PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NXF1	0	RPUSD4	3	affinity chromatography technology	Castello A (2012)	1
MOV10	6	RPUSD4	3	affinity chromatography technology	Castello A (2012)	1
SRRM2	18	U2AF1	0	biochemical	Havugimana PC (2012)	1
HINFP	0	ATN1	2	two hybrid	Miele A (2007)	1
NXF1	0	CDYL2	4	affinity chromatography technology	Castello A (2012)	1
NXF1	0	U2AF1	0	two hybrid, pull down	Zolotukhin AS (2002), Zolotukhin AS (2002)	2
HINFP	0	ZNHIT1	0	two hybrid	Miele A (2007)	1
HINFP	0	GSPT1	3	two hybrid	Miele A (2007)	1
HINFP	0	CCDC36	1	two hybrid	Yu H (2011)	1
MDC1	8	MKI67	7	affinity chromatography technology	Woods NT (2012)	1
HINFP	0	CDYL2	4	two hybrid	Miele A (2007)	1
HINFP	0	RPUSD4	3	two hybrid	Miele A (2007)	1
HINFP	0	TRA2B	3	two hybrid	Miele A (2007)	1
HINFP	0	U2AF1	0	two hybrid	Miele A (2007)	1
TRIM39	0	TP53	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Zhang L (2012), Zhang L (2012), Zhang L (2012)	3
HINFP	0	TRIM44	2	two hybrid	Miele A (2007)	1
MOV10	6	CDYL2	4	affinity chromatography technology	Castello A (2012)	1
SREBF2	5	HINFP	0	affinity chromatography technology, affinity chromatography technology	Li H (2012), Li H (2012)	2
HINFP	0	SRRM2	18	two hybrid, affinity chromatography technology, affinity chromatography technology	Miele A (2007), Miele A (2007), Miele A (2007)	3
HINFP	0	NIPBL	10	two hybrid	Miele A (2007)	1
HINFP	0	PRRC2C	9	two hybrid, pull down	Miele A (2007), Miele A (2007)	2
SRRM2	18	EFTUD2	12	affinity chromatography technology	McCracken S (2005)	1
HINFP	0	MKI67	7	two hybrid, pull down	Miele A (2007), Miele A (2007)	2
HINFP	0	MORF4L1	1	two hybrid	Miele A (2007)	1
MOV10	6	HINFP	0	affinity chromatography technology	Castello A (2012)	1
SHMT2	3	HINFP	0	affinity chromatography technology	Castello A (2012)	1
NXF1	0	HINFP	0	affinity chromatography technology	Castello A (2012)	1
TRAF2	1	ZBTB49	5	two hybrid	Rolland T (2014)	1
HINFP	0	TLE3	2	two hybrid	Miele A (2007)	1
NXF1	0	TRA2B	3	two hybrid	Wang J (2011)	1
TP53	0	MOV10	6	affinity chromatography technology	Li X (2015)	1
MDC1	8	TP53	0	affinity chromatography technology	Xu X (2003)	1
TP53	0	ZNHIT1	0	pull down	Cuadrado A (2007)	1
TRAF2	1	THAP7	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
HINFP	0	RBM26	3	two hybrid	Miele A (2007)	1
HINFP	0	MIF4GD	1	two hybrid	Miele A (2007)	1
MBD2	1	HINFP	0	two hybrid, pull down, affinity chromatography technology	Sekimata M (2001), Sekimata M (2001), Sekimata M (2001)	3
HINFP	0	THAP7	0	two hybrid, affinity chromatography technology	Miele A (2007), Miele A (2007)	2
TP53	0	RPUSD4	3	genetic interference	Xie L (2013)	1
HINFP	0	TP53	0	two hybrid	Yu H (2011)	1
HINFP	0	TRIM39	0	two hybrid	Yu H (2011)	1
HINFP	0	MDC1	8	two hybrid	Miele A (2007)	1
HINFP	0	EFTUD2	12	two hybrid	Miele A (2007)	1
MDC1	8	RBM17	1	affinity chromatography technology	Woods NT (2012)	1
HINFP	0	JUND	2	two hybrid	Miele A (2007)	1
HINFP	0	NPAT	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, two hybrid, affinity chromatography technology, affinity chromatography technology	Miele A (2005), Miele A (2005), Miele A (2005), Miele A (2005), Miele A (2005), Miele A (2005), Mitra P (2003), Li H (2012), Li H (2012)	9
TP53	0	PRRC2C	9	affinity chromatography technology	Fogeron ML (2013)	1
SREBF2	5	NPAT	4	affinity chromatography technology, affinity chromatography technology	Li H (2012), Li H (2012)	2
HINFP	0	NPDC1	2	two hybrid	Miele A (2007)	1
HINFP	0	RBM17	1	two hybrid	Miele A (2007)	1
SHMT2	3	ELP4	2	affinity chromatography technology	Castello A (2012)	1
ZBTB49	5	HINFP	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Jeon BN (2014), Jeon BN (2014), Jeon BN (2014)	3
HINFP	0	TTF2	4	two hybrid	Miele A (2007)	1
HINFP	0	ELP4	2	two hybrid	Miele A (2007)	1
HINFP	0	POM121C	5	two hybrid	Miele A (2007)	1
TRAF2	1	HINFP	0	two hybrid	Rual JF (2005)	1