Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
GABRA2 2555 GABOXADOL CHEMBL312443 agonist TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions
GABRA2 2555 TEMAZEPAM CHEMBL967 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 20138190
GABRA2 2555 PRIMIDONE CHEMBL856 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11264449, 10209232
GABRA2 2555 HALAZEPAM CHEMBL970 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2867566, 6738302
GABRA2 2555 MEPHOBARBITAL CHEMBL45029 potentiator DrugBank 11264449, 10209232, 21194017
GABRA2 2555 CLOBAZAM CHEMBL70418 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRA2 2555 FLUMAZENIL CHEMBL407 allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
GABRA2 2555 CHEMBL200177 CHEMBL200177 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 BARBITAL CHEMBL444 potentiator DrugBank 11264449, 10209232
GABRA2 2555 BROMAZEPAM CHEMBL277062 potentiator TdgClinicalTrial, TEND, DrugBank 18384456
GABRA2 2555 FLUDIAZEPAM CHEMBL13291 potentiator TdgClinicalTrial, TEND, DrugBank 2857046
GABRA2 2555 QUAZEPAM CHEMBL1200472 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 3017690, 2892106
GABRA2 2555 CINOLAZEPAM CHEMBL2104926 potentiator TdgClinicalTrial, TEND, DrugBank 7849137
GABRA2 2555 LORAZEPAM CHEMBL580 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRA2 2555 PENTOBARBITAL SODIUM CHEMBL971 positive allosteric modulator ChemblInteractions
GABRA2 2555 SECOBARBITAL SODIUM CHEMBL1200903 positive allosteric modulator ChemblInteractions
GABRA2 2555 FLURAZEPAM HYDROCHLORIDE CHEMBL1200602 positive allosteric modulator ChemblInteractions
GABRA2 2555 ADIPIPLON CHEMBL2103791 partial agonist TdgClinicalTrial, ChemblInteractions
GABRA2 2555 PF-06372865 CHEMBL3707402 agonist ChemblInteractions
GABRA2 2555 BUTABARBITAL CHEMBL449 TdgClinicalTrial, TEND
GABRA2 2555 CHLORDIAZEPOXIDE HYDROCHLORIDE CHEMBL1200703 positive allosteric modulator ChemblInteractions
GABRA2 2555 MEPROBAMATE CHEMBL979 agonist TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 19244096, 9067327
GABRA2 2555 THIOPENTAL CHEMBL441 potentiator TdgClinicalTrial, TEND, DrugBank 11264449, 10209232
GABRA2 2555 TRIAZOLAM CHEMBL646 potentiator, allosteric modulator, positive allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRA2 2555 ESTAZOLAM CHEMBL285674 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 2889803, 639854
GABRA2 2555 MUSCIMOL CHEMBL273481 agonist GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL34155 CHEMBL34155 agonist GuideToPharmacologyInteractions
GABRA2 2555 FLUNITRAZEPAM CHEMBL13280 potentiator, allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, TEND, DrugBank 17139284, 17016423, 20858465, 20638393, 2570451, 17976880
GABRA2 2555 CHEMBL17468 CHEMBL17468 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL363211 CHEMBL363211 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 ALPRAZOLAM CHEMBL661 allosteric modulator, positive allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
GABRA2 2555 AMOBARBITAL CHEMBL267894 potentiator DrugBank 11264449, 10209232
GABRA2 2555 BUTETHAL CHEMBL404422 potentiator TdgClinicalTrial, TEND, DrugBank 11264449, 10209232
GABRA2 2555 HEXOBARBITAL CHEMBL7728 potentiator TdgClinicalTrial, TEND, DrugBank 11264449, 10209232
GABRA2 2555 NITRAZEPAM CHEMBL13209 potentiator TdgClinicalTrial, TEND, DrugBank 18384456, 11752090
GABRA2 2555 CLORAZEPATE DIPOTASSIUM CHEMBL2096631 positive allosteric modulator ChemblInteractions
GABRA2 2555 ENFLURANE CHEMBL1257 ChemblInteractions
GABRA2 2555 MIDAZOLAM HYDROCHLORIDE CHEMBL1200420 positive allosteric modulator ChemblInteractions
GABRA2 2555 SEVOFLURANE CHEMBL1200694 positive allosteric modulator ChemblInteractions
GABRA2 2555 RESEQUINIL CHEMBL2107801 inverse agonist ChemblInteractions
GABRA2 2555 FLURAZEPAM CHEMBL968 TdgClinicalTrial, TEND
GABRA2 2555 DESFLURANE CHEMBL1200733 positive allosteric modulator ChemblInteractions
GABRA2 2555 ACAMPROSATE CALCIUM CHEMBL2068724 ChemblInteractions
GABRA2 2555 CLOTIAZEPAM CHEMBL1697737 potentiator TdgClinicalTrial, TEND, DrugBank 18855614
GABRA2 2555 PHENOBARBITAL CHEMBL40 TdgClinicalTrial, TEND
GABRA2 2555 BUTALBITAL CHEMBL454 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11264449, 10209232
GABRA2 2555 TALBUTAL CHEMBL1200802 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11264449, 10209232
GABRA2 2555 ADINAZOLAM CHEMBL328250 potentiator TdgClinicalTrial, TEND, DrugBank 6148400, 6320036
GABRA2 2555 ZOPICLONE CHEMBL135400 potentiator TdgClinicalTrial, TEND, DrugBank 18973287, 19942638, 20303942
GABRA2 2555 ISONIPECOTIC ACID CHEMBL279998 agonist GuideToPharmacologyInteractions
GABRA2 2555 ISOGUVACINE CHEMBL39071 agonist GuideToPharmacologyInteractions
GABRA2 2555 CGS-8216 CHEMBL19732 agonist GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL70176 CHEMBL70176 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL302715 CHEMBL302715 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 BRETAZENIL CHEMBL366947 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 ZINC ION CHEMBL1236970 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL274866 CHEMBL274866 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 RO-194603 CHEMBL269366 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL1080588 CHEMBL1080588 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CLONAZEPAM CHEMBL452 allosteric modulator, positive allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND
GABRA2 2555 METHOCTRAMINE CHEMBL27673 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 T-BUTYLBICYCLOPHOSPHOROTHIONATE CHEMBL485673 channel blocker GuideToPharmacologyInteractions
GABRA2 2555 PRAZEPAM CHEMBL969 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 7773620
GABRA2 2555 CHLORDIAZEPOXIDE CHEMBL451 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRA2 2555 PROPOFOL CHEMBL526 positive allosteric modulator ChemblInteractions
GABRA2 2555 THIOPENTAL SODIUM CHEMBL738 positive allosteric modulator ChemblInteractions
GABRA2 2555 AZD6280 CHEMBL1783256 positive allosteric modulator ChemblInteractions
GABRA2 2555 TOPIRAMATE CHEMBL220492 ChemblInteractions
GABRA2 2555 Lorediplon CHEMBL3707317 positive allosteric modulator ChemblInteractions
GABRA2 2555 CLORAZEPIC ACID CHEMBL1213252 TdgClinicalTrial, TEND
GABRA2 2555 ESZOPICLONE CHEMBL1522 agonist, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, DrugBank 18973287, 19942638
GABRA2 2555 SECOBARBITAL CHEMBL447 potentiator TdgClinicalTrial, TEND, DrugBank 11264449, 10209232
GABRA2 2555 METHARBITAL CHEMBL450 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11264449, 10209232
GABRA2 2555 DIAZEPAM CHEMBL12 potentiator, allosteric modulator, positive allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, ChemblInteractions, TEND, DrugBank 18384456, 11752090, 15009644
GABRA2 2555 OXAZEPAM CHEMBL568 potentiator, positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 18384456, 11752090
GABRA2 2555 CHEMBL1518572 CHEMBL1518572 agonist GuideToPharmacologyInteractions
GABRA2 2555 METHADONE CHEMBL651 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 CHEMBL373250 CHEMBL373250 allosteric modulator GuideToPharmacologyInteractions
GABRA2 2555 OCINAPLON CHEMBL2105199 allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions
GABRA2 2555 AZD7325 CHEMBL1783282 allosteric modulator, positive allosteric modulator GuideToPharmacologyInteractions, ChemblInteractions
GABRA2 2555 ZOLPIDEM CHEMBL911 allosteric modulator TdgClinicalTrial, GuideToPharmacologyInteractions, TEND
GABRA2 2555 BICUCULLINE CHEMBL417990 antagonist GuideToPharmacologyInteractions
GABRA2 2555 GABAZINE CHEMBL32503 antagonist GuideToPharmacologyInteractions
GABRA2 2555 PICROTOXIN CHEMBL1908342 channel blocker GuideToPharmacologyInteractions
GABRA2 2555 APROBARBITAL CHEMBL7863 potentiator DrugBank 11264449, 10209232
GABRA2 2555 HEPTABARBITAL CHEMBL468837 potentiator DrugBank 11264449, 10209232
GABRA2 2555 GANAXOLONE CHEMBL1568698 TdgClinicalTrial, DrugBank
GABRA2 2555 METHOXYFLURANE CHEMBL1341 ChemblInteractions
GABRA2 2555 BUTABARBITAL SODIUM CHEMBL1200982 positive allosteric modulator ChemblInteractions
GABRA2 2555 GLUTETHIMIDE CHEMBL1102 ChemblInteractions
GABRA2 2555 ETHCHLORVYNOL CHEMBL591 ChemblInteractions
GABRA2 2555 PENTOBARBITAL CHEMBL448 positive allosteric modulator TdgClinicalTrial, ChemblInteractions, TEND
GABRA2 2555 THIAMYLAL SODIUM CHEMBL1201065 positive allosteric modulator ChemblInteractions
GABRA2 2555 ETOMIDATE CHEMBL681 ChemblInteractions
GABRA2 2555 HALOTHANE CHEMBL931 positive allosteric modulator ChemblInteractions
GABRA2 2555 ISOFLURANE CHEMBL1256 positive allosteric modulator ChemblInteractions
GABRA2 2555 TRICLOFOS SODIUM CHEMBL1200789 ChemblInteractions
GABRA2 2555 MIDAZOLAM CHEMBL655 TdgClinicalTrial, TEND
GABRA2 2555 METHOHEXITAL SODIUM CHEMBL30219 positive allosteric modulator ChemblInteractions
GABRA2 2555 METHYPRYLON CHEMBL1200790 positive allosteric modulator ChemblInteractions
GABRA2 2555 ETAZOLATE CHEMBL356388 TdgClinicalTrial
GABRA2 2555 PAGOCLONE CHEMBL2104745 TdgClinicalTrial, DrugBank 16430927

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
GABRA2 rs11503014 CC propofol other yes Patients with the CC genotype had significantly smaller decreases (-9.44% +/-6.94%) in heart rate after propofol anesthesia as compared to patients with the CG or GG genotypes (-12.85% +/- 8.54). Please note: the authors examined 58 SNPs but did not do multiple testing corrections. Genotype CC is associated with decreased response to propofol as compared to genotypes CG + GG. 28611364 1449005403