PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SUMO2	0	KDM1A	2	pull down	Ouyang J (2009)	1
UBE2I	0	RNF40	11	two hybrid	Rolland T (2014)	1
SUV39H1	0	KDM1A	2	two hybrid	Weimann M (2013)	1
CDCA4	1	KDM1A	2	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
JMJD6	1	UBE2I	0	biochemical	Kristensen AR (2012)	1
PRMT8	2	PRMT1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Lee J (2005), Weimann M (2013), Weimann M (2013), Weimann M (2013), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	7
MPP5	2	ZNF451	3	affinity chromatography technology, affinity chromatography technology	Waaijers S (2013), Waaijers S (2013)	2
CDC5L	2	SUMO1	0	affinity chromatography technology	Lleres D (2010)	1
ZNF451	3	PIAS2	2	two hybrid	Karvonen U (2008)	1
ZNF451	3	SUV39H1	0	two hybrid	Weimann M (2013)	1
HTT	14	PIAS1	4	two hybrid	Suter B (2013)	1
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
SUMO1	0	PIAS2	2	two hybrid, two hybrid, two hybrid, two hybrid, pull down, two hybrid	Lee BH (2003), Stehmeier P (2009), Wang J (2011), Hecker CM (2006), Hecker CM (2006), Rolland T (2014)	6
CDCA4	1	SUV39H1	0	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
ZNF451	3	PRMT8	2	two hybrid	Weimann M (2013)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
RNF40	11	ZNF451	3	two hybrid	Rual JF (2005)	1
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
PIAS1	4	PML	7	affinity chromatography technology, affinity chromatography technology, enzymatic study	Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	3
UBC	7	CALCOCO2	0	pull down, affinity chromatography technology, two hybrid, pull down, x-ray crystallography, pull down, affinity chromatography technology, imaging technique, pull down, imaging technique	Fenner BJ (2009), Fenner BJ (2009), Rolland T (2014), Tumbarello DA (2015), Xie X (2015), Xie X (2015), Xie X (2015), Xie X (2015), Ordureau A (2015), Minowa-Nozawa A (2017)	10
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
ZNF451	3	JMJD6	1	two hybrid	Weimann M (2013)	1
ZNF451	3	PML	7	enzymatic study	Koidl S (2016)	1
SUMO2	0	PIAS1	4	pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Gocke CB (2008), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ullmann R (2012), Ouyang J (2009)	9
CPTP	0	ZNF451	3	two hybrid	Wang J (2011)	1
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
AR	3	PIAS1	4	two hybrid, affinity chromatography technology	Kotaja N (2000), Toropainen S (2015)	2
CREB1	1	PIAS1	4	two hybrid	Bandyopadhyay S (2010)	1
ZNF451	3	CDCA4	1	two hybrid	Yu H (2011)	1
ZNF451	3	PIAS1	4	two hybrid, imaging technique	Karvonen U (2008), Karvonen U (2008)	2
CREB1	1	ZNF451	3	two hybrid	Bandyopadhyay S (2010)	1
RNF40	11	AR	3	affinity chromatography technology	Jaeaeskelaeinen T (2011)	1
CDC5L	2	ZNF451	3	two hybrid	Camargo LM (2007)	1
ZNF451	3	PRMT1	3	two hybrid	Weimann M (2013)	1
CDC5L	2	KDM1A	2	two hybrid	Camargo LM (2007)	1
PML	7	HTT	14	pull down, pull down	Guo L (2014), Guo L (2014)	2
CREB1	1	UBE2I	0	two hybrid	Bandyopadhyay S (2010)	1
SUMO1	0	PIAS1	4	two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, pull down, pull down, pull down	Lee BH (2003), Kahyo T (2001), Stehmeier P (2009), Stehmeier P (2009), Stehmeier P (2009), Ullmann R (2012), Ullmann R (2012), Hecker CM (2006), Hecker CM (2006), Gocke CB (2008), Ullmann R (2012), Ledsaak M (2016)	12
ZNF451	3	AR	3	affinity chromatography technology, two hybrid	Karvonen U (2008), Karvonen U (2008)	2
PCBD1	0	FXR2	2	two hybrid, two hybrid, two hybrid	Rual JF (2005), Rolland T (2014), Yu H (2011)	3
BATF3	0	ZNF451	3	affinity chromatography technology	Huttlin EL (2017)	1
PRPF40A	5	PIAS1	4	two hybrid	Colland F (2004)	1
FXR2	2	ZNF451	3	two hybrid	Rual JF (2005)	1
RAP1GDS1	0	ZNF451	3	two hybrid	Rual JF (2005)	1
SUMO2	0	ZNF451	3	pull down	Ouyang J (2009)	1
SUMO2	0	PIAS2	2	two hybrid, two hybrid, pull down, pull down, pull down	Stehmeier P (2009), Hecker CM (2006), Hecker CM (2006), Ullmann R (2012), Ouyang J (2009)	5
SUMO1	0	ZNF451	3	pull down	Karvonen U (2008)	1
PRMT1	3	AR	3	pull down	Koh SS (2001)	1
HTT	14	PRPF40A	5	two hybrid, pull down, two hybrid	Faber PW (1998), Faber PW (1998), Goehler H (2004)	3
ZNF451	3	FAM118A	1	two hybrid	Yu H (2011)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
PIK3R3	0	ZNF451	3	two hybrid	Grossmann A (2015)	1
ZNF451	3	ZNF451	3	two hybrid	Karvonen U (2008)	1
UBE2I	0	ZNF451	3	two hybrid, two hybrid, enzymatic study, two hybrid, two hybrid	Rual JF (2005), Bandyopadhyay S (2010), Karvonen U (2008), Karvonen U (2008), Yu H (2011)	5
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
PRPF40A	5	UBE2I	0	two hybrid	Colland F (2004)	1
AR	3	KDM1A	2	affinity chromatography technology, bioid	Choi H (2016), Lempiaeinen JK (2017)	2
UBC	7	ZNF451	3	pull down, pull down	Karvonen U (2008), Zhang X (2017)	2
PCBD1	0	ZNF451	3	two hybrid	Ravasi T (2010)	1
PRPF40A	5	ZNF451	3	two hybrid	Colland F (2004)	1
HTT	14	ZNF451	3	two hybrid	Suter B (2013)	1
PIAS2	2	PML	7	imaging technique, affinity chromatography technology, affinity chromatography technology, enzymatic study	Cuchet-Lourenco D (2011), Rabellino A (2012), Rabellino A (2012), Rabellino A (2012)	4
AR	3	PIAS2	2	two hybrid, two hybrid, pull down, pull down	Kotaja N (2000), Moilanen AM (1999), Moilanen AM (1999), Kotaja N (2000)	4
LZTR1	16	ZNF451	3	two hybrid	Ravasi T (2010)	1
ZNF451	3	KDM1A	2	two hybrid	Weimann M (2013)	1
CREB1	1	HTT	14	affinity chromatography technology	Lee J (2005)	1
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
UBE2I	0	KDM1A	2	enzymatic study	Gocke CB (2005)	1
CALCOCO2	0	ZNF451	3	two hybrid	Rual JF (2005)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
FXR2	2	CALCOCO2	0	two hybrid	Rual JF (2005)	1
JMJD6	1	PRPF40A	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rahman S (2011), Huttlin EL (2015), Huttlin EL (2017)	3