Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
WWTR1 rs3811715 GG cetuximab efficacy no No significant difference in tumor response, progression-free survival or overall survival was seen between the genotype groups. Patients also receiving treatment with fluorouracil, leucovorin and irinotecan (FOLFIRI). Please note that alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to cetuximab in people with Colorectal Neoplasms as compared to genotypes AA + AG. 27698403 1449750606