PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRPRB	0	RNF167	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
AP3S1	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2W	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
UBE2D1	0	RNF13	0	two hybrid, pull down	van Wijk SJ (2009), Zhang Q (2012)	2
LGALS3	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D3	1	RNF167	2	two hybrid	van Wijk SJ (2009)	1
RNF13	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
PON2	0	RNF167	2	affinity chromatography technology	Huttlin EL (2015)	1
UBE2E3	0	RNF13	0	two hybrid	van Wijk SJ (2009)	1
UBE2K	0	RNF167	2	two hybrid	Markson G (2009)	1
B4GAT1	2	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2D4	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
UBE2E1	1	RNF13	0	two hybrid	van Wijk SJ (2009)	1
RNF13	0	AP3S1	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2E3	0	RNF167	2	two hybrid	van Wijk SJ (2009)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
UBE2E1	1	RNF167	2	two hybrid, pull down	van Wijk SJ (2009), Yamada HY (2006)	2
A4GNT	0	RNF167	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	RNF13	0	two hybrid	van Wijk SJ (2009)	1
RNF167	2	SLC22A18	1	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Yamada HY (2006), Yamada HY (2006), Yamada HY (2006), Yamada HY (2006)	4
SRPRB	0	AP3S1	0	affinity chromatography technology	Huttlin EL (2015)	1
HLA-DPA1	1	SLC22A18	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D2	0	RNF13	0	two hybrid	van Wijk SJ (2009)	1
UBE2D1	0	RNF167	2	two hybrid, pull down	van Wijk SJ (2009), Yamada HY (2006)	2
RNF167	2	CCDC59	1	affinity chromatography technology	Ewing RM (2007)	1
RNF167	2	RNF167	2	enzymatic study, affinity chromatography technology	Yamada HY (2006), van Dijk JR (2014)	2
UBE2N	1	RNF167	2	two hybrid	van Wijk SJ (2009)	1
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
UBE2D4	0	RNF13	0	two hybrid	van Wijk SJ (2009)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2N	1	RNF13	0	two hybrid	van Wijk SJ (2009)	1
HLA-DPA1	1	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1
TMPRSS11B	0	RNF167	2	affinity chromatography technology	Huttlin EL (2017)	1