PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHPRH	7	FBXW7	2	two hybrid	Stelzl U (2005)	1
SHPRH	7	UBTF	8	affinity chromatography technology	Lee D (2017)	1
SHPRH	7	25885	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Lee D (2017), Lee D (2017), Lee D (2017)	3
HLTF	7	SHPRH	7	affinity chromatography technology	Lin JR (2011)	1
HIST1H4A	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Huttlin EL (2017), Kleiner RE (2018), Kleiner RE (2018)	4
BORCS6	0	SHPRH	7	two hybrid	Rolland T (2014)	1
HLTF	7	UBE2N	1	affinity chromatography technology, pull down, pull down, enzymatic study	Unk I (2008), Unk I (2008), Masuda Y (2012), Masuda Y (2012)	4
HIST1H3A	3	SHPRH	7	bioid, pull down, affinity chromatography technology, affinity chromatography technology	Lambert JP (2015), Lee D (2017), Lee D (2017), Lee D (2017)	4
USP36	4	SHPRH	7	affinity chromatography technology	Sowa ME (2009)	1
RBBP7	1	SHPRH	7	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3A	3	RBBP7	1	affinity chromatography technology	Foltz DR (2009)	1
EDARADD	0	SHPRH	7	two hybrid	Rolland T (2014)	1
USP49	1	SHPRH	7	affinity chromatography technology	Sowa ME (2009)	1
PCNA	0	DTL	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Jascur T (2011), Jascur T (2011), Dar A (2014), Terai K (2010), Higa LA (2006), Higa LA (2006)	6
SHPRH	7	UBE2A	0	affinity chromatography technology	Unk I (2006)	1
SHPRH	7	UBE2V2	0	affinity chromatography technology, pull down	Unk I (2006), Unk I (2006)	2
HLTF	7	RAD18	3	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Unk I (2008), Unk I (2008), Lin JR (2011), Lin JR (2011), Lin JR (2011), Sertic S (2013), Zeman MK (2014)	7
HLTF	7	UBE2V2	0	affinity chromatography technology, pull down, pull down	Unk I (2008), Unk I (2008), Masuda Y (2012)	3
DTL	0	HLTF	7	affinity chromatography technology, affinity chromatography technology	Sertic S (2013), Sertic S (2013)	2
RAD18	3	UBE2A	0	two hybrid, affinity chromatography technology, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Xin H (2000), Xin H (2000), Tateishi S (2000), Tateishi S (2000), Markson G (2009), Inagaki A (2011), Watanabe K (2004), Masuda Y (2012), Masuda Y (2012), Masuda Y (2012), Watson NB (2008), Miyase S (2005), Barkley LR (2012), Unk I (2006), Kumar R (2014), Kumar R (2014), Zeman MK (2014), Masuda Y (2012), Hong JH (2015), Hein MY (2015), Hein MY (2015), Masuda Y (2015)	22
FBXW7	2	USP36	4	affinity chromatography technology, affinity chromatography technology	Sun XX (2015), Sun XX (2015)	2
HNRNPL	3	SHPRH	7	affinity chromatography technology	Fei T (2017)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
SHPRH	7	PCNA	0	enzymatic study	Unk I (2006)	1
HLTF	7	UBE2A	0	enzymatic study	Masuda Y (2012)	1
UBTF	8	25885	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tsai YC (2012), Tsai YC (2012), Tsai YC (2012), Lee D (2017)	4
RAD18	3	PCNA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Song IY (2010), Inagaki A (2011), Kobayashi J (2010), Masuda Y (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Notenboom V (2007), Notenboom V (2007), Wong RP (2011), Masuda Y (2012), Unk I (2006), Tomida J (2008), Durando M (2013), Han J (2014), Han J (2014), Han J (2014), Masuda Y (2012), Masuda Y (2015), Guan J (2017)	20
DTL	0	RAD18	3	affinity chromatography technology	Sertic S (2013)	1
HNRNPL	3	25885	0	affinity chromatography technology	Fei T (2017)	1
DTL	0	UBE2N	1	pull down	Cheng YC (2013)	1
DTL	0	SHPRH	7	affinity chromatography technology	Sertic S (2013)	1
UBE2A	0	PCNA	0	enzymatic study	Unk I (2006)	1
HLTF	7	PCNA	0	affinity chromatography technology, enzymatic study, enzymatic study	Unk I (2008), Masuda Y (2012), Achar YJ (2015)	3
SHPRH	7	UBE2N	1	affinity chromatography technology, pull down	Unk I (2006), Unk I (2006)	2
SHPRH	7	FDFT1	1	two hybrid	Stelzl U (2005)	1
UBE2V2	0	UBE2N	1	pull down, two hybrid, x-ray crystallography, two hybrid, two hybrid, two hybrid, pull down, pull down, x-ray crystallography, affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, two hybrid, pull down, biochemical, x-ray crystallography, pull down, affinity chromatography technology, pull down, x-ray crystallography, biochemical, x-ray crystallography, affinity chromatography technology	Andersen PL (2005), Andersen PL (2005), Markin CJ (2010), Wooff J (2004), Wooff J (2004), Plans V (2006), Wu PY (2003), McKenna S (2003), McKenna S (2003), Zou W (2005), Takeuchi T (2005), Pastushok L (2005), Pastushok L (2005), Pastushok L (2005), Huen MS (2008), Huen MS (2008), Ye Y (2003), Havugimana PC (2012), Moraes TF (2001), Pastushok L (2007), Zou W (2005), McKenna S (2001), Hodge CD (2015), Wan C (2015), Branigan E (2015), Boldt K (2016)	26
RAD18	3	SHPRH	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Lin JR (2011), Lin JR (2011), Unk I (2006), Zeman MK (2014), Zeman MK (2014), Zeman MK (2014)	6
HIST1H4A	0	SHPRH	7	affinity chromatography technology	Huttlin EL (2017)	1