PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TSGA10	0	BCL6B	0	two hybrid	Rolland T (2014)	1
MID2	1	BCL6B	0	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
KRTAP10-5	2	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
CALCOCO2	0	BCL6B	0	two hybrid	Rolland T (2014)	1
KRTAP10-5	2	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
BCL6B	0	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
TRAF4	1	CALCOCO2	0	two hybrid	Rozan LM (2006)	1
PLSCR1	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
BCL6B	0	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
BCL6B	0	BCL6	6	two hybrid, pull down, two hybrid	Takenaga M (2003), Takenaga M (2003), Rolland T (2014)	3
BCL6B	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
RBPMS	0	BCL6B	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
KRTAP10-1	4	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
HDAC1	4	BCL6	6	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	David G (1998), Deltour S (1999), Fujita N (2004), Fujita N (2004), Dhordain P (1998), Miles RR (2005)	6
PLSCR1	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
PLSCR1	0	BCL6B	0	two hybrid	Rolland T (2014)	1
KRTAP10-1	4	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
KRTAP10-9	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
BCL6B	0	KRTAP10-9	1	two hybrid	Rolland T (2014)	1
KRTAP10-3	1	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
RBPJ	1	SIN3A	13	pull down	Zhou S (2000)	1
CALCOCO2	0	MID2	1	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
BCL6B	0	SIN3A	13	two hybrid	Takenaga M (2003)	1
BCL6B	0	SULT4A1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BCL6	6	SIN3A	13	pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Wong CW (1998), Dhordain P (1998), Dhordain P (1998), Dhordain P (1998), Miles RR (2005)	5
GOLGA2	2	BCL6B	0	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	KRTAP10-5	2	two hybrid	Rolland T (2014)	1
GOLGA2	2	MID2	1	two hybrid	Rolland T (2014)	1
BCL6B	0	KRTAP10-1	4	two hybrid	Rolland T (2014)	1
KRTAP10-7	0	NOTCH2NL	1	two hybrid	Rolland T (2014)	1
MID2	1	TSGA10	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
RBPJ	1	BCL6B	0	affinity chromatography technology	Ohnuki H (2012)	1
TRAF4	1	BCL6B	0	two hybrid	Rolland T (2014)	1
BCL6B	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
BCL6B	0	HDAC1	4	two hybrid	Takenaga M (2003)	1