PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CNTRL	5	C2CD3	7	bioid	Gupta GD (2015)	1
CEP135	2	C2CD3	7	bioid	Gupta GD (2015)	1
CDC14A	4	CEP135	2	bioid	St-Denis N (2016)	1
CEP89	2	MED4	2	bioid	Gupta GD (2015)	1
MED4	2	PCM1	5	bioid, affinity chromatography technology, affinity chromatography technology, bioid	Lambert JP (2015), Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP89	2	C2CD3	7	bioid	Gupta GD (2015)	1
SPICE1	2	PCM1	5	affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Huttlin EL (2017)	4
MED4	2	TRIM25	5	bioid	Lambert JP (2015)	1
CEP162	3	OFD1	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CEP128	1	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	SPICE1	2	bioid	Gupta GD (2015)	1
SPICE1	2	C2CD3	7	bioid	Gupta GD (2015)	1
CDC14A	4	C2CD3	7	bioid	St-Denis N (2016)	1
SPICE1	2	CEP135	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	CEP162	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP128	1	C2CD3	7	bioid	Gupta GD (2015)	1
CEP135	2	PCM1	5	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP63	2	CEP128	1	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
PCM1	5	CEP89	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	CEP135	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
CENPJ	6	C2CD3	7	bioid	Firat-Karalar EN (2014)	1
CEP128	1	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CEP63	2	SPICE1	2	bioid	Firat-Karalar EN (2014)	1
CEP128	1	CEP89	2	bioid	Gupta GD (2015)	1
CEP128	1	MED4	2	bioid	Gupta GD (2015)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
CNTRL	5	PCM1	5	bioid	Gupta GD (2015)	1
SPICE1	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
MED4	2	OFD1	3	bioid	Lambert JP (2015)	1
CENPJ	6	OFD1	3	bioid	Gupta GD (2015)	1
OFD1	3	C2CD3	7	affinity chromatography technology	Hein MY (2015)	1
CEP162	3	SPICE1	2	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4
CEP128	1	CEP135	2	affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CDC14A	4	SPICE1	2	bioid	St-Denis N (2016)	1
PCM1	5	C2CD3	7	bioid	Gupta GD (2015)	1
PCM1	5	CENPJ	6	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CEP63	2	OFD1	3	bioid, bioid, bioid	Firat-Karalar EN (2014), Gupta GD (2015), Gupta GD (2015)	3
CEP162	3	CEP89	2	bioid	Gupta GD (2015)	1
CEP89	2	OFD1	3	bioid	Gupta GD (2015)	1
CEP128	1	CNTRL	5	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
MED4	2	C2CD3	7	bioid	Lambert JP (2015)	1
CEP63	2	C2CD3	7	bioid	Firat-Karalar EN (2014)	1
CEP63	2	MED4	2	bioid	Gupta GD (2015)	1
CNTRL	5	OFD1	3	bioid	Gupta GD (2015)	1
PCM1	5	CEP63	2	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CEP135	2	OFD1	3	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CNTRL	5	MED4	2	bioid	Gupta GD (2015)	1
CEP135	2	CEP162	3	affinity chromatography technology, affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	3
CNTRL	5	CEP89	2	bioid	Gupta GD (2015)	1
MED4	2	CEP162	3	bioid, affinity chromatography technology, bioid	Lambert JP (2015), Gupta GD (2015), Gupta GD (2015)	3
CDC14A	4	CEP162	3	bioid	St-Denis N (2016)	1
PCM1	5	CEP162	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	5
CEP162	3	C2CD3	7	affinity chromatography technology	Gupta GD (2015)	1
MED4	2	SPICE1	2	bioid, bioid	Lambert JP (2015), Gupta GD (2015)	2
TRIM25	5	C2CD3	7	affinity chromatography technology	Choudhury NR (2017)	1
SPICE1	2	CENPJ	6	bioid	Gupta GD (2015)	1
CNTRL	5	CEP162	3	bioid	Gupta GD (2015)	1