Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GABRP 2568 OXAZEPAM CHEMBL568 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRP 2568 TRIAZOLAM CHEMBL646 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRP 2568 BROMAZEPAM CHEMBL277062 potentiator TdgClinicalTrial, TEND, DrugBank 18384456
GABRP 2568 CINOLAZEPAM CHEMBL2104926 potentiator TdgClinicalTrial, TEND, DrugBank 7849137
GABRP 2568 BUTALBITAL CHEMBL454 positive allosteric modulator ChemblInteractions
GABRP 2568 CLONAZEPAM CHEMBL452 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRP 2568 METHOHEXITAL SODIUM CHEMBL30219 positive allosteric modulator ChemblInteractions
GABRP 2568 PENTOBARBITAL CHEMBL448 positive allosteric modulator ChemblInteractions
GABRP 2568 TRICLOFOS SODIUM CHEMBL1200789 ChemblInteractions
GABRP 2568 CLORAZEPIC ACID CHEMBL1213252 TdgClinicalTrial, TEND
GABRP 2568 ADINAZOLAM CHEMBL328250 potentiator TdgClinicalTrial, TEND, DrugBank 6148400, 6320036
GABRP 2568 HALAZEPAM CHEMBL970 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2867566, 6738302
GABRP 2568 PRAZEPAM CHEMBL969 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 7773620
GABRP 2568 METHOXYFLURANE CHEMBL1341 ChemblInteractions
GABRP 2568 ALPRAZOLAM CHEMBL661 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRP 2568 BUTABARBITAL SODIUM CHEMBL1200982 positive allosteric modulator ChemblInteractions
GABRP 2568 GLUTETHIMIDE CHEMBL1102 ChemblInteractions
GABRP 2568 METHYPRYLON CHEMBL1200790 positive allosteric modulator ChemblInteractions
GABRP 2568 SEVOFLURANE CHEMBL1200694 positive allosteric modulator ChemblInteractions
GABRP 2568 THIOPENTAL SODIUM CHEMBL738 positive allosteric modulator ChemblInteractions
GABRP 2568 FLURAZEPAM HYDROCHLORIDE CHEMBL1200602 positive allosteric modulator ChemblInteractions
GABRP 2568 HALOTHANE CHEMBL931 positive allosteric modulator ChemblInteractions
GABRP 2568 GABOXADOL CHEMBL312443 TdgClinicalTrial
GABRP 2568 CHLORDIAZEPOXIDE HYDROCHLORIDE CHEMBL1200703 positive allosteric modulator ChemblInteractions
GABRP 2568 ESZOPICLONE CHEMBL1522 positive allosteric modulator ChemblInteractions
GABRP 2568 TEMAZEPAM CHEMBL967 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 20138190
GABRP 2568 DIAZEPAM CHEMBL12 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRP 2568 NITRAZEPAM CHEMBL13209 potentiator TdgClinicalTrial, TEND, DrugBank 18384456, 11752090
GABRP 2568 CLORAZEPATE DIPOTASSIUM CHEMBL2096631 positive allosteric modulator ChemblInteractions
GABRP 2568 MEPROBAMATE CHEMBL979 agonist ChemblInteractions
GABRP 2568 CLOBAZAM CHEMBL70418 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRP 2568 DESFLURANE CHEMBL1200733 positive allosteric modulator ChemblInteractions
GABRP 2568 TALBUTAL CHEMBL1200802 positive allosteric modulator ChemblInteractions
GABRP 2568 THIAMYLAL SODIUM CHEMBL1201065 positive allosteric modulator ChemblInteractions
GABRP 2568 ISOFLURANE CHEMBL1256 positive allosteric modulator ChemblInteractions
GABRP 2568 TOPIRAMATE CHEMBL220492 ChemblInteractions
GABRP 2568 FLURAZEPAM CHEMBL968 TdgClinicalTrial, TEND
GABRP 2568 FLUMAZENIL CHEMBL407 ChemblInteractions
GABRP 2568 MIDAZOLAM CHEMBL655 TdgClinicalTrial, TEND
GABRP 2568 ENFLURANE CHEMBL1257 ChemblInteractions
GABRP 2568 PRIMIDONE CHEMBL856 positive allosteric modulator ChemblInteractions
GABRP 2568 MIDAZOLAM HYDROCHLORIDE CHEMBL1200420 positive allosteric modulator ChemblInteractions
GABRP 2568 OCINAPLON CHEMBL2105199 TdgClinicalTrial
GABRP 2568 PF-06372865 CHEMBL3707402 agonist ChemblInteractions
GABRP 2568 ESTAZOLAM CHEMBL285674 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2889803, 639854
GABRP 2568 CLOTIAZEPAM CHEMBL1697737 potentiator TdgClinicalTrial, TEND, DrugBank 18855614
GABRP 2568 FLUDIAZEPAM CHEMBL13291 potentiator TdgClinicalTrial, TEND, DrugBank 2857046
GABRP 2568 QUAZEPAM CHEMBL1200472 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 3017690, 2892106
GABRP 2568 CHLORDIAZEPOXIDE CHEMBL451 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRP 2568 ACAMPROSATE CALCIUM CHEMBL2068724 ChemblInteractions
GABRP 2568 LORAZEPAM CHEMBL580 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRP 2568 METHARBITAL CHEMBL450 positive allosteric modulator ChemblInteractions
GABRP 2568 PROPOFOL CHEMBL526 positive allosteric modulator ChemblInteractions
GABRP 2568 PENTOBARBITAL SODIUM CHEMBL971 positive allosteric modulator ChemblInteractions
GABRP 2568 SECOBARBITAL SODIUM CHEMBL1200903 positive allosteric modulator ChemblInteractions
GABRP 2568 ADIPIPLON CHEMBL2103791 TdgClinicalTrial
GABRP 2568 ETOMIDATE CHEMBL681 ChemblInteractions
GABRP 2568 ETHCHLORVYNOL CHEMBL591 ChemblInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GABRP rs10036156 CC + CT Selective serotonin reuptake inhibitors efficacy no However this was not statistically significant after permutation correction. Those with the CC/ CT genotype are more likely to be responders. Please note; in the paper this SNP was reported with A and G alleles - here we use T and C to represent these. Genotypes CC + CT are associated with increased response to Selective serotonin reuptake inhibitors or venlafaxine in people with Depressive Disorder, Major as compared to genotype TT. 23394390 982030334