PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRMT1	3	FUS	0	enzymatic study, enzymatic study, two hybrid, affinity chromatography technology	Wada K (2002), Lee J (2002), Stelzl U (2005), Wang T (2014)	4
SFPQ	2	HNRNPD	3	biochemical	Wan C (2015)	1
CDC5L	2	ILF3	5	affinity chromatography technology	Lleres D (2010)	1
LMNA	2	SF1	9	bioid	Roux KJ (2012)	1
TARDBP	4	HNRNPU	12	affinity chromatography technology	Freibaum BD (2010)	1
HSPA5	0	HNRNPD	3	affinity chromatography technology	Li J (2013)	1
TRIM25	5	HNRNPA3	0	affinity chromatography technology	Choudhury NR (2017)	1
HSPA5	0	HNRNPU	12	affinity chromatography technology, biochemical	Li J (2013), Wan C (2015)	2
HNRNPL	3	HNRNPA3	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Fei T (2017)	2
EWSR1	2	PRMT1	3	affinity chromatography technology, two hybrid	Weimann M (2013), Weimann M (2013)	2
TRIM25	5	UBA1	1	affinity chromatography technology	Pauli EK (2014)	1
HNRNPD	3	UBE2I	0	two hybrid, pull down	Moraes KC (2003), Moraes KC (2003)	2
LMNA	2	SFPQ	2	affinity chromatography technology	Depreux FF (2015)	1
LMNA	2	NONO	3	biochemical, bioid, affinity chromatography technology	Havugimana PC (2012), Roux KJ (2012), Depreux FF (2015)	3
CDC5L	2	HNRNPU	12	affinity chromatography technology	Lleres D (2010)	1
HSPA5	0	FUS	0	affinity chromatography technology, affinity chromatography technology	Li J (2013), Wang T (2014)	2
HNRNPU	12	YBX1	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
TRIM25	5	PRMT1	3	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
PA2G4	1	UBE2I	0	affinity chromatography technology, affinity chromatography technology	Oh SM (2010), Oh SM (2010)	2
UBE2I	0	HNRNPU	12	enzymatic study	Matafora V (2009)	1
FUS	0	HNRNPD	3	affinity chromatography technology, biochemical	Wang T (2014), Wan C (2015)	2
UBE2I	0	SFPQ	2	enzymatic study	Matafora V (2009)	1
TP63	0	EEF1A1	0	affinity chromatography technology	Amoresano A (2010)	1
PSMD12	1	FUS	0	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Wang T (2014)	2
YBX1	1	EWSR1	2	affinity chromatography technology	Dutertre M (2010)	1
TDRD3	0	EEF1A1	0	affinity chromatography technology, affinity chromatography technology	Goulet I (2008), Goulet I (2008)	2
TARDBP	4	FUS	0	affinity chromatography technology, pull down	Kim SH (2010), Kim SH (2010)	2
FUS	0	HNRNPA3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TARDBP	4	ILF3	5	affinity chromatography technology	Freibaum BD (2010)	1
TARDBP	4	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Freibaum BD (2010), Lleres D (2010)	2
SFPQ	2	NONO	3	two hybrid, affinity chromatography technology, pull down, pull down, pull down, biochemical, two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology	Peng R (2002), Peng R (2002), Peng R (2002), Ito T (2008), Dong X (2007), Havugimana PC (2012), Wang J (2011), Hall-Pogar T (2007), Wan C (2015), Huttlin EL (2017)	10
TRIM25	5	SFPQ	2	affinity chromatography technology	Choudhury NR (2017)	1
TP63	0	VCP	6	affinity chromatography technology	Amoresano A (2010)	1
FUS	0	SF1	9	pull down, affinity chromatography technology	Zhang D (1998), Wang T (2014)	2
UBA1	1	FUS	0	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Wang T (2014)	2
UBE2I	0	NONO	3	enzymatic study	Matafora V (2009)	1
PA2G4	1	FUS	0	affinity chromatography technology, enzymatic study, affinity chromatography technology	Oh SM (2010), Oh SM (2010), Oh SM (2010)	3
ILF3	5	EEF1A1	0	affinity chromatography technology	Chu L (2012)	1
TARDBP	4	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gitcho MA (2009), Gitcho MA (2009), Freibaum BD (2010)	3
EEF1A1	0	HNRNPL	3	biochemical	Havugimana PC (2012)	1
SFPQ	2	HNRNPA3	0	biochemical	Wan C (2015)	1
TRIM25	5	ILF3	5	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
LMNA	2	CTNNB1	30	affinity chromatography technology	Choi J (2004)	1
HNRNPL	3	SFPQ	2	biochemical	Havugimana PC (2012)	1
HNRNPD	3	HNRNPL	3	biochemical	Havugimana PC (2012)	1
EEF1A1	0	FUS	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Wang T (2014)	2
HNRNPU	12	HNRNPL	3	affinity chromatography technology	Hein MY (2015)	1
HSPA5	0	YBX1	1	biochemical	Havugimana PC (2012)	1
HSPA5	0	EWSR1	2	affinity chromatography technology	Li J (2013)	1
FUS	0	NONO	3	biochemical, affinity chromatography technology, biochemical	Havugimana PC (2012), Wang T (2014), Wan C (2015)	3
TRIM25	5	HNRNPU	12	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
CDC5L	2	PSMD12	1	affinity chromatography technology	Lleres D (2010)	1
FUS	0	VCP	6	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Wang T (2014)	2
HNRNPA3	0	PGK1	1	biochemical	Wan C (2015)	1
SFPQ	2	SF1	9	affinity chromatography technology	Huttlin EL (2017)	1
TP63	0	NONO	3	affinity chromatography technology	Amoresano A (2010)	1
HNRNPU	12	NONO	3	biochemical	Havugimana PC (2012)	1
SF1	9	ILF3	5	two hybrid, two hybrid	Hegele A (2012), Hegele A (2012)	2
RELA	1	HSPA5	0	affinity chromatography technology	Veena MS (2014)	1
VCP	6	TRIM25	5	affinity chromatography technology, affinity chromatography technology	Yu CC (2013), Choudhury NR (2017)	2
EWSR1	2	NONO	3	two hybrid	Wang J (2011)	1
EWSR1	2	HNRNPA3	0	affinity chromatography technology, bioid	Elzi DJ (2014), Elzi DJ (2014)	2
ILF3	5	SFPQ	2	biochemical	Havugimana PC (2012)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
NONO	3	SPI1	1	pull down, pull down, affinity chromatography technology	Hallier M (1996), Hallier M (1996), Hallier M (1996)	3
TP63	0	HSPA5	0	affinity chromatography technology	Amoresano A (2010)	1
TARDBP	4	HNRNPA3	0	affinity chromatography technology	Freibaum BD (2010)	1
LMNA	2	HNRNPU	12	affinity chromatography technology	Depreux FF (2015)	1
FUS	0	RELA	1	affinity chromatography technology, pull down	Uranishi H (2001), Uranishi H (2001)	2
PRMT1	3	RELA	1	affinity chromatography technology, affinity chromatography technology, pull down	Hassa PO (2008), Hassa PO (2008), Hassa PO (2008)	3
TARDBP	4	HSPA5	0	affinity chromatography technology	Freibaum BD (2010)	1
TRIM25	5	NONO	3	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPD	3	SRSF10	0	affinity chromatography technology	Hein MY (2015)	1
FUS	0	HNRNPU	12	biochemical, affinity chromatography technology	Kristensen AR (2012), Wang T (2014)	2
CDC5L	2	LMNA	2	affinity chromatography technology, affinity chromatography technology	Lleres D (2010), Depreux FF (2015)	2
EWSR1	2	PGK1	1	bioid	Elzi DJ (2014)	1
FUS	0	HNRNPL	3	affinity chromatography technology, biochemical	Wang T (2014), Wan C (2015)	2
TP63	0	UBE2I	0	two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study	Huang YP (2004), Huang YP (2004), Huang YP (2004), Ghioni P (2005)	4
HNRNPL	3	SF1	9	biochemical	Wan C (2015)	1
PGK1	1	SFPQ	2	biochemical	Wan C (2015)	1
FUS	0	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Wang T (2014), Lleres D (2010)	2
HNRNPU	12	HNRNPD	3	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Hegele A (2012), Hegele A (2012), Hein MY (2015), Hein MY (2015)	4
CDC5L	2	SFPQ	2	affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Ajuh P (2000), Ajuh P (2000), Havugimana PC (2012), Wan C (2015), Lleres D (2010)	5
LMNA	2	ILF3	5	affinity chromatography technology	Depreux FF (2015)	1
SF1	9	EWSR1	2	two hybrid, pull down	Zhang D (1998), Zhang D (1998)	2
PA2G4	1	YBX1	1	biochemical, affinity chromatography technology	Kristensen AR (2012), Palicharla VR (2015)	2
CTNNB1	30	FUS	0	affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Sato S (2005), Sato S (2005), Sato S (2005), Sato S (2005)	4
TRIM25	5	HSPA5	0	affinity chromatography technology	Choudhury NR (2017)	1
PRMT1	3	HNRNPU	12	enzymatic study	Lee J (2002)	1
LMNA	2	HNRNPA3	0	affinity chromatography technology	Depreux FF (2015)	1
HNRNPD	3	YBX1	1	two hybrid, pull down, affinity chromatography technology	Moraes KC (2003), Moraes KC (2003), Hein MY (2015)	3
NONO	3	HNRNPA3	0	biochemical	Wan C (2015)	1
HSPA5	0	HNRNPA3	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Li J (2013)	2
CDC5L	2	HSPA5	0	affinity chromatography technology	Lleres D (2010)	1
HNRNPU	12	ILF3	5	affinity chromatography technology	Hein MY (2015)	1
TRIM25	5	HNRNPD	3	affinity chromatography technology	Choudhury NR (2017)	1
LMNA	2	YBX1	1	affinity chromatography technology	Depreux FF (2015)	1
YEATS4	0	FUS	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SFPQ	2	EWSR1	2	affinity chromatography technology	Huttlin EL (2017)	1
TDRD3	0	FUS	0	affinity chromatography technology, affinity chromatography technology, two hybrid	Goulet I (2008), Goulet I (2008), Wang J (2011)	3
CDC5L	2	NONO	3	affinity chromatography technology	Lleres D (2010)	1
FUS	0	PGK1	1	affinity chromatography technology, biochemical	Wang T (2014), Wan C (2015)	2
HNRNPU	12	HNRNPA3	0	biochemical	Havugimana PC (2012)	1
SPI1	1	FUS	0	biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Hallier M (1998), Hallier M (1998), Hallier M (1998), Hallier M (1998)	4
TP63	0	FUS	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Amoresano A (2010), Amoresano A (2010), Amoresano A (2010)	3
HSPA5	0	HNRNPL	3	biochemical	Havugimana PC (2012)	1
VCP	6	HSPA5	0	affinity chromatography technology	Yu CC (2013)	1
FUS	0	SFPQ	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Wang T (2014), Wang T (2014), Wang T (2014), Wan C (2015)	4
FUS	0	SRSF10	0	affinity chromatography technology, two hybrid	Yang L (2000), Yang L (2000)	2
EEF1A1	0	YBX1	1	biochemical	Havugimana PC (2012)	1
TARDBP	4	PGK1	1	affinity chromatography technology	Davis SA (2018)	1
YBX1	1	FUS	0	affinity chromatography technology, biochemical	Rapp TB (2002), Kristensen AR (2012)	2
ILF3	5	FUS	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Saunders LR (2001), Saunders LR (2001), Saunders LR (2001)	3
LMNA	2	HNRNPL	3	affinity chromatography technology	Depreux FF (2015)	1
TP63	0	RELA	1	affinity chromatography technology, affinity chromatography technology	Sen T (2011), Sen T (2011)	2
VCP	6	LMNA	2	affinity chromatography technology	Yu CC (2013)	1
HSPA5	0	ILF3	5	biochemical	Havugimana PC (2012)	1
TP63	0	HNRNPL	3	affinity chromatography technology	Amoresano A (2010)	1
TRIM25	5	FUS	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
HNRNPD	3	HNRNPA3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
TRIM25	5	LMNA	2	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	ILF3	5	affinity chromatography technology, pull down, affinity chromatography technology	Yao P (2013), Yao P (2013), Yao P (2013)	3
HNRNPD	3	PGK1	1	biochemical	Wan C (2015)	1
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
TP63	0	HNRNPA3	0	affinity chromatography technology	Amoresano A (2010)	1
EWSR1	2	FUS	0	two hybrid, bioid	Wang J (2011), Elzi DJ (2014)	2
EWSR1	2	HNRNPD	3	bioid	Elzi DJ (2014)	1
TRIM25	5	YBX1	1	affinity chromatography technology	Choudhury NR (2017)	1
PRMT1	3	ILF3	5	two hybrid, affinity chromatography technology, pull down, enzymatic study, enzymatic study	Tang J (2000), Tang J (2000), Tang J (2000), Tang J (2000), Lee J (2002)	5
TARDBP	4	HNRNPD	3	affinity chromatography technology	Davis SA (2018)	1
TRIM25	5	EEF1A1	0	biochemical	Wan C (2015)	1
TARDBP	4	EEF1A1	0	affinity chromatography technology	Davis SA (2018)	1
TRIM25	5	PGK1	1	affinity chromatography technology	Choudhury NR (2017)	1
LMNA	2	FUS	0	bioid, affinity chromatography technology, affinity chromatography technology	Roux KJ (2012), Wang T (2014), Depreux FF (2015)	3
CTNNB1	30	NONO	3	affinity chromatography technology, affinity chromatography technology	Sato S (2005), Sato S (2005)	2
UBE2I	0	LMNA	2	two hybrid, affinity chromatography technology, enzymatic study	Zhong N (2005), Zhong N (2005), Matafora V (2009)	3
PGK1	1	EEF1A1	0	biochemical	Wan C (2015)	1
UBE2I	0	FUS	0	affinity chromatography technology, affinity chromatography technology	Oh SM (2010), Oh SM (2010)	2
TDRD3	0	EWSR1	2	affinity chromatography technology, affinity chromatography technology	Goulet I (2008), Goulet I (2008)	2
PGK1	1	SF1	9	biochemical	Wan C (2015)	1