PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HERC2	9	CST4	0	affinity chromatography technology	Galligan JT (2015)	1
ATP6V1B1	4	FTH1	0	affinity chromatography technology	Nylandsted J (2011)	1
CSNK2B	5	SUPT16H	4	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
FTH1	0	ASAH1	0	affinity chromatography technology	Huttlin EL (2017)	1
HERC2	9	AURKB	2	affinity chromatography technology	Galligan JT (2015)	1
FTH1	0	SOX5	11	two hybrid	Wang J (2011)	1
FTH1	0	PCBP3	2	affinity chromatography technology	Leidgens S (2013)	1
FTH1	0	3514	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAE	0	PCBP1	2	affinity chromatography technology	Zuo S (2010)	1
CEP57	0	FTL	0	affinity chromatography technology	Fogeron ML (2013)	1
CDH1	4	PCBP1	2	bioid	Guo Z (2014)	1
TP53	0	CSNK2B	5	protein complementation assay	Srivastav RK (2011)	1
FTH1	0	SERPINB4	1	affinity chromatography technology	Huttlin EL (2017)	1
HSPB1	2	LBP	2	two hybrid	Wang J (2011)	1
FTH1	0	SEMG2	1	affinity chromatography technology	Huttlin EL (2017)	1
SEMG1	1	SEMG2	1	affinity chromatography technology	Peter A (1998)	1
DAXX	5	TP53	0	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, unspecified method	Tang J (2006), Kim EJ (2003), Kim EJ (2003), Kim EJ (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Ohiro Y (2003), Wethkamp N (2011), Zhao LY (2004), Zhao LY (2004), Zhao LY (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Gostissa M (2004), Zhao LY (2004), Zhao LY (2004), Zhang H (2013), Zhang H (2013), Chen TC (2014), Li Z (2017)	23
TOLLIP	3	FTH1	0	two hybrid	Bandyopadhyay S (2010)	1
CST1	0	CST4	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	PLBD1	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	CALML3	0	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	FTH1	0	two hybrid	Wang J (2011)	1
CFTR	5	PCBP2	3	affinity chromatography technology	Pankow S (2015)	1
AURKA	1	KLK5	1	two hybrid	Arroyo R (2015)	1
FTH1	0	TGM1	5	affinity chromatography technology	Huttlin EL (2017)	1
ATP6V1B1	4	PLBD1	0	affinity chromatography technology	Nylandsted J (2011)	1
PACSIN1	0	FTH1	0	two hybrid	Bandyopadhyay S (2010)	1
AURKB	2	FTH1	0	affinity chromatography technology	Fogeron ML (2013)	1
FTH1	0	WDYHV1	0	two hybrid	Rolland T (2014)	1
CDC25A	2	FTH1	0	two hybrid	Wang J (2011)	1
CFTR	5	CDH1	4	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
UCHL5	1	SET	8	pull down	Fang Y (2011)	1
FTH1	0	FXR2	2	two hybrid	Rual JF (2005)	1
DAXX	5	SUPT16H	4	affinity chromatography technology	Hein MY (2015)	1
FTH1	0	195814	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	CST4	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	KLK5	1	affinity chromatography technology	Huttlin EL (2017)	1
SET	8	NR3C1	2	two hybrid, affinity chromatography technology	Ichijo T (2008), Ichijo T (2008)	2
NR1I3	2	FTH1	0	two hybrid	Albers M (2005)	1
FTH1	0	SERPINB7	1	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	FTH1	0	two hybrid	Rolland T (2014)	1
FTH1	0	KLK11	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	TICAM2	0	two hybrid	Wang J (2011)	1
FTH1	0	MYL3	0	two hybrid	Wang J (2011)	1
MAPK9	3	FTH1	0	affinity chromatography technology	Varjosalo M (2013)	1
PCBP3	2	PCBP1	2	affinity chromatography technology	Leidgens S (2013)	1
FTH1	0	FLG	17	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	TGM3	3	affinity chromatography technology	Pankow S (2015)	1
FTH1	0	CRNN	3	affinity chromatography technology	Huttlin EL (2017)	1
UCHL5	1	HERC2	9	affinity chromatography technology	Huttlin EL (2015)	1
LUC7L2	0	FTL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CFTR	5	ALOX12B	4	affinity chromatography technology	Pankow S (2015)	1
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
FTH1	0	KPNA2	0	two hybrid	Wang J (2011)	1
SET	8	TP53	0	affinity chromatography technology, pull down	Kim JY (2012), Kim JY (2012)	2
UCHL5	1	FTH1	0	affinity chromatography technology	Fang Y (2011)	1
GRB2	2	KPNA2	0	two hybrid	Wang J (2011)	1
AURKB	2	AURKA	1	affinity chromatography technology	Fogeron ML (2013)	1
SDCBP	0	SET	8	two hybrid	Rolland T (2014)	1
IGSF8	1	PCBP2	3	affinity chromatography technology	Perez-Hernandez D (2013)	1
FTH1	0	BRD7	2	two hybrid	Stelzl U (2005)	1
TP53	0	ELL3	1	genetic interference, pull down, affinity chromatography technology	Xie L (2013), Ahn HJ (2015), Ahn HJ (2015)	3
CDC25A	2	SOX5	11	two hybrid	Wang J (2011)	1
CDH1	4	FTH1	0	bioid	Guo Z (2014)	1
DAXX	5	HSPB1	2	affinity chromatography technology, imaging technique	Charette SJ (2000), Chen TC (2014)	2
HERC2	9	NCCRP1	1	affinity chromatography technology	Galligan JT (2015)	1
FTH1	0	NCCRP1	1	affinity chromatography technology	Huttlin EL (2017)	1
SERPINB3	0	SERPINB4	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CEP57	0	FTH1	0	affinity chromatography technology	Fogeron ML (2013)	1
FTH1	0	IL37	0	affinity chromatography technology	Huttlin EL (2017)	1
TP53	0	MAPK9	3	affinity chromatography technology, enzymatic study, affinity chromatography technology	Hu MC (1997), Lin Y (2002), Li Y (2012)	3
UCHL5	1	IVL	1	pull down	Fang Y (2011)	1
NR5A2	4	FTH1	0	two hybrid	Albers M (2005)	1
ASB15	1	FTH1	0	affinity chromatography technology	Andresen CA (2014)	1
FTH1	0	LUC7L2	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	IVL	1	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	YWHAE	0	affinity chromatography technology	Pankow S (2015)	1
PIAS4	5	HERC2	9	affinity chromatography technology	Rendtlew Danielsen J (2012)	1
CDH1	4	IVL	1	bioid	Guo Z (2014)	1
FTH1	0	KLK10	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	CPA4	2	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	TP53	0	affinity chromatography technology	Pankow S (2015)	1
FTH1	0	CST6	1	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	TREX2	0	affinity chromatography technology	Huttlin EL (2017)	1
BRD7	2	TP53	0	affinity chromatography technology, pull down, imaging technique	Drost J (2010), Drost J (2010), Drost J (2010)	3
FTH1	0	FTL	0	two hybrid, two hybrid, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Stelzl U (2005), Havugimana PC (2012), Rolland T (2014), Yu H (2011), Huttlin EL (2017)	6
FTH1	0	CPM	2	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	DAXX	5	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, two hybrid, imaging technique, affinity chromatography technology	Lin DY (2003), Lin DY (2003), Lin DY (2003), Lin DY (2006), Lin DY (2006), Lin DY (2006), Lin DY (2006), Obradovic D (2004)	8
FTH1	0	PCBP2	3	affinity chromatography technology, pull down	Leidgens S (2013), Leidgens S (2013)	2
CFTR	5	FTH1	0	affinity chromatography technology	Pankow S (2015)	1
TRUB2	1	FTH1	0	affinity chromatography technology	Floyd BJ (2016)	1
NR3C1	2	TP53	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Sengupta S (2000), Sengupta S (2001), Sengupta S (2001), Sengupta S (2001)	4
IGSF8	1	SUPT16H	4	affinity chromatography technology	Perez-Hernandez D (2013)	1
FTH1	0	POF1B	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPB1	2	FTH1	0	two hybrid, affinity chromatography technology	Katsogiannou M (2014), Katsogiannou M (2014)	2
CDC25A	2	YWHAE	0	two hybrid	Conklin DS (1995)	1
FTH1	0	PIAS4	5	two hybrid	Wang J (2011)	1
TOLLIP	3	WDYHV1	0	two hybrid	Rolland T (2014)	1
HSPB1	2	YWHAE	0	two hybrid	Katsogiannou M (2014)	1
AURKA	1	FTL	0	affinity chromatography technology	Fogeron ML (2013)	1
PACSIN1	0	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
SEMG2	1	CALML3	0	affinity chromatography technology	Huttlin EL (2017)	1
CEP57	0	HSPB1	2	affinity chromatography technology	Fogeron ML (2013)	1
CDH1	4	PPL	6	bioid	Guo Z (2014)	1
UCHL5	1	HSPB1	2	pull down	Fang Y (2011)	1
FTH1	0	RBP4	0	affinity chromatography technology	Huttlin EL (2017)	1
HERC2	9	FTL	0	affinity chromatography technology	Galligan JT (2015)	1
UCHL5	1	TGM3	3	pull down	Fang Y (2011)	1
FTH1	0	TGM5	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	SEMG1	1	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	CALML3	0	affinity chromatography technology	Pankow S (2015)	1
SUPT16H	4	FTH1	0	biochemical	Kristensen AR (2012)	1
CDH1	4	SDCBP	0	bioid	Guo Z (2014)	1
GRB2	2	RBP4	0	two hybrid	Wang J (2008)	1
GRB2	2	YWHAE	0	affinity chromatography technology	Bisson N (2011)	1
ASB16	2	FTH1	0	affinity chromatography technology	Andresen CA (2014)	1
HERC2	9	ASAH1	0	affinity chromatography technology	Galligan JT (2015)	1
IGSF8	1	SET	8	affinity chromatography technology	Perez-Hernandez D (2013)	1
GOLM1	1	FTH1	0	two hybrid	Stelzl U (2005)	1
FTH1	0	SERPINB3	0	affinity chromatography technology	Huttlin EL (2017)	1
CDC16	2	FTH1	0	two hybrid	Wang J (2011)	1
HERC2	9	TP53	0	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Cubillos-Rojas M (2014), Bai B (2016)	4
TP53	0	FTH1	0	affinity chromatography technology	Fogeron ML (2013)	1
FTH1	0	SDCBP	0	two hybrid	Rolland T (2014)	1
FTH1	0	ACPP	1	affinity chromatography technology	Huttlin EL (2017)	1
AURKA	1	FTH1	0	affinity chromatography technology	Fogeron ML (2013)	1
FTH1	0	CASP14	2	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	YWHAE	0	bioid	Guo Z (2014)	1
FTH1	0	HAL	1	affinity chromatography technology	Huttlin EL (2017)	1
IGSF8	1	FTH1	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
FTH1	0	TGM3	3	affinity chromatography technology	Huttlin EL (2017)	1
IGSF8	1	FTL	0	affinity chromatography technology	Perez-Hernandez D (2013)	1
CEP57	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
CST1	0	CTSV	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	A2ML1	4	affinity chromatography technology	Huttlin EL (2017)	1
NCOA4	4	FTH1	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017), Goodwin JM (2017)	4
FTH1	0	UBR1	3	two hybrid	Stelzl U (2005)	1
FTH1	0	YWHAE	0	two hybrid	Wang J (2011)	1
TP53	0	AURKA	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, genetic interference, pull down, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Chen SS (2002), Katayama H (2004), Katayama H (2004), Katayama H (2004), Katayama H (2004), Hsueh KW (2013), Huttlin EL (2015), Huttlin EL (2017)	12
FTH1	0	ARHGAP1	0	biochemical	Wan C (2015)	1
CDH1	4	PCBP2	3	bioid	Guo Z (2014)	1
PCBP1	2	PCBP2	3	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical	Lim J (2006), Lim J (2006), Leidgens S (2013), Wan C (2015)	4
FTH1	0	ALOX12B	4	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	LBP	2	two hybrid	Wang J (2011)	1
TP53	0	PCBP1	2	affinity chromatography technology	Fogeron ML (2013)	1
CDH1	4	POF1B	0	bioid	Guo Z (2014)	1
FTH1	0	CST1	0	affinity chromatography technology	Huttlin EL (2017)	1
UCHL5	1	CASP14	2	pull down	Fang Y (2011)	1
FTH1	0	PPL	6	affinity chromatography technology	Huttlin EL (2017)	1
TRAF4	1	FTH1	0	two hybrid	Rozan LM (2006)	1
GRB2	2	MAPK9	3	pull down, pull down	Saleem A (1995), Kharbanda S (1995)	2
CDH1	4	CD99	0	bioid	Guo Z (2014)	1
UCHL5	1	POF1B	0	pull down	Fang Y (2011)	1
CFTR	5	POF1B	0	affinity chromatography technology	Pankow S (2015)	1
CFTR	5	HSPB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ahner A (2013), Wang X (2006), Gong X (2016), Pankow S (2015)	4
UCHL5	1	FTL	0	affinity chromatography technology	Fang Y (2011)	1
HERC2	9	NCOA4	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Galligan JT (2015), Mancias JD (2015), Mancias JD (2015), Mancias JD (2015), Huttlin EL (2017)	5
ELL3	1	FTH1	0	two hybrid	Stelzl U (2005)	1
NCOA4	4	NR3C1	2	two hybrid	Gao T (1999)	1
HERC2	9	FTH1	0	affinity chromatography technology, affinity chromatography technology	Galligan JT (2015), Galligan JT (2015)	2
FTH1	0	SERPINA12	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	KLK7	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	PCBP1	2	affinity chromatography technology, pull down	Leidgens S (2013), Leidgens S (2013)	2
CFTR	5	KPNA2	0	affinity chromatography technology	Pankow S (2015)	1
FTH1	0	CTSV	0	affinity chromatography technology	Huttlin EL (2017)	1
CFTR	5	PCBP3	2	affinity chromatography technology	Pankow S (2015)	1
GRB2	2	FTL	0	two hybrid	Wang J (2008)	1
FTH1	0	GRB2	2	two hybrid	Wang J (2011)	1
SET	8	FTH1	0	biochemical	Kristensen AR (2012)	1
FTH1	0	CAPNS2	0	affinity chromatography technology	Huttlin EL (2017)	1
FTH1	0	ECM1	1	affinity chromatography technology	Huttlin EL (2017)	1
NR3C1	2	FTH1	0	two hybrid	Albers M (2005)	1
TP53	0	YWHAE	0	affinity chromatography technology	Fogeron ML (2013)	1
FTH1	0	CRMP1	0	two hybrid	Stelzl U (2005)	1
SPP1	0	FTH1	0	two hybrid	Long P (2012)	1
FTH1	0	ME1	1	affinity chromatography technology	Huttlin EL (2017)	1
FTL	0	SDCBP	0	two hybrid	Rolland T (2014)	1
MAX	0	FTH1	0	pull down, pull down	Miyamoto-Sato E (2010), Miyamoto-Sato E (2010)	2
DAXX	5	FTH1	0	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Liu F (2012), Liu F (2012), Liu F (2012), Liu F (2012), Wang J (2011)	5
FTH1	0	IL1RN	2	affinity chromatography technology	Huttlin EL (2017)	1
UCHL5	1	SERPINB3	0	pull down	Fang Y (2011)	1
CDH1	4	ARHGAP1	0	bioid	Guo Z (2014)	1
CDH1	4	SET	8	affinity chromatography technology	Catimel B (2005)	1
UCHL5	1	FLG	17	pull down	Fang Y (2011)	1
FTH1	0	CALML5	0	affinity chromatography technology	Huttlin EL (2017)	1
HSPB1	2	TP53	0	two hybrid, affinity chromatography technology, imaging technique	Stelzl U (2005), Sun Y (2007), Chen TC (2014)	3
TP53	0	AURKB	2	affinity chromatography technology	Wu L (2011)	1
NCOA4	4	FTL	0	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	GM2A	2	bioid	Guo Z (2014)	1
CD99	0	FTH1	0	two hybrid	Kim HJ (2004)	1
FTH1	0	GM2A	2	affinity chromatography technology	Huttlin EL (2017)	1