PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO1	8	SETDB1	3	affinity chromatography technology	Kirli K (2015)	1
TKT	2	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
POLA2	2	PARP1	3	affinity chromatography technology, far western blotting	Dantzer F (1998), Dantzer F (1998)	2
STN1	0	PRIM2	1	affinity chromatography technology	Huttlin EL (2015)	1
TULP2	1	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
XPO1	8	POLA2	2	affinity chromatography technology	Kirli K (2015)	1
MMS19	5	POLA1	0	affinity chromatography technology	Stehling O (2012)	1
POLA2	2	SETDB1	3	two hybrid	Stelzl U (2005)	1
POLA2	2	APP	1	pull down	Olah J (2011)	1
RAC1	7	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
HELB	1	POLA2	2	pull down	Taneja P (2002)	1
POP7	2	APP	1	pull down	Olah J (2011)	1
DHX34	7	POLA2	2	two hybrid	Stelzl U (2005)	1
FAM219A	1	POLA2	2	two hybrid	Stelzl U (2005)	1
DCP2	0	POLA2	2	two hybrid	Lehner B (2004)	1
STN1	0	APP	1	pull down	Olah J (2011)	1
STN1	0	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
ARPC5	2	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
RAE1	0	PRIM1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
MMS19	5	PRIM1	1	affinity chromatography technology	Stehling O (2012)	1
HDAC6	0	XPO1	8	affinity chromatography technology, affinity chromatography technology	Riolo MT (2012), Kirli K (2015)	2
POLA1	0	PRIM1	1	biochemical, biochemical, biochemical, affinity chromatography technology	Kilkenny ML (2012), Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	4
STK40	4	APP	1	pull down	Olah J (2011)	1
EIF6	2	CRELD1	0	two hybrid	Stelzl U (2005)	1
RAE1	0	POLA1	0	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
MMS19	5	HDAC6	0	affinity chromatography technology	Stehling O (2012)	1
EZH2	4	ATP5C1	0	affinity chromatography technology	Cao Q (2014)	1
MMS19	5	DCP2	0	affinity chromatography technology	Stehling O (2012)	1
NR4A1	4	POLA2	2	two hybrid	Vinayagam A (2011)	1
KCNE3	0	POLA2	2	two hybrid	Vinayagam A (2011)	1
XPO1	8	NR4A1	4	affinity chromatography technology	Kirli K (2015)	1
MMS19	5	XPO1	8	affinity chromatography technology	Stehling O (2012)	1
EZH2	4	POLA2	2	two hybrid	Stelzl U (2005)	1
PRPF38A	3	APP	1	pull down	Olah J (2011)	1
POLA1	0	PRIM2	1	biochemical, biochemical, biochemical, biochemical	Kilkenny ML (2012), Kilkenny ML (2012), Havugimana PC (2012), Kristensen AR (2012)	4
CRELD1	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
IGFBP3	1	POLA2	2	two hybrid	Stelzl U (2005)	1
ATP5C1	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
POLA2	2	PRIM1	1	biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Wan C (2015), Huttlin EL (2017)	3
RBM23	0	POLA2	2	two hybrid	Stelzl U (2005)	1
LRPAP1	2	POLA2	2	two hybrid	Stelzl U (2005)	1
HGH1	0	POLA2	2	two hybrid	Stelzl U (2005)	1
CIAO1	3	PRIM2	1	affinity chromatography technology	Stehling O (2013)	1
POLA2	2	REPIN1	3	biochemical	Kristensen AR (2012)	1
PRPF38A	3	POLA2	2	two hybrid	Stelzl U (2005)	1
UBE2O	5	POP7	2	biochemical	Kristensen AR (2012)	1
STN1	0	POLA1	0	affinity chromatography technology	Huttlin EL (2015)	1
POLA2	2	PRIM2	1	biochemical, biochemical	Havugimana PC (2012), Kristensen AR (2012)	2
CIAO1	3	PRIM1	1	affinity chromatography technology	Stehling O (2013)	1
SSH3	3	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
MMS19	5	POLD2	2	affinity chromatography technology, biochemical	Stehling O (2012), Wan C (2015)	2
POP7	2	EPB41L1	4	biochemical	Kristensen AR (2012)	1
POLA1	0	PARP1	3	affinity chromatography technology, far western blotting	Dantzer F (1998), Dantzer F (1998)	2
MPZL1	0	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
MMS19	5	POLA2	2	affinity chromatography technology	Stehling O (2012)	1
EZH2	4	POU5F1	0	affinity chromatography technology	Hawkins PG (2010)	1
LGALS7	0	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
SNU13	0	POLA2	2	two hybrid	Stelzl U (2005)	1
KLF6	0	POLA2	2	two hybrid	Stelzl U (2005)	1
EPB41L1	4	APP	1	pull down	Olah J (2011)	1
LIPH	1	PRIM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ULK2	0	SETDB1	3	two hybrid	Stelzl U (2005)	1
SNX21	2	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
DDX24	1	SNU13	0	biochemical	Wan C (2015)	1
EIF6	2	SNU13	0	biochemical	Wan C (2015)	1
AKTIP	3	POLA2	2	two hybrid	Stelzl U (2005)	1
XPNPEP1	4	POLA2	2	two hybrid	Stelzl U (2005)	1
ZBBX	2	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
SCYL1	5	APP	1	pull down	Olah J (2011)	1
LIPH	1	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
STN1	0	PRIM1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EZH2	4	LGALS7	0	affinity chromatography technology	Cao Q (2014)	1
HELB	1	POLA1	0	pull down	Taneja P (2002)	1
STK40	4	POLA2	2	two hybrid	Stelzl U (2005)	1
SNX21	2	APP	1	pull down	Olah J (2011)	1
CIAO1	3	APP	1	pull down	Olah J (2011)	1
HDAC6	0	POLA2	2	two hybrid	Vinayagam A (2011)	1
NR4A1	4	HDAC6	0	affinity chromatography technology	Rambaud J (2009)	1
PRIM1	1	PRIM2	1	biochemical, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2017)	2
XPO1	8	POLD2	2	affinity chromatography technology	Kirli K (2015)	1
CIAO1	3	POLA1	0	affinity chromatography technology	Stehling O (2013)	1
POLA2	2	POLA1	0	pull down, biochemical, biochemical, biochemical	Collins KL (1993), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015)	4
MMS19	5	PRIM2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Stehling O (2012), Gari K (2012), Gari K (2012)	3
DDX24	1	POLA2	2	two hybrid	Stelzl U (2005)	1
POLA2	2	HEXIM1	1	biochemical	Kristensen AR (2012)	1
CAPN1	3	POLA2	2	affinity chromatography technology	Hein MY (2015)	1
SETDB1	3	POU5F1	0	affinity chromatography technology, affinity chromatography technology	Yuan P (2009), Yuan P (2009)	2
FRZB	2	POLA2	2	two hybrid	Vinayagam A (2011)	1
KLF6	0	APP	1	pull down	Olah J (2011)	1
LRRC27	5	POLA2	2	affinity chromatography technology	Huttlin EL (2017)	1
UBE2O	5	POLA2	2	biochemical	Kristensen AR (2012)	1
EIF6	2	CAPN1	3	biochemical	Kristensen AR (2012)	1
CPE	2	POLA2	2	two hybrid	Stelzl U (2005)	1
POLA2	2	SCYL1	5	biochemical	Wan C (2015)	1
XPO1	8	LGALS7	0	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	PRPF38A	3	affinity chromatography technology	Kirli K (2015)	1
RAE1	0	POLA2	2	affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015)	2
POLA2	2	POP7	2	biochemical	Kristensen AR (2012)	1
POLA2	2	EPB41L1	4	biochemical	Kristensen AR (2012)	1
XPO1	8	SCYL1	5	affinity chromatography technology	Kirli K (2015)	1
HEXIM1	1	UBE2O	5	affinity chromatography technology	Huttlin EL (2015)	1
CIAO1	3	POLA2	2	affinity chromatography technology	Stehling O (2013)	1
FGFR3	7	POLA2	2	two hybrid	Stelzl U (2005)	1
POU5F1	0	POLA2	2	affinity chromatography technology	Oliviero G (2015)	1
EIF6	2	POLA2	2	two hybrid	Stelzl U (2005)	1
ASCC2	3	POLA2	2	two hybrid	Stelzl U (2005)	1
ATP5C1	0	POLA2	2	two hybrid	Stelzl U (2005)	1
ULK2	0	POLA2	2	two hybrid	Stelzl U (2005)	1
EIF6	2	APP	1	pull down	Olah J (2011)	1
POLD2	2	POLA2	2	biochemical	Wan C (2015)	1
CIAO1	3	MMS19	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, two hybrid, affinity chromatography technology	Havugimana PC (2012), Stehling O (2012), Stehling O (2012), Lev I (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Gari K (2012), Gari K (2012), Huttlin EL (2015), Wan C (2015), Yu H (2011), Huttlin EL (2017)	14
XPO1	8	SNX21	2	affinity chromatography technology	Kirli K (2015)	1
TULP2	1	HDAC6	0	affinity chromatography technology	Huttlin EL (2017)	1
RAE1	0	PRIM2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Huttlin EL (2015), Huttlin EL (2017)	3
POU5F1	0	DDX24	1	affinity chromatography technology	Oliviero G (2015)	1
SSH3	3	APP	1	pull down	Olah J (2011)	1
XPO1	8	STN1	0	affinity chromatography technology	Kirli K (2015)	1
CRELD1	0	POLA2	2	two hybrid	Stelzl U (2005)	1