PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BLM	2	FBXW7	2	pull down, affinity chromatography technology	Chandra S (2013), Chandra S (2013)	2
HIST1H2BA	0	MMS22L	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFX	1	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Du YC (2006), Lee HS (2010), Yang X (2010)	3
H2AFX	1	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
MCM4	3	SUPT16H	4	affinity chromatography technology, pull down	Tan BC (2006), Tan BC (2006)	2
HIST1H3E	0	ASF1A	0	affinity chromatography technology, affinity chromatography technology	Drane P (2010), Drane P (2010)	2
ASF1A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
MCM2	3	HIST1H3A	3	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
PVR	1	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	MCM7	5	pull down, pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Drissi R (2015), Boldt K (2016)	14
HIST1H4A	0	MCM4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
MMS22L	6	MCM6	5	affinity chromatography technology, biochemical	OConnell BC (2010), Duro E (2010)	2
TMEM206	5	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	H2AFX	1	affinity chromatography technology, affinity chromatography technology	Drissi R (2015), Huttlin EL (2017)	2
ASF1A	0	ASF1B	0	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Hein MY (2015)	2
MCM4	3	MCM7	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, biochemical, biochemical, affinity chromatography technology	Yabuta N (2003), Fujita M (1997), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Ramachandran N (2004), Kristensen AR (2012), Wan C (2015), Boldt K (2016)	9
HIST1H4A	0	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	ASF1B	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Drane P (2010), Campos EI (2015), Campos EI (2015), Campos EI (2015)	4
MMS22L	6	FBXW7	2	two hybrid	Stelzl U (2005)	1
FBXW7	2	H2AFY2	0	genetic interference	Bailey ML (2015)	1
MMS22L	6	SUPT16H	4	affinity chromatography technology	OConnell BC (2010)	1
HIST1H2BA	0	MCM6	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
H2AFY2	0	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
UPF2	2	BLM	2	two hybrid	Lehner B (2004)	1
HIST1H2BA	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST3H3	0	ASF1A	0	pull down, affinity chromatography technology, affinity chromatography technology	Zhang R (2007), Zhang R (2007), Han J (2013)	3
H2AFX	1	HIST1H3A	3	affinity chromatography technology, imaging technique	Lee HS (2010), Soldi M (2013)	2
ASF1B	0	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Piwko W (2010), Piwko W (2010), Duro E (2010), Huttlin EL (2017)	5
H2AFY2	0	MCM2	3	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	MCM2	3	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Drissi R (2015)	2
HIST1H3A	3	MCM6	5	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	HIST1H4A	0	affinity chromatography technology	Shuaib M (2010)	1
HIST3H3	0	ASF1B	0	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Campos EI (2010), Campos EI (2010), Campos EI (2010), Duro E (2010), Han J (2013)	5
SSRP1	1	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
NPY2R	0	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	H2AFY2	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3A	3	ASF1B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017)	6
MMS22L	6	UPF2	2	biochemical	Havugimana PC (2012)	1
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
HIST1H3E	0	MMS22L	6	biochemical	Campos EI (2015)	1
ASF1B	0	MMS22L	6	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Duro E (2010), Duro E (2010), Huttlin EL (2017)	4
HIST1H4A	0	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
HIST1H2BA	0	SSRP1	1	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
HIST1H3A	3	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	SUPT16H	4	affinity chromatography technology	Campos EI (2015)	1
H2AFX	1	SSRP1	1	affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Huttlin EL (2017)	3
H2AFX	1	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
H2AFY2	0	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
MMS22L	6	ASF1A	0	biochemical	Duro E (2010)	1
HIST1H4A	0	ASF1A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Akai Y (2010), Ask K (2012), Groth A (2005)	4
ASF1B	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Huttlin EL (2017)	2
MMS22L	6	MCM4	3	affinity chromatography technology	OConnell BC (2010)	1
HIST1H3A	3	TONSL	4	bioid, affinity chromatography technology	Lambert JP (2015), Huttlin EL (2017)	2
HIST1H3A	3	SSRP1	1	pull down, affinity chromatography technology	Kouskouti A (2005), Huttlin EL (2017)	2
HIST1H2BA	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Drissi R (2015), Huttlin EL (2017)	3
HIST1H4A	0	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
H2AFY2	0	MCM4	3	affinity chromatography technology	Huttlin EL (2017)	1
MCM2	3	HIST3H3	0	affinity chromatography technology	Drissi R (2015)	1
HIST1H3A	3	SUPT16H	4	affinity chromatography technology	Huttlin EL (2017)	1
H2AFY2	0	SSRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
SSRP1	1	MCM7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
MCM4	3	MCM2	3	pull down, two hybrid, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), Ishimi Y (1996), Tan BC (2006), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Drissi R (2015), Boldt K (2016)	11
MCM2	3	MCM6	5	two hybrid, pull down, pull down, two hybrid, two hybrid, two hybrid, biochemical, affinity chromatography technology, biochemical, biochemical, two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Yabuta N (2003), Yabuta N (2003), Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), You Z (1999), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Rolland T (2014), Wan C (2015), Hein MY (2015), Drissi R (2015), Boldt K (2016)	15
TONSL	4	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010), Piwko W (2010), Duro E (2010)	4
TONSL	4	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, imaging technique	OConnell BC (2010), Piwko W (2010), Hill SJ (2014)	3
FBXW7	2	SSRP1	1	affinity chromatography technology	Kourtis N (2015)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
OPRM1	0	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
TONSL	4	SSRP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Piwko W (2010), Hill SJ (2014), Huttlin EL (2017)	6
ASF1A	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ask K (2012), Drissi R (2015), Drissi R (2015), Huttlin EL (2017), Pchelintsev NA (2013)	5
MMS22L	6	INO80C	1	biochemical	Havugimana PC (2012)	1
H2AFX	1	TONSL	4	affinity chromatography technology	Huttlin EL (2017)	1
H2AFX	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Du YC (2006), Heo K (2008), Heo K (2008), Heo K (2008), Huttlin EL (2017)	5
TONSL	4	HIST1H3E	0	affinity chromatography technology, biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015), Campos EI (2015)	3
ASF1A	0	MCM6	5	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
HIST1H4A	0	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Huttlin EL (2017)	3
HIST1H4A	0	TONSL	4	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H2BA	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST1H3E	0	MCM7	5	biochemical, affinity chromatography technology	Campos EI (2015), Campos EI (2015)	2
MCM6	5	MCM7	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Fujita M (1997), You Z (2002), Havugimana PC (2012), Ryu MJ (2006), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
BLM	2	H2AFX	1	affinity chromatography technology, imaging technique	Sengupta S (2004), Sengupta S (2004)	2
SSRP1	1	HIST1H4A	0	pull down, affinity chromatography technology	Winkler DD (2011), Huttlin EL (2017)	2
ASF1A	0	MCM4	3	affinity chromatography technology, affinity chromatography technology	Ask K (2012), Huttlin EL (2017)	2
HIST1H3E	0	SSRP1	1	affinity chromatography technology	Campos EI (2015)	1
H2AFY2	0	TONSL	4	affinity chromatography technology	Huttlin EL (2017)	1
TONSL	4	MCM4	3	affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010)	2
SSRP1	1	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	3
MCM4	3	MCM6	5	pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Yabuta N (2003), Kneissl M (2003), Kneissl M (2003), Ishimi Y (1996), You Z (2002), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Boldt K (2016)	10
MMS22L	6	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Piwko W (2010), Piwko W (2010), Piwko W (2010), Piwko W (2010), Duro E (2010), Duro E (2010)	10
HIST1H3A	3	ASF1A	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	Tagami H (2004), Tagami H (2004), Akai Y (2010), Foltz DR (2009), Ask K (2012), Groth A (2005), Groth A (2005), Lambert JP (2015), Huttlin EL (2017), Zhang H (2013)	10
MMS22L	6	SSRP1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010), Huttlin EL (2017)	4
HIST1H3A	3	MCM7	5	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	MCM6	5	affinity chromatography technology	Campos EI (2015)	1
NCR3LG1	1	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
ASF1A	0	TONSL	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ask K (2012), Piwko W (2010), Duro E (2010), Huttlin EL (2017)	4
ASF1B	0	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jasencakova Z (2010), Duro E (2010), Campos EI (2015), Huttlin EL (2017)	4
HIST1H2BA	0	TONSL	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TONSL	4	MCM7	5	affinity chromatography technology	OConnell BC (2010)	1
ASF1B	0	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jasencakova Z (2010), Campos EI (2015), Drissi R (2015), Huttlin EL (2017)	4
MMS22L	6	MCM7	5	affinity chromatography technology	OConnell BC (2010)	1
MMS22L	6	MCM2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), OConnell BC (2010), OConnell BC (2010)	3
HIST1H3A	3	MMS22L	6	affinity chromatography technology	Huttlin EL (2017)	1
MMS22L	6	HIST3H3	0	biochemical	Duro E (2010)	1
BLM	2	MMS22L	6	genetic interference	Vizeacoumar FJ (2013)	1
ASF1B	0	MCM7	5	affinity chromatography technology, affinity chromatography technology	Campos EI (2015), Huttlin EL (2017)	2
H2AFX	1	MCM6	5	affinity chromatography technology	Huttlin EL (2017)	1
TONSL	4	HIST3H3	0	affinity chromatography technology	Duro E (2010)	1
HIST1H2BA	0	SUPT16H	4	affinity chromatography technology, biochemical, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Huttlin EL (2017)	3
MCM2	3	HIST1H4A	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Saade E (2009), Saade E (2009), Saade E (2009), Drissi R (2015), Huttlin EL (2017)	5
HIST1H4A	0	ASF1B	0	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H3E	0	MCM4	3	affinity chromatography technology	Campos EI (2015)	1
TONSL	4	MCM6	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	OConnell BC (2010), Piwko W (2010), Duro E (2010)	3
HIST1H3A	3	H2AFY2	0	bioid	Lambert JP (2015)	1
SSRP1	1	MCM4	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Tan BC (2006), Tan BC (2006), Tan BC (2006), OConnell BC (2010), Huttlin EL (2017)	5
HIST3H3	0	MCM7	5	affinity chromatography technology	Campos EI (2010)	1