PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
JAK2	1	EGFR	5	affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study	Olayioye MA (1999), Olayioye MA (1999), Jones RB (2006), He K (2013)	4
HNRNPL	3	MEF2A	1	affinity chromatography technology	Fei T (2017)	1
RHBG	1	SH2B1	7	two hybrid	Wang J (2011)	1
HNRNPL	3	IGF1R	5	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	JAK2	1	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	SH2B1	7	affinity chromatography technology	Fei T (2017)	1
FGFR3	7	HNRNPL	3	two hybrid	Stelzl U (2005)	1
INSR	9	SH2B1	7	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Kotani K (1998), Kotani K (1998), Nelms K (1999), Nelms K (1999), Nishi M (2005)	5
IRS1	7	SH2B1	7	unspecified method	Liu BA (2012)	1
BRCA1	7	HNRNPL	3	affinity chromatography technology	Ertych N (2016)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
EGFR	5	SH2B1	7	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	IRS1	7	unspecified method	Jones RB (2006)	1
SH2B1	7	SH2B2	1	two hybrid, affinity chromatography technology	Nishi M (2005), Nishi M (2005)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
SH2B1	7	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Kotani K (1998)	2
JAK2	1	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Chauhan D (1995), Chauhan D (1995), Giorgetti-Peraldi S (1995), Brizzi MF (1996)	4
MEF2A	1	SH2B1	7	affinity chromatography technology	Li X (2015)	1
INSR	9	JAK2	1	affinity chromatography technology, affinity chromatography technology	Maegawa H (1996), Le MN (2002)	2
SH2B2	1	INSR	9	affinity chromatography technology, affinity chromatography technology, two hybrid	Onnockx S (2008), Onnockx S (2008), Ahn MY (2004)	3
NTRK1	1	SH2B1	7	two hybrid, affinity chromatography technology, two hybrid	Qian X (1998), Qian X (1998), Koch A (2000)	3
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
SH2B1	7	IGF1R	5	two hybrid	Nishi M (2005)	1
NTRK1	1	IGF1R	5	affinity chromatography technology	Emdal KB (2015)	1
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
IRS1	7	GRB2	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology	Skolnik EY (1993), Skolnik EY (1993), Skolnik EY (1993), Morrison KB (2002), Giorgetti-Peraldi S (1995), Liu BA (2012), Bisson N (2011)	7
NTRK2	10	SH2B1	7	two hybrid	Suzuki S (2002)	1
KIAA0319	4	SH2B1	7	two hybrid	Nakayama M (2002)	1
SH2B1	7	SH2B1	7	two hybrid	Nishi M (2005)	1
INSR	9	IRS1	7	two hybrid, two hybrid, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Aguirre V (2002), Sawka-Verhelle D (1996), Strack V (2002), Wolf G (1995), Kwon H (2015), Kwon H (2015)	6
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
JAK2	1	SH2B2	1	enzymatic study	Wakioka T (1999)	1
HNRNPL	3	INSR	9	affinity chromatography technology	Fei T (2017)	1
SH2B1	7	BRCA1	7	affinity chromatography technology	Li Z (2007)	1
FGFR3	7	GRB2	2	affinity chromatography technology, biochemical	Kanai M (1997), Wan C (2015)	2
SH2B2	1	GRB2	2	affinity chromatography technology, pull down	Qian X (1998), Yokouchi M (1997)	2
CCDC102B	0	SH2B1	7	affinity chromatography technology	Huttlin EL (2017)	1
SH2B1	7	CSAD	7	two hybrid	Grossmann A (2015)	1
JAK2	1	IRS1	7	enzymatic study, affinity chromatography technology	Gual P (1998), Kawazoe Y (2001)	2
FRS3	0	SH2B1	7	two hybrid	Grossmann A (2015)	1
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
NTRK1	1	SH2B2	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Qian X (1998), Qian X (1998), Emdal KB (2015)	3
SH2B1	7	FGFR3	7	affinity chromatography technology	Kong M (2002)	1
EGFR	5	NTRK2	10	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
JAK2	1	SH2B1	7	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Rui L (1997), Rui L (1997), Rui L (1997), Xie S (2002), Li Z (2007), Nishi M (2005), Nishi M (2005)	7
IGF1R	5	IRS1	7	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Tartare-Deckert S (1995), Dey BR (1996), Dey BR (1996), Manes S (1999)	4
BRCA1	7	JAK2	1	affinity chromatography technology	Gao B (2001)	1