Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
IL27 rs8049439 CT + TT adalimumab efficacy no After 4 and 12 weeks of treatment, a greater percentage of those with the CT or TT genotype had biological response to treatment as compared to those with the CC genotype. Biological response assessed using change in C-reactive protein (CRP). However, this association did not remain significant after correction for multiple testing (p=0.183) Genotypes CT + TT is associated with increased response to adalimumab in people with Crohn Disease as compared to genotype CC. 25712183 1444936506