers S (2006), Norman JA (2006), Bennett EJ (2010)	3
YAP1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
NTRK1	1	DDB1	6	affinity chromatography technology	Emdal KB (2015)	1
UBE2V2	0	ZYX	2	biochemical	Havugimana PC (2012)	1
NSFL1C	1	UFD1	1	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Wan C (2015), Raman M (2015), Raman M (2015)	4
UBE4B	5	ZRANB2	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	TNFAIP1	4	affinity chromatography technology	Raman M (2015)	1
TCEANC2	0	UBXN7	3	affinity chromatography technology	Huttlin EL (2017)	1
AMFR	2	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Wang Q (2011), Wang Q (2011)	2
NTRK1	1	AMFR	2	affinity chromatography technology	Emdal KB (2015)	1
UBXN1	0	BTBD9	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
VCPIP1	4	VCP	6	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Totsukawa G (2011), Totsukawa G (2013), Totsukawa G (2013), Zhang X (2014), Raman M (2015)	6
UBXN7	3	CSNK1G3	5	affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015)	2
UBE2B	3	USP9X	15	biochemical	Havugimana PC (2012)	1
KCNK16	3	UFD1	1	affinity chromatography technology	Huttlin EL (2015)	1
UBE2B	3	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBE2V1	0	ZYX	2	biochemical	Havugimana PC (2012)	1
SSSCA1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
FAM189B	2	UFD1	1	affinity chromatography technology	Huttlin EL (2017)	1
UBE2V2	0	UBXN1	0	biochemical	Havugimana PC (2012)	1
UBC	7	NSFL1C	1	pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Fenner BJ (2009), Shibata Y (2012), Alexandru G (2008), Raasi S (2005), Zhang X (2017)	5
UBR4	15	USP9X	15	biochemical	Havugimana PC (2012)	1
NTRK1	1	KLHL13	0	affinity chromatography technology	Emdal KB (2015)	1
UCHL3	1	UBC	7	enzymatic study, enzymatic study, enzymatic study, x-ray crystallography, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, pull down, pull down	Bremm A (2010), Boudreaux D (2012), Misaghi S (2005), Misaghi S (2005), Wilkinson KD (1999), Wilkinson KD (1999), Phillips AH (2013), Larsen CN (1998), Wada H (1998), Hemelaar J (2004), Altun M (2015), Flierman D (2016), Zhang X (2017), Kwasna D (2018), Lee YC (2017), Lee YC (2017), Hanpude P (2017)	17
UBC	7	KLHL12	4	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), McGourty CA (2016)	2
UFC1	0	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
UBC	7	USP34	7	pull down	Kwasna D (2018)	1
CUL4B	8	APP	1	pull down	Olah J (2011)	1
KBTBD7	3	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Behrends C (2010), Bennett EJ (2010), Genau HM (2015), Genau HM (2015), Huttlin EL (2017)	5
FAF1	1	UBR2	8	affinity chromatography technology	Alexandru G (2008)	1
FAM189B	2	AMFR	2	affinity chromatography technology	Huttlin EL (2017)	1
TTLL12	3	ZRANB2	0	biochemical	Havugimana PC (2012)	1
NEDD8	0	SEC23A	3	affinity chromatography technology	Bennett EJ (2010)	1
UBXN7	3	KLHDC2	1	affinity chromatography technology	Raman M (2015)	1
NEDD8	0	KCTD10	1	affinity chromatography technology	Bennett EJ (2010)	1
RBX1	2	CUL4A	2	affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, enzymatic study, pull down, biochemical	Dias DC (2002), Ohta T (1999), Guerrero-Santoro J (2008), Hu J (2004), Furukawa M (2002), Maddika S (2009), Tron AE (2012), Tron AE (2012), He YJ (2006), Gastaldello S (2012), Olma MH (2009), Kristensen AR (2012), Huang DT (2009), Pick E (2007), Yang Y (2016), Scherer PC (2016), Nguyen TV (2016)	17
UBXN7	3	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Bandau S (2012), Besten Wd (2012), Kelsall IR (2013)	3
UBXN7	3	ZFYVE19	0	biochemical	Havugimana PC (2012)	1
ASPSCR1	3	NPLOC4	4	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Raman M (2015)	2
CUL3	17	KBTBD2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Zhang Z (2016), Huttlin EL (2017)	3
UBE2D2	0	PJA2	4	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down	Yu P (2002), Yu P (2002), van Wijk SJ (2009), Yu P (2002), Faust TB (2017)	5
UBXN7	3	KLHL22	3	affinity chromatography technology	Alexandru G (2008)	1
RAD23B	1	UBE4B	5	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D2	0	UFM1	0	two hybrid	van Wijk SJ (2009)	1
ERCC8	1	RBX1	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Groisman R (2003), Groisman R (2003), Groisman R (2006), Groisman R (2006)	4
UBE2B	3	ZYX	2	biochemical	Havugimana PC (2012)	1
VHL	0	PSMD2	2	affinity chromatography technology, affinity chromatography technology	Liu Y (2016), Liu Y (2016)	2
DCAF1	5	UBC	7	affinity chromatography technology	Li W (2010)	1
BIRC2	1	UBR5	13	affinity chromatography technology	Goncharov T (2013)	1
UBR5	13	UBE2D2	0	pull down, pull down, pull down, enzymatic study, pull down	Maddika S (2009), Honda Y (2002), Cojocaru M (2011), Matta-Camacho E (2012), Zhang W (2016)	5
DDB1	6	UBR5	13	affinity chromatography technology	Maddika S (2009)	1
UBXN7	3	ALPP	1	affinity chromatography technology	Alexandru G (2008)	1
RAD23B	1	ZYX	2	biochemical	Wan C (2015)	1
VPS26A	0	ZPR1	1	biochemical	Havugimana PC (2012)	1
SKP1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
CUL4A	2	BRWD1	6	affinity chromatography technology, affinity chromatography technology	Angers S (2006), Bennett EJ (2010)	2
MAP3K1	4	UBXN7	3	enzymatic study	Charlaftis N (2014)	1
NEDD8	0	KLHL12	4	affinity chromatography technology	Bennett EJ (2010)	1
FAF2	4	CUL1	7	affinity chromatography technology	Alexandru G (2008)	1
UBXN1	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Bennett EJ (2010)	3
UBE2D1	0	YAP1	0	biochemical	Havugimana PC (2012)	1
USP9X	15	ATP6V1F	1	biochemical	Havugimana PC (2012)	1
FAF2	4	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
DDB1	6	DCAF1	5	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Jin J (2006), Jin J (2006), Ahn J (2010), Maddika S (2009), Maddika S (2009), McCall CM (2008), McCall CM (2008), Hrecka K (2007), Hrecka K (2007), Le Rouzic E (2007), Le Rouzic E (2007), Olma MH (2009), Pham TN (2011), Gerard FC (2014), Nakagawa T (2015), Wan C (2015), Kyei GB (2015), Cassiday PA (2015), Gao J (2015), Gao J (2015), Wu Y (2016), Wu Y (2016), Wang H (2017), Zhou X (2016), Zhou X (2016), Wang X (2017)	26
NUBP2	0	USP9X	15	biochemical	Havugimana PC (2012)	1
CUL4A	2	NEDD8	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dias DC (2002), Angers S (2006), Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Gastaldello S (2012), Olma MH (2009)	7
TTLL12	3	UBE2B	3	biochemical	Havugimana PC (2012)	1
SMURF1	4	VHL	0	affinity chromatography technology	Zhang C (2016)	1
CUL4A	2	SKP1	0	affinity chromatography technology, affinity chromatography technology	Bennett EJ (2010), Gastaldello S (2012)	2
UBE2D1	0	PJA2	4	two hybrid	van Wijk SJ (2009)	1
UBXN7	3	KCTD13	1	affinity chromatography technology	Raman M (2015)	1
UBE2C	1	USP34	7	biochemical	Havugimana PC (2012)	1
NEDD8	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Norman JA (2006), Bennett EJ (2010), Bennett EJ (2010), Wimuttisuk W (2007)	4
FAF1	1	UFD1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Haenzelmann P (2011), Lee JJ (2013), Raman M (2015), Raman M (2015)	6
UBXN7	3	ELOC	0	affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Bandau S (2012)	2
NTRK1	1	WDR11	4	affinity chromatography technology	Emdal KB (2015)	1
KLHL12	4	CUL1	7	affinity chromatography technology	McGourty CA (2016)	1
SULT1A1	0	UBXN7	3	biochemical	Havugimana PC (2012)	1
TYMS	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
VCP	6	HIF1A	1	affinity chromatography technology	Alexandru G (2008)	1
NEDD8	0	KBTBD7	3	affinity chromatography technology	Bennett EJ (2010)	1
UBXN7	3	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
CUL3	17	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Bennett EJ (2010), Olma MH (2009), Huttlin EL (2017), Ren K (2014), Pinkas DM (2017), Dubiel D (2017)	6
MAP3K1	4	VHL	0	genetic interference	Shen JP (2017)	1
TYMS	0	UBE2C	1	biochemical	Havugimana PC (2012)	1
NSFL1C	1	NPLOC4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Alexandru G (2008), Alexandru G (2008), Raman M (2015), Raman M (2015)	4
DCAF1	5	UBR5	13	affinity chromatography technology, affinity chromatography technology	Maddika S (2009), Maddika S (2009)	2
ERCC3	3	UBXN7	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Raman M (2015), Raman M (2015), Raman M (2015)	3
UBXN1	0	KCTD10	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Raman M (2015), Huttlin EL (2017)	3
TTLL12	3	NSUN2	0	biochemical	Kristensen AR (2012)	1
UBXN7	3	BTBD9	2	affinity chromatography technology	Raman M (2015)	1
HIF1A	1	NEDD8	0	affinity chromatography technology, affinity chromatography technology, pull down	Ryu JH (2011), Ryu JH (2011), Ryu JH (2011)	3
UBE2V1	0	ATP6V1B2	3	biochemical	Havugimana PC (2012)	1
JUN	0	UBC	7	two hybrid, protein complementation assay	Bandyopadhyay S (2010), Fang D (2004)	2
NUBP2	0	RAD23B	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TYMS	0	UFC1	0	biochemical	Havugimana PC (2012)	1
UBXN7	3	UBR2	8	affinity chromatography technology	Alexandru G (2008)	1
NTRK1	1	DCAF1	5	affinity chromatography technology	Emdal KB (2015)	1
ASPSCR1	3	VCPIP1	4	affinity chromatography technology	Alexandru G (2008)	1
CUL2	3	UBR1	3	affinity chromatography technology	Bennett EJ (2010)	1
BIRC2	1	UBR4	15	affinity chromatography technology	Goncharov T (2013)	1
CUL3	17	USP9X	15	affinity chromatography technology	Bennett EJ (2010)	1
UFM1	0	ZFYVE19	0	biochemical	Havugimana PC (2012)	1