PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	TP73	2	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology	Stindt MH (2015), Puca R (2011), De Laurenzi V (1998), Di Como CJ (1999)	4
HOXB5	0	RCHY1	0	protein complementation assay	Bridoux L (2015)	1
NLK	1	MDM2	2	affinity chromatography technology	Zhang HH (2014)	1
UBE2D4	0	RCHY1	0	two hybrid	Markson G (2009)	1
RNF2	1	UBE2D2	0	enzymatic study, two hybrid, pull down	Lee SJ (2001), Markson G (2009), Dou H (2012)	3
CAMK2A	6	CAMK2G	4	affinity chromatography technology	So J (2015)	1
BRCA1	7	CAMK2D	3	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	AR	3	pull down, pull down, two hybrid	Park JJ (2000), Yeh S (2000), Yeh S (2000)	3
CDKN1B	1	YWHAE	0	affinity chromatography technology, pull down	Sekimoto T (2004), Sekimoto T (2004)	2
PMM1	0	RCHY1	0	two hybrid	Wang J (2011)	1
CALM1	0	COX6C	1	affinity chromatography technology	Boldt K (2016)	1
TMEM184A	1	RBM38	0	affinity chromatography technology	Huttlin EL (2017)	1
RCHY1	0	CDK9	3	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Bagashev A (2013), Bagashev A (2013), Bagashev A (2013), Bagashev A (2013)	4
UBC	7	COPE	2	affinity chromatography technology	Matsumoto M (2005)	1
F7	4	RCHY1	0	two hybrid	Wang J (2011)	1
KAT5	1	AR	3	enzymatic study, two hybrid, two hybrid, pull down, two hybrid, pull down	Gaughan L (2002), Gaughan L (2002), Brady ME (1999), Brady ME (1999), Gaughan L (2001), Gaughan L (2001)	6
CALM1	0	AR	3	affinity chromatography technology, pull down, imaging technique	Cifuentes E (2004), Cifuentes E (2004), Cifuentes E (2004)	3
CHD8	44	TP53	0	affinity chromatography technology	Nishiyama M (2009)	1
RCHY1	0	UBE2D1	0	pull down, pull down	Abou Zeinab R (2013), McClurg UL (2016)	2
ATN1	2	RCHY1	0	two hybrid	Lim J (2006)	1
NKD2	1	UBE2D2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
KRTAP9-2	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
CHEK2	2	TP53	0	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Louria-Hayon I (2003), Shieh SY (2000), Bjorling-Poulsen M (2005), Hirao A (2000), Adams CJ (2008)	5
TP73	2	RCHY1	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study	Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011), Wu H (2011)	5
AOX1	1	RCHY1	0	two hybrid	Wang J (2011)	1
BRCA1	7	YWHAE	0	affinity chromatography technology	Ertych N (2016)	1
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
MDM2	2	UBC	7	pull down, enzymatic study, enzymatic study	Higashitsuji H (2005), Luo J (2013), Poyurovsky MV (2007)	3
RCHY1	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Corcoran CA (2009), Wang L (2011), Wang L (2011), Corcoran CA (2009)	4
TP53	0	UBC	7	affinity chromatography technology, affinity chromatography technology	Ayroldi E (2014), Ke JY (2014)	2
RBM38	0	MDM2	2	affinity chromatography technology, unspecified method	Xu E (2013), Xu E (2013)	2
POLH	1	BRCA1	7	affinity chromatography technology	Tian F (2013)	1
MEOX2	2	KRTAP9-2	0	two hybrid	Rolland T (2014)	1
MDM2	2	CDK9	3	affinity chromatography technology	Lau J (2009)	1
BRCA1	7	UBE2D2	0	two hybrid, two hybrid, x-ray crystallography, pull down	Dynek JN (2010), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009)	4
TP53	0	TRIM8	6	affinity chromatography technology	Caratozzolo MF (2012)	1
TP63	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Jung YS (2012), Jung YS (2012), Jung YS (2012)	3
UBC	7	CDKN1B	1	affinity chromatography technology	Huang G (2014)	1
MDM4	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
KAT5	1	PLAGL2	1	affinity chromatography technology, affinity chromatography technology	Ning J (2008), Ning J (2008)	2
RCHY1	0	ALAS1	2	affinity chromatography technology	Huttlin EL (2017)	1
RCHY1	0	TMEM184A	1	two hybrid	Wang J (2011)	1
PGLS	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRAS	1	UBE2D1	0	genetic interference	Luo J (2009)	1
SEMA4C	5	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
CYBA	0	RCHY1	0	two hybrid	Wang J (2011)	1
MDM4	0	MDM2	2	pull down, two hybrid, enzymatic study, pull down, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, two hybrid, affinity chromatography technology, enzymatic study, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, pull down, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology	Kadakia M (2002), Tanimura S (1999), Badciong JC (2002), Tanimura S (1999), Tanimura S (1999), Linke K (2008), Okamoto K (2005), Pan Y (2003), Kashuba E (2011), Kashuba E (2011), Ohtsubo C (2009), Singh RK (2007), Zhu Y (2009), Zhu Y (2009), Allende-Vega N (2010), Okamoto K (2009), Okamoto K (2009), Li X (2011), Nie J (2010), Nie J (2010), Li M (2011), Li M (2011), Singh RK (2007), de Graaf P (2003), Wade M (2012), Uldrijan S (2007), Wade M (2012), Stad R (2000), Dolezelova P (2012), Kulikov R (2005), Kawai H (2007), Kawai H (2007), Miller KR (2010), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Sharp DA (1999), Li C (2002), Wu S (2012), Ranaweera RS (2013), Woodsmith J (2012), Wang J (2011), Egorova O (2014), Chang YS (2013), Malbert-Colas L (2014), Yasuhara T (2014), Yasuhara T (2014), Iyappan S (2010), Stad R (2001), Marcar L (2015), Ling X (2014), Leslie PL (2015), Jacob AG (2014), Jacob AG (2014), Tournillon AS (2015), Tournillon AS (2015), Tournillon AS (2015), Zhang H (2015), Chen L (2015), Pellegrino M (2015), Pellegrino M (2015), Pellegrino M (2015), Medina-Medina I (2016), Medina-Medina I (2016), Moscetti I (2016), Liu T (2017), Liu T (2017), Liu T (2017), Huttlin EL (2017), Wu W (2015), Ivanov AA (2017), Mancini F (2016), Mancini F (2016)	74
BRCA1	7	RPLP1	0	affinity chromatography technology	Ertych N (2016)	1
CAMK2A	6	RCHY1	0	enzymatic study	Duan S (2007)	1
MDM2	2	RNF2	1	affinity chromatography technology, affinity chromatography technology	Wen W (2013), Wen W (2013)	2
CDKN1B	1	CDK6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Lin J (2001), Radu M (2008), Bockstaele L (2006), Chen TC (2014), Carrasco-Garcia E (2011), Huttlin EL (2017)	6
AR	3	RCHY1	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Beitel LK (2002), Beitel LK (2002), Maruyama S (2008), Maruyama S (2008), Logan IR (2006), Logan IR (2006), McClurg UL (2016)	7
RCHY1	0	USP28	3	affinity chromatography technology	Bohgaki M (2013)	1
RFWD2	0	UBE2D1	0	pull down, pull down	Choi HH (2011), Lu G (2014)	2
RCHY1	0	SERTAD1	0	two hybrid	Wang J (2011)	1
COX6C	1	RCHY1	0	two hybrid	Wang J (2011)	1
RFWD2	0	CDKN1B	1	biochemical, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Choi HH (2015), Choi HH (2015), Choi HH (2015), Choi HH (2015), Choi HH (2015)	5
RCHY1	0	CALM1	0	affinity chromatography technology	Duan S (2007)	1
RCHY1	0	RPN2	0	two hybrid	Wang J (2011)	1
UBE2D1	0	TRIM8	6	two hybrid	Markson G (2009)	1
RCHY1	0	SRPRB	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Abe K (2008), Abe K (2008), Abe K (2008)	3
BRCA1	7	UBE2D3	1	two hybrid, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, x-ray crystallography, pull down, pull down, pull down, pull down	Dynek JN (2010), Polanowska J (2006), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Calvo V (2011), Wu-Baer F (2010), Yu X (2006), Starita LM (2005), Sato K (2012), Starita LM (2004), Wei L (2011), Wu W (2007), David Y (2011), Kentsis A (2002), Kleiman FE (2005), Zhao GY (2007), Wenzel DM (2011), Wenzel DM (2011), McGinty RK (2014), Chen A (2002), Shabbeer S (2013), Ando K (2017)	23
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
MDM4	0	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
RCHY1	0	PLAGL2	1	affinity chromatography technology	Zheng G (2007)	1
KRAS	1	RCHY1	0	genetic interference	Luo J (2009)	1
USP28	3	UBC	7	enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, pull down	Loch CM (2012), Zhen Y (2014), Wen Y (2015), Wen Y (2015), Wen Y (2015), Wrigley JD (2017), Kwasna D (2018)	7
CDK6	0	AR	3	imaging technique	Chen TC (2014)	1
KAT5	1	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2002), Legube G (2002), Wu Q (2009), Dohmesen C (2008), Dohmesen C (2008), Kim JW (2008)	6
RCHY1	0	WDR74	0	two hybrid	Rolland T (2014)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
NLK	1	RCHY1	0	two hybrid	Wang J (2011)	1
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
UBC	7	UBASH3B	4	pull down, pull down, affinity chromatography technology, pull down, pull down	Kowanetz K (2004), Ikeda F (2007), Brehme M (2009), Hoeller D (2006), Zhang X (2017)	5
RCHY1	0	TMEM14C	0	two hybrid	Wang J (2011)	1
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
UBE2D4	0	TRIM8	6	two hybrid	Markson G (2009)	1
UBE2D3	1	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
DCUN1D5	0	RCHY1	0	two hybrid	Wang J (2011)	1
RCHY1	0	KRTAP9-2	0	two hybrid	Rolland T (2014)	1
NKD2	1	RCHY1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
MDM2	2	GORAB	1	affinity chromatography technology, affinity chromatography technology, pull down	Yan J (2010), Yan J (2010), Yan J (2010)	3
CHEK2	2	MDM2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study	Pereg Y (2006), Kass EM (2009), Kass EM (2009), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005), Bjorling-Poulsen M (2005)	7
TP63	0	CHEK2	2	affinity chromatography technology	Huttlin EL (2017)	1
BIRC3	1	UBE2D3	1	affinity chromatography technology, two hybrid, pull down, pull down	Hu S (2003), Dynek JN (2010), Darding M (2011), Hu S (2003)	4
UBE2D2	0	TRIM8	6	two hybrid, pull down	Markson G (2009), Li Q (2011)	2
RCHY1	0	RCHY1	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, two hybrid	Sheng Y (2008), Zheng G (2007), Corcoran CA (2009), Corcoran CA (2009), Duan S (2007), Shloush J (2011), Abou Zeinab R (2013), Rolland T (2014)	8
CDK6	0	RCHY1	0	affinity chromatography technology	Huttlin EL (2015)	1
TP53	0	CDK6	0	fluorescent resonance energy transfe	Ivanov AA (2017)	1
RNF2	1	RCHY1	0	affinity chromatography technology	Cao Q (2014)	1
TP53	0	CDK9	3	genetic interference, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	De Falco G (2000), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006), Claudio PP (2006)	6
RCHY1	0	KRIT1	1	two hybrid, affinity chromatography technology, affinity chromatography technology	Duan S (2007), Duan S (2007), Duan S (2007)	3
TP53	0	KAT5	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Legube G (2004), Tyteca S (2006), Tyteca S (2006), Kurash JK (2008), Cheng Z (2008), Cheng Z (2008), Cheng Z (2008), Tang Y (2006), Tang Y (2006), Tang Y (2006), Dai C (2013)	11
LIMS2	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
GORAB	1	RCHY1	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid	Zhang L (2005), Zhang L (2005), Zhang L (2005), Zhang L (2005), Wang J (2011)	5
RNF2	1	CALM1	0	affinity chromatography technology	Cao Q (2014)	1
POLH	1	MDM2	2	affinity chromatography technology	Jung YS (2012)	1
RCHY1	0	KRT18	2	pull down, affinity chromatography technology, affinity chromatography technology	Duan S (2009), Duan S (2009), Duan S (2009)	3
BIRC3	1	RCHY1	0	two hybrid	Wang J (2011)	1
MEOX2	2	KAT5	1	two hybrid	Rolland T (2014)	1
UBE2D3	1	RPLP1	0	two hybrid	Vinayagam A (2011)	1
MDM4	0	UBE2D3	1	pull down	Zhu Y (2009)	1
MT2A	0	RCHY1	0	two hybrid	Wang J (2011)	1
CAMK2A	6	CAMK2D	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), So J (2015), Huttlin EL (2017)	3
UBC	7	SRPRB	0	pull down	Zhang X (2017)	1
CHD8	44	RCHY1	0	two hybrid	Wang J (2011)	1
KAT5	1	TP73	2	affinity chromatography technology	Kim JW (2008)	1
ANGPTL8	0	RCHY1	0	two hybrid	Wang J (2011)	1
NKD2	1	YWHAE	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
CAMK2D	3	CAMK2G	4	affinity chromatography technology	Huttlin EL (2017)	1
BRCA1	7	RCHY1	0	affinity chromatography technology	Ertych N (2016)	1
BRCA1	7	MSH3	4	unspecified method, pull down	Rodriguez M (2003), Wang Q (2001)	2
CAMK2G	4	RCHY1	0	enzymatic study	Duan S (2007)	1
TP63	0	MDM2	2	pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zdzalik M (2010), Zdzalik M (2010), Galli F (2010), Calabro V (2002), Calabro V (2002), Stindt MH (2015)	6
3211	0	RCHY1	0	protein complementation assay	Bridoux L (2015)	1
RCHY1	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
AIG1	3	RCHY1	0	two hybrid, pull down, pull down, affinity chromatography technology, two hybrid	Wu G (2011), Wu G (2011), Wu G (2011), Wang J (2011), Wang J (2011)	5
KRAS	1	HOXB5	0	genetic interference	Luo J (2009)	1
RNF2	1	UBE2D1	0	enzymatic study, two hybrid	Lee SJ (2001), Markson G (2009)	2
MDM4	0	TP53	0	enzymatic study, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, protein complementation assay, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, protein complementation assay, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, fluorescent resonance energy transfe, pull down	Badciong JC (2002), Shvarts A (1997), Shvarts A (1997), Tang Y (2008), Okamoto K (2005), Chen L (2005), Wang X (2001), Ohtsubo C (2009), Zdzalik M (2010), Singh RK (2007), Kim S (2010), Li M (2011), Li M (2011), David Y (2011), de Graaf P (2003), Wade M (2012), Wade M (2012), Wade M (2012), Stad R (2000), Stad R (2000), Bernal F (2010), Bernal F (2010), Bernal F (2010), Bernal F (2010), Miller KR (2010), Zuckerman V (2009), Kallen J (2009), Czarna A (2009), Czarna A (2009), Popowicz GM (2008), Hu B (2007), Sharp DA (1999), Li C (2002), Di Conza G (2012), Mancini F (2009), Mancini F (2009), Wu S (2012), Shan B (2012), Wu S (2012), Wu S (2012), Ranaweera RS (2013), Bista M (2013), Bista M (2013), Wang CL (2014), Wang CL (2014), Rallapalli R (1999), Chang YS (2013), Chang YS (2013), Tan BX (2014), Huttlin EL (2015), Sanchez MC (2010), Sanchez MC (2010), Li YC (2014), Li X (2015), Chen X (2015), Chen L (2015), Chen L (2015), Chen L (2015), Wei X (2016), Wei X (2016), Xie X (2016), Huttlin EL (2017), Borcherds W (2017), Shangary S (2008), Ivanov AA (2017), Mancini F (2016)	66
RNF2	1	AR	3	affinity chromatography technology	Cao Q (2014)	1
RCHY1	0	UBE2D3	1	pull down	Abou Zeinab R (2013)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
BRCA1	7	CDK9	3	two hybrid	Woods NT (2012)	1
YWHAE	0	MDM4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	LeBron C (2006), Okamoto K (2005), Okamoto K (2005), Lopez-Pajares V (2008), Lopez-Pajares V (2008)	5
KLHL41	2	RCHY1	0	two hybrid	Rolland T (2014)	1
CHD8	44	AR	3	affinity chromatography technology, pull down	Menon T (2010), Menon T (2010)	2
MSH3	4	RCHY1	0	two hybrid	Wang J (2011)	1
RCHY1	0	CAMK2D	3	affinity chromatography technology	Ma-Lauer Y (2016)	1
MDM4	0	TP73	2	affinity chromatography technology, pull down, affinity chromatography technology	Wang X (2001), Zdzalik M (2010), Huttlin EL (2017)	3
MDM2	2	TP73	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Balint E (1999), Zeng X (1999), Zeng X (1999), Chen L (2010), Zdzalik M (2010), Kim JW (2008), Balint E (1999), Balint E (1999), Wang J (2011), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Ongkeko WM (1999), Wu H (2015), Stindt MH (2015), Zhou X (2015), Zhou X (2015)	17
YWHAE	0	RCHY1	0	affinity chromatography technology	Choudhary C (2009)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
UBE2D3	1	RNF2	1	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Markson G (2009), Bentley ML (2011), Li Z (2006), Pan MR (2011), Zhang Y (2014), Xia P (2014), Gearhart MD (2006), McGinty RK (2014), Cao Q (2014), Gao Z (2014)	10
CHEK2	2	BRCA1	7	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, imaging technique	Lee JS (2000), Lee JS (2000), Chabalier-Taste C (2008), Chabalier-Taste C (2008), Liu Y (2002), Inoue Y (2007), Dutta D (2015), Dutta D (2015)	8
RCHY1	0	SEMA4C	5	two hybrid	Rolland T (2014)	1
UBE2D4	0	RNF2	1	two hybrid	Markson G (2009)	1
RCHY1	0	UBC	7	enzymatic study	Wu G (2010)	1
KRT18	2	KRT8	3	two hybrid, two hybrid	Schnabel J (1998), Wang J (2011)	2
UBC	7	PRDX4	0	pull down	Zhang X (2017)	1
PRDX4	0	RCHY1	0	two hybrid	Wang J (2011)	1
RCHY1	0	RPLP1	0	two hybrid	Wang J (2011)	1
RCHY1	0	TMBIM1	1	two hybrid	Wang J (2011)	1
RNF2	1	UBC	7	enzymatic study	Woodsmith J (2012)	1
HOXC4	1	RCHY1	0	protein complementation assay	Bridoux L (2015)	1
TP53	0	NLK	1	affinity chromatography technology, pull down, pull down, genetic interference, affinity chromatography technology	Zhang HH (2014), Zhang HH (2014), Zhang HH (2014), Zhang HH (2014), Zhang HH (2014)	5
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HRG	4	RCHY1	0	two hybrid	Wang J (2011)	1
SRPRB	0	TMBIM1	1	biochemical	Havugimana PC (2012)	1
RCHY1	0	LIMS2	1	two hybrid	Rolland T (2014)	1
BRCA1	7	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, biochemical, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Abramovitch S (2004), Ouchi T (1998), Dong Y (2003), Dong Y (2003), Chai YL (1999), Chai YL (1999), Zhang H (1998), Dong Y (2003), Chen Y (2006), Quaresima B (2006), Zhang H (1998), Zhang H (1998), Mark WY (2005), Jin S (2009), Jiang J (2011), Rasti M (2015), Rasti M (2015)	17
UBE2D1	0	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
UBC	7	POLH	1	pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology	Bienko M (2005), Plosky BS (2006), Sekimoto T (2010), Bienko M (2005), Plosky BS (2006), Ahmed-Seghir S (2015)	6
TP63	0	MDM4	0	pull down, pull down	Zdzalik M (2010), Zdzalik M (2010)	2
RCHY1	0	ZNF160	2	two hybrid	Wang J (2011)	1
UBC	7	BRCA1	7	pull down, enzymatic study	Sobhian B (2007), Zhao GY (2007)	2
BRCA1	7	COPE	2	affinity chromatography technology	Woods NT (2012)	1
RNF2	1	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Calao M (2012), Wen W (2013), Wen W (2013)	3
RNF2	1	RPLP1	0	affinity chromatography technology	Cao Q (2014)	1
UBE2D3	1	TRIM8	6	two hybrid	Markson G (2009)	1
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
AR	3	TP53	0	genetic interference	Shenk JL (2001)	1
RCHY1	0	KRT8	3	pull down, affinity chromatography technology, affinity chromatography technology	Duan S (2009), Duan S (2009), Duan S (2009)	3
UBE2D2	0	UBASH3B	4	enzymatic study	Hoeller D (2007)	1
RCHY1	0	SERPINA5	3	two hybrid	Wang J (2011)	1
FADS6	3	RCHY1	0	two hybrid	Wang J (2011)	1
BRCA1	7	TP73	2	affinity chromatography technology	Ibrahim N (2010)	1
KAT5	1	RCHY1	0	two hybrid, two hybrid, affinity chromatography technology, imaging technique	Hejna J (2008), Logan IR (2004), Logan IR (2004), Logan IR (2004)	4
HOXB5	0	HOXC4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MDM2	2	RFWD2	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
RFWD2	0	TP53	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dornan D (2006), Dornan D (2004), Dornan D (2004), Dornan D (2004), Dornan D (2004), Choi HH (2011), Yamada T (2013), Zou S (2016)	8
RCHY1	0	UBASH3B	4	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
GFI1B	1	RCHY1	0	two hybrid	Lim J (2006)	1
TP53	0	TP63	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McDade SS (2011), Lu D (2013), Chae YS (2012), Chae YS (2012), Stindt MH (2015), Wei S (2014)	6
ARF4	0	RCHY1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
CHEK2	2	MDM4	0	enzymatic study	Chen L (2005)	1
RFWD2	0	UBE2D2	0	pull down, pull down, pull down	Dornan D (2006), Dornan D (2004), Choi HH (2011)	3
GFI1B	1	BRCA1	7	two hybrid	Lim J (2006)	1
RCHY1	0	HOXA2	1	two hybrid, affinity chromatography technology, protein complementation assay	Bergiers I (2013), Bergiers I (2013), Bridoux L (2015)	3
CHEK2	2	RCHY1	0	affinity chromatography technology, affinity chromatography technology, enzymatic study	Bohgaki M (2013), Bohgaki M (2013), Bohgaki M (2013)	3
RCHY1	0	POLH	1	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Jung YS (2011), Jung YS (2011), Jung YS (2010), Jung YS (2010)	4
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
BRCA1	7	UBE2D1	0	pull down, pull down, pull down, pull down, pull down, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down	Mallery DL (2002), Brzovic PS (2003), Nishikawa H (2004), Dong Y (2003), Wu-Baer F (2003), Hashizume R (2001), Christensen DE (2009), Christensen DE (2009), Christensen DE (2009), Morris JR (2006), Vandenberg CJ (2003), Morris JR (2006), Nhukeaw T (2014), Thakar A (2010)	14
UBASH3B	4	KRT8	3	affinity chromatography technology	Brehme M (2009)	1
RCHY1	0	COPE	2	two hybrid, enzymatic study, affinity chromatography technology	Maruyama S (2008), Maruyama S (2008), Maruyama S (2008)	3
AR	3	MDM2	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Gaughan L (2005), Gaughan L (2005), Chymkowitch P (2011), Chymkowitch P (2011), Liu T (2012), Liu T (2012), Deep G (2008), Deep G (2008), Lin HK (2002), Lin HK (2002), Zhang A (2015), Kwegyir-Afful AK (2015), McClurg UL (2016), McClurg UL (2016), Liao Y (2017), Steely AM (2017), Zhai W (2016)	18
YWHAE	0	CALM1	0	two hybrid, pull down	Luk SC (1999), Luk SC (1999)	2
RCHY1	0	TP53	0	affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Leng RP (2003), Leng RP (2003), Sheng Y (2008), Sheng Y (2008), Corcoran CA (2009), Duan S (2007), Duan S (2007), Duan S (2007), Duan S (2007), Shloush J (2011), Jung YS (2011), Wu G (2010), Wu G (2010), Wang J (2011), Abou Zeinab R (2013), Corcoran CA (2009), Corcoran CA (2009), Yan W (2014), Yan W (2014), Yan W (2014)	20
CALM1	0	KRAS	1	affinity chromatography technology, pull down, pull down, two hybrid	Villalonga P (2001), Villalonga P (2001), Sidhu RS (2003), Sidhu RS (2003)	4
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
UBE2D2	0	CDKN1B	1	enzymatic study	Ryu KS (2008)	1
CALM1	0	CAMK2G	4	pull down	Kwiatkowski AP (2000)	1
CAMK2D	3	ALAS1	2	affinity chromatography technology	Huttlin EL (2017)	1
RBM38	0	RCHY1	0	two hybrid	Wang J (2011)	1
RAB11A	4	RCHY1	0	two hybrid	Wang J (2011)	1
RCHY1	0	TRIM8	6	two hybrid	Woodsmith J (2012)	1
CDK9	3	AR	3	affinity chromatography technology, pull down	Lee DK (2001), Lee DK (2001)	2
MEOX2	2	RCHY1	0	two hybrid	Rolland T (2014)	1
RCHY1	0	ADAMTSL4	6	two hybrid	Rolland T (2014)	1
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
KAT5	1	BRCA1	7	two hybrid	Hill SJ (2014)	1
TAOK2	8	RCHY1	0	two hybrid	Corominas R (2014)	1
RCHY1	0	CDKN1B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hattori T (2007), Hattori T (2007), Huang X (2011)	3
RCHY1	0	RILP	0	two hybrid	Wang J (2011)	1
PGLS	0	RCHY1	0	two hybrid	Rolland T (2014)	1
UBC	7	CALM1	0	affinity chromatography technology	Bish RA (2007)	1
ADAMTSL4	6	KRTAP9-2	0	two hybrid	Rolland T (2014)	1
BRCA1	7	KRT18	2	affinity chromatography technology	Ertych N (2016)	1
TP63	0	TP73	2	affinity chromatography technology	Huttlin EL (2017)	1
RCHY1	0	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Hattori T (2007), Duan S (2007), Sheng Y (2008), Wu G (2010), Corcoran CA (2009), Abe K (2008), Shloush J (2011), Bohgaki M (2013), Abou Zeinab R (2013)	9
BRCA1	7	TP63	0	affinity chromatography technology, imaging technique	Buckley NE (2011), Buckley NE (2014)	2
RFWD2	0	RCHY1	0	affinity chromatography technology, affinity chromatography technology	Wang L (2011), Wang L (2011)	2
RCHY1	0	SERPINA1	1	two hybrid	Wang J (2011)	1