PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BCAR3	5	GLCE	0	two hybrid	Arroyo R (2015)	1
ELAVL1	0	GLCE	0	affinity chromatography technology	Abdelmohsen K (2009)	1
ERBB2	6	GLCE	0	two hybrid	Arroyo R (2015)	1
FBXO7	1	ERBB2	6	enzymatic study	Teixeira FR (2016)	1
FBXO7	1	GLCE	0	enzymatic study	Teixeira FR (2016)	1
CASP8	1	GLCE	0	two hybrid	Arroyo R (2015)	1
BAG4	2	GLCE	0	two hybrid	Arroyo R (2015)	1
ELAVL1	0	BAG4	2	affinity chromatography technology	Abdelmohsen K (2009)	1
ERBB2	6	FGFR4	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
ESR1	0	GLCE	0	two hybrid	Arroyo R (2015)	1
ELAVL1	0	PEX19	2	affinity chromatography technology	Abdelmohsen K (2009)	1
RB1CC1	9	GLCE	0	two hybrid	Arroyo R (2015)	1
PEX19	2	GLCE	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FGFR4	6	GLCE	0	two hybrid	Arroyo R (2015)	1
GINM1	1	GLCE	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PAX2	2	GLCE	0	two hybrid	Arroyo R (2015)	1
PPM1D	11	GLCE	0	two hybrid	Arroyo R (2015)	1
HAUS7	0	GLCE	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FBXO7	1	FGFR2	6	enzymatic study	Teixeira FR (2016)	1
ESR1	0	ERBB2	6	affinity chromatography technology	Yang Z (2004)	1
BCAR3	5	DEFA5	1	affinity chromatography technology	Huttlin EL (2017)	1
DEFA5	1	GLCE	0	affinity chromatography technology	Huttlin EL (2017)	1
FGFR2	6	GLCE	0	two hybrid	Arroyo R (2015)	1
ERBB2	6	BCAR3	5	unspecified method	Jones RB (2006)	1