PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TP53	0	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Wang C (2003), Akakura S (2001), Peng Y (2001), Nagata Y (1999), Wang J (2011), Burch L (2004), Taipale M (2012), Fogeron ML (2013), Walerych D (2004)	9
FGFR1OP	0	BLM	2	affinity chromatography technology	Boldt K (2016)	1
TP53	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
PATZ1	1	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
SUPT5H	2	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
WDR24	0	MIOS	3	affinity chromatography technology, affinity chromatography technology	Bar-Peled L (2013), Boldt K (2016)	2
NUB1	2	UBD	0	affinity chromatography technology, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Hipp MS (2004), Hipp MS (2004), Rani N (2012), Rani N (2012), Schmidtke G (2006), Schmidtke G (2006), Theng SS (2014), Theng SS (2014)	8
AIPL1	3	UBD	0	affinity chromatography technology	Bett JS (2012)	1
BLM	2	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
AIPL1	3	NUB1	2	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology	Akey DT (2002), Akey DT (2002), Bett JS (2012), Kanaya K (2004), Kanaya K (2004), Kanaya K (2004), Akey DT (2004)	7
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
MIOS	3	FGFR1OP	0	affinity chromatography technology	Boldt K (2016)	1
TP53	0	BLM	2	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sengupta S (2004), Sengupta S (2004), Sengupta S (2004), Wang XW (2001), Wang XW (2001), Wang XW (2001), Wang XW (2001), Garkavtsev IV (2001), Garkavtsev IV (2001), Yang Q (2002), Yang Q (2002), Wang J (2013)	12
FGFR1OP	0	WDR24	0	affinity chromatography technology	Boldt K (2016)	1
POT1	2	AIPL1	3	two hybrid	Lee OH (2011)	1
ACD	1	AIPL1	3	two hybrid	Lee OH (2011)	1
FGFR1OP	0	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	HSPA4	3	affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Kim TS (2006), Hidalgo-de-Quintana J (2008), Skarra DV (2011), Wan C (2015)	4
FGFR1OP	0	FKBP15	8	affinity chromatography technology	Boldt K (2016)	1
AIPL1	3	UBA6	4	affinity chromatography technology	Bett JS (2012)	1
SEC16A	7	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
AIPL1	3	HSP90AA1	7	pull down	Hidalgo-de-Quintana J (2008)	1
FGFR1OP	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	PATZ1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Valentino T (2013), Valentino T (2013), Keskin N (2015), Keskin N (2015)	4
WASF1	10	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	HSPA4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Muller P (2008), Fraser JA (2010), Sun Y (2007), Wang J (2011), Horikawa I (2014), Horikawa I (2014), Kishor A (2013)	7
PATZ1	1	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	HSPA8	4	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Akakura S (2001), Kaur J (1996), Fogeron ML (2013), Horikawa I (2014), Matsumoto H (1994), Matsumoto H (1994), Karras GI (2017)	7
MIOS	3	PATZ1	1	affinity chromatography technology	Boldt K (2016)	1
PDE5A	3	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
UBA6	4	UBD	0	pull down, enzymatic study, two hybrid, affinity chromatography technology, imaging technique	Gavin JM (2012), Gavin JM (2012), Aichem A (2010), Theng SS (2014), Theng SS (2014)	5
TINF2	1	AIPL1	3	two hybrid	Lee OH (2011)	1
WDR24	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
HSPA4	3	HSPA8	4	biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical	Hidalgo-de-Quintana J (2008), Havugimana PC (2012), Taipale M (2014), Taipale M (2014), Wan C (2015)	5
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
BLM	2	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology	Bhattacharyya S (2009), Bhattacharyya S (2009)	2
TP53	0	UBD	0	affinity chromatography technology, affinity chromatography technology	Li T (2011), Theng SS (2014)	2
CXorf57	0	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
HSPA8	4	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Polanowska-Grabowska R (1997), Giommarelli C (2010), Gano JJ (2010), Skarra DV (2011), Wan C (2015), Sun L (2012)	6
MIOS	3	BLM	2	affinity chromatography technology	Boldt K (2016)	1
FGFR1OP	0	SUPT5H	2	affinity chromatography technology	Boldt K (2016)	1
HSP90AA1	7	SUPT5H	2	biochemical	Havugimana PC (2012)	1
MIOS	3	FKBP15	8	affinity chromatography technology	Boldt K (2016)	1
MIOS	3	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
TP53	0	NUB1	2	affinity chromatography technology, affinity chromatography technology	Liu G (2010), Liu G (2010)	2
BLM	2	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
MIOS	3	SUPT5H	2	affinity chromatography technology	Boldt K (2016)	1
SUPT5H	2	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
FKBP15	8	PDE5A	3	affinity chromatography technology	Boldt K (2016)	1
AIPL1	3	HSPA4	3	biochemical	Hidalgo-de-Quintana J (2008)	1
MIOS	3	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
AIPL1	3	HSPA8	4	biochemical, pull down	Hidalgo-de-Quintana J (2008), Hidalgo-de-Quintana J (2008)	2
HSPA4	3	NUB1	2	biochemical	Hidalgo-de-Quintana J (2008)	1
FKBP15	8	AIPL1	3	affinity chromatography technology	Boldt K (2016)	1
BLM	2	SUPT5H	2	genetic interference	Vizeacoumar FJ (2013)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
FGFR1OP	0	PATZ1	1	affinity chromatography technology	Boldt K (2016)	1
PDE5A	3	WDR24	0	affinity chromatography technology	Boldt K (2016)	1