Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GAD1 2571 L-GLUTAMATE CHEMBL575060 DrugBank 17600364, 16643338, 17445798, 17562689, 16769115
GAD1 2571 PYRIDOXAL PHOSPHATE CHEMBL82202 cofactor DrugBank 12535612, 15686475, 15381280, 11488610, 12067524, 16075246, 17139284, 17016423, 8499653, 10978228

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GAD1 rs769404 TT methadone dosage yes Variant referred to in the paper as rs11542313, which has now been merged into rs769404. Genotype TT is associated with decreased dose of methadone in people with Heroin Dependence as compared to genotype CC. 31866536 1451138001
GAD1 rs3762555 G methadone dosage yes The G allele was significantly more frequent in patients taking a high daily dose of methadone compared to in those taking a low daily dose. Allele G is associated with increased dose of methadone in people with Heroin Dependence as compared to allele C. 31866536 1451137960
GAD1 rs3791878 T methadone dosage no Allele T is not associated with dose of methadone in people with Heroin Dependence as compared to allele G. 31866536 1451138021
GAD1 rs769395 A methadone dosage no Allele A is not associated with dose of methadone in people with Heroin Dependence as compared to allele G. 31866536 1451138043
GAD1 rs769404 CT methadone dosage no Variant referred to in the paper as rs11542313, which has now been merged into rs769404. Although the association was initially significant, significance was lost following Bonferroni correction. Genotype CT is not associated with dose of methadone in people with Heroin Dependence as compared to genotype CC. 31866536 1451137985
GAD1 rs3749034 G methadone dosage yes The G allele was significantly more frequent in patients taking a high daily dose of methadone compared to in those taking a low daily dose. Allele G is associated with increased dose of methadone in people with Heroin Dependence as compared to allele A. 31866536 1451137970
GAD1 rs3762556 G methadone dosage yes The G allele was significantly more frequent in patients taking a high daily dose of methadone compared to in those taking a low daily dose. Allele G is associated with increased dose of methadone in people with Heroin Dependence as compared to allele C. 31866536 1451137980