PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTF1A	1	AAMP	3	two hybrid	Hanoun N (2014)	1
RBPJ	1	KAT2B	2	affinity chromatography technology, two hybrid	Kurooka H (2000), Kurooka H (2000)	2
TCF4	26	TCF3	7	two hybrid, affinity chromatography technology	Ravasi T (2010), Huttlin EL (2017)	2
KAT2B	2	PTF1A	1	affinity chromatography technology, enzymatic study	Rodolosse A (2009), Rodolosse A (2009)	2
PTF1A	1	CCDC27	5	two hybrid	Hanoun N (2014)	1
KAT2A	1	PTF1A	1	affinity chromatography technology	Rodolosse A (2009)	1
PTF1A	1	SPATA7	1	two hybrid	Hanoun N (2014)	1
TCF3	7	KAT2B	2	biochemical, affinity chromatography technology, enzymatic study, genetic interference, pull down	Bradney C (2003), Bradney C (2003), Bradney C (2003), Bradney C (2003), Bayly R (2004)	5
PTF1A	1	RPGRIP1	6	two hybrid	Hanoun N (2014)	1
PTF1A	1	TCF3	7	affinity chromatography technology	Rodolosse A (2009)	1
RBPJ	1	KAT2A	1	two hybrid	Kurooka H (2000)	1
TCF3	7	KAT2A	1	pull down, fluorescent resonance energy transfe	Holmlund T (2012), Ivanov AA (2017)	2
PTF1A	1	CCNDBP1	0	two hybrid	Hanoun N (2014)	1
PTF1A	1	ZW10	2	two hybrid	Hanoun N (2014)	1
PTF1A	1	RBPJL	3	affinity chromatography technology	Rodolosse A (2009)	1
PTF1A	1	RBPJ	1	two hybrid	Hanoun N (2014)	1
PTF1A	1	TRIP12	20	two hybrid, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe	Hanoun N (2014), Hanoun N (2014), Hanoun N (2014), Hanoun N (2014)	4
PTF1A	1	TCF4	26	two hybrid	Hanoun N (2014)	1